Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | No references |
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Bacillus anthracis | Anthrax lethal factor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Loa Loa (eye worm) | cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Brugia malayi | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Brugia malayi | Cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0925 | 0.208 |
Echinococcus multilocularis | thymidine phosphorylase | 0.0612 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0086 | 0.1153 | 0.1153 |
Onchocerca volvulus | 0.0068 | 0.0843 | 1 | |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0366 | 0.0535 |
Brugia malayi | follicle stimulating hormone receptor | 0.0282 | 0.4447 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.0797 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0367 | 0.0826 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0735 | 0.0735 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0062 | 0.0139 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.014 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0153 | 0.228 | 0.4975 |
Brugia malayi | hypothetical protein | 0.0242 | 0.3781 | 0.8457 |
Echinococcus multilocularis | muscleblind protein | 0.0153 | 0.228 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1114 | 0.2504 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 0.3781 | 0.3781 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.014 | 0.5 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0282 | 0.4447 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0095 | 0.0095 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0882 | 0.3359 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.014 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0165 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.228 | 0.5128 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.014 | 0.5 |
Echinococcus granulosus | jun protein | 0.0086 | 0.1153 | 0.1153 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 0.3781 | 0.3781 |
Brugia malayi | hypothetical protein | 0.0026 | 0.014 | 0.0012 |
Echinococcus granulosus | geminin | 0.0174 | 0.2626 | 0.2626 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0086 | 0.1153 | 0.1153 |
Echinococcus granulosus | muscleblind protein | 0.0153 | 0.228 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.228 | 0.5128 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0537 | 0.2046 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0165 | 0.0372 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.014 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.0612 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0735 | 0.0735 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0537 | 0.0932 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0043 | 0.0166 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0441 | 0.0992 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1763 | 0.3966 |
Brugia malayi | bZIP transcription factor family protein | 0.0086 | 0.1153 | 0.2361 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1763 | 0.3966 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0043 | 0.0043 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1763 | 0.3776 |
Echinococcus multilocularis | geminin | 0.0174 | 0.2626 | 0.2626 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0011 | 0.0024 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0325 | 0.0325 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0325 | 0.0325 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0153 | 0.228 | 0.228 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.2626 | 1 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0043 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0062 | 0.0235 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.014 | 0.0316 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0537 | 0.2046 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.3781 | 0.8504 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.2626 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0095 | 0.036 |
Brugia malayi | hypothetical protein | 0.0068 | 0.0843 | 0.164 |
Schistosoma mansoni | jun-related protein | 0.007 | 0.0882 | 0.3359 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0173 | 0.2612 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0086 | 0.1153 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0408 | 0.0918 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.014 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.0999 | 0.2002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (ADMET) | = 0.0126 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.