Detailed information for compound 1335686

Basic information

Technical information
  • TDR Targets ID: 1335686
  • Name: 1-[1-(phenylmethyl)indol-3-yl]propan-1-one
  • MW: 263.334 | Formula: C18H17NO
  • H donors: 0 H acceptors: 1 LogP: 3.75 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)c1cn(c2c1cccc2)Cc1ccccc1
  • InChi: 1S/C18H17NO/c1-2-18(20)16-13-19(12-14-8-4-3-5-9-14)17-11-7-6-10-15(16)17/h3-11,13H,2,12H2,1H3
  • InChiKey: RUTDSHNZPIVSLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[1-(phenylmethyl)-3-indolyl]propan-1-one
  • 1-[1-(benzyl)indol-3-yl]propan-1-one
  • 1-(1-Benzyl-1H-indol-3-yl)-propan-1-one
  • BAS 08197537
  • ZINC00560717
  • MLS000764732
  • SMR000290337

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0032 0.0157 0.1438
Onchocerca volvulus 0.0032 0.0157 0.1438
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0479 0.962
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0493 0.0727
Schistosoma mansoni hypothetical protein 0.0197 0.2205 0.325
Brugia malayi Cation transporter family protein 0.0059 0.0493 0.0493
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0032 0.0157 0.0231
Loa Loa (eye worm) hypothetical protein 0.0798 0.9663 0.9663
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0059 0.0493 0.0493
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0157 0.0157
Onchocerca volvulus Putative nachr subunit 0.0059 0.0493 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0059 0.0493 0.0727
Onchocerca volvulus 0.0059 0.0493 1
Schistosoma mansoni hypothetical protein 0.0041 0.0274 0.0404
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0493 0.0727
Loa Loa (eye worm) hypothetical protein 0.003 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0027 0.01 0.0148
Brugia malayi RNA binding protein 0.0076 0.0713 0.0713
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0059 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0059 0.0493 0.0493
Schistosoma mansoni lamin 0.003 0.0139 0.0205
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.035 0.411 0.6058
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0493 0.0727
Echinococcus granulosus intermediate filament protein 0.003 0.0139 0.0205
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0493 0.0727
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Brugia malayi hypothetical protein 0.0027 0.01 0.01
Schistosoma mansoni neurotransmitter gated ion channel 0.0027 0.01 0.0148
Schistosoma mansoni intermediate filament proteins 0.003 0.0139 0.0205
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0493 0.0727
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0479 0.0479
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0493 0.0727
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0066 0.0577 0.0577
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0157 0.0231
Schistosoma mansoni nAChR subunit 0.0027 0.01 0.0148
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0059 0.0493 0.0727
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Schistosoma mansoni nAChR subunit 0.0059 0.0493 0.0727
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0493 0.0493
Brugia malayi hypothetical protein 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.0493 0.0493
Schistosoma mansoni nAChR subunit 0.0027 0.01 0.0148
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0577 0.0851
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0577 0.0851
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0027 0.01 0.01
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Echinococcus granulosus tar DNA binding protein 0.0076 0.0713 0.1051
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0577 0.0851
Echinococcus granulosus geminin 0.0197 0.2205 0.325
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.2581 0.3804
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0493 0.0493
Entamoeba histolytica hypothetical protein 0.0032 0.0157 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0059 0.0493 0.0727
Onchocerca volvulus 0.003 0.0139 0.0982
Onchocerca volvulus 0.0059 0.0493 1
Schistosoma mansoni nAChR subunit 0.0059 0.0493 0.0727
Loa Loa (eye worm) hypothetical protein 0.003 0.0132 0.0132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0139 0.0139
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0027 0.01 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0493 0.0727
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.01 0.01
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.2581 0.3804
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0059 0.0493 0.0727
Echinococcus multilocularis geminin 0.0197 0.2205 0.325
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0493 0.0493
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0059 0.0493 0.0493
Echinococcus multilocularis lamin dm0 0.003 0.0139 0.0205
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0059 0.0493 0.0727
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0027 0.01 0.01
Onchocerca volvulus 0.0059 0.0493 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.1051
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0059 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Brugia malayi mbt repeat family protein 0.0058 0.0479 0.0479
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.0493 0.0727
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0479 0.0705
Echinococcus granulosus lamin dm0 0.003 0.0139 0.0205
Schistosoma mansoni hypothetical protein 0.0197 0.2205 0.325
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0479 0.0705
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Loa Loa (eye worm) MBCTL1 0.0066 0.0577 0.0577
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0139 0.0139
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0493 0.0727
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0027 0.01 0.0148
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0577 0.0577
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.006 0.0511 0.0511
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0059 0.0493 0.0727
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0059 0.0493 0.0727
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0479 0.0705
Brugia malayi Cation transporter family protein 0.0059 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Onchocerca volvulus 0.003 0.0139 0.0982
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0493 0.0727
Schistosoma mansoni lamin 0.003 0.0139 0.0205
Echinococcus multilocularis nAChR subunit 0.0032 0.0157 0.0231
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0713 0.1051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0493 0.0727
Brugia malayi map kinase activated protein kinase protein 2 0.0566 0.6784 0.6784
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0493 0.0727
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0493 0.0493
Loa Loa (eye worm) RNA binding protein 0.0076 0.0713 0.0713
Brugia malayi excitatory GABA receptor EXP-1A 0.0059 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0493 0.0727
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0511 0.0511
Loa Loa (eye worm) LGC-31 protein 0.0059 0.0493 0.0493
Brugia malayi hypothetical protein 0.0027 0.01 0.01
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0059 0.0493 0.0727
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0493 0.0727
Loa Loa (eye worm) acetylcholine receptor protein 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0825 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0493 0.0727
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0493 0.0727
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0493 0.0727
Brugia malayi TAR-binding protein 0.0076 0.0713 0.0713
Schistosoma mansoni nAChR subunit 0.0059 0.0493 0.0727
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0479 0.0705
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0511 0.0511
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0493 0.0493
Brugia malayi Cation transporter family protein 0.0059 0.0493 0.0493
Echinococcus granulosus nAChR subunit 0.0059 0.0493 0.0727
Brugia malayi hypothetical protein 0.0027 0.01 0.01
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0027 0.01 0.01
Schistosoma mansoni acetylcholine receptor-related 0.0027 0.01 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Echinococcus multilocularis lamin 0.003 0.0139 0.0205
Schistosoma mansoni nAChR subunit 0.0059 0.0493 0.0727
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0059 0.0493 0.0493
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0577 0.0851
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.1051
Brugia malayi mbt repeat family protein 0.0058 0.0479 0.0479
Schistosoma mansoni nAChR subunit 0.0059 0.0493 0.0727
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0059 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.1051
Loa Loa (eye worm) intermediate filament protein 0.003 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Schistosoma mansoni nAChR subunit 0.0059 0.0493 0.0727
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Schistosoma mansoni nAChR subunit 0.0059 0.0493 0.0727
Echinococcus granulosus lamin 0.003 0.0139 0.0205
Echinococcus multilocularis nAChR subunit 0.0059 0.0493 0.0727
Echinococcus multilocularis musashi 0.003 0.0139 0.0205
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0493 0.0493
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0027 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0027 0.01 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.0493
Onchocerca volvulus 0.0058 0.0479 0.962
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0059 0.0493 0.0493
Echinococcus granulosus nAChR subunit 0.0032 0.0157 0.0231
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0566 0.6784 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0059 0.0493 0.0727
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0059 0.0493 0.0493
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.1051
Loa Loa (eye worm) GABA receptor subunit 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0059 0.0493 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.0493 0.0727
Brugia malayi intermediate filament protein 0.003 0.0139 0.0139
Schistosoma mansoni neurotransmitter gated ion channel 0.0032 0.0157 0.0231
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0493 0.0727
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.1051
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0479 0.0705
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0493 0.0727
Schistosoma mansoni acetylcholine receptor subunit beta 0.0027 0.01 0.0148
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0713 0.0713
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0059 0.0493 0.0493
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0479 0.0705
Loa Loa (eye worm) hypothetical protein 0.0058 0.0479 0.0479
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0566 0.6784 1
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0479 0.0705
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0566 0.6784 0.6784
Schistosoma mansoni serine/threonine protein kinase 0.0566 0.6784 1
Onchocerca volvulus 0.0059 0.0493 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0493 0.0493
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0493 0.0493
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0059 0.0493 0.0727
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0027 0.01 0.0148
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0493 0.0493
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0493 0.0493
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.01
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0059 0.0493 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0059 0.0493 0.0493
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0577 0.0851
Brugia malayi hypothetical protein 0.0027 0.01 0.01
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0511 0.0511
Schistosoma mansoni neurotransmitter gated ion channel 0.0027 0.01 0.0148
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0493 0.0727
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0274 0.0274

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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