TDR Targets

Basic information

Technical information

TDR Targets ID: 1337529
Name: N-(4-ethoxyphenyl)-N-methyl-3-(6-morpholin-4- yl-[1,2,4]triazolo[5,4-f]pyridazin-3-yl)propa namide
MW: 410.47 | Formula: C21H26N6O3
H donors: 0 H acceptors: 4 LogP: 1.44 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)N(C(=O)CCc1nnc2n1nc(cc2)N1CCOCC1)C
InChi: 1S/C21H26N6O3/c1-3-30-17-6-4-16(5-7-17)25(2)21(28)11-10-19-23-22-18-8-9-20(24-27(18)19)26-12-14-29-15-13-26/h4-9H,3,10-15H2,1-2H3
InChiKey: SKCGISLMNCBMCU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-ethoxyphenyl)-N-methyl-3-(6-morpholino-[1,2,4]triazolo[5,4-f]pyridazin-3-yl)propanamide
N-(4-ethoxyphenyl)-N-methyl-3-(6-morpholino-[1,2,4]triazolo[5,4-f]pyridazin-3-yl)propionamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0045	0.0045
Onchocerca volvulus		0.001	0.0038	0.024
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.024
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0741	0.0741
Brugia malayi	steroid hormone receptor	0.001	0.0038	0.024
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0178	0.0178
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0038	0.024
Loa Loa (eye worm)	hypothetical protein	0.006	0.0593	0.3754
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0038	0.024
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0045	0.0286
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.4402	0.5074
Loa Loa (eye worm)	hypothetical protein	0.012	0.1252	0.7925
Echinococcus multilocularis	geminin	0.0167	0.178	0.178
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0178	0.1421
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0178	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.012	0.1252	0.7925
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0178	0.1421
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.012	0.1252	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0038	0.024
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0045	0.0052
Schistosoma mansoni	hypothetical protein	0.0167	0.178	0.178
Trypanosoma brucei	unspecified product	0.0019	0.0138	0.5152
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0137	0.0869
Schistosoma mansoni	hypothetical protein	0.0019	0.0137	0.0137
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0178	0.5
Plasmodium vivax	hypothetical protein, conserved	0.012	0.1252	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0138	0.0159
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Schistosoma mansoni	hypothetical protein	0.0404	0.4402	0.4402
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0138	0.4297
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0138	0.1098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0038	0.024
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0138	0.087
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0038	0.024
Echinococcus granulosus	dna polymerase eta	0.0019	0.0138	0.0159
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Brugia malayi	nuclear receptor NHR-88	0.001	0.0038	0.024
Echinococcus multilocularis	cpg binding protein	0.0037	0.0332	0.0332
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0038	0.0038
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.012	0.1252	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0038	0.0038
Entamoeba histolytica	hypothetical protein	0.0036	0.032	1
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0038	0.0038
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0038	0.0038
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0138	0.1098
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0138	0.1098
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0178	0.0205
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0038	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0178	0.1421
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0178	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.012	0.1252	0.7925
Trypanosoma brucei	unspecified product	0.0013	0.0072	0.2697
Leishmania major	UDP-galactopyranose mutase	0.012	0.1252	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0138	0.087
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0022	0.0022
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0072	0.2697
Echinococcus multilocularis	abhydrolase domain containing protein	0.0037	0.0341	0.0341
Trypanosoma cruzi	UDP-galactopyranose mutase	0.012	0.1252	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0038	0.0038
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0178	0.0178
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.032	0.032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0038	0.024
Leishmania major	DNA polymerase eta, putative	0.0019	0.0138	0.1098
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0138	0.5152
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0751
Trypanosoma brucei	unspecified product	0.0013	0.0072	0.2697
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0038	0.024
Echinococcus granulosus	cpg binding protein	0.0037	0.0332	0.0383
Echinococcus granulosus	lysine specific histone demethylase 1A	0.012	0.1252	0.1443
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0137	0.0869
Entamoeba histolytica	hypothetical protein	0.0036	0.032	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0138	0.0138
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0038	0.0044
Echinococcus granulosus	GPCR family 2	0.0019	0.0137	0.0158
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0138	0.0138
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0038	0.0038
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0038	0.0044
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0038	0.024
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.032	0.032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0038	0.024
Loa Loa (eye worm)	hydrolase	0.0037	0.0341	0.2156
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0138	0.5152
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0138	0.7731
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0038	0.0044
Schistosoma mansoni	hydrolase	0.0037	0.0341	0.0341
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0138	0.087
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0044	0.0276
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0138	0.5152
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0138	0.0138
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0751
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.012	0.1252	0.7925
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0022	0.0022
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.091	1	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0137	0.0137
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.012	0.1252	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.1252	0.7925
Schistosoma mansoni	cpg binding protein	0.0037	0.0332	0.0332
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0038	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0149	0.158	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0038	0.0038
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0138	0.0138
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.4402	0.4402
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0038	0.024
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0137	0.0137
Onchocerca volvulus		0.012	0.1252	0.7925
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0122	0.1275	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.024
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0038	0.0044
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0038	0.0038
Schistosoma mansoni	ap endonuclease	0.0023	0.0178	0.0178
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0038	0.0038
Brugia malayi	SWIRM domain containing protein	0.012	0.1252	0.7925
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0038	0.024
Loa Loa (eye worm)	hypothetical protein	0.012	0.1252	0.7925
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0038	0.0038
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0138	0.0159
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0138	0.0138
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0138	0.1098
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0038	0.024
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0138	0.087
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0031	0.0267	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0022	0.0025
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0593	0.3754
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.031	0.1965
Onchocerca volvulus		0.0014	0.0085	0.054
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0038	0.024
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0382	0.2419
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0178	0.1126
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0137	0.0869
Plasmodium falciparum	epoxide hydrolase 1	0.0037	0.0341	0.272
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.024
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.024
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0751
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Brugia malayi	ecdysteroid receptor	0.001	0.0038	0.024
Brugia malayi	hypothetical protein	0.0036	0.032	0.2026
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0178	0.0205
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0038	0.024
Brugia malayi	CXXC zinc finger family protein	0.0035	0.031	0.1965
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0038	0.0038
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0178	0.6664
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0038	0.0038
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.032	0.0369
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0038	0.024
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.012	0.1252	0.1252
Onchocerca volvulus		0.0035	0.031	0.1965
Schistosoma mansoni	hypothetical protein	0.0036	0.032	0.032
Mycobacterium ulcerans	monoamine oxidase	0.012	0.1252	0.1252
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0138	0.0138
Schistosoma mansoni	hypothetical protein	0.0019	0.0137	0.0137
Schistosoma mansoni	ap endonuclease	0.0023	0.0178	0.0178
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0137	0.0158
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0038	0.024
Entamoeba histolytica	hypothetical protein	0.0036	0.032	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0178	0.1421
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0138	0.1098
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0178	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0751
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.012	0.1252	1
Echinococcus granulosus	abhydrolase domain containing protein	0.0037	0.0341	0.0393
Mycobacterium tuberculosis	Conserved hypothetical protein	0.012	0.1252	0.1443
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0038	0.024
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.024
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.012	0.1252	0.1252
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0178	0.1126
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0138	0.1098
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0038	0.0044
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0038	0.0044
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0038	0.024
Plasmodium falciparum	protoporphyrinogen oxidase	0.012	0.1252	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0149	0.158	1
Schistosoma mansoni	microtubule-associated protein tau	0.0682	0.7477	0.7477
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0038	0.024
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0038	0.024
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0137	0.0158
Echinococcus granulosus	geminin	0.0167	0.178	0.2052
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0138	0.1098
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.024
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Brugia malayi	hydrolase, alpha/beta fold family protein	0.0037	0.0341	0.2156
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0137	0.0137
Schistosoma mansoni	amine oxidase	0.012	0.1252	0.1252
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0178	0.5
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0178	0.5558
Brugia malayi	nuclear hormone receptor	0.001	0.0038	0.024
Loa Loa (eye worm)	hypothetical protein	0.012	0.1252	0.7925
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0072	0.2697
Schistosoma mansoni	coup transcription factor	0.001	0.0038	0.0038
Schistosoma mansoni	amine oxidase	0.012	0.1252	0.1252
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0013	0.0751
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0178	0.1421
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0038	0.024
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0382	0.2419
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0593	0.3754
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0654	0.5128
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0138	0.7731
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0038	0.024
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0138	0.0159
Mycobacterium tuberculosis	Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO)	0.079	0.8675	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.024
Schistosoma mansoni	cpg binding protein	0.0037	0.0332	0.0332
Toxoplasma gondii	histone lysine-specific demethylase	0.012	0.1252	0.9816
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0038	0.0038
Brugia malayi	hypothetical protein	0.012	0.1252	0.7925
Mycobacterium ulcerans	dehydrogenase	0.012	0.1252	0.1252
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0593	0.3754
Schistosoma mansoni	hypothetical protein	0.0019	0.0137	0.0137
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0038	0.0038
Onchocerca volvulus		0.0149	0.158	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0751
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0138	0.5152
Mycobacterium tuberculosis	Possible oxidoreductase	0.012	0.1252	0.1443
Leishmania major	hypothetical protein, conserved	0.0037	0.0341	0.272
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0137	0.0869
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0038	0.024
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0751
Mycobacterium ulcerans	oxidoreductase	0.012	0.1252	0.1252
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Entamoeba histolytica	hypothetical protein	0.0036	0.032	1
Onchocerca volvulus		0.0031	0.0267	0.1689
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0138	0.0138
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0138	0.7731
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0072	0.2697
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0137	0.0137
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0038	0.0038
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0013	0.0751
Trichomonas vaginalis	helicase, putative	0.0008	0.0013	0.0751
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0038	0.024
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0038	0.024
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0038	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0138	0.5152
Schistosoma mansoni	hypothetical protein	0.0167	0.178	0.178
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0138	0.0138
Toxoplasma gondii	exonuclease III APE	0.0023	0.0178	0.1395
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0038	0.024
Echinococcus multilocularis	microtubule associated protein 2	0.0682	0.7477	0.7477
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.024
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0038	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.091	1	1
Echinococcus granulosus	microtubule associated protein 2	0.0682	0.7477	0.8619
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0022	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0751
Schistosoma mansoni	hypothetical protein	0.0041	0.0382	0.0382
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.091	1	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.012	0.1252	0.1443
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.012	0.1252	0.1252
Echinococcus multilocularis	protoporphyrinogen oxidase	0.091	1	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.012	0.1252	0.1252
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0138	0.0159
Trypanosoma cruzi	UDP-galactopyranose mutase	0.012	0.1252	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0038	0.0044
Echinococcus granulosus	protoporphyrinogen oxidase	0.079	0.8675	1
Plasmodium vivax	hypothetical protein, conserved	0.012	0.1252	1
Echinococcus multilocularis		0.012	0.1252	0.1252
Schistosoma mansoni	cpg binding protein	0.0035	0.031	0.031

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0024 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1428893

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1337529