Detailed information for compound 1348676

Basic information

Technical information
  • TDR Targets ID: 1348676
  • Name: 1,3-dimethyl-N-[3-(3-methylpiperidin-1-yl)-3- oxopropyl]-2,4-dioxoquinazoline-6-sulfonamide
  • MW: 422.499 | Formula: C19H26N4O5S
  • H donors: 1 H acceptors: 5 LogP: 0.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCN(C1)C(=O)CCNS(=O)(=O)c1ccc2c(c1)c(=O)n(c(=O)n2C)C
  • InChi: 1S/C19H26N4O5S/c1-13-5-4-10-23(12-13)17(24)8-9-20-29(27,28)14-6-7-16-15(11-14)18(25)22(3)19(26)21(16)2/h6-7,11,13,20H,4-5,8-10,12H2,1-3H3
  • InChiKey: JFVFFFKVADFVBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-dimethyl-N-[3-(3-methyl-1-piperidyl)-3-oxo-propyl]-2,4-dioxo-quinazoline-6-sulfonamide
  • 1,3-dimethyl-N-[3-(3-methyl-1-piperidinyl)-3-oxopropyl]-2,4-dioxo-6-quinazolinesulfonamide
  • 2,4-diketo-N-[3-keto-3-(3-methyl-1-piperidyl)propyl]-1,3-dimethyl-quinazoline-6-sulfonamide
  • 1,3-dimethyl-N-[3-(3-methylpiperidin-1-yl)-3-oxo-propyl]-2,4-dioxo-quinazoline-6-sulfonamide
  • ChemDiv3_010312

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0115 0.0654 0.0615
Toxoplasma gondii AGC kinase 0.0098 0.0535 0.633
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0104 0.0579 0.6852
Schistosoma mansoni tyrosine kinase 0.0059 0.0263 0.0758
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0579 0.351
Schistosoma mansoni tyrosine kinase 0.0258 0.1668 0.4813
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0263 0.0758
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0055 0.0232 0.2743
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0055 0.0232 0.0669
Echinococcus granulosus geminin 0.0205 0.129 0.3721
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0139 0.0828 0.0789
Schistosoma mansoni hypothetical protein 0.0205 0.129 0.3721
Loa Loa (eye worm) gastrulation defective protein 1 0.0128 0.0751 0.0712
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0073 0.0032
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0142 0.0845 1
Schistosoma mansoni vam6/vps39 related 0.0055 0.0232 0.0669
Leishmania major protein kinase A catalytic subunit 0.0098 0.0535 0.633
Plasmodium vivax serine/threonine kinase-1, putative 0.0142 0.0845 1
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0309 0.0891
Onchocerca volvulus 0.0459 0.3085 0.8887
Brugia malayi SRC-1 0.0059 0.0263 0.0222
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0104 0.0579 0.054
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0066 0.0309 0.0891
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0066 0.0309 0.0557
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0535 0.2434
Loa Loa (eye worm) TK protein kinase 0.0049 0.0195 0.0154
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0513 0.3467 0.3439
Echinococcus granulosus tyrosine protein kinase HCK 0.004 0.0125 0.0361
Brugia malayi Protein kinase domain containing protein 0.0514 0.347 0.3442
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0579 0.1671
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0378 0.2515 0.2484
Plasmodium falciparum glycogen synthase kinase 3 0.0115 0.0654 0.7744
Echinococcus multilocularis cyclin dependent kinase 5 0.0104 0.0579 0.1044
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0083 0.0435 0.0395
Loa Loa (eye worm) TK/FAK protein kinase 0.0261 0.1689 0.1654
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0161 0.098 0.1767
Brugia malayi EGF-like domain containing protein 0.0028 0.0043 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0654 0.5349
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0196 0.1229 0.3545
Entamoeba histolytica cell division protein kinase 2, putative 0.0104 0.0579 0.2303
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0263 0.0473
Echinococcus multilocularis rho associated protein kinase 0.047 0.3162 0.5701
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0059 0.0263 0.0473
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0378 0.2515 0.4533
Onchocerca volvulus 0.0028 0.0042 0.0000072528
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0066 0.0309 0.0557
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0104 0.0579 0.1671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0236 0.0681
Echinococcus granulosus tyrosine kinase 0.0049 0.0195 0.0562
Echinococcus granulosus hypothetical protein 0.0131 0.0768 0.2216
Trypanosoma brucei protein kinase, putative 0.0115 0.0654 0.7744
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0098 0.0535 0.633
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0196 0.1229 0.1192
Schistosoma mansoni tyrosine kinase 0.003 0.006 0.0174
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.1543
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0535 0.1543
Echinococcus multilocularis dual specificity mitogen activated protein 0.0083 0.0435 0.0785
Plasmodium falciparum protein serine/threonine kinase-1 0.0142 0.0845 1
Schistosoma mansoni protein kinase 0.0083 0.0435 0.1256
Schistosoma mansoni tyrosine kinase 0.0151 0.0912 0.2632
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0654 0.5349
Onchocerca volvulus 0.0028 0.0042 0.0000072528
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0104 0.0579 0.054
Loa Loa (eye worm) AGC/PKA protein kinase 0.0098 0.0535 0.0495
Echinococcus multilocularis 0.0131 0.0768 0.1384
Loa Loa (eye worm) hypothetical protein 0.0093 0.0502 0.0462
Plasmodium falciparum protein kinase 5 0.0104 0.0579 0.6852
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0236 0.0426
Echinococcus granulosus CDC7 cell division cycle 7 0.0134 0.0791 0.2282
Trypanosoma cruzi cdc2-related kinase 1 0.0104 0.0579 0.6852
Loa Loa (eye worm) hypothetical protein 0.0475 0.3197 0.3168
Echinococcus granulosus cyclin dependent kinase 0.0104 0.0579 0.1671
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0104 0.0579 0.6852
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.1543
Loa Loa (eye worm) hypothetical protein 0.0098 0.0535 0.0495
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0098 0.0535 0.633
Echinococcus multilocularis tyrosine protein kinase Abl 0.003 0.006 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0309 0.0891
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0083 0.0435 0.515
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0083 0.0435 0.515
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0098 0.0535 0.633
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0104 0.0579 0.054
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0141 0.0841 0.0803
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0059 0.0263 0.0758
Echinococcus multilocularis CDC7 cell division cycle 7 0.0134 0.0791 0.1426
Brugia malayi cell division control protein 2 homolog 0.0104 0.0579 0.054
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0845 0.2438
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0185 0.115 0.3316
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0579 0.351
Onchocerca volvulus Slit protein homolog 0.0028 0.0043 0.0004
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0055 0.0232 0.2743
Brugia malayi Protein kinase domain containing protein 0.0261 0.1689 0.1654
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0513 0.3467 0.3439
Loa Loa (eye worm) hypothetical protein 0.0131 0.0768 0.0729
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0059 0.0263 0.0758
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0118 0.0341
Giardia lamblia Kinase, AGC PKA 0.0098 0.0535 0.2434
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0378 0.2515 0.7255
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0513 0.3467 0.6249
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.0654 0.2602
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0098 0.0535 0.633
Brugia malayi probable protein kinase 0.0196 0.1227 0.119
Echinococcus multilocularis tyrosine protein kinase Blk 0.0049 0.0195 0.0351
Echinococcus granulosus c src tyrosine kinase 0.003 0.006 0.0174
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0118 0.0213
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0066 0.0309 0.0891
Echinococcus multilocularis tyrosine protein kinase Srms 0.0049 0.0195 0.0351
Echinococcus granulosus tyrosine protein kinase Src42A 0.0059 0.0263 0.0758
Loa Loa (eye worm) hypothetical protein 0.0185 0.115 0.1112
Echinococcus granulosus cyclin dependent kinase 1 0.0104 0.0579 0.1671
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0115 0.0654 0.7744
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0066 0.0309 0.0891
Brugia malayi intracellular kinase 0.0115 0.0654 0.0615
Brugia malayi Protein kinase domain containing protein 0.0139 0.0828 0.0789
Schistosoma mansoni protein kinase 0.0066 0.0309 0.0891
Schistosoma mansoni hypothetical protein 0.0028 0.0042 0.0121
Echinococcus granulosus MAM 0.0028 0.0042 0.0121
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0845 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0049 0.0195 0.0562
Echinococcus multilocularis cyclin dependent kinase 19 0.0139 0.0828 0.1493
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0161 0.098 0.2828
Giardia lamblia Kinase, CMGC GSK 0.0115 0.0654 0.5349
Plasmodium vivax glycogen synthase kinase 3, putative 0.0115 0.0654 0.3852
Loa Loa (eye worm) CDC7 protein kinase 0.0134 0.0791 0.0752
Brugia malayi Protein kinase domain containing protein 0.0142 0.0845 0.0807
Echinococcus multilocularis MAM 0.0028 0.0042 0.0075
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0263 0.0473
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0115 0.0654 0.0615
Echinococcus granulosus tyrosine protein kinase Src64B 0.0059 0.0263 0.0758
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0142 0.0845 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0066 0.0309 0.0557
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0196 0.1229 0.2215
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0073 0.0032
Schistosoma mansoni protein kinase 0.0196 0.1227 0.3539
Echinococcus multilocularis 0.0141 0.0841 0.1517
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0049 0.0195 0.0562
Echinococcus granulosus slit 2 protein 0.0028 0.0043 0.0124
Echinococcus multilocularis geminin 0.0205 0.129 0.2325
Echinococcus granulosus dual specificity mitogen activated protein 0.0083 0.0435 0.1256
Echinococcus multilocularis c src tyrosine kinase 0.003 0.006 0.0109
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0263 0.0758
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0059 0.0263 0.0473
Plasmodium vivax protein kinase Crk2 0.0104 0.0579 0.1423
Brugia malayi Protein kinase domain containing protein 0.0104 0.0579 0.054
Brugia malayi Protein kinase domain containing protein 0.0134 0.0791 0.0752
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0236 0.0195
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0115 0.0654 0.118
Loa Loa (eye worm) hypothetical protein 0.0055 0.0232 0.0191
Echinococcus granulosus protein kinase 0.0141 0.0841 0.2427
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0115 0.0654 0.1888
Schistosoma mansoni hypothetical protein 0.0205 0.129 0.3721
Onchocerca volvulus 0.047 0.3162 0.9112
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0845 0.2438
Trypanosoma cruzi cdc2-related kinase 1 0.0104 0.0579 0.6852
Entamoeba histolytica cell division protein kinase 2, putative 0.0104 0.0579 0.2303
Schistosoma mansoni tyrosine kinase 0.0059 0.0263 0.0758
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0083 0.0435 0.0395
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.1229 0.3545
Echinococcus multilocularis cyclin dependent kinase 0.0104 0.0579 0.1044
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0066 0.0309 0.0268
Brugia malayi Tyrosine-protein kinase abl-1 0.003 0.006 0.0019
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.006 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0236 0.0681
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0236 0.0426
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0098 0.0535 0.633
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.0964
Onchocerca volvulus 0.0115 0.0654 0.1789
Loa Loa (eye worm) TK protein kinase 0.004 0.0125 0.0084
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0104 0.0579 0.6852
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.0964
Leishmania major protein kinase A catalytic subunit isoform 1 0.0098 0.0535 0.633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0236 0.0681
Schistosoma mansoni hypothetical protein 0.0028 0.0042 0.0121
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.0545 0.2165
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0579 0.351
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0087 0.0458 0.1321
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.1543
Brugia malayi hypothetical protein 0.0055 0.0232 0.0191
Echinococcus multilocularis death associated protein kinase 1 0.0808 0.5548 1
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0791 0.8683
Giardia lamblia Kinase, CDC7 0.0134 0.0791 0.8683
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1439 1 1
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0055 0.0232 0.0669
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0055 0.0232 0.2743
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0142 0.0845 0.0807
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0791 0.2282
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0263 0.0758
Echinococcus granulosus protein tyrosine kinase 0.0258 0.1668 0.4813
Trypanosoma cruzi cdc2-related kinase 3 0.0104 0.0579 0.6852
Entamoeba histolytica protein kinase domain containing protein 0.0378 0.2515 1
Brugia malayi Protein kinase domain containing protein 0.0066 0.0309 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0579 0.1671
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.0545 0.2165
Brugia malayi Temporarily assigned gene name protein 59 0.0055 0.0232 0.0191
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0115 0.0654 0.7744
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.0964
Schistosoma mansoni hypothetical protein 0.0055 0.0232 0.0669
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0236 0.0195
Schistosoma mansoni protein kinase 0.0141 0.0841 0.2427
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0828 0.2388
Loa Loa (eye worm) SRC-1 0.0059 0.0263 0.0222
Echinococcus multilocularis slit 2 protein 0.0028 0.0043 0.0078
Echinococcus multilocularis cyclin dependent kinase 1 0.0104 0.0579 0.1044
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0115 0.0654 0.7744
Echinococcus multilocularis tyrosine protein kinase HCK 0.004 0.0125 0.0226
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0142 0.0845 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0098 0.0535 0.0495
Onchocerca volvulus 0.0134 0.0791 0.2188
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0059 0.0263 0.0473
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.2515 0.7255
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0513 0.3467 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.0654 0.2602
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0535 0.1543
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0001
Brugia malayi Protein kinase domain containing protein 0.0513 0.3467 0.3439
Brugia malayi hypothetical protein 0.0196 0.1229 0.1192
Brugia malayi Serine/threonine-protein kinase SULU 0.0196 0.1229 0.1192
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0115 0.0654 0.1888
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0059 0.0263 0.0473
Echinococcus granulosus dual specificity protein kinase clk2 0.0142 0.0845 0.2438
Giardia lamblia Kinase, CMGC GSK 0.0115 0.0654 0.5349
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0098 0.0535 0.633
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0142 0.0845 1
Schistosoma mansoni tyrosine kinase 0.003 0.006 0.0174
Schistosoma mansoni rap gtpase-activating protein 0.0055 0.0232 0.0669
Onchocerca volvulus 0.0134 0.0791 0.2188
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0098 0.0535 0.0495
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0195 0.0351
Trypanosoma cruzi cdc2-related kinase 3 0.0104 0.0579 0.6852
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0059 0.0263 0.0473
Giardia lamblia Kinase, CMGC CDK 0.0104 0.0579 0.351
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0142 0.0845 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0098 0.0535 0.633
Echinococcus granulosus rho-associated protein kinase 1 0.047 0.3162 0.9123
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0535 0.1543
Echinococcus granulosus twitchin 0.0023 0.0008 0.0022
Entamoeba histolytica protein kinase, putative 0.0115 0.0654 0.2602
Trypanosoma brucei cdc2-related kinase 1 0.0104 0.0579 0.6852
Schistosoma mansoni serine/threonine protein kinase 0.0513 0.3467 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0232 0.0191
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.0964
Echinococcus granulosus tyrosine protein kinase Lyn 0.007 0.034 0.098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0236 0.0681
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0513 0.3467 0.3439
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0087 0.0458 0.0825
Echinococcus multilocularis dual specificity protein kinase clk2 0.0142 0.0845 0.1523
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0055 0.0232 0.0669
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0378 0.2515 0.2484
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0142 0.0845 1
Echinococcus granulosus cyclin dependent kinase 5 0.0104 0.0579 0.1671
Brugia malayi protein-tyrosine kinase 0.0049 0.0195 0.0154
Echinococcus multilocularis cyclin dependent kinase 1 0.0104 0.0579 0.1044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0236 0.0681
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0098 0.0535 0.633
Loa Loa (eye worm) TK/ALK protein kinase 0.0513 0.3469 0.3441
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0055 0.0232 0.0418
Toxoplasma gondii AGC kinase 0.0098 0.0535 0.633
Giardia lamblia Kinase, CMGC CDK 0.0104 0.0579 0.351
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0142 0.0845 1
Echinococcus granulosus protein kinase shaggy 0.0115 0.0654 0.1888
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0263 0.0473
Echinococcus multilocularis protein tyrosine kinase 0.0258 0.1668 0.3007
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0098 0.0535 0.633
Echinococcus multilocularis protein kinase shaggy 0.0115 0.0654 0.118
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0791 0.8683
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0513 0.3467 1
Leishmania major protein kinase, putative 0.0142 0.0845 1
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0083 0.0435 0.515
Echinococcus granulosus Vam6:Vps39 protein 0.0055 0.0232 0.0669
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0059 0.0263 0.0473
Schistosoma mansoni serine/threonine protein kinase 0.047 0.3162 0.9123
Leishmania major protein kinase, putative 0.0142 0.0845 1
Trypanosoma brucei cdc2-related kinase 3 0.0104 0.0579 0.6852
Entamoeba histolytica protein kinase, putative 0.004 0.0125 0.0497
Onchocerca volvulus 0.0055 0.0232 0.0555
Giardia lamblia Kinase, CMGC CLK 0.0142 0.0845 1
Leishmania major protein kinase A catalytic subunit isoform 2 0.0098 0.0535 0.633
Echinococcus granulosus cyclin dependent kinase 19 0.0139 0.0828 0.2388
Loa Loa (eye worm) hypothetical protein 0.0055 0.0232 0.0191
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0791 0.8683

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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