TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 313.378 | Formula: C15H15N5OS
H donors: 0 H acceptors: 3 LogP: 2.2 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCn1c(S)nnc1c1nn(ccc1=O)c1ccc(cc1)C
InChi: 1S/C15H15N5OS/c1-3-19-14(16-17-15(19)22)13-12(21)8-9-20(18-13)11-6-4-10(2)5-7-11/h4-9H,3H2,1-2H3,(H,17,22)
InChiKey: DEHRBVPGHLIAFC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4E	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	huntingtin	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Leishmania major	cathepsin L-like protease	0.007	0.1119	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0114	0.2522	0.4629
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0656	0.0656
Echinococcus granulosus	cathepsin l1	0.0047	0.0382	0.0382
Echinococcus multilocularis	cathepsin L cysteine protease	0.007	0.1119	0.1105
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0382	0.0367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Onchocerca volvulus		0.0036	0.0042	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0036	0.0038	0.0023
Toxoplasma gondii	phosphotransferase enzyme family protein	0.0348	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0656	0.0641
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Brugia malayi	Pre-SET motif family protein	0.0251	0.6924	0.6919
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0656	0.1182
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Loa Loa (eye worm)	choline/ethanolamine kinase	0.0348	1	1
Plasmodium falciparum	choline kinase	0.0348	1	1
Onchocerca volvulus		0.0286	0.8034	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0042	0.005
Entamoeba histolytica	cysteine proteinase, putative	0.007	0.1119	1
Leishmania major	cathepsin L-like protease	0.007	0.1119	0.5
Echinococcus granulosus	lysine specific demethylase 5A	0.0114	0.2522	0.2522
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0047	0.0382	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0656	0.1182
Onchocerca volvulus		0.007	0.1119	0.1377
Loa Loa (eye worm)	hypothetical protein	0.0148	0.3619	0.3609
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.1119	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.007	0.1119	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0148	0.3619	0.3609
Leishmania major	cathepsin L-like protease	0.007	0.1119	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.007	0.1119	0.2038
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0382	0.0367
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0042	0.005
Brugia malayi	Cathepsin L-like precursor	0.007	0.1119	0.1105
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0114	0.2522	0.4629
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.007	0.1119	0.1352
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0382	0.3182
Loa Loa (eye worm)	jmjC domain-containing protein	0.0114	0.2522	0.2511
Loa Loa (eye worm)	fibroinase	0.007	0.1119	0.1105
Echinococcus granulosus	cathepsin L cysteine proteinase	0.007	0.1119	0.1119
Brugia malayi	jmjC domain containing protein	0.0114	0.2522	0.2511
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Onchocerca volvulus	Cathepsin F homolog	0.007	0.1119	0.1377
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0042	0.005
Onchocerca volvulus	Huntingtin homolog	0.0148	0.3619	0.4494
Echinococcus granulosus	cathepsin L	0.0036	0.0038	0.0038
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0042	0.0042
Onchocerca volvulus		0.007	0.1119	0.1377
Onchocerca volvulus		0.0047	0.0382	0.0457
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0042	0.0027
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.007	0.1119	0.1105
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0015	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Echinococcus granulosus	cysteine protease	0.0036	0.0038	0.0038
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0186	0.4846	0.4846
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Loa Loa (eye worm)	ctsf protein	0.007	0.1119	0.1105
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0047	0.0382	0.0367
Brugia malayi	Cathepsin L-like precursor	0.007	0.1119	0.1105
Onchocerca volvulus	Huntingtin homolog	0.0148	0.3619	0.4494
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0382	0.0367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.007	0.1119	0.1352
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0456	0.0441
Brugia malayi	Cathepsin L-like precursor	0.007	0.1119	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0042	0.0027
Onchocerca volvulus		0.007	0.1119	0.1377
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.1119	1
Giardia lamblia	PHD finger protein 15	0.0035	0.0015	0.5
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1425	0.1412
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0382	0.0367
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0042	0.0027
Plasmodium vivax	vivapain-2	0.007	0.1119	0.1105
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.6924	0.6919
Brugia malayi	jmjC domain containing protein	0.0186	0.4846	0.4838
Echinococcus multilocularis	cysteine protease	0.007	0.1119	0.1105
Brugia malayi	Papain family cysteine protease containing protein	0.007	0.1119	0.1105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Plasmodium vivax	vivapain-3	0.0036	0.0038	0.0023
Plasmodium vivax	vivapain-2	0.007	0.1119	0.1105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.8034	1
Echinococcus granulosus	cathepsin l1	0.007	0.1119	0.1119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Onchocerca volvulus		0.007	0.1119	0.1377
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0038	0.0042
Trypanosoma cruzi	cruzipain precursor, putative	0.007	0.1119	1
Brugia malayi	cathepsin L-like precursor	0.0047	0.0382	0.0367
Echinococcus multilocularis	cathepsin L	0.0036	0.0038	0.0023
Echinococcus multilocularis	geminin	0.0205	0.5431	0.5424
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.007	0.1119	0.1105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Echinococcus granulosus	geminin	0.0205	0.5431	0.5431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Echinococcus multilocularis	choline:ethanolamine kinase	0.0348	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1119	0.1105
Brugia malayi	hypothetical protein	0.0148	0.3619	0.3609
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0656	0.0641
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Brugia malayi	Cathepsin L-like precursor	0.007	0.1119	0.1105
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.007	0.1119	0.1105
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0656	0.0641
Brugia malayi	Cathepsin L-like precursor	0.007	0.1119	0.1105
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0656	0.0641
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Leishmania major	cathepsin L-like protease	0.007	0.1119	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0042	0.005
Brugia malayi	Pre-SET motif family protein	0.0036	0.0042	0.0027
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.007	0.1119	0.1105
Plasmodium vivax	SET domain protein, putative	0.0036	0.0042	0.0027
Onchocerca volvulus		0.007	0.1119	0.1377
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.007	0.1119	0.1105
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.007	0.1119	0.1105
Plasmodium vivax	unspecified product	0.0036	0.0038	0.0023
Schistosoma mansoni	cathepsin F (C01 family)	0.007	0.1119	0.2038
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.1119	1
Schistosoma mansoni	jumonji domain containing protein	0.0163	0.4089	0.7521
Brugia malayi	Cathepsin L-like precursor	0.007	0.1119	0.1105
Entamoeba histolytica	cysteine proteinase, putative	0.007	0.1119	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0186	0.4846	0.4838
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0382	0.0367
Echinococcus granulosus	cathepsin l cysteine peptidase	0.007	0.1119	0.1119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Onchocerca volvulus		0.007	0.1119	0.1377
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0382	0.0677
Schistosoma mansoni	hypothetical protein	0.0205	0.5431	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.1119	0.1352
Plasmodium vivax	choline kinase, putative	0.0348	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.1214	0.12
Leishmania major	cathepsin L-like protease	0.007	0.1119	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0038	0.0023
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0038	0.0042
Leishmania major	cathepsin L-like protease	0.007	0.1119	0.5
Loa Loa (eye worm)	cysteine protease	0.007	0.1119	0.1105
Echinococcus granulosus	choline:ethanolamine kinase	0.0348	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.007	0.1119	0.1105
Echinococcus granulosus	peregrin	0.0035	0.0015	0.0015
Leishmania major	cathepsin L-like protease	0.007	0.1119	0.5
Leishmania major	cathepsin L-like protease	0.007	0.1119	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0656	0.1182
Echinococcus granulosus	cathepsin L cysteine protease	0.0036	0.0038	0.0038
Onchocerca volvulus	Cathepsin L homolog	0.007	0.1119	0.1377
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0038	0.0042
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0042	0.0027
Plasmodium vivax	vivapain-1	0.0036	0.0038	0.0023
Echinococcus multilocularis	lysine specific demethylase 5A	0.0114	0.2522	0.2511
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0038	0.0023
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0656	0.0656
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0382	0.043
Leishmania major	cysteine peptidase A (CPA)	0.007	0.1119	0.5
Toxoplasma gondii	cathepsin CPL	0.007	0.1119	0.1105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.1119	0.1352
Schistosoma mansoni	hypothetical protein	0.0205	0.5431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0382	0.043
Echinococcus multilocularis	cysteine protease	0.007	0.1119	0.1105
Entamoeba histolytica	cysteine protease, putative	0.007	0.1119	1
Onchocerca volvulus		0.007	0.1119	0.1377
Onchocerca volvulus	Cathepsin L homolog	0.007	0.1119	0.1377
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.1119	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.636 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1479793

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1359312