Detailed information for compound 135938

Basic information

Technical information
  • TDR Targets ID: 135938
  • Name: 2-(2-sulfanylidene-1,3-dihydroindol-3-yl)acet ic acid
  • MW: 207.249 | Formula: C10H9NO2S
  • H donors: 1 H acceptors: 2 LogP: 1.13 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CC1C(=Nc2c1cccc2)S
  • InChi: 1S/C10H9NO2S/c12-9(13)5-7-6-3-1-2-4-8(6)11-10(7)14/h1-4,7H,5H2,(H,11,14)(H,12,13)
  • InChiKey: KTIODNZPIYCZSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-thioxoindolin-3-yl)acetic acid
  • 2-(2-thioxo-3-indolinyl)acetic acid
  • 2-(2-sulfanylidene-1,3-dihydroindol-3-yl)ethanoic acid
  • 2-thioxo-1H-indole-3-alkanoic acid deriv. 5

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cpg binding protein 0.003 0.0236 0.0278
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0053 0.0053
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.032 0.0075
Schistosoma mansoni myosin xvIII 0.0016 0.0053 0.0062
Brugia malayi MH1 domain containing protein 0.0013 0.0024 0.0041
Echinococcus granulosus orexin receptor type 2 0.0016 0.0053 0.0062
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0294 0.8879
Schistosoma mansoni tyrosine kinase 0.0097 0.1072 0.1263
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0237 0.2742
Schistosoma mansoni cpg binding protein 0.003 0.0236 0.0278
Echinococcus granulosus serotonin receptor 0.0016 0.0053 0.0062
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0459 0.0801
Echinococcus multilocularis geminin 0.0352 0.4275 0.4275
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0237 0.028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.3814 1
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0053 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0237 0.028
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0318 0.5
Brugia malayi MH2 domain containing protein 0.0354 0.43 0.7502
Onchocerca volvulus Alhambra homolog 0.006 0.0606 0.1994
Schistosoma mansoni vesicular acetylcholine transporter 0.0226 0.2699 0.3179
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0053 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0053 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.1692 0.1994
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni cpg binding protein 0.003 0.0236 0.0278
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.09 0.09
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0053 0.0062
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni transcription factor btf3 0.0035 0.0294 0.0346
Echinococcus granulosus neuropeptide s receptor 0.0474 0.5808 0.6842
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.3814 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0039 0.0352 0.0415
Brugia malayi RE15519p 0.0016 0.0053 0.0092
Schistosoma mansoni hypothetical protein 0.002 0.0101 0.0119
Schistosoma mansoni tyrosine kinase 0.0058 0.0579 0.0682
Echinococcus granulosus allatostatin A receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0053 0.0053
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0053 0.0053
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0053 0.0053
Schistosoma mansoni histamine h1 receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis vesicular acetylcholine transporter 0.0226 0.2699 0.2699
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.1159 0.2022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Schistosoma mansoni amine GPCR 0.0016 0.0053 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0371 0.0371
Echinococcus multilocularis smad 0.0024 0.0159 0.0159
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.2119 0.2119
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.005 0.0487 0.0849
Treponema pallidum fructose-bisphosphate aldolase 0.0315 0.3814 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0784 0.1368
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0053 0.0062
Schistosoma mansoni adenoreceptor 0.0016 0.0053 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0053 0.0053
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0053 0.0053
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0606 0.0714
Brugia malayi jmjC domain containing protein 0.0019 0.0098 0.0171
Schistosoma mansoni jumonji domain containing protein 0.0155 0.1807 0.2129
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni tyrosine kinase 0.0096 0.1059 0.1248
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0053 0.0092
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0353 0.0615
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0053 0.0092
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0053 0.0062
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0053 0.0092
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0053 0.0092
Echinococcus multilocularis protein patched 0.0041 0.0371 0.0371
Echinococcus multilocularis sex peptide receptor 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.0501
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0528 0.0528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0053 0.0092
Schistosoma mansoni hypothetical protein 0.0048 0.0459 0.0541
Loa Loa (eye worm) hypothetical protein 0.0146 0.1692 0.2952
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0053 0.0062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0353 0.0416
Leishmania major basic transcription factor 3a, putative 0.0035 0.0294 0.8879
Echinococcus multilocularis expressed conserved protein 0.009 0.0983 0.0983
Plasmodium vivax SET domain protein, putative 0.003 0.0237 0.2742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0528 0.0622
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.1789 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0294 0.0512
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0101 0.0139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2467 0.4305
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0053 0.0062
Echinococcus multilocularis protein dispatched 1 0.0047 0.0443 0.0443
Brugia malayi neuropeptide F receptor 0.0016 0.0053 0.0092
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0053 0.0062
Brugia malayi sulfakinin receptor protein 0.0016 0.0053 0.0092
Brugia malayi Inositol-1 0.0037 0.0318 0.0555
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0053 0.0062
Schistosoma mansoni hypothetical protein 0.0048 0.0459 0.0541
Brugia malayi Pre-SET motif family protein 0.0208 0.2467 0.4305
Loa Loa (eye worm) hypothetical protein 0.0146 0.1692 0.2952
Brugia malayi larval opioid receptor 0.0016 0.0053 0.0092
Schistosoma mansoni hypothetical protein 0.0016 0.0053 0.0062
Echinococcus granulosus neuropeptide receptor 0.0016 0.0053 0.0062
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0053 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0352 0.4275 0.5036
Brugia malayi Smad1 0.0024 0.0159 0.0277
Echinococcus granulosus geminin 0.0352 0.4275 0.5036
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0459 0.0541
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0053 0.0092
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0053 0.0062
Schistosoma mansoni inositol monophosphatase 0.0037 0.0318 0.0375
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.0784 0.0924
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0294 0.3846
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.1404 0.245
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.8489 0.8489
Schistosoma mansoni amine GPCR 0.0016 0.0053 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0053 0.0062
Brugia malayi jmjC domain containing protein 0.0019 0.0098 0.0171
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0098 0.0098
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0159 0.0187
Schistosoma mansoni inositol monophosphatase 0.0037 0.0318 0.0375
Brugia malayi MH1 domain containing protein 0.0024 0.0159 0.0277
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0294 0.8879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0053 0.0053
Brugia malayi Dopamine receptor protein 1 0.0016 0.0053 0.0092
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0318 0.007
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0159 0.0187
Schistosoma mansoni tyrosine kinase 0.018 0.2119 0.2497
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Brugia malayi jmjC domain containing protein 0.0195 0.2312 0.4034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.3814 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0053 0.0062
Schistosoma mansoni biogenic amine receptor 0.0016 0.0053 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.3814 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0053 0.0062
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0294 0.3846
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0053 0.0062
Plasmodium vivax hypothetical protein, conserved 0.006 0.0606 1
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0101 0.006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0784 0.0924
Schistosoma mansoni smad1 5 8 and 0.0024 0.0159 0.0187
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0053 0.0092
Brugia malayi G protein-coupled receptor 0.0016 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni tyrosine kinase 0.0097 0.1072 0.1263
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni opsin-like receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0053 0.0053
Echinococcus multilocularis somatostatin receptor 0.0016 0.0053 0.0053
Schistosoma mansoni patched 1 0.0041 0.0371 0.0437
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1055 0.1243
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0053 0.0062
Brugia malayi MH2 domain containing protein 0.0024 0.0159 0.0277
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0119 0.0119
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0053 0.0062
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.5808 0.6842
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0159 0.0277
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0053 0.0062
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0318 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0053 0.0062
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1055 0.1841
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0053 0.0062
Brugia malayi Serotonin receptor 0.0016 0.0053 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0528 0.0622
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0053 0.0053
Schistosoma mansoni smad1 5 8 and 0.0024 0.0159 0.0187
Schistosoma mansoni hypothetical protein 0.0016 0.0053 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0053 0.0053
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis GPCR, family 2 0.0048 0.0459 0.0459
Schistosoma mansoni smad1 5 8 and 0.0024 0.0159 0.0187
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus granulosus peregrin 0.006 0.0606 0.0714
Echinococcus granulosus g protein coupled receptor 0.0016 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni hypothetical protein 0.0039 0.0352 0.0415
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.3814 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0764 0.0764
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0053 0.0062
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0371 0.0437
Echinococcus multilocularis serotonin receptor 0.0146 0.1692 0.1692
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0104 0.1159 0.2022
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.006 0.0606 0.0714
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0632 0.0744
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.2119 0.3697
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0579 0.0579
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0398 0.0469
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0053 0.0062
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0101 0.006
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0606 0.1057
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0053 0.0053
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1055 0.2164
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0318 0.007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0459 0.0459
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0102 0.1142 0.1992
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0053 0.0062
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0318 0.007
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1074 0.1265
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0053 0.0053
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0159 0.0277
Echinococcus granulosus g protein coupled receptor 0.0016 0.0053 0.0062
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0053 0.0062
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0225 0.0392
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0053 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0459 0.0459
Schistosoma mansoni hypothetical protein 0.0352 0.4275 0.5036
Schistosoma mansoni hypothetical protein 0.0104 0.1159 0.1365
Brugia malayi beta-NAC-like protein 0.0035 0.0294 0.0512
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0318 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0579 0.1011
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0098 0.0098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0551 0.8907
Echinococcus granulosus transcription factor btf3 0.0035 0.0294 0.0346
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0784 0.0924
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.2119 0.3697
Schistosoma mansoni tyrosine kinase 0.0058 0.0579 0.0682
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis serotonin receptor 0.0146 0.1692 0.1692
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0123 0.0491
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0053 0.0053
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0053 0.0053
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0053 0.0053
Echinococcus granulosus smad 0.0024 0.0159 0.0187
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2827 0.7197
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0053 0.0053
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0119 0.014
Brugia malayi CXXC zinc finger family protein 0.0029 0.0215 0.0376
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0053 0.0092
Onchocerca volvulus 0.0029 0.0215 0.0585
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0237 0.0237
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0053 0.0062
Schistosoma mansoni hypothetical protein 0.0048 0.0459 0.0541
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0398 0.0469
Brugia malayi G-protein coupled receptor 0.0016 0.0053 0.0092
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0318 0.0318
Brugia malayi GnHR receptor homolog 0.0016 0.0053 0.0092
Brugia malayi Protein kinase domain containing protein 0.0058 0.0579 0.1011
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0053 0.0053
Schistosoma mansoni biogenic amine receptor 0.0016 0.0053 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.43 0.7502
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0053 0.0053
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0098 0.0116
Onchocerca volvulus 0.003 0.0237 0.0665
Echinococcus multilocularis transcription factor btf3 0.0035 0.0294 0.0294
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0294 0.3846
Schistosoma mansoni tyrosine kinase 0.0096 0.1059 0.1248
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.1072 0.1072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0053 0.0053
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0053 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Schistosoma mansoni neuropeptide receptor 0.0016 0.0053 0.0062
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0098 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0053 0.0062
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0098 0.0116
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0171
Loa Loa (eye worm) Smad1 0.0024 0.0159 0.0277
Echinococcus granulosus expressed conserved protein 0.009 0.0983 0.1158
Echinococcus multilocularis 0.0056 0.0557 0.0557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0237 0.028
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.8489 1
Schistosoma mansoni tyrosine kinase 0.0096 0.1059 0.1248
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0098 0.0116
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0053 0.0062
Brugia malayi AKH receptor 0.0016 0.0053 0.0092
Brugia malayi neuropeptide F receptor 0.0016 0.0053 0.0092
Brugia malayi Serotonin receptor 0.0016 0.0053 0.0092
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0215 0.0376
Loa Loa (eye worm) inositol-1 0.0037 0.0318 0.0555
Schistosoma mansoni hypothetical protein 0.0016 0.0053 0.0062
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0318 0.007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0159 0.0159
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0101 0.0139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0528 0.0922
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0053 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0204 0.0241
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0053 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0237 0.028
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.5808 0.5808
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0098 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0053 0.0053
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.3814 1
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0098 0.0116
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0098 0.0171
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Brugia malayi Pre-SET motif family protein 0.003 0.0237 0.0414
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0053 0.0092
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0053 0.0062
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0468 0.5732 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0353 0.0615
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.1762 0.3074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus granulosus phd:f box containing protein 0.0019 0.0098 0.0116
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0053 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0053 0.0062
Brugia malayi Dopamine receptor 0.0016 0.0053 0.0092
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0226 0.2699 0.4708
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.1789 1
Brugia malayi MH1 domain containing protein 0.0013 0.0024 0.0041
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.4973 0.4973
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0053 0.0053
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.1762 0.3074
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0159 0.0159
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0053 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0195 0.2312 0.2312
Brugia malayi ORL1-like opioid receptor 0.0016 0.0053 0.0092
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0606 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Brugia malayi Bromodomain containing protein 0.006 0.0606 0.1057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.5808 0.5808
Schistosoma mansoni smad 0.0024 0.0159 0.0187
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0053 0.0062
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0098 0.0171
Echinococcus granulosus g protein coupled receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis peregrin 0.006 0.0606 0.0606
Echinococcus granulosus vesicular acetylcholine transporter 0.0226 0.2699 0.3179
Giardia lamblia Fructose-bisphosphate aldolase 0.0315 0.3814 1
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni amine GPCR 0.0016 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.3814 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis Smad4 0.0024 0.0159 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.3814 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.1692 0.1994
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus granulosus GPCR family 2 0.0048 0.0459 0.0541
Echinococcus granulosus jumonji domain containing protein 0.0083 0.09 0.106
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0053 0.0062
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Echinococcus granulosus microtubule associated protein 2 0.0687 0.8489 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Brugia malayi MH1 domain containing protein 0.0024 0.0159 0.0277
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0053 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0528 0.0622
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0098 0.0116
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0216 0.0254
Schistosoma mansoni hypothetical protein 0.0407 0.4973 0.5858
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.006 0.0606 0.1057
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0195 0.2312 0.2724
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0459 0.0801
Schistosoma mansoni hypothetical protein 0.0039 0.0352 0.0415
Loa Loa (eye worm) hypothetical protein 0.0152 0.1762 0.3074
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0226 0.2699 0.9537
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0053 0.0062
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0159 0.0187
Echinococcus granulosus epidermal growth factor receptor 0.018 0.2119 0.2497
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni amine GPCR 0.0016 0.0053 0.0062
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0318 1
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.157 0.1849
Schistosoma mansoni neuropeptide receptor 0.0016 0.0053 0.0062
Brugia malayi AF-10 protein 0.002 0.0101 0.0177
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0171
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0053 0.0053
Echinococcus granulosus neuropeptide receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0053 0.0053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0053 0.0062
Schistosoma mansoni hypothetical protein 0.0048 0.0459 0.0541
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0606 1
Onchocerca volvulus 0.0236 0.2827 1
Schistosoma mansoni Smad4 0.0024 0.0159 0.0187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0528 0.0622
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0606 0.0714
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.3814 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1055 0.1841
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0353 0.0353
Schistosoma mansoni hypothetical protein 0.0016 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.1072 0.1263
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0371 0.0219
Brugia malayi jmjC domain containing protein 0.0019 0.0098 0.0171
Loa Loa (eye worm) hypothetical protein 0.0041 0.0371 0.0647
Echinococcus granulosus Smad4 0.0024 0.0159 0.0187
Plasmodium falciparum phd finger protein, putative 0.006 0.0606 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.157 0.157
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0294 0.8879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0237 0.028
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.43 0.7502
Echinococcus multilocularis cpg binding protein 0.003 0.0236 0.0236
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0459 0.0801
Brugia malayi follicle stimulating hormone receptor 0.0468 0.5732 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0053 0.0092
Brugia malayi putative neuropeptide receptor 0.0016 0.0053 0.0092
Brugia malayi G-protein coupled receptor 0.0016 0.0053 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.3814 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0237 0.0414
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.1762 0.3074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Loa Loa (eye worm) nuclear factor I 0.0013 0.0024 0.0041
Echinococcus granulosus sex peptide receptor 0.0016 0.0053 0.0062
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.1789 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0371 0.0647
Schistosoma mansoni cpg binding protein 0.0029 0.0215 0.0254
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0098 0.0171
Schistosoma mansoni biogenic amine receptor 0.0016 0.0053 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0053 0.0062
Echinococcus granulosus dnaJ subfamily B 0.0407 0.4973 0.5858
Brugia malayi hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0528 0.0622
Echinococcus granulosus hypothetical protein 0.0016 0.0053 0.0062
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0053 0.0092
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0237 0.0237
Brugia malayi CHE-14 protein 0.0041 0.0371 0.0647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni neuropeptide receptor 0.0016 0.0053 0.0062
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0053 0.0053
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0053 0.0062
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0371 0.0437
Brugia malayi vesicular acetylcholine transporter unc-17 0.0226 0.2699 0.4708
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0053 0.0053
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0053 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Schistosoma mansoni opsin-like receptor 0.0016 0.0053 0.0062
Brugia malayi PHD-finger family protein 0.0021 0.0122 0.0212
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.1072 0.1263
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0053 0.0062
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0123 0.0491
Echinococcus granulosus somatostatin receptor 0.0016 0.0053 0.0062
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0318 0.0375
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1055 0.1055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0459 0.0801
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0053 0.0092
Brugia malayi PHD-finger family protein 0.006 0.0606 0.1057
Schistosoma mansoni hypothetical protein 0.0039 0.0352 0.0415
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0212
Brugia malayi Melatonin receptor type 1A 0.0016 0.0053 0.0092
Brugia malayi jmjC domain containing protein 0.0019 0.0098 0.0171
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0053 0.0053
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0053 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0053 0.0062
Echinococcus multilocularis insulin receptor 0.0058 0.0579 0.0579
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0098 0.0116
Brugia malayi Dopamine receptor protein 2 0.0016 0.0053 0.0092
Schistosoma mansoni neuropeptide receptor 0.0016 0.0053 0.0062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0528 0.0922
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0053 0.0062
Brugia malayi jmjC domain containing protein 0.0074 0.0784 0.1368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Schistosoma mansoni amine GPCR 0.0016 0.0053 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0053 0.0062
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0053 0.0062
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0459 0.0541
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.0579 0.0682
Brugia malayi MH2 domain containing protein 0.0024 0.0159 0.0277
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.032 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0053 0.0062
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0318 0.4332
Echinococcus granulosus insulin receptor 0.0058 0.0579 0.0682
Schistosoma mansoni opsin-like receptor 0.0016 0.0053 0.0062
Echinococcus granulosus fmrfamide receptor 0.0016 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0092
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0053 0.0062

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 14.9 uM Inhibition of EGF-stimulated EGFR tyrosine kinase activity using plasma membrane vesicles shed from cultured human A431 carcinoma cells ChEMBL. 8355247
IC50 (functional) = 14.9 uM Inhibition of EGF-stimulated EGFR tyrosine kinase activity using plasma membrane vesicles shed from cultured human A431 carcinoma cells ChEMBL. 8355247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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