Detailed information for compound 1359463

Basic information

Technical information
  • TDR Targets ID: 1359463
  • Name: N-(1,4-dimethyl-2,3-dioxo-7-pyrrolidin-1-ylqu inoxalin-6-yl)-3,4-diethoxybenzamide
  • MW: 466.53 | Formula: C25H30N4O5
  • H donors: 1 H acceptors: 3 LogP: 2.93 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1OCC)C(=O)Nc1cc2c(cc1N1CCCC1)n(C)c(=O)c(=O)n2C
  • InChi: 1S/C25H30N4O5/c1-5-33-21-10-9-16(13-22(21)34-6-2)23(30)26-17-14-19-20(15-18(17)29-11-7-8-12-29)28(4)25(32)24(31)27(19)3/h9-10,13-15H,5-8,11-12H2,1-4H3,(H,26,30)
  • InChiKey: BICQDGGTKYGVBA-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-(1,4-dimethyl-2,3-dioxo-7-pyrrolidin-1-yl-quinoxalin-6-yl)-3,4-diethoxy-benzamide
  • N-(1,4-dimethyl-2,3-dioxo-7-1-pyrrolidinyl-6-quinoxalinyl)-3,4-diethoxybenzamide
  • N-(2,3-diketo-1,4-dimethyl-7-pyrrolidin-1-yl-quinoxalin-6-yl)-3,4-diethoxy-benzamide
  • C301-6681
  • NCGC00107466-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0039 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.0567 0.1161
Brugia malayi nuclear receptor NHR-88 0.004 0.0222 0.0406
Loa Loa (eye worm) oxidoreductase 0.0035 0.0183 0.0398
Brugia malayi Uncoordinated protein 44 0.0016 0.0036 0.000000040887
Trypanosoma cruzi aldo-keto reductase 0.0035 0.0183 0.1249
Echinococcus multilocularis conserved hypothetical protein 0.0763 0.5774 0.915
Echinococcus granulosus carbonic anhydrase 0.0031 0.015 0.0238
Echinococcus granulosus death domain containing protein 0.0016 0.0036 0.0058
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0222 0.0482
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0036 0.000000029754
Loa Loa (eye worm) hypothetical protein 0.0093 0.0625 0.1357
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0347 1
Echinococcus multilocularis Protein lozenge 0.0061 0.0386 0.0612
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0222 0.0352
Schistosoma mansoni rab6-interacting 0.0022 0.0082 0.0072
Echinococcus multilocularis 0.0093 0.0625 0.099
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.013 0.091 0.1392
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.1231
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0199
Brugia malayi ecdysteroid receptor 0.0085 0.0567 0.1161
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0074 0.0117
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0093 0.0148
Onchocerca volvulus Bile acid receptor homolog 0.0085 0.0567 0.1457
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0023 0.0091 0.0145
Echinococcus multilocularis aldo keto reductase 0.0035 0.0183 0.0291
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0093 0.0625 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0085 0.0567 0.0898
Loa Loa (eye worm) runx1 0.0061 0.0386 0.0839
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.013 0.091 0.1442
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.013 0.091 0.1442
Entamoeba histolytica aldose reductase, putative 0.0035 0.0183 0.7496
Echinococcus granulosus geminin 0.0187 0.1353 0.2144
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.631 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0347 0.1482
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0222 0.0406
Echinococcus multilocularis voltage dependent calcium channel 0.013 0.091 0.1442
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0135 0.0949 0.1455
Schistosoma mansoni hypothetical protein 0.0139 0.0983 0.1509
Brugia malayi conserved hypotetical protein 0.004 0.0222 0.0406
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0222 0.0406
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0196 0.0255
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0259 0.0355
Echinococcus multilocularis aldo keto reductase 0.0035 0.0183 0.0291
Onchocerca volvulus 0.0035 0.0183 0.0404
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0259 0.0563
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0093 0.0625 0.0937
Echinococcus granulosus carbonic anhydrase 0.0031 0.015 0.0238
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0036 0.0058
Trypanosoma cruzi UDP-galactopyranose mutase 0.0093 0.0625 0.629
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0093 0.0148
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0082 0.0178
Entamoeba histolytica P-glycoprotein-5 0.0023 0.0093 0.1328
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0093 0.026
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Plasmodium falciparum carbonic anhydrase 0.0031 0.015 0.1385
Entamoeba histolytica P-glycoprotein-1 0.0023 0.0093 0.1328
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0093 0.026
Entamoeba histolytica P-glycoprotein-2 0.0023 0.0093 0.1328
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Entamoeba histolytica P-glycoprotein 5, putative 0.0023 0.0093 0.1328
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0347 0.1482
Loa Loa (eye worm) hypothetical protein 0.0093 0.0625 0.1357
Loa Loa (eye worm) calcium channel 0.013 0.091 0.1977
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Echinococcus granulosus aldehyde reductase 0.0025 0.0105 0.0167
Schistosoma mansoni hypothetical protein 0.0611 0.4602 0.7277
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.0567 0.1161
Loa Loa (eye worm) multidrug resistance protein 3 0.0023 0.0093 0.0203
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0082 0.013
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0347 0.3119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.0567 0.1161
Schistosoma mansoni multidrug resistance protein 0.0023 0.0093 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0222 0.0352
Entamoeba histolytica hypothetical protein 0.004 0.022 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0082 0.013
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.1231
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0222 0.0482
Echinococcus granulosus lysine specific histone demethylase 1A 0.0093 0.0625 0.099
Loa Loa (eye worm) hypothetical protein 0.0045 0.0259 0.0563
Echinococcus multilocularis carbonic anhydrase 0.0031 0.015 0.0238
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0085 0.0567 0.0845
Schistosoma mansoni cpg binding protein 0.0032 0.0158 0.0194
Schistosoma mansoni hypothetical protein 0.0057 0.0354 0.0505
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0036 0.0058
Onchocerca volvulus Protein ultraspiracle homolog 0.0085 0.0567 0.1457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0085 0.0567 0.1231
Brugia malayi hypothetical protein 0.0045 0.0259 0.0487
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0135 0.0949 0.2
Onchocerca volvulus 0.0022 0.0082 0.0125
Brugia malayi Pre-SET motif family protein 0.0037 0.0196 0.035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0085 0.0567 0.1161
Brugia malayi tailless protein 0.004 0.0222 0.0406
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0023 0.0093 0.026
Echinococcus granulosus hypothetical protein 0.0035 0.0183 0.0291
Loa Loa (eye worm) hypothetical protein 0.0093 0.0625 0.1357
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0081
Echinococcus granulosus carbonic anhydrase II 0.0135 0.0949 0.1504
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0093 0.0625 1
Brugia malayi nuclear receptor NHR-67 0.004 0.0222 0.0406
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0347 0.055
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0093 0.0148
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0082 0.013
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0023 0.0093 0.0221
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0387 0.5527
Trypanosoma brucei prostaglandin f synthase 0.0035 0.0183 0.1249
Brugia malayi steroid hormone receptor 0.0085 0.0567 0.1161
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0093 0.0148
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2115 1
Leishmania major UDP-galactopyranose mutase 0.0093 0.0625 0.629
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0035 0.0183 0.0322
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0347 0.3119
Entamoeba histolytica hypothetical protein 0.004 0.022 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0093 0.0148
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0094 0.0639 1
Onchocerca volvulus 0.0085 0.0567 0.1457
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0093 0.026
Plasmodium vivax multidrug resistance protein 1, putative 0.0023 0.0093 0.0352
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.022 0.0348
Entamoeba histolytica P-glycoprotein-2, putative 0.0023 0.0093 0.1328
Toxoplasma gondii hypothetical protein 0.0031 0.015 0.1349
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.054 0.0855
Brugia malayi Death domain containing protein 0.0016 0.0036 0.000000040887
Echinococcus granulosus RUN 0.0022 0.0082 0.013
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.015 0.0182
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0035 0.0183 0.0322
Brugia malayi hypothetical protein 0.0022 0.0082 0.0099
Echinococcus granulosus dnaJ subfamily B 0.0453 0.3388 0.5368
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0093 0.026
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Loa Loa (eye worm) hypothetical protein 0.0065 0.0415 0.0902
Loa Loa (eye worm) voltage-dependent calcium channel 0.0074 0.0484 0.1051
Schistosoma mansoni cpg binding protein 0.0034 0.0172 0.0216
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0079
Schistosoma mansoni loxhd1 0.0022 0.0082 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0347 0.1482
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0093 0.026
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0093 0.0625 0.099
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.054 0.0855
Schistosoma mansoni lipoxygenase 0.013 0.0916 0.1402
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0093 0.026
Schistosoma mansoni aldo-keto reductase 0.0035 0.0183 0.0234
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Entamoeba histolytica hypothetical protein 0.004 0.022 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0222 0.0406
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0196 0.0255
Plasmodium vivax SET domain protein, putative 0.0037 0.0196 0.2222
Brugia malayi hypothetical protein 0.0093 0.0625 0.1288
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0093 0.026
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0035 0.0183 0.0322
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.015 0.0249
Loa Loa (eye worm) hypothetical protein 0.0045 0.0259 0.0563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0085 0.0567 0.1231
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.0983 0.1558
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0625 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0085 0.0567 0.0898
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.0983 0.1558
Loa Loa (eye worm) hypothetical protein 0.013 0.091 0.1977
Brugia malayi CXXC zinc finger family protein 0.0032 0.0158 0.0267
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0085 0.0567 0.0845
Schistosoma mansoni transcription factor LCR-F1 0.004 0.022 0.0292
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0093 0.026
Loa Loa (eye worm) hypothetical protein 0.0093 0.0625 0.1357
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.015 0.0249
Trichomonas vaginalis abcb9, putative 0.0023 0.0093 0.026
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0093 0.026
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Brugia malayi multidrug resistance protein 3 0.0023 0.0093 0.0125
Schistosoma mansoni lozenge 0.0061 0.0386 0.0557
Entamoeba histolytica P-glycoprotein-2 0.0023 0.0093 0.1328
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.1231
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0093 0.0148
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0347 0.3119
Loa Loa (eye worm) oxidoreductase 0.0035 0.0183 0.0398
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0031 0.015 0.0249
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0196 0.0311
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Brugia malayi hypothetical protein 0.0022 0.0082 0.0099
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0427
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0347 0.3119
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.015 0.0249
Schistosoma mansoni pol-related 0.0035 0.0183 0.0234
Brugia malayi Nuclear hormone receptor E75 0.004 0.0222 0.0406
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0031 0.015 0.0327
Schistosoma mansoni nuclear hormone receptor 0.0085 0.0567 0.0845
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0398
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0074 0.0484 0.4682
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0347 0.0495
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.1231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0567 0.0898
Entamoeba histolytica P-glyco protein 6, putative 0.0023 0.0093 0.1328
Schistosoma mansoni hypothetical protein 0.0187 0.1353 0.2099
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0136 0.0297
Schistosoma mansoni retinoic acid receptor RXR 0.0194 0.1404 0.2179
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0085 0.0567 0.0898
Brugia malayi Nuclear hormone receptor E75 0.004 0.0222 0.0406
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0093 0.0148
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.1231
Onchocerca volvulus 0.0035 0.0183 0.0404
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0093 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0085 0.0567 0.1231
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.0327
Loa Loa (eye worm) hypothetical protein 0.0093 0.0625 0.1357
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0347 0.3119
Brugia malayi SWIRM domain containing protein 0.0093 0.0625 0.1288
Echinococcus multilocularis aldehyde reductase 0.0025 0.0105 0.0167
Leishmania major aldo-keto reductase-like protein 0.0035 0.0183 0.1249
Loa Loa (eye worm) oxidoreductase 0.0035 0.0183 0.0398
Echinococcus granulosus cpg binding protein 0.0034 0.0172 0.0273
Trichomonas vaginalis aldo/keto reductase, putative 0.0035 0.0183 0.0694
Schistosoma mansoni cpg binding protein 0.0034 0.0172 0.0216
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.0567 0.1161
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0292
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0093 0.026
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0093 0.0148
Schistosoma mansoni polycystin 1-related 0.0022 0.0082 0.0072
Loa Loa (eye worm) hypothetical protein 0.0045 0.0259 0.0563
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Trypanosoma brucei aldo-keto reductase, putative 0.0035 0.0183 0.1249
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0196 0.2163
Schistosoma mansoni hypothetical protein 0.0611 0.4602 0.7277
Brugia malayi nuclear hormone receptor 0.0085 0.0567 0.1161
Mycobacterium tuberculosis Probable oxidoreductase 0.0035 0.0183 0.0119
Echinococcus granulosus aldo keto reductase 0.0035 0.0183 0.0291
Trichomonas vaginalis taga, putative 0.0023 0.0093 0.026
Echinococcus multilocularis multidrug resistance protein 1 0.0016 0.0039 0.0062
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.0327
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Echinococcus granulosus Ankyrin 0.0016 0.0037 0.0059
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0135 0.0949 0.2
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Giardia lamblia Aldose reductase 0.0035 0.0183 0.4004
Echinococcus granulosus ecdysone induced protein 78C 0.0085 0.0567 0.0898
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0074 0.0484 0.4682
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0085 0.0567 0.0898
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0093 0.026
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0347 0.055
Schistosoma mansoni lipoxygenase 0.0091 0.0614 0.0921
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0347 0.4828
Schistosoma mansoni rab6-interacting 0.0022 0.0082 0.0072
Echinococcus multilocularis dnaJ subfamily B 0.0453 0.3388 0.5368
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0222 0.0482
Trichomonas vaginalis abcb9, putative 0.0023 0.0093 0.026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0085 0.0567 0.1161
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0093 0.026
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.013 0.091 0.1442
Schistosoma mansoni thyroid hormone receptor 0.0224 0.1636 0.2549
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0222 0.0296
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0203
Echinococcus multilocularis ecdysone induced protein 78C 0.0085 0.0567 0.0898
Onchocerca volvulus 0.004 0.0222 0.051
Schistosoma mansoni amine oxidase 0.0093 0.0625 0.0937
Trichomonas vaginalis abcb9, putative 0.0023 0.0093 0.026
Echinococcus multilocularis FTZ F1 alpha 0.0085 0.0567 0.0898
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0222 0.0352
Schistosoma mansoni nuclear receptor 0.004 0.0222 0.0296
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0259 0.041
Echinococcus granulosus aldo keto reductase 0.0035 0.0183 0.0291
Echinococcus granulosus arachidonate 5 lipoxygenase 0.013 0.0916 0.1451
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0158 0.0344
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0093 0.026
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.013 0.091 0.1913
Schistosoma mansoni zinc finger protein 0.004 0.0222 0.0296
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0567 0.0898
Brugia malayi Protein kinase domain containing protein 0.0016 0.004 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0085 0.0567 0.1161
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0023 0.0093 0.026
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0135 0.0949 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0074 0.0167
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0196 0.0311
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.0327
Loa Loa (eye worm) hypothetical protein 0.049 0.3675 0.7986
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Echinococcus granulosus voltage dependent calcium channel 0.0074 0.0484 0.0767
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Brugia malayi hypothetical protein 0.0045 0.0259 0.0487
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.015 0.0182
Brugia malayi Cytochrome P450 family protein 0.0029 0.0136 0.0219
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0093 0.026
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0093 0.0625 1
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1222 0.929 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.013 0.091 0.1442
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0035 0.0183 0.1249
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0222 0.0352
Schistosoma mansoni nuclear hormone receptor 0.004 0.0222 0.0296
Echinococcus multilocularis aldo keto reductase 0.0035 0.0183 0.0291
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0222 0.0352
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Echinococcus granulosus aldo keto reductase 0.0035 0.0183 0.0291
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0567 0.0898
Toxoplasma gondii histone lysine-specific demethylase 0.0093 0.0625 0.9737
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0093 0.026
Loa Loa (eye worm) hypothetical protein 0.049 0.3675 0.7986
Onchocerca volvulus 0.0022 0.0082 0.0125
Echinococcus multilocularis carbonic anhydrase II 0.0135 0.0949 0.1504
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0222 0.0352
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0085 0.0567 0.0845
Schistosoma mansoni hypothetical protein 0.0453 0.3388 0.5341
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0093 0.026
Brugia malayi nuclear hormone receptor 0.004 0.0222 0.0406
Loa Loa (eye worm) oxidoreductase 0.0035 0.0183 0.0398
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0035 0.0183 0.0694
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0222 0.0296
Brugia malayi hypothetical protein 0.004 0.0222 0.0406
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0347 0.1482
Schistosoma mansoni nuclear hormone receptor 0.004 0.0222 0.0296
Brugia malayi nuclear receptor RXR 0.0045 0.0259 0.0487
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0074 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0074 0.5
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0082 0.014
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0036 0.0058
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0074 0.0167
Echinococcus multilocularis RUN 0.0022 0.0082 0.013
Echinococcus multilocularis cpg binding protein 0.0034 0.0172 0.0273
Schistosoma mansoni voltage-gated cation channel 0.013 0.091 0.1392
Trichomonas vaginalis aldo/keto reductase, putative 0.0035 0.0183 0.0694
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0203
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0259 0.0487
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0023 0.0093 0.0203
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0135 0.0949 1
Echinococcus multilocularis geminin 0.0187 0.1353 0.2144
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.015 0.0182
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0085 0.0567 0.0845
Plasmodium falciparum protoporphyrinogen oxidase 0.0093 0.0625 1
Schistosoma mansoni amine oxidase 0.0093 0.0625 0.0937
Schistosoma mansoni RAR-like nuclear receptor 0.0085 0.0567 0.0845
Toxoplasma gondii aldose reductase, putative 0.0035 0.0183 0.1933
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Loa Loa (eye worm) hypothetical protein 0.0045 0.0259 0.0563
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0181 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0085 0.0567 0.1161
Schistosoma mansoni smdr2 0.0023 0.0093 0.0091
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1849 0.4017
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0222 0.0296
Schistosoma mansoni coup transcription factor 0.0085 0.0567 0.0845
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Loa Loa (eye worm) carbonic anhydrase 3 0.0135 0.0949 0.2063
Loa Loa (eye worm) hypothetical protein 0.0065 0.0415 0.0902
Echinococcus multilocularis carbonic anhydrase 0.0031 0.015 0.0238
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0093 0.026
Onchocerca volvulus 0.0093 0.0625 0.1616
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1314 1 1
Onchocerca volvulus 0.0032 0.0158 0.0335
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0082 0.013
Mycobacterium ulcerans oxidoreductase 0.0035 0.0183 0.011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0194 0.1404 0.2224
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0036 0.0058
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.022 0.0348
Loa Loa (eye worm) hypothetical protein 0.0045 0.0259 0.0563
Brugia malayi indoleamine 2,3-dioxygenase 0.0611 0.4602 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0347 0.055
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0023 0.0093 0.0342
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0222 0.051
Schistosoma mansoni nuclear receptor 0.004 0.0222 0.0296
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0259 0.041
Loa Loa (eye worm) steroid hormone receptor 0.0085 0.0567 0.1231
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0093 0.026
Loa Loa (eye worm) DR-78 0.004 0.0222 0.0482
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0347 0.0754
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.013 0.091 0.1392
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.0183 0.0291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0567 0.0898
Loa Loa (eye worm) hypothetical protein 0.0093 0.0625 0.1357
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0135 0.0949 0.1455
Loa Loa (eye worm) hypothetical protein 0.0074 0.0484 0.1051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0074 0.0161
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.0567 0.0845
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0093 0.026
Onchocerca volvulus 0.0035 0.0183 0.0404
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0222 0.0352
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0085 0.0567 0.1457
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0035 0.0183 0.0322
Brugia malayi nuclear receptor NHR-88 0.0085 0.0567 0.1161
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0035 0.0183 0.0694
Mycobacterium tuberculosis Possible oxidoreductase 0.0093 0.0625 0.0597
Trypanosoma brucei carbonic anhydrase-like protein 0.0135 0.0949 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0093 0.026
Brugia malayi nuclear receptor RXR 0.004 0.0222 0.0406
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0442 0.0646
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0135 0.0949 0.2063
Trypanosoma brucei protein kinase, putative 0.0056 0.0347 0.3119
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0222 0.0352
Brugia malayi hypothetical protein 0.004 0.022 0.0402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0085 0.0567 0.1231
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0085 0.0567 0.1161
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0093 0.0625 1
Onchocerca volvulus 0.049 0.3675 1
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0611 0.4602 0.7293
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0093 0.0625 0.0555
Echinococcus granulosus lysine specific histone demethylase 1A 0.0093 0.0625 0.099
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0093 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0196 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0085 0.0567 0.1161
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0222 0.051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0085 0.0567 0.1231
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0023 0.0093 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0085 0.0567 0.0898
Brugia malayi amine oxidase, flavin-containing family protein 0.0093 0.0625 0.1288
Leishmania major carbonic anhydrase-like protein 0.0135 0.0949 1
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0093 0.0625 1
Entamoeba histolytica aldose reductase, putative 0.0035 0.0183 0.7496
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0347 0.055
Trichomonas vaginalis aldo/keto reductase, putative 0.0035 0.0183 0.0694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0085 0.0567 0.1231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0196 0.0255
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0625 1
Mycobacterium ulcerans dehydrogenase 0.0093 0.0625 0.0555
Brugia malayi Pre-SET motif family protein 0.0252 0.1849 0.3969
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0611 0.4602 0.7293
Giardia lamblia Aldose reductase 0.0035 0.0183 0.4004
Brugia malayi hypothetical protein 0.004 0.0222 0.0406
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0093 0.0625 0.0937
Trypanosoma cruzi aldo/keto reductase, putative 0.0035 0.0183 0.1249
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.0567 0.1161
Mycobacterium ulcerans monoamine oxidase 0.0093 0.0625 0.0555
Echinococcus multilocularis protoporphyrinogen oxidase 0.0093 0.0625 0.099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0222 0.0352
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0036 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.0085 0.0567 0.0845
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0035 0.0183 0.0694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0085 0.0567 0.1231
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0035 0.0183 0.1501
Entamoeba histolytica hypothetical protein 0.004 0.022 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0222 0.0352
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0196 0.0311
Toxoplasma gondii transporter, cation channel family protein 0.0074 0.0484 0.7248
Toxoplasma gondii hypothetical protein 0.0065 0.0415 0.6033
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0085 0.0567 0.0898
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0082 0.013
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0611 0.4602 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.0567 0.1161
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0074 0.0082
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0037 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482
Mycobacterium ulcerans oxidoreductase 0.0093 0.0625 0.0555
Plasmodium falciparum multidrug resistance protein 1 0.0023 0.0093 0.0352
Echinococcus granulosus microtubule associated protein 2 0.0833 0.631 1
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0093 0.0148
Schistosoma mansoni hypothetical protein 0.0022 0.0082 0.0072
Echinococcus multilocularis carbonic anhydrase 0.0031 0.015 0.0238
Onchocerca volvulus 0.004 0.0222 0.051
Echinococcus multilocularis ATP binding cassette sub family B 0.0023 0.0091 0.0145
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0031 0.015 0.0249
Onchocerca volvulus 0.0035 0.0183 0.0404
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Brugia malayi Doublecortin family protein 0.0022 0.0082 0.0099
Echinococcus granulosus FTZ F1 alpha 0.0085 0.0567 0.0898
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0074 0.0117
Brugia malayi Steroid receptor seven-up type 2 0.0085 0.0567 0.1161
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0082 0.013
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.013 0.0916 0.1451
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0085 0.0567 0.1161
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.013 0.091 0.1442
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0093 0.026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0085 0.0567 0.0898
Echinococcus multilocularis Ankyrin 0.0016 0.0037 0.0059
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0093 0.0148
Schistosoma mansoni aldo-keto reductase 0.0035 0.0183 0.0234
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.1231
Onchocerca volvulus 0.0035 0.0183 0.0404
Echinococcus multilocularis voltage dependent calcium channel 0.013 0.091 0.1442
Schistosoma mansoni carbonic anhydrase 0.0031 0.015 0.0182
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0023 0.0093 0.0342
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0149 0.1059 0.1678
Brugia malayi ABC transporter family protein 0.0023 0.0093 0.0125
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0093 0.0148
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.631 1
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0259 0.0487
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0093 0.0148
Echinococcus granulosus hypothetical protein 0.0769 0.5814 0.9214
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.1231
Loa Loa (eye worm) oxidoreductase 0.0035 0.0183 0.0398
Schistosoma mansoni ap endonuclease 0.0021 0.0074 0.006
Onchocerca volvulus 0.0023 0.0093 0.0157
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0035 0.0183 0.1249
Leishmania major prostaglandin f synthase, putative 0.0035 0.0183 0.1249
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0085 0.0567 0.1161
Echinococcus multilocularis thyroid hormone receptor alpha 0.0224 0.1636 0.2592
Brugia malayi ecdysone receptor 0.004 0.0222 0.0406
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0085 0.0567 0.0845
Onchocerca volvulus 0.0287 0.2116 0.5715
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0093 0.026
Echinococcus granulosus voltage dependent calcium channel 0.013 0.091 0.1442
Onchocerca volvulus 0.0037 0.0196 0.044
Mycobacterium tuberculosis Conserved hypothetical protein 0.0093 0.0625 0.0597
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.013 0.091 0.1442
Entamoeba histolytica aldose reductase, putative 0.0035 0.0183 0.7496
Schistosoma mansoni multidrug resistance protein 0.0023 0.0093 0.0091
Echinococcus multilocularis aldo keto reductase 0.0035 0.0183 0.0291
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0178
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.0567 0.1161
Schistosoma mansoni ap endonuclease 0.0021 0.0074 0.006
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0222 0.0352
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0222 0.0406
Schistosoma mansoni thyroid hormone receptor 0.0224 0.1636 0.2549
Chlamydia trachomatis protoporphyrinogen oxidase 0.0093 0.0625 1
Brugia malayi hypothetical protein 0.049 0.3675 0.797
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0039 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0178
Brugia malayi MAP kinase sur-1 0.0056 0.0347 0.068
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0082 0.014
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0347 0.3119
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.1231
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.0183 0.0694
Trypanosoma cruzi UDP-galactopyranose mutase 0.0093 0.0625 0.629
Echinococcus granulosus carbonic anhydrase 0.0031 0.015 0.0238
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0093 0.026
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0085 0.0567 0.0898
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0259 0.0355
Schistosoma mansoni multidrug resistance protein 0.0023 0.0093 0.0091
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0347 0.3119
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.0183 0.0291
Leishmania major p-glycoprotein 0.0023 0.0093 0.0221
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0093 0.0148
Onchocerca volvulus 0.0035 0.0183 0.0404
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.013 0.091 0.1442
Schistosoma mansoni hypothetical protein 0.0187 0.1353 0.2099
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0482

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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