Detailed information for compound 1367898

Basic information

Technical information
  • TDR Targets ID: 1367898
  • Name: [2-(cyclopentylamino)-2-oxoethyl] 2,3-dichlor obenzoate
  • MW: 316.18 | Formula: C14H15Cl2NO3
  • H donors: 1 H acceptors: 2 LogP: 3.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCC1)COC(=O)c1cccc(c1Cl)Cl
  • InChi: 1S/C14H15Cl2NO3/c15-11-7-3-6-10(13(11)16)14(19)20-8-12(18)17-9-4-1-2-5-9/h3,6-7,9H,1-2,4-5,8H2,(H,17,18)
  • InChiKey: DPKJCYYRXOKBFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(cyclopentylamino)-2-oxo-ethyl] 2,3-dichlorobenzoate
  • 2,3-dichlorobenzoic acid [2-(cyclopentylamino)-2-oxoethyl] ester
  • 2,3-dichlorobenzoic acid [2-(cyclopentylamino)-2-keto-ethyl] ester
  • T0516-3278
  • ZINC03319346

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.2249 0.723
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0356 0.1143
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0577 0.1854
Loa Loa (eye worm) sugar transporter 0.003 0.0196 0.063
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0358 0.1021
Entamoeba histolytica DNA topoisomerase III, putative 0.0015 0.0035 0.009
Schistosoma mansoni sugar transporter 0.003 0.0196 0.063
Plasmodium falciparum hexose transporter 0.021 0.2249 0.2226
Loa Loa (eye worm) hypothetical protein 0.0193 0.206 0.6622
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.2249 0.723
Toxoplasma gondii protein kinase, putative 0.0594 0.661 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.034 0.3721 0.5618
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0695 0.1915
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0166 0.042
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0167 0.1756 1
Trypanosoma brucei heat shock protein, putative 0.0015 0.0029 0.0038
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0146
Toxoplasma gondii DNA topoisomerase family protein 0.0015 0.0035 0.0029
Schistosoma mansoni pyruvate dehydrogenase 0.0015 0.0029 0.0094
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0601 0.1932
Entamoeba histolytica deoxycytidyl transferase, putative 0.0035 0.0256 0.065
Giardia lamblia GTOR 0.0022 0.0108 0.0202
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0154 0.0496
Loa Loa (eye worm) hypothetical protein 0.0051 0.0442 0.1422
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0167 0.1756 0.2638
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0577 0.1854
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0153 0.0437
Leishmania major glucose transporter, lmgt1 0.0065 0.0601 0.1643
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0166 0.0137
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0108 0.0348
Onchocerca volvulus 0.003 0.0196 0.0794
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0108 0.0348
Echinococcus multilocularis heat shock protein 90 0.0015 0.0029 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0592 0.1901
Echinococcus multilocularis solute carrier family 22 0.003 0.0196 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0201 0.0646
Onchocerca volvulus 0.003 0.0196 0.0794
Mycobacterium ulcerans hypothetical protein 0.0164 0.1727 0.9832
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0015 0.0029 0.0084
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0393 0.2108
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0592 0.1901
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0108 0.0348
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0568 0.1581
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0108 0.0309
Loa Loa (eye worm) hypothetical protein 0.0156 0.1633 0.5249
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0015 0.0035 0.0114
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0393 0.0572
Brugia malayi isocitrate dehydrogenase 0.0016 0.0045 0.0146
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0015 0.0035 0.009
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0108 0.0264
Loa Loa (eye worm) endoplasmin 0.0015 0.0029 0.0094
Trypanosoma cruzi hexose transporter, putative 0.003 0.0196 0.0558
Trypanosoma brucei heat shock protein, putative 0.0015 0.0029 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Schistosoma mansoni flap endonuclease-1 0.0024 0.0136 0.0438
Loa Loa (eye worm) sugar transporter 0.021 0.2249 0.723
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.034 0.3721 0.3702
Trypanosoma brucei heat shock protein, putative 0.0015 0.0029 0.0038
Schistosoma mansoni transient receptor potential channel 0.0066 0.0613 0.1971
Trichomonas vaginalis conserved hypothetical protein 0.021 0.2249 0.723
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0592 0.0873
Echinococcus granulosus dna polymerase eta 0.0035 0.0256 0.0824
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.0145
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0282 0.0907
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0081 0.0259
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0035 0.0256 0.0824
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0789
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0393 0.0365
Onchocerca volvulus Putative transporter 0.003 0.0196 0.0794
Entamoeba histolytica DNA topoisomerase III, putative 0.0015 0.0035 0.009
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0592 0.1901
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0334 0.1763
Toxoplasma gondii hypothetical protein 0.005 0.0432 0.063
Giardia lamblia Hexose transporter 0.003 0.0196 0.0426
Trypanosoma brucei glucose transporter, putative 0.0065 0.0601 0.1675
Onchocerca volvulus 0.003 0.0196 0.0794
Trypanosoma brucei DNA topoisomerase II beta, putative 0.027 0.2935 0.8358
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Loa Loa (eye worm) hypothetical protein 0.0116 0.1182 0.38
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0081 0.023
Schistosoma mansoni DNA topoisomerase II 0.0286 0.3111 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0211 0.0557
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0167 0.1756 1
Giardia lamblia DNA topoisomerase III 0.0015 0.0035 0.0015
Trypanosoma brucei heat shock protein, putative 0.0015 0.0029 0.0038
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0999 0.3211
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0081 0.0259
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0999 0.3211
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0016 0.0051
Loa Loa (eye worm) DNA topoisomerase III 0.0015 0.0035 0.0114
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0256 0.1315
Echinococcus granulosus solute carrier family 22 0.003 0.0196 0.063
Trypanosoma cruzi DNA topoisomerase II, putative 0.027 0.2935 0.8366
Echinococcus granulosus geminin 0.0175 0.1848 0.5941
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0045 0.0146
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0196 0.0965
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0613 0.1971
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0196 0.063
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0601 0.1932
Entamoeba histolytica heat shock protein 90, putative 0.0015 0.0029 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0601 0.1932
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0108 0.0264
Toxoplasma gondii sugar transporter ST1 0.003 0.0196 0.0273
Schistosoma mansoni terminal deoxycytidyl transferase 0.0035 0.0256 0.0824
Schistosoma mansoni glucose transport protein 0.021 0.2249 0.723
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0044
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0393 0.1046
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0577 0.1854
Schistosoma mansoni glucose transport protein 0.021 0.2249 0.723
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0393 0.1264
Trichomonas vaginalis glucose transporter, putative 0.003 0.0196 0.063
Chlamydia trachomatis DNA gyrase subunit B 0.0167 0.1756 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0613 0.1971
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0467 0.1332
Chlamydia trachomatis DNA gyrase subunit B 0.0132 0.1358 0.7695
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0358 0.1021
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0592 0.1901
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0592 0.0564
Schistosoma mansoni sugar transporter 0.003 0.0196 0.063
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.2249 0.723
Brugia malayi Probable DNA topoisomerase II 0.0286 0.3111 1
Brugia malayi GRF zinc finger family protein 0.0015 0.0035 0.0114
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0108 0.0309
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0334 0.0875
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0015 0.0035 0.0029
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0029 0.002
Echinococcus multilocularis protein dispatched 1 0.005 0.0426 0.1369
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0193 0.2057 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0592 0.0873
Onchocerca volvulus 0.003 0.0196 0.0794
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0193 0.2057 1
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0393 0.2108
Echinococcus multilocularis heat shock protein 0.0015 0.0029 0.0094
Plasmodium falciparum DNA topoisomerase 3, putative 0.0015 0.0035 0.0006
Schistosoma mansoni protein kinase 0.0064 0.0592 0.1901
Schistosoma mansoni hypothetical protein 0.0042 0.0338 0.1086
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0166 0.0227
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0108 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0145
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0108 0.014
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0015 0.0029 0.0094
Plasmodium vivax DNA gyrase subunit A, putative 0.0061 0.0559 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0016 0.0051
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0393 0.1121
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0035 0.0256 0.0824
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0196 0.063
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0029 0.0084
Echinococcus multilocularis dna polymerase eta 0.0035 0.0256 0.0824
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.0145
Trypanosoma brucei unspecified product 0.0024 0.0133 0.0336
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0196 0.063
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0015 0.0035 0.0114
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0695 0.1982
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0196 0.063
Schistosoma mansoni hypothetical protein 0.0037 0.0282 0.0907
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0108 0.0227
Loa Loa (eye worm) hypothetical protein 0.0064 0.0592 0.1901
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0156 0.0127
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0108 0.0227
Trypanosoma cruzi glucose transporter, putative 0.003 0.0196 0.0558
Entamoeba histolytica hypothetical protein 0.0037 0.0282 0.0716
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0286 0.3111 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1511 0.4857
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0166 0.0532
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0592 0.0564
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0015 0.0029 0.0094
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0081 0.0131
Entamoeba histolytica protein kinase, putative 0.0064 0.0592 0.1502
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0393 0.0365
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0592 0.1901
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.026 0.0835
Mycobacterium ulcerans DNA gyrase subunit B 0.0167 0.1756 1
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0356 0.1143
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0358 0.098
Echinococcus multilocularis expressed conserved protein 0.0095 0.0945 0.3038
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0568 0.1581
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0061 0.0559 0.0824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0145
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0108 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0577 0.1854
Plasmodium falciparum DNA topoisomerase 2 0.0286 0.3111 0.3091
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0081 0.0297
Brugia malayi Cam kinase protein 1 0.0064 0.0592 0.1901
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0256 0.073
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0108 0.0264
Schistosoma mansoni hypothetical protein 0.0042 0.0338 0.1086
Echinococcus granulosus heat shock protein 90 0.0015 0.0029 0.0094
Leishmania major DNA topoisomerase ii 0.027 0.2935 0.8352
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1727 0.9832
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0061 0.0559 0.3069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Toxoplasma gondii DNA topoisomerase 2, putative 0.0286 0.3111 0.4693
Trypanosoma brucei glucose transporter, putative 0.0065 0.0601 0.1675
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0196 0.0515
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0601 0.1932
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0081 0.0259
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0029 0.0094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0592 0.1901
Trypanosoma cruzi DNA topoisomerase III, putative 0.0015 0.0035 0.0101
Leishmania major hypothetical protein, conserved 0.003 0.0196 0.0479
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0015 0.0029 0.0094
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0156 0.04
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0029 0.0094
Leishmania major DNA polymerase kappa, putative 0.0042 0.0334 0.0875
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0592 0.0564
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trypanosoma cruzi Heat shock protein 83, putative 0.0015 0.0029 0.0084
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0015 0.0035 0.0114
Trypanosoma brucei developmentally regulated phosphoprotein 0.0015 0.0029 0.0038
Leishmania major DNA topoisomerase 1A 0.0015 0.0035 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0109 0.031
Schistosoma mansoni hypothetical protein 0.0035 0.026 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.0029 0.0084
Plasmodium falciparum protein kinase 7 0.0594 0.661 0.66
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0577 0.1854
Echinococcus granulosus solute carrier family 22 0.003 0.0196 0.063
Mycobacterium ulcerans DNA topoisomerase I 0.0015 0.0035 0.0035
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0393 0.0931
Toxoplasma gondii exonuclease III APE 0.0019 0.0081 0.0098
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0108 0.0264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.2249 0.723
Onchocerca volvulus 0.003 0.0196 0.0794
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0094
Entamoeba histolytica hypothetical protein 0.003 0.0201 0.051
Brugia malayi kinase, mitochondrial precursor 0.0015 0.0029 0.0094
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0166 0.0472
Mycobacterium ulcerans DNA gyrase subunit A 0.0061 0.0559 0.3069
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0045 0.0146
Chlamydia trachomatis DNA topoisomerase I 0.0015 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0592 0.0564
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0286 0.3111 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0327 0.1053
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1261 0.4053
Schistosoma mansoni glucose transport protein 0.021 0.2249 0.723
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0081 0.023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0986
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0113 0.0486
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0102 0.1015 0.3263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0568 0.1619
Leishmania major glucose transporter, lmgt2 0.0065 0.0601 0.1643
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0108 0.0348
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0282 0.0907
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0156 0.0127
Toxoplasma gondii facilitative glucose transporter GT1 0.021 0.2249 0.3386
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Leishmania major glucose transporter, lmgt3 0.0065 0.0601 0.1643
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Plasmodium falciparum flap endonuclease 1 0.0027 0.0166 0.0137
Trichomonas vaginalis endoplasmin, putative 0.0015 0.0029 0.0094
Schistosoma mansoni ap endonuclease 0.0019 0.0081 0.0259
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0108 0.0348
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0166 0.0532
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0695 0.0668
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0321 0.3509 1
Trypanosoma brucei heat shock protein, putative 0.0015 0.0029 0.0038
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0196 0.063
Echinococcus multilocularis protein patched 0.0044 0.0356 0.1143
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0568 0.3122
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0051
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0029 0.0094
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0166 0.0532
Trypanosoma brucei DNA topoisomerase IA, putative 0.0015 0.0035 0.0055
Loa Loa (eye worm) hypothetical protein 0.0193 0.206 0.6622
Brugia malayi major facilitator superfamily protein 0.003 0.0196 0.063
Echinococcus multilocularis rho GTPase activating protein 20 0.0015 0.0035 0.0114
Entamoeba histolytica hypothetical protein 0.0047 0.0393 0.0998
Trypanosoma brucei heat shock protein, putative 0.0015 0.0029 0.0038
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0156 0.0127
Plasmodium falciparum DNA gyrase subunit A 0.0061 0.0559 0.0531
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0568 0.1619
Giardia lamblia DNA topoisomerase II 0.0271 0.2942 0.7448
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0015 0.0035 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Schistosoma mansoni DNA polymerase eta 0.0035 0.0256 0.0824
Leishmania major DNA polymerase eta, putative 0.0035 0.0256 0.0652
Entamoeba histolytica protein kinase, putative 0.0064 0.0592 0.1502
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0393 0.1264
Echinococcus granulosus General substrate transporter 0.0181 0.1913 0.615
Trypanosoma brucei sugar transporter, putative 0.003 0.0196 0.0515
Brugia malayi major facilitator superfamily protein 0.003 0.0196 0.063
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0081 0.0259
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1511 0.4857
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0045 0.0146
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.1015 0.3263
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0546 0.1756
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0029 0.0094
Plasmodium falciparum mitogen-activated protein kinase 2 0.034 0.3721 0.3702
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0108 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0196 0.063
Toxoplasma gondii sugar transporter ST2 0.003 0.0196 0.0273
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Brugia malayi hypothetical protein 0.003 0.0196 0.063
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0568 0.1827
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0592 0.1901
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0045 0.0129
Trypanosoma brucei glucose transporter, putative 0.0065 0.0601 0.1675
Trichomonas vaginalis DNA topoisomerase II, putative 0.0286 0.3111 1
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0393 0.1264
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1261 0.4053
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0196 0.0965
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0102 0.1021 0.2591
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0577 0.14
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0986
Plasmodium vivax DNA topoisomerase II, putative 0.0286 0.3111 0.3091
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0045 0.0093
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.1033 0.3321
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0695 0.1982
Brugia malayi hypothetical protein 0.003 0.0196 0.063
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.0029 0.0084
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0081 0.0185
Trypanosoma brucei heat shock protein, putative 0.0015 0.0029 0.0038
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0108 0.0227
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0129
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0084
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0109 0.0228
Trypanosoma brucei glucose transporter 2A 0.0065 0.0601 0.1675
Onchocerca volvulus 0.003 0.0196 0.0794
Echinococcus granulosus solute carrier family 22 0.003 0.0196 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Onchocerca volvulus 0.003 0.0196 0.0794
Brugia malayi hypothetical protein 0.0037 0.0282 0.0907
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0695 0.103
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0029 0.0094
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.1015 0.3263
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0613 0.1971
Brugia malayi DNA topoisomerase III beta-1 0.0015 0.0035 0.0114
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Toxoplasma gondii sugar transporter ST3 0.003 0.0196 0.0273
Schistosoma mansoni sugar transporter 0.003 0.0196 0.063
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0029 0.0094
Plasmodium vivax hexose transporter 0.021 0.2249 0.2226
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0284 0.0911
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0015 0.0035 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0295 0.0799
Echinococcus multilocularis General substrate transporter 0.0181 0.1913 0.615
Onchocerca volvulus 0.003 0.0196 0.0794
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0256 0.0824
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0286 0.3111 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0321 0.3509 1
Plasmodium falciparum DNA gyrase subunit B 0.0167 0.1756 0.1731
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0256 0.0824
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.2249 0.723
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0196 0.063
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0196 0.063
Onchocerca volvulus 0.003 0.0196 0.0794
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0568 0.1619
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0312 0.3404 0.9699
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0108 0.0348
Trypanosoma cruzi sugar transporter, putative 0.003 0.0196 0.0558
Loa Loa (eye worm) hypothetical protein 0.0047 0.0393 0.1264
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0334 0.0909
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.0491 0.1359
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0015 0.0035 0.0114
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.027 0.2935 0.8358
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0081 0.0297
Onchocerca volvulus 0.003 0.0196 0.0794
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Loa Loa (eye worm) hypothetical protein 0.0063 0.0577 0.1854
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0015 0.0035 0.0114
Brugia malayi CHE-14 protein 0.0044 0.0356 0.1143
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0156 0.0212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0201 0.0646
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0601 0.1712
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.3404 0.97
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0196 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0201 0.0646
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0393 0.1264
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0108 0.0348
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0999 0.3211
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0108 0.0275
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Schistosoma mansoni hypothetical protein 0.0175 0.1848 0.5941
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0211 0.0557
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0029 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Leishmania major mitochondrial DNA polymerase beta 0.0312 0.3404 0.9698
Plasmodium vivax DNA gyrase subunit B, putative 0.0167 0.1756 0.1731
Schistosoma mansoni transient receptor potential channel 0.0066 0.0613 0.1971
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0445 0.143
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0145
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0081 0.0259
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0592 0.1901
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0029 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0282 0.0907
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0145
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0313 0.1642
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0592 0.0564
Plasmodium vivax sugar transporter, putative 0.003 0.0196 0.0167
Schistosoma mansoni patched 1 0.0044 0.0356 0.1143
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0961 0.3089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Entamoeba histolytica DNA topoisomerase II, putative 0.0286 0.3111 0.7897
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0986
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0286 0.3111 1
Entamoeba histolytica heat shock protein 90, putative 0.0015 0.0029 0.0074
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Brugia malayi Endoplasmin precursor 0.0015 0.0029 0.0094
Trypanosoma cruzi hexose transporter 0.0065 0.0601 0.1712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0695 0.1915
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0577 0.1854
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0156 0.0444
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0201 0.0573
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0568 0.1827
Loa Loa (eye worm) hypothetical protein 0.0038 0.0295 0.0948
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0201 0.0646
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.1015 0.3263
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0196 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.0145
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Schistosoma mansoni endoplasmin 0.0015 0.0029 0.0094
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0015 0.0035 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0695 0.1945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.1537 0.4381
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0961 0.3089
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0284 0.0911
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0015 0.0035 0.0035
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0358 0.1021
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0196 0.063
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0061 0.0559 0.3069
Loa Loa (eye worm) hypothetical protein 0.0044 0.0356 0.1143
Schistosoma mansoni ap endonuclease 0.0019 0.0081 0.0259
Loa Loa (eye worm) hypothetical protein 0.0026 0.0153 0.0493
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0196 0.063
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0081 0.0297
Schistosoma mansoni hypothetical protein 0.0042 0.0338 0.1086
Echinococcus granulosus heat shock protein 0.0015 0.0029 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0156 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0601 0.1932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Echinococcus multilocularis geminin 0.0175 0.1848 0.5941
Schistosoma mansoni protein kinase 0.0064 0.0592 0.1901
Trypanosoma brucei glucose transporter, putative 0.0065 0.0601 0.1675
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0166 0.0348
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0568 0.3122
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0193 0.2057 1
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0613 0.1971
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0256 0.0688
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0577 0.1854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Brugia malayi Sugar transporter family protein 0.021 0.2249 0.723
Brugia malayi polk-prov protein 0.0038 0.0295 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0284 0.0911
Echinococcus granulosus serine protein kinase ATM 0.003 0.0201 0.0646
Onchocerca volvulus 0.003 0.0196 0.0794
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0145
Trypanosoma brucei heat shock protein 90, putative 0.0015 0.0029 0.0038
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0146
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0113 0.0486
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0356 0.1143
Leishmania major hypothetical protein, conserved 0.0026 0.0156 0.0363
Trypanosoma brucei glucose transporter, putative 0.0065 0.0601 0.1675
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0393 0.2108
Echinococcus multilocularis solute carrier family 22 0.003 0.0196 0.063
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0601 0.1932
Trypanosoma brucei glucose transporter, putative 0.0065 0.0601 0.1675
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0211 0.0557
Schistosoma mansoni glucose transporter 0.003 0.0196 0.063
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0081 0.0051
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0196 0.0965
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0074 0.0705 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0601 0.1643
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0015 0.0035 0.0101
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0108 0.0309
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0695 0.0668
Trypanosoma brucei glucose transporter 1E 0.0065 0.0601 0.1675
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0081 0.0205
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0196 0.063
Schistosoma mansoni transient receptor potential channel 0.01 0.0999 0.3211
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0145
Trypanosoma brucei unspecified product 0.0055 0.0491 0.1359
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0592 0.1901
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0592 0.0873
Loa Loa (eye worm) hypothetical protein 0.0063 0.0577 0.1854
Echinococcus granulosus solute carrier family 22 0.003 0.0196 0.063
Onchocerca volvulus 0.003 0.0196 0.0794
Echinococcus granulosus expressed conserved protein 0.0095 0.0945 0.3038
Entamoeba histolytica hypothetical protein 0.0037 0.0282 0.0716
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0081 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Loa Loa (eye worm) hypothetical protein 0.0116 0.1182 0.38
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0108 0.0264
Treponema pallidum DNA topoisomerase I (topA) 0.0015 0.0035 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0445 0.143
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.2249 0.723
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trypanosoma cruzi DNA topoisomerase III, putative 0.0015 0.0035 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0196 0.0965
Onchocerca volvulus 0.003 0.0196 0.0794
Trypanosoma brucei unspecified product 0.0024 0.0133 0.0336
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0113 0.0486
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0044
Brugia malayi Sugar transporter family protein 0.003 0.0196 0.063
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0045 0.0146
Leishmania major mitochondrial DNA topoisomerase II 0.0321 0.3509 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0592 0.0564
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0045 0.0016
Loa Loa (eye worm) hypothetical protein 0.0063 0.0575 0.1849
Loa Loa (eye worm) hypothetical protein 0.01 0.0999 0.3211
Entamoeba histolytica hypothetical protein 0.0037 0.0282 0.0716
Giardia lamblia DNA repair protein RAD52 0.0359 0.3939 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0196 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Entamoeba histolytica hypothetical protein 0.0037 0.0282 0.0716
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0568 0.1827
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0081 0.0051
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0108 0.0227
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0196 0.063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0568 0.1619
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0265 0.0755
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0601 0.1712
Giardia lamblia DNA topoisomerase III 0.0015 0.0035 0.0015
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Brugia malayi hypothetical protein 0.0156 0.1633 0.5249
Onchocerca volvulus 0.003 0.0196 0.0794
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Leishmania major DNA topoisomerase III, putative 0.0015 0.0035 0.0017
Toxoplasma gondii heat shock protein HSP90 0.0015 0.0029 0.002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0045 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma brucei DNA topoisomerase III, putative 0.0015 0.0035 0.0055
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.006 0.0067
Trypanosoma brucei Heat shock protein 83, putative 0.0015 0.0029 0.0038
Brugia malayi Flap endonuclease-1 0.0027 0.0166 0.0532
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0201 0.053
Brugia malayi MH2 domain containing protein 0.0123 0.1261 0.4053
Trichomonas vaginalis sensor histidine kinase, putative 0.0015 0.0029 0.0094
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0108 0.0348
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0108 0.0348
Trypanosoma brucei glucose transporter, putative 0.0065 0.0601 0.1675
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0166 0.0428
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0029 0.0094
Onchocerca volvulus 0.003 0.0196 0.0794
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.1537 0.4333
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0029 0.0084
Giardia lamblia DINP protein human, muc B family 0.0042 0.0334 0.0778
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0196 0.0167
Brugia malayi hypothetical protein 0.0026 0.0156 0.0501
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0313 0.4198
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0029 0.0084
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0145
Trypanosoma brucei DNA topoisomerase III, putative 0.0015 0.0035 0.0055
Loa Loa (eye worm) heat shock protein 90 0.0015 0.0029 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.2249 0.723
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0359 0.3939 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0108 0.0309
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0592 0.0564
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Onchocerca volvulus 0.0156 0.1633 0.7903
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0393 0.1264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0601 0.1675
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0146
Trypanosoma cruzi DNA topoisomerase II, putative 0.027 0.2935 0.8366
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0356 0.1143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0081 0.0297
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0196 0.0273
Brugia malayi heat shock protein 90 0.0015 0.0029 0.0094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0592 0.1901
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0196 0.063
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0592 0.0564
Brugia malayi hypothetical protein 0.003 0.0196 0.063
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.021 0.2249 0.723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0081 0.0259
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0029 0.0084
Schistosoma mansoni hypothetical protein 0.0175 0.1848 0.5941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0601 0.1932
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0196 0.063
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0045 0.0084
Toxoplasma gondii FATC domain-containing protein 0.003 0.0201 0.0281
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0601 0.1712
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0393 0.108
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0196 0.0965
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0356 0.1143
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0393 0.5388
Schistosoma mansoni heat shock protein 0.0015 0.0029 0.0094
Giardia lamblia Sugar-proton symporter 0.003 0.0196 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0145
Loa Loa (eye worm) TOPoisomerase family member 0.0286 0.3111 1
Echinococcus granulosus dna polymerase kappa 0.0062 0.0568 0.1827
Trypanosoma brucei DNA topoisomerase ii 0.0321 0.3509 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0196 0.063
Loa Loa (eye worm) hypothetical protein 0.0051 0.0445 0.143
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0295 0.0799
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0156 0.0444
Plasmodium vivax CDK-related protein kinase 6, putative 0.0892 1 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0592 0.1901
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.0835
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0145
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.3404 0.97
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0592 0.1901
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0108 0.0309
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0393 0.1264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.1537 0.4355
Trypanosoma brucei heat shock protein, putative 0.0015 0.0029 0.0038
Plasmodium vivax DNA topoisomerase 3, putative 0.0015 0.0035 0.0006
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0313 0.1642
Onchocerca volvulus 0.003 0.0196 0.0794
Trypanosoma brucei glucose transporter, putative 0.0065 0.0601 0.1675
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0015 0.0035 0.0101
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0166 0.0391
Chlamydia trachomatis DNA gyrase subunit A 0.0061 0.0559 0.3069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Loa Loa (eye worm) hypothetical protein 0.0053 0.0467 0.1502
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0196 0.0965
Leishmania major protein kinase, putative 0.0064 0.0592 0.1616
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0035 0.0256 0.0824
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0146
Schistosoma mansoni sugar transporter 0.003 0.0196 0.063
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0196 0.0479
Echinococcus multilocularis solute carrier family 22 0.003 0.0196 0.063
Schistosoma mansoni hypothetical protein 0.0042 0.0338 0.1086
Trypanosoma brucei heat shock protein 90, putative 0.0015 0.0029 0.0038
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0015 0.0029 0.0094
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0592 0.1901
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0577 0.1464
Trichomonas vaginalis sugar transporter, putative 0.003 0.0196 0.063
Brugia malayi DNA topoisomerase III 0.0015 0.0035 0.0114
Toxoplasma gondii heat shock protein 90, putative 0.0015 0.0029 0.002
Chlamydia trachomatis DNA gyrase subunit A 0.0061 0.0559 0.3069
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.1015 0.2577
Brugia malayi hypothetical protein 0.0017 0.0051 0.0164
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0911
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0592 0.1648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0108 0.0348
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0061 0.0559 0.3069
Entamoeba histolytica hypothetical protein 0.0102 0.1021 0.2591
Leishmania major DNA topoisomerase III, putative 0.0015 0.0035 0.0017
Schistosoma mansoni heat shock protein 0.0015 0.0029 0.0094
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0167 0.1756 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0145
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0592 0.0564
Echinococcus granulosus flap endonuclease 1 0.0027 0.0166 0.0532
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0546 0.1756
Schistosoma mansoni endoplasmin 0.0015 0.0029 0.0094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0445 0.143
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0035 0.0256 0.0824
Trypanosoma cruzi DNA topoisomerase III, putative 0.0015 0.0035 0.0101
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0601 0.1675
Mycobacterium ulcerans sugar transporter 0.003 0.0196 0.0965
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.063
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0029 0.0038
Schistosoma mansoni protein kinase 0.0064 0.0592 0.1901
Schistosoma mansoni hypothetical protein 0.021 0.2249 0.723
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0568 0.1581
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0601 0.1675
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0577 0.8105
Brugia malayi Sugar transporter family protein 0.003 0.0196 0.063
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0045 0.0016

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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