Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosine kinase | 0.0158 | 0.0278 | 1 |
Leishmania major | ribokinase, putative | 0.0158 | 0.0278 | 1 |
Entamoeba histolytica | ribokinase, putative | 0.0158 | 0.0278 | 1 |
Leishmania major | putative PfkB family sugar kinase | 0.0158 | 0.0278 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0158 | 0.0278 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.0158 | 0.0278 | 1 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0158 | 0.0278 | 0.5 |
Leishmania major | tagatose-6-phosphate kinase-like protein | 0.0158 | 0.0278 | 1 |
Entamoeba histolytica | kinase, PfkB family | 0.0158 | 0.0278 | 1 |
Leishmania major | adenosine kinase-like protein | 0.0158 | 0.0278 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0158 | 0.0278 | 1 |
Trypanosoma brucei | ribokinase, putative | 0.0158 | 0.0278 | 1 |
Giardia lamblia | Ribokinase | 0.0158 | 0.0278 | 0.5 |
Echinococcus granulosus | pseudouridine metabolizing bifunctional protein | 0.0158 | 0.0278 | 1 |
Leishmania major | tagatose-6-phosphate kinase-like protein | 0.0158 | 0.0278 | 1 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0158 | 0.0278 | 0.5 |
Echinococcus granulosus | ribokinase | 0.0158 | 0.0278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0278 | 0.0278 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0158 | 0.0278 | 0.5 |
Entamoeba histolytica | fructokinase, putative | 0.0158 | 0.0278 | 1 |
Trypanosoma brucei | ribokinase, putative | 0.0158 | 0.0278 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | ribokinase | 0.0158 | 0.0278 | 1 |
Leishmania major | adenosine kinase-like protein | 0.0158 | 0.0278 | 1 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0158 | 0.0278 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0158 | 0.0278 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0158 | 0.0278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4122 | 1 | 1 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0158 | 0.0278 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0158 | 0.0278 | 1 |
Onchocerca volvulus | 0.4122 | 1 | 1 | |
Leishmania major | adenosine kinase, putative | 0.0158 | 0.0278 | 1 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0158 | 0.0278 | 1 |
Echinococcus multilocularis | ribokinase | 0.0158 | 0.0278 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0158 | 0.0278 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0158 | 0.0278 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0158 | 0.0278 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0158 | 0.0278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0278 | 0.0278 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0158 | 0.0278 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.0278 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0158 | 0.0278 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0158 | 0.0278 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0158 | 0.0278 | 1 |
Trypanosoma cruzi | ribokinase, putative | 0.0158 | 0.0278 | 1 |
Echinococcus multilocularis | pseudouridine metabolizing bifunctional protein | 0.0158 | 0.0278 | 1 |
Brugia malayi | Adenosine kinase-like | 0.0158 | 0.0278 | 0.0278 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0158 | 0.0278 | 1 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0158 | 0.0278 | 1 |
Brugia malayi | Ribokinase | 0.0158 | 0.0278 | 0.0278 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.