TDR Targets

Basic information

Technical information

TDR Targets ID: 1383246
Name: tert-butyl 4-[2-(4-methylphenyl)-4-[[1-[(4-me thylphenyl)methyl]piperidin-4-yl]methylcarbam oyl]pyrazol-3-yl]piperidine-1-carboxylate
MW: 585.779 | Formula: C35H47N5O3
H donors: 1 H acceptors: 3 LogP: 5.64 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: Cc1ccc(cc1)n1ncc(c1C1CCN(CC1)C(=O)OC(C)(C)C)C(=O)NCC1CCN(CC1)Cc1ccc(cc1)C
InChi: 1S/C35H47N5O3/c1-25-6-10-28(11-7-25)24-38-18-14-27(15-19-38)22-36-33(41)31-23-37-40(30-12-8-26(2)9-13-30)32(31)29-16-20-39(21-17-29)34(42)43-35(3,4)5/h6-13,23,27,29H,14-22,24H2,1-5H3,(H,36,41)
InChiKey: GNKRILAVIKCVRL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

tert-butyl 4-[2-(4-methylphenyl)-4-[[1-[(4-methylphenyl)methyl]-4-piperidyl]methylcarbamoyl]pyrazol-3-yl]piperidine-1-carboxylate
4-[2-(4-methylphenyl)-4-[[[1-[(4-methylphenyl)methyl]-4-piperidinyl]methylamino]-oxomethyl]-3-pyrazolyl]-1-piperidinecarboxylic acid tert-butyl ester
4-[4-[[1-(4-methylbenzyl)-4-piperidyl]methylcarbamoyl]-2-(4-methylphenyl)pyrazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester
NCGC00126945-01
E951-0880

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Aminopeptidase M1, putative	0.0034	0.081	0.122
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0022	0.04	0.0597
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0012	0.0054	0.005
Schistosoma mansoni	transcription factor LCR-F1	0.0025	0.052	0.0777
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0012	0.0054	0.0081
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0054	0.008
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.001	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0837	0.0834
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0045	0.1221	0.1824
Schistosoma mansoni	cathepsin D (A01 family)	0.0044	0.1166	0.1742
Schistosoma mansoni	ap endonuclease	0.001	0.0003	0.0005
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0034	0.081	0.1224
Brugia malayi	hypothetical protein	0.0034	0.081	0.0807
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0092	0.2848	0.2846
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0012	0.0054	0.008
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0022	0.04	0.06
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0015	0.016	0.0242
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0012	0.0054	0.0076
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Brugia malayi	TATA binding protein associated factor	0.0012	0.0054	0.005
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0023	0.044	0.0657
Entamoeba histolytica	protein kinase domain containing protein	0.02	0.6614	1
Entamoeba histolytica	protein kinase domain containing protein	0.02	0.6614	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0023	0.044	0.0657
Onchocerca volvulus		0.0022	0.0425	0.0567
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.001	0.0003	0.0005
Onchocerca volvulus		0.0114	0.3604	0.5412
Loa Loa (eye worm)	TATA binding protein associated factor	0.0012	0.0054	0.005
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.02	0.6614	0.6612
Echinococcus granulosus	lamin dm0	0.0015	0.0159	0.0238
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0015	0.0159	0.0156
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0012	0.0054	0.0076
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0034	0.081	0.0807
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Schistosoma mansoni	hypothetical protein	0.0012	0.0055	0.0083
Schistosoma mansoni	lamin	0.0015	0.0159	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.04	0.0397
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0011	0.0028	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0837	0.0834
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0034	0.081	0.1224
Echinococcus multilocularis	lamin dm0	0.0015	0.0159	0.0238
Plasmodium vivax	plasmepsin IV, putative	0.0015	0.016	0.0237
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0012	0.0054	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.005
Toxoplasma gondii	peptidase family M13 protein	0.0045	0.1221	0.1843
Entamoeba histolytica	hypothetical protein	0.0025	0.052	0.0782
Trypanosoma cruzi	aminopeptidase, putative	0.0012	0.0054	0.0076
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0012	0.0054	0.0076
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0011	0.0028	0.0042
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0837	0.0834
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0011	0.0028	0.0042
Mycobacterium ulcerans	aminopeptidase N PepN	0.0012	0.0054	0.0439
Toxoplasma gondii	aspartyl protease ASP1	0.0015	0.016	0.0237
Treponema pallidum	exodeoxyribonuclease (exoA)	0.001	0.0003	1
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0034	0.081	0.1209
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.001	0.0003	1
Trypanosoma cruzi	aminopeptidase, putative	0.0034	0.081	0.122
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0012	0.0054	0.0076
Trichomonas vaginalis	CMGC family protein kinase	0.02	0.6614	1
Entamoeba histolytica	hypothetical protein	0.0025	0.052	0.0782
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0034	0.081	0.122
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.02	0.6614	1
Brugia malayi	hypothetical protein	0.0025	0.052	0.0517
Plasmodium vivax	glycogen synthase kinase 3, putative	0.02	0.6614	1
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0023	0.044	0.0657
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0015	0.016	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3194	0.3192
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0015	0.016	0.0157
Toxoplasma gondii	aminopeptidase N protein	0.0012	0.0054	0.0076
Echinococcus multilocularis	endothelin converting enzyme 1	0.0045	0.1221	0.1824
Entamoeba histolytica	hypothetical protein	0.0025	0.052	0.0782
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0011	0.0028	0.0025
Schistosoma mansoni	hypothetical protein	0.0012	0.0055	0.0083
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.02	0.6614	0.6612
Loa Loa (eye worm)	intermediate filament protein	0.0015	0.0159	0.0156
Echinococcus multilocularis	lamin	0.0015	0.0159	0.0238
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0034	0.081	0.122
Loa Loa (eye worm)	hypothetical protein	0.0034	0.081	0.0807
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0034	0.081	0.122
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.005
Schistosoma mansoni	neprilysin	0.0012	0.0055	0.0083
Onchocerca volvulus		0.0034	0.081	0.1152
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.02	0.6614	0.9877
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0054	0.008
Loa Loa (eye worm)	hypothetical protein	0.0022	0.04	0.0397
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0012	0.0055	0.0083
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0045	0.1221	0.1218
Echinococcus multilocularis	musashi	0.0015	0.0159	0.0238
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0022	0.04	0.0597
Giardia lamblia	Kinase, CMGC GSK	0.02	0.6614	1
Echinococcus granulosus	lamin	0.0015	0.0159	0.0238
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0012	0.0054	0.008
Onchocerca volvulus		0.0015	0.0159	0.0161
Brugia malayi	Intermediate filament tail domain containing protein	0.0015	0.0159	0.0156
Trichomonas vaginalis	ap endonuclease, putative	0.001	0.0003	0.0005
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0011	0.0028	0.0042
Brugia malayi	intracellular kinase	0.02	0.6614	0.6612
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0012	0.0054	0.0076
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0015	0.016	0.0239
Brugia malayi	Peptidase family M1 containing protein	0.0114	0.3604	0.3602
Giardia lamblia	Kinase, CMGC GSK	0.02	0.6614	1
Schistosoma mansoni	lamin	0.0015	0.0159	0.0238
Brugia malayi	Peptidase family M1 containing protein	0.0034	0.081	0.0807
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.02	0.6614	0.9877
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0012	0.0054	0.008
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0025	0.052	0.0777
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0015	0.016	0.0239
Plasmodium falciparum	plasmepsin IV	0.0015	0.016	0.0237
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0012	0.0054	0.0076
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0011	0.0028	0.0042
Schistosoma mansoni	ap endonuclease	0.001	0.0003	0.0005
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0025	0.052	0.0777
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.001	0.0003	0.0027
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0012	0.0054	0.0076
Trypanosoma brucei	aminopeptidase, putative	0.0012	0.0054	0.0076
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0034	0.081	0.1209
Echinococcus granulosus	protein kinase shaggy	0.02	0.6614	0.9877
Trichomonas vaginalis	ap endonuclease, putative	0.001	0.0003	0.0005
Schistosoma mansoni	hypothetical protein	0.0012	0.0055	0.0083
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.02	0.6614	1
Onchocerca volvulus		0.0015	0.0159	0.0161
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0015	0.016	0.0239
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0023	0.044	0.0657
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.02	0.6614	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0157
Schistosoma mansoni	hypothetical protein	0.0012	0.0055	0.0083
Schistosoma mansoni	hypothetical protein	0.0203	0.6696	1
Entamoeba histolytica	protein kinase, putative	0.02	0.6614	1
Echinococcus granulosus	geminin	0.0203	0.6696	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0034	0.081	0.6629
Brugia malayi	hypothetical protein	0.0012	0.0054	0.005
Entamoeba histolytica	hypothetical protein	0.0025	0.052	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1221	0.1218
Echinococcus multilocularis	protein kinase shaggy	0.02	0.6614	0.9877
Schistosoma mansoni	hypothetical protein	0.0203	0.6696	1
Brugia malayi	Peptidase family M13 containing protein	0.0045	0.1221	0.1218
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0012	0.0054	0.008
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0034	0.081	0.1209
Trypanosoma brucei	Aminopeptidase M1, putative	0.0034	0.081	0.122
Echinococcus multilocularis	aminopeptidase N	0.0114	0.3604	0.5383
Toxoplasma gondii	aminopeptidase n, putative	0.0012	0.0054	0.0076
Schistosoma mansoni	endothelin-converting enzyme-related	0.0011	0.0028	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0837	0.0834
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0023	0.044	0.0657
Mycobacterium leprae	probable zinc metalloprotease	0.0045	0.1221	1
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0045	0.1221	1
Echinococcus multilocularis	geminin	0.0203	0.6696	1
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0034	0.081	0.122
Schistosoma mansoni	hypothetical protein	0.0025	0.052	0.0777
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.001	0.0003	0.0027
Brugia malayi	peptidase family M13 containing protein	0.0011	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0034	0.081	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1221	0.1218
Echinococcus granulosus	aminopeptidase N	0.0114	0.3604	0.5383
Loa Loa (eye worm)	hypothetical protein	0.0015	0.015	0.0147
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0012	0.0054	0.0076
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0034	0.081	0.122
Brugia malayi	intermediate filament protein	0.0015	0.0159	0.0156
Loa Loa (eye worm)	hypothetical protein	0.008	0.2438	0.2436
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0425	0.0422
Plasmodium falciparum	plasmepsin I	0.0015	0.016	0.0237
Schistosoma mansoni	intermediate filament proteins	0.0015	0.0159	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0837	0.0834
Entamoeba histolytica	aminopeptidase, putative	0.0034	0.081	0.122
Schistosoma mansoni	hypothetical protein	0.0012	0.0055	0.0083
Plasmodium falciparum	plasmepsin II	0.0015	0.016	0.0237
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0034	0.081	0.0807
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Plasmodium falciparum	plasmepsin VI	0.0015	0.016	0.0237
Loa Loa (eye worm)	aminopeptidase N	0.0034	0.081	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.005
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0054	0.005
Plasmodium vivax	aspartyl proteinase, putative	0.0015	0.016	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0159	0.0156
Echinococcus granulosus	intermediate filament protein	0.0015	0.0159	0.0238
Onchocerca volvulus		0.02	0.6614	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0837	0.0834
Echinococcus granulosus	endothelin converting enzyme 1	0.0045	0.1221	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1221	0.1218
Plasmodium falciparum	glycogen synthase kinase 3	0.02	0.6614	1
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.02	0.6614	0.9877
Schistosoma mansoni	hypothetical protein	0.0012	0.0055	0.0083
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.081	0.1209
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0298	1	1
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0012	0.0054	0.008
Trypanosoma brucei	protein kinase, putative	0.02	0.6614	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0044	0.1166	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0034	0.081	0.0807
Trichomonas vaginalis	CMGC family protein kinase	0.02	0.6614	1
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0012	0.0054	0.0076
Toxoplasma gondii	aminopeptidase N, putative	0.0012	0.0054	0.0076
Mycobacterium ulcerans	zinc metalloprotease	0.0045	0.1221	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.081	0.0807

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1534120

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1383246