Detailed information for compound 1383565

Basic information

Technical information
  • TDR Targets ID: 1383565
  • Name: 6-imidazol-1-yl-N-phenylpyridazin-3-amine
  • MW: 237.26 | Formula: C13H11N5
  • H donors: 1 H acceptors: 3 LogP: 1.8 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)Nc1ccc(nn1)n1cncc1
  • InChi: 1S/C13H11N5/c1-2-4-11(5-3-1)15-12-6-7-13(17-16-12)18-9-8-14-10-18/h1-10H,(H,15,16)
  • InChiKey: FJHISDRNODLIQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-imidazol-1-yl-N-phenyl-pyridazin-3-amine
  • 6-(1-imidazolyl)-N-phenyl-3-pyridazinamine
  • (6-imidazol-1-ylpyridazin-3-yl)-phenyl-amine
  • AQ-432/42260201
  • IDI1_025119
  • (6-Imidazol-1-ylpyridazin-3-yl)(phenyl)amine
  • A3600/0152521
  • ChemDiv3_007209
  • ZINC01425839
  • 6-(1H-imidazol-1-yl)-N-phenyl-3-pyridazinamine
  • MLS000679843
  • SMR000296716

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus activin receptor type 0.005 0.0064 0.0076
Schistosoma mansoni nephrin 0.0097 0.0309 0.0292
Echinococcus granulosus c src tyrosine kinase 0.0042 0.0022 0.0026
Entamoeba histolytica protein kinase, putative 0.0065 0.0141 0.0833
Schistosoma mansoni serine/threonine protein kinase 0.1961 1 1
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi hypothetical protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1961 1 1
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Abl 0.0042 0.0022 0.0026
Echinococcus granulosus exocyst complex component 2 0.0123 0.0443 0.053
Brugia malayi Tyrosine-protein kinase abl-1 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0042 0.0022 0.0004
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0042 0.0022 0.0026
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Onchocerca volvulus 0.011 0.0379 0.1118
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0443 0.2931
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) hypothetical protein 0.0123 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0657 0.322 0.322
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0318 0.1458 0.1458
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Echinococcus multilocularis protein KINase family member (kin 25) 0.0042 0.0022 0.0026
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0065 0.0141 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0042 0.0022 0.0026
Echinococcus multilocularis c src tyrosine kinase 0.0042 0.0022 0.0026
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0042 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Brugia malayi Guanylyl cyclase protein 23 0.0042 0.0022 0.0022
Echinococcus granulosus regulator of G protein signaling 7 0.0318 0.1458 0.1747
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0022 0.0004
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0042 0.0022 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0443 0.2931
Echinococcus granulosus fibroblast growth factor receptor 4 0.0042 0.0022 0.0026
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0318 0.1458 0.1443
Loa Loa (eye worm) sema domain-containing protein 0.028 0.126 0.126
Schistosoma mansoni z-protein (S1r protein) 0.0318 0.1458 0.1443
Echinococcus granulosus semaphorin 1A 0.028 0.126 0.1509
Echinococcus multilocularis axis inhibition protein axin 0.0318 0.1458 0.1747
Brugia malayi Matrixin family protein 0.0078 0.021 0.021
Brugia malayi regulator of G-protein signaling rgs-7 0.0318 0.1458 0.1458
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0042 0.0022 0.0026
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0141 0.0141
Schistosoma mansoni protein kinase 0.0065 0.0141 0.0123
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Schistosoma mansoni semaphorin 5-related 0.028 0.126 0.1244
Echinococcus multilocularis Immunoglobulin 0.0097 0.0309 0.037
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus G protein coupled receptor kinase 1 0.1185 0.5967 0.7149
Loa Loa (eye worm) hypothetical protein 0.0318 0.1458 0.1458
Echinococcus granulosus tyrosine protein kinase HCK 0.0042 0.0022 0.0026
Brugia malayi Matrixin family protein 0.0188 0.0784 0.0784
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0022 0.0026
Brugia malayi hypothetical protein 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Entamoeba histolytica protein kinase, putative 0.0065 0.0141 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0443 0.2931
Loa Loa (eye worm) hypothetical protein 0.0123 0.0443 0.0443
Brugia malayi ephrin receptor 1 precursor 0.0042 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0123 0.0443 0.0426
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0123 0.0443 0.2931
Schistosoma mansoni axis inhibition protein axin 0.0318 0.1458 0.1443
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0042 0.0022 0.0026
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0123 0.0443 0.2931
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0064 0.0294
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1643 0.8347 0.8347
Echinococcus granulosus beta-adrenergic receptor kinase 0.1503 0.762 0.9129
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0019 0.0019
Schistosoma mansoni protein kinase 0.0042 0.0022 0.0004
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0097 0.0309 0.037
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0022 0.0026
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0064 0.3526
Mycobacterium leprae PROBABLE HYDROLASE 0.0095 0.0298 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0118 0.0118
Brugia malayi Matrixin family protein 0.0078 0.021 0.021
Brugia malayi protein-tyrosine kinase 0.0042 0.0022 0.0022
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0097 0.0309 0.0292
Schistosoma mansoni protein kinase 0.005 0.0064 0.0046
Echinococcus multilocularis activated cdc42 kinase 1 0.0042 0.0022 0.0026
Loa Loa (eye worm) serine/threonine protein kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.1458 1
Echinococcus granulosus tyrosine protein kinase csk 0.0042 0.0022 0.0026
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0064 0.3526
Echinococcus multilocularis ephrin type A receptor 4 A 0.0042 0.0022 0.0026
Echinococcus granulosus retinal guanylyl cyclase 2 0.0042 0.0022 0.0026
Echinococcus granulosus regulator of G protein signaling 3 0.0318 0.1458 0.1747
Schistosoma mansoni hypothetical protein 0.011 0.0379 0.0362
Loa Loa (eye worm) hypothetical protein 0.0318 0.1458 0.1458
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0042 0.0022 0.0004
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0042 0.0022 0.0026
Echinococcus granulosus tyrosine kinase 0.0042 0.0022 0.0026
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0022 0.0026
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1643 0.8347 1
Schistosoma mansoni protein kinase 0.0042 0.0022 0.0004
Echinococcus multilocularis regulator of G protein signaling 0.0318 0.1458 0.1747
Echinococcus multilocularis epidermal growth factor receptor 0.0042 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Onchocerca volvulus 0.0657 0.322 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0042 0.0022 0.0026
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Schistosoma mansoni protein kinase 0.005 0.0064 0.0046
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Echinococcus multilocularis tyrosine protein kinase pr2 0.0042 0.0022 0.0026
Onchocerca volvulus Matrilysin homolog 0.0173 0.0703 0.213
Loa Loa (eye worm) matrixin family protein 0.0173 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Echinococcus multilocularis protein kinase 0.0042 0.0022 0.0026
Brugia malayi serine/threonine protein kinase 6 0.0065 0.0141 0.0141
Echinococcus granulosus tyrosine protein kinase pr2 0.0042 0.0022 0.0026
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0138 0.0525 0.0525
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Echinococcus multilocularis roundabout 2 0.0097 0.0309 0.037
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi Regulator of G protein signaling domain containing protein 0.0318 0.1458 0.1458
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase csk 0.0042 0.0022 0.0026
Schistosoma mansoni protein kinase 0.005 0.0064 0.0046
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0042 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Brugia malayi C-terminal src kinase protein 1 0.0042 0.0022 0.0022
Echinococcus granulosus activated cdc42 kinase 1 0.0042 0.0022 0.0026
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0118 0.0118
Entamoeba histolytica hypothetical protein 0.0123 0.0443 0.2931
Loa Loa (eye worm) TK/EPH protein kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0078 0.021 0.021
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0042 0.0022 0.0026
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1643 0.8347 1
Schistosoma mansoni protein kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) hypothetical protein 0.028 0.126 0.126
Schistosoma mansoni regulator of G protein signaling 0.0318 0.1458 0.1443
Schistosoma mansoni regulator of G protein signaling 0.0318 0.1458 0.1443
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi hypothetical protein 0.028 0.126 0.126
Brugia malayi Sema domain containing protein 0.028 0.126 0.126
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0042 0.0022 0.0026
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0042 0.0022 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0318 0.1458 0.1443
Brugia malayi Matrixin family protein 0.0078 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Echinococcus granulosus roundabout 2 0.0097 0.0309 0.037
Loa Loa (eye worm) hypothetical protein 0.0123 0.0443 0.0443
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0042 0.0022 0.0022
Onchocerca volvulus Matrix metalloproteinase homolog 0.0173 0.0703 0.213
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Echinococcus granulosus activated cdc42 kinase 1 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0042 0.0022 0.0026
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0097 0.0309 0.037
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0042 0.0022 0.0026
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Schistosoma mansoni protein kinase 0.0042 0.0022 0.0004
Echinococcus multilocularis tyrosine kinase 0.0042 0.0022 0.0026
Leishmania major protein kinase, putative 0.005 0.0064 0.3526
Echinococcus multilocularis integrin linked protein kinase 0.0042 0.0022 0.0026
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0022 0.0026
Echinococcus granulosus tyrosine protein kinase Blk 0.0042 0.0022 0.0026
Echinococcus multilocularis receptor type guanylyl cyclase 0.0042 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.028 0.126 0.126
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK/CSK protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0042 0.0022 0.0026
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Blk 0.0042 0.0022 0.0026
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0042 0.0022 0.0022
Loa Loa (eye worm) plexin A 0.0779 0.3857 0.3857
Echinococcus granulosus neuroglian 0.0097 0.0309 0.037
Loa Loa (eye worm) matrix metalloproteinase 0.0078 0.021 0.021
Entamoeba histolytica protein kinase , putative 0.0065 0.0141 0.0833
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0042 0.0022 0.0022
Echinococcus multilocularis protein kinase 0.0042 0.0022 0.0026
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0042 0.0022 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Brugia malayi hypothetical protein 0.0097 0.0309 0.0309
Echinococcus multilocularis activin receptor type 0.005 0.0064 0.0076
Echinococcus multilocularis kinase suppressor of Ras 1 0.0042 0.0022 0.0026
Schistosoma mansoni protein kinase 0.0042 0.0022 0.0004
Schistosoma mansoni ephrin receptor 0.0042 0.0022 0.0004
Brugia malayi PXA domain containing protein 0.0318 0.1458 0.1458
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.0022 0.0026
Schistosoma mansoni cell adhesion molecule 0.0097 0.0309 0.0292
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Entamoeba histolytica tyrosin kinase, putative 0.0164 0.0659 0.4436
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) SRC-1 0.0042 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0318 0.1458 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0042 0.0022 0.0026
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) protein kinase domain-containing protein 0.0042 0.0022 0.0022
Brugia malayi Tyrosine-protein kinase PR2 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK/ROR protein kinase 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0065 0.0141 0.0169
Brugia malayi integrin-linked kinase 0.0042 0.0022 0.0022
Echinococcus granulosus receptor type guanylyl cyclase 0.0042 0.0022 0.0026
Echinococcus multilocularis tyrosine protein kinase csk 0.0042 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Echinococcus granulosus defective proboscis extension response 0.0097 0.0309 0.037
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0042 0.0022 0.0026
Echinococcus multilocularis neuroglian 0.0097 0.0309 0.037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0019
Loa Loa (eye worm) TK/RYK protein kinase 0.0042 0.0022 0.0022
Echinococcus multilocularis epidermal growth factor receptor 0.0042 0.0022 0.0026
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Schistosoma mansoni protein kinase 0.0042 0.0022 0.0004
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0082 0.0232 0.0215
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0042 0.0022 0.0026
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0065 0.0141 0.0833
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Src42A 0.0042 0.0022 0.0026
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Entamoeba histolytica cell surface protease gp63, putative 0.0123 0.0443 0.2931
Loa Loa (eye worm) hypothetical protein 0.006 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0443 0.2931
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0042 0.0022 0.0026
Echinococcus granulosus retinal guanylyl cyclase 2 0.0042 0.0022 0.0026
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1503 0.762 0.762
Loa Loa (eye worm) hypothetical protein 0.028 0.126 0.126
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0123 0.0443 0.2931
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0042 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0318 0.1458 0.1458
Entamoeba histolytica protein kinase domain containing protein 0.0164 0.0659 0.4436
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0042 0.0022 0.0026
Schistosoma mansoni plexin 0.0377 0.1766 0.1751
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0022 0.0026
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0065 0.0141 0.0833
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0123 0.0443 0.0443
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK/DDR protein kinase 0.0042 0.0022 0.0022
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0042 0.0022 0.0004
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0042 0.0022 0.0026
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0042 0.0022 0.0026
Echinococcus multilocularis tyrosine protein kinase shark 0.0042 0.0022 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.1458 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0095 0.0298 0.5
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0283 0.1277 0.1529
Echinococcus multilocularis Regulator of G protein signaling 20 0.0318 0.1458 0.1747
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Echinococcus granulosus tyrosine protein kinase ABL1 0.0042 0.0022 0.0026
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0042 0.0022 0.0022
Brugia malayi Probable exocyst complex component Sec5 0.0123 0.0443 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0443 0.2931
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi SH2 domain containing protein 0.0042 0.0022 0.0022
Brugia malayi Raf kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0042 0.0022 0.0022
Echinococcus multilocularis Immunoglobulin 0.0097 0.0309 0.037
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi Hemopexin family protein 0.011 0.0379 0.0379
Onchocerca volvulus 0.0078 0.021 0.0589
Brugia malayi hypothetical protein 0.0318 0.1458 0.1458
Entamoeba histolytica hypothetical protein 0.0318 0.1458 1
Echinococcus granulosus protein kinase 0.0042 0.0022 0.0026
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Toxoplasma gondii aurora kinase 0.0065 0.0141 1
Echinococcus granulosus epidermal growth factor receptor 0.0042 0.0022 0.0026
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0318 0.1458 0.1443
Loa Loa (eye worm) hypothetical protein 0.0095 0.0298 0.0298
Brugia malayi Furin-like cysteine rich region family protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Echinococcus multilocularis transfer RNA-Thr 0.0042 0.0022 0.0026
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0064 0.3526
Echinococcus granulosus semaphorin 5B 0.028 0.126 0.1509
Echinococcus granulosus tyrosine protein kinase Lyn 0.005 0.0064 0.0076
Brugia malayi A-kinase anchor protein 10, precursor 0.0318 0.1458 0.1458
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) TK/ALK protein kinase 0.0042 0.0022 0.0022
Brugia malayi DNA-binding protein LAG-1 0.0123 0.0443 0.0443
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0141 0.0833
Plasmodium falciparum serine/threonine protein kinase, putative 0.0065 0.0141 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0042 0.0022 0.0026
Echinococcus multilocularis regulator of G protein signaling 7 0.0318 0.1458 0.1747
Schistosoma mansoni regulator of G protein signaling 0.0318 0.1458 0.1443
Echinococcus granulosus regulator of G protein signaling 3 0.0318 0.1458 0.1747
Trypanosoma cruzi aurora B kinase, putative 0.0065 0.0141 1
Echinococcus multilocularis hypothetical protein 0.028 0.126 0.1509
Echinococcus granulosus tyrosine protein kinase Src64B 0.0042 0.0022 0.0026
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0042 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase 0.0042 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Brugia malayi Fibronectin type III domain containing protein 0.0097 0.0309 0.0309
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0318 0.1458 0.1747
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0318 0.1458 0.1443
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Echinococcus granulosus aurora kinase A 0.0065 0.0141 0.0169
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0042 0.0022 0.0026
Loa Loa (eye worm) PXA domain-containing protein 0.0318 0.1458 0.1458
Brugia malayi Immunoglobulin I-set domain containing protein 0.0138 0.0525 0.0525
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Mycobacterium ulcerans hydrolase 0.0095 0.0298 0.5
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0042 0.0022 0.0022
Plasmodium falciparum protein kinase, putative 0.005 0.0064 0.3526
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Brugia malayi Plexin repeat family protein 0.0657 0.322 0.322
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.1458 1
Echinococcus granulosus twitchin 0.0105 0.0351 0.0421
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0123 0.0443 0.2931
Loa Loa (eye worm) hypothetical protein 0.028 0.126 0.126
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0318 0.1458 1
Schistosoma mansoni hypothetical protein 0.0041 0.0019 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.1503 0.762 0.7616
Schistosoma mansoni protein tyrosine kinase 0.0042 0.0022 0.0004
Echinococcus granulosus tyrosine protein kinase Srms 0.0042 0.0022 0.0026
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Trypanosoma brucei protein kinase, putative 0.005 0.0064 0.3526
Echinococcus granulosus transcription factor collier 0.0123 0.0443 0.053
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Brugia malayi plexin A 0.0779 0.3857 0.3857
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0141 0.0833
Echinococcus multilocularis dual specificity testis specific protein kinase 0.005 0.0064 0.0076
Onchocerca volvulus Matrilysin homolog 0.0078 0.021 0.0589
Schistosoma mansoni hypothetical protein 0.0042 0.0022 0.0004
Echinococcus granulosus Regulator of G protein signaling 20 0.0318 0.1458 0.1747
Echinococcus multilocularis regulator of G protein signaling 3 0.0318 0.1458 0.1747
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0065 0.0141 0.0169
Schistosoma mansoni hypothetical protein 0.028 0.126 0.1244
Echinococcus multilocularis tyrosine protein kinase HCK 0.0042 0.0022 0.0026
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0042 0.0022 0.0026
Entamoeba histolytica hypothetical protein 0.0318 0.1458 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.028 0.126 0.126
Echinococcus granulosus kinase suppressor of Ras 1 0.0042 0.0022 0.0026
Echinococcus granulosus tyrosine kinase 0.0042 0.0022 0.0026
Schistosoma mansoni serine/threonine RGC 0.0042 0.0022 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.0318 0.1458 0.1747
Loa Loa (eye worm) hypothetical protein 0.028 0.126 0.126
Echinococcus multilocularis beta adrenergic receptor kinase 0.1503 0.762 0.9129
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0141 0.0123
Echinococcus multilocularis expressed protein 0.0318 0.1458 0.1747
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0318 0.1458 0.1747
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0118 0.0118
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0022 0.0026
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Echinococcus granulosus dual specificity testis-specific protein kinase 0.005 0.0064 0.0076
Echinococcus granulosus tyrosine protein kinase shark 0.0042 0.0022 0.0026
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0042 0.0022 0.0026
Brugia malayi IPT/TIG domain containing protein 0.0123 0.0443 0.0443
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi PXA domain containing protein 0.0318 0.1458 0.1458
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0097 0.0309 0.0292
Echinococcus granulosus plexin a4 0.0779 0.3857 0.4621
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Echinococcus multilocularis tyrosine kinase 0.0042 0.0022 0.0026
Echinococcus multilocularis exocyst complex component 2 0.0123 0.0443 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.1458 1
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0141 0.0833
Brugia malayi regulator of G-protein signaling egl-10 0.0318 0.1458 0.1458
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.1503 0.762 0.7616
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0042 0.0022 0.0026
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Brugia malayi hypothetical protein 0.0318 0.1458 0.1458
Echinococcus multilocularis tyrosine protein kinase csk 0.0042 0.0022 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.1458 1
Echinococcus multilocularis semaphorin 5B 0.028 0.126 0.1509
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Echinococcus granulosus natriuretic peptide receptor 1 0.0042 0.0022 0.0026
Echinococcus granulosus axis inhibition protein axin 0.0318 0.1458 0.1747
Giardia lamblia Aurora kinase 0.0065 0.0141 1
Loa Loa (eye worm) TK/Met protein kinase 0.0042 0.0022 0.0022
Onchocerca volvulus 0.028 0.126 0.3871
Echinococcus multilocularis plexin a4 0.0779 0.3857 0.4621
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0123 0.0443 0.2931
Echinococcus multilocularis aurora kinase A 0.0065 0.0141 0.0169
Loa Loa (eye worm) hypothetical protein 0.0377 0.1766 0.1766
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0141 0.0833
Echinococcus granulosus tyrosine protein kinase 0.0042 0.0022 0.0026
Schistosoma mansoni tyrosine protein kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0123 0.0443 0.2931
Echinococcus multilocularis FL cytokine receptor 0.0042 0.0022 0.0026
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1643 0.8347 0.8347
Schistosoma mansoni axis inhibition protein axin 0.0318 0.1458 0.1443
Brugia malayi SH2 domain containing protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0078 0.021 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0443 0.2931
Schistosoma mansoni plexin 0.0657 0.322 0.3208
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0042 0.0022 0.0026
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0078 0.021 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.1458 1
Echinococcus granulosus integrin linked protein kinase 0.0042 0.0022 0.0026
Brugia malayi Sema domain containing protein 0.028 0.126 0.126
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0042 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase csk 0.0042 0.0022 0.0026
Loa Loa (eye worm) sema domain-containing protein 0.028 0.126 0.126
Loa Loa (eye worm) TK/ABL protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase csk 0.0042 0.0022 0.0026
Echinococcus granulosus Immunoglobulin 0.0097 0.0309 0.037
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Echinococcus multilocularis protein tyrosine kinase 0.0042 0.0022 0.0026
Loa Loa (eye worm) RGS-3 protein 0.0318 0.1458 0.1458
Brugia malayi SRC-1 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0042 0.0022 0.0022
Brugia malayi serine/threonine-protein kinase 6 0.0065 0.0141 0.0141
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0318 0.1458 0.1458
Echinococcus multilocularis transcription factor collier 0.0123 0.0443 0.053
Brugia malayi Regulator of G protein signaling domain containing protein 0.0318 0.1458 0.1458
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Schistosoma mansoni ephrin receptor 0.0042 0.0022 0.0004
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.005 0.0064 0.3526
Leishmania major protein kinase, putative 0.0065 0.0141 1
Schistosoma mansoni hypothetical protein 0.0123 0.0443 0.0426
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Echinococcus granulosus ephrin type A receptor 4 A 0.0042 0.0022 0.0026
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0123 0.0443 0.2931
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0141 0.0833
Brugia malayi Matrixin family protein 0.0078 0.021 0.021
Echinococcus granulosus expressed protein 0.0318 0.1458 0.1747
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Echinococcus multilocularis heat shock protein 70 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK/ACK protein kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus retinal guanylyl cyclase 2 0.0042 0.0022 0.0026
Schistosoma mansoni hypothetical protein 0.028 0.126 0.1244
Loa Loa (eye worm) hypothetical protein 0.0318 0.1458 0.1458
Echinococcus multilocularis regulator of G protein signaling 7 0.0318 0.1458 0.1747
Brugia malayi hypothetical protein 0.0042 0.0022 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0318 0.1458 0.1443
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0022 0.0026
Echinococcus granulosus protein tyrosine kinase 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK/FAK protein kinase 0.0042 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK/EGFR protein kinase 0.0042 0.0022 0.0022
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0042 0.0022 0.0026
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1643 0.8347 0.8347
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0042 0.0022 0.0026
Brugia malayi hypothetical protein 0.028 0.126 0.126
Schistosoma mansoni protein kinase 0.0042 0.0022 0.0004
Echinococcus multilocularis axis inhibition protein axin 0.0318 0.1458 0.1747
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0042 0.0022 0.0004
Trypanosoma brucei aurora B kinase 0.0065 0.0141 1
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0042 0.0022 0.0022
Loa Loa (eye worm) matrixin family protein 0.0188 0.0784 0.0784
Echinococcus multilocularis tyrosine protein kinase csk 0.0042 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0318 0.1458 0.1458
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0443 0.2931
Brugia malayi bone morphogenetic protein type 1 receptor 0.0042 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Schistosoma mansoni protein kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0141 0.0141
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Brugia malayi serine/threonine kinase 12 0.0065 0.0141 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0022 0.0004
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0022
Schistosoma mansoni fibrocystin l 0.0123 0.0443 0.0426
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0078 0.021 0.0192
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0042 0.0022 0.0026
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0042 0.0022 0.0026
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0095 0.0298 0.0298
Echinococcus multilocularis insulin receptor 0.0042 0.0022 0.0026
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1185 0.5967 0.7149
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0123 0.0443 0.2931
Echinococcus multilocularis regulator of G protein signaling 3 0.0318 0.1458 0.1747
Echinococcus granulosus tyrosine kinase 0.0042 0.0022 0.0026
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0042 0.0022 0.0026
Schistosoma mansoni hypothetical protein 0.0377 0.1766 0.1751
Echinococcus granulosus axis inhibition protein axin 0.0318 0.1458 0.1747
Echinococcus multilocularis tyrosine protein kinase Srms 0.0042 0.0022 0.0026
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0042 0.0022 0.0026
Echinococcus granulosus insulin receptor 0.0042 0.0022 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0022 0.0022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0097 0.0309 0.0309
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0042 0.0022 0.0026
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0042 0.0022 0.0022
Echinococcus granulosus epidermal growth factor receptor 0.0042 0.0022 0.0026
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0042 0.0022 0.0026
Schistosoma mansoni vesicular amine transporter 0.0099 0.0322 0.0304
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0283 0.1277 0.1529
Schistosoma mansoni tyrosine kinase 0.0042 0.0022 0.0004
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0065 0.0141 0.0833

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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