Detailed information for compound 1391424

Basic information

Technical information
  • TDR Targets ID: 1391424
  • Name: 132605-27-7
  • MW: 280.409 | Formula: C13H16N2OS2
  • H donors: 1 H acceptors: 1 LogP: 3.38 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(=S)[nH]c2c(c1=O)c1CCCCCc1s2
  • InChi: 1S/C13H16N2OS2/c1-2-15-12(16)10-8-6-4-3-5-7-9(8)18-11(10)14-13(15)17/h2-7H2,1H3,(H,14,17)
  • InChiKey: LCZHFPBORGBNNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_212643
  • ZINC01616767
  • AIDS131132
  • EU-0012214
  • NSC622291
  • 3-Ethyl-2-thioxo-1,2,3,5,6,7,8,9-octahydro-4H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-one
  • AIDS-131132
  • MLS000676242
  • SMR000271993
  • T0513-5907
  • 3-Ethyl-1,2,3,5,6,7,8,9-octahydro-2-thioxo-4H-cyclohepta(4,5)thieno(2,3-d)pyrimidin-4-one
  • 4H-Cyclohepta(4,5)thieno(2,3-d)pyrimidin-4-one, 1,2,3,5,6,7,8,9-octahydro-3-ethyl-2-thioxo-
  • BRN 4192893

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major GTP-binding protein, putative 0.0026 0.0038 0.0082
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0092 0.0345 0.1037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0064
Entamoeba histolytica hypothetical protein 0.0563 0.2521 0.7895
Giardia lamblia Telomerase catalytic subunit 0.0595 0.2673 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0016 0.0064
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.005 0.0106
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0065 0.0153
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0486 0.2165 0.6773
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0707 0.3189 0.44
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0319
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0016 0.0022
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0065 0.0257
Echinococcus granulosus geminin 0.0205 0.0865 0.2677
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0237 0.1013 0.3752
Schistosoma mansoni hypothetical protein 0.0205 0.0865 0.2677
Echinococcus multilocularis musashi 0.0033 0.007 0.017
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0092 0.0345 0.1037
Schistosoma mansoni importin beta-1 0.0035 0.008 0.0202
Echinococcus multilocularis importin subunit beta 1 0.0035 0.008 0.0202
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0092 0.0345 0.1037
Echinococcus granulosus intermediate filament protein 0.0033 0.007 0.017
Loa Loa (eye worm) hypothetical protein 0.0249 0.1071 0.4249
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0314 0.1369 0.4265
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0016 0.0022
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0038 0.0068
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0707 0.3189 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0686 0.3092 0.9695
Plasmodium vivax importin-beta 2, putative 0.0035 0.008 0.0242
Plasmodium falciparum importin beta, putative 0.0035 0.008 0.0242
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0563 0.2521 0.7895
Echinococcus multilocularis geminin 0.0205 0.0865 0.2677
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0016 0.0064
Echinococcus granulosus flap endonuclease 1 0.0031 0.0065 0.0153
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0038 0.0082
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0595 0.2673 0.8374
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0038 0.0052
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0065 0.0183
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0038 0.0082
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0092 0.0345 0.1239
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0092 0.0345 0.1037
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0065 0.0183
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0065 0.0153
Echinococcus multilocularis Zinc finger, PHD finger 0.0092 0.0345 0.1037
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0092 0.0345 0.1239
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0216 0.0916 0.2837
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0092 0.0345 0.1239
Schistosoma mansoni hypothetical protein 0.0205 0.0865 0.2677
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0266
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0092 0.0345 0.1037
Trichomonas vaginalis ran, putative 0.0026 0.0038 0.0068
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0065 0.0153
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0092 0.0345 0.1239
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0237 0.1013 0.3142
Schistosoma mansoni ran 0.0026 0.0038 0.0068
Trypanosoma brucei telomerase reverse transcriptase 0.0595 0.2673 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0603 0.2394
Schistosoma mansoni lamin 0.0033 0.007 0.017
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0092 0.0345 0.1037
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0707 0.3189 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0458 0.2037 0.6369
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0016 0.0064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.007 0.0277
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0016 0.0064
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0038 0.0068
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0092 0.0345 0.1037
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0707 0.3189 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0065 0.0183
Loa Loa (eye worm) phosphatidylinositol 3 0.0563 0.2521 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0341 0.1497 0.5575
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0092 0.0345 0.1037
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0038 0.0082
Brugia malayi RNA, U transporter 1 0.0099 0.0377 0.052
Loa Loa (eye worm) phosphatidylinositol kinase 0.0021 0.0016 0.0064
Echinococcus granulosus lamin dm0 0.0033 0.007 0.017
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0707 0.3189 1
Brugia malayi intermediate filament protein 0.0033 0.007 0.0096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0038 0.0082
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0707 0.3189 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0707 0.3189 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0016 0.0022
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0016 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0016 0.0022
Onchocerca volvulus 0.0033 0.007 0.0054
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0165 0.0684 0.2513
Plasmodium falciparum telomerase reverse transcriptase 0.0595 0.2673 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0065 0.0153
Brugia malayi hypothetical protein 0.0148 0.0603 0.0833
Brugia malayi Flap endonuclease-1 0.0031 0.0065 0.0089
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0237 0.1013 0.3142
Trichomonas vaginalis importin beta-1, putative 0.0028 0.005 0.0106
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0038 0.0068
Schistosoma mansoni hypothetical protein 0.0372 0.1638 0.5112
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.008 0.0242
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0595 0.2673 0.8374
Onchocerca volvulus Huntingtin homolog 0.0148 0.0603 0.0588
Leishmania major phosphatidylinositol 3-kinase, putative 0.0092 0.0345 0.1239
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0092 0.0345 0.1037
Echinococcus multilocularis snurportin 1 0.0372 0.1638 0.5112
Echinococcus granulosus lamin 0.0033 0.007 0.017
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0092 0.0345 0.1239
Echinococcus granulosus snurportin 1 0.0372 0.1638 0.5112
Schistosoma mansoni lamin 0.0033 0.007 0.017
Plasmodium falciparum flap endonuclease 1 0.0031 0.0065 0.0183
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.005 0.0106
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1638 0.6498
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0092 0.0345 0.0476
Entamoeba histolytica hypothetical protein 0.0028 0.005 0.0106
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0458 0.2037 0.6369
Onchocerca volvulus Huntingtin homolog 0.0148 0.0603 0.0588
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0237 0.1013 0.1398
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0237 0.1013 0.3142
Echinococcus multilocularis lamin dm0 0.0033 0.007 0.017
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0038 0.0068
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0092 0.0345 0.1369
Schistosoma mansoni intermediate filament proteins 0.0033 0.007 0.017
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0092 0.0345 0.1037
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0092 0.0345 0.1037
Onchocerca volvulus 0.0033 0.007 0.0054
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0237 0.1013 0.3142
Loa Loa (eye worm) intermediate filament protein 0.0033 0.007 0.0277
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0016 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0016 0.0022
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0016 0.5
Echinococcus granulosus importin subunit beta 1 0.0035 0.008 0.0202
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0016 0.0064
Schistosoma mansoni flap endonuclease-1 0.0028 0.0051 0.0109
Plasmodium vivax telomerase reverse transcriptase, putative 0.0595 0.2673 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0216 0.0916 0.3634
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0277
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.005 0.0106
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0092 0.0345 0.1037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0458 0.2037 0.808
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0237 0.1013 0.3142
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0065 0.0183
Loa Loa (eye worm) hypothetical protein 0.0148 0.0603 0.2394
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.008 0.0242
Brugia malayi Importin beta-1 subunit 0.0035 0.008 0.0111
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0092 0.0345 0.1239
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.008 0.0242
Entamoeba histolytica Ran family GTPase 0.0026 0.0038 0.0068
Brugia malayi Telomerase reverse transcriptase 0.1585 0.7247 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0707 0.3189 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.2165 0.6773
Toxoplasma gondii RNA-directed DNA polymerase 0.0595 0.2673 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.005 0.0127
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0065 0.0183
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0016 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0458 0.2037 0.2811
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0237 0.1013 0.3142
Echinococcus multilocularis lamin 0.0033 0.007 0.017
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0237 0.1013 0.3142
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0038 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0064
Leishmania major telomerase reverse transcriptase, putative 0.0595 0.2673 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.007 0.0096
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0707 0.3189 1
Schistosoma mansoni ran 0.0026 0.0038 0.0068
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0707 0.3189 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0038 0.015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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