TDR Targets

Basic information

Technical information

TDR Targets ID: 1393543
Name: 2,4-dimethyl-3-(tetrazol-1-yl)benzenesulfonam ide
MW: 253.281 | Formula: C9H11N5O2S
H donors: 1 H acceptors: 5 LogP: 0.52 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1n1cnnn1)C)S(=O)(=O)N
InChi: 1S/C9H11N5O2S/c1-6-3-4-8(17(10,15)16)7(2)9(6)14-5-11-12-13-14/h3-5H,1-2H3,(H2,10,15,16)
InChiKey: ZGEJQVRYHPUISD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2,4-dimethyl-3-(1-tetrazolyl)benzenesulfonamide
2,4-dimethyl-3-(1,2,3,4-tetrazol-1-yl)benzenesulfonamide
ZINC01428814
2,4-dimethyl-3-(1H-tetrazol-1-yl)benzenesulfonamide
MLS000674497
SMR000313699
A3687/0156424

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0103	0.053	0.0582
Echinococcus granulosus	mitogen activated protein kinase 3	0.0057	0.0119	0.013
Giardia lamblia	Kinase, CMGC MAPK	0.0057	0.0119	0.0621
Echinococcus multilocularis	PAK box P21 Rho binding	0.0099	0.0494	0.0542
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0103	0.053	0.0582
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0148	0.0148
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0092	0.1727
Schistosoma mansoni	tyrosine kinase	0.0099	0.0494	0.4377
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.1374	0.1507
Loa Loa (eye worm)	CAMK/CAMKL/MARK protein kinase	0.0046	0.0024	0.0024
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.106	0.9115	1
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0024	0.0446
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.106	0.9115	1
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0103	0.053	0.0582
Echinococcus multilocularis	cyclin dependent kinase 1	0.0091	0.0428	0.047
Echinococcus multilocularis	serine:threonine protein kinase	0.0046	0.0024	0.0026
Echinococcus multilocularis	cyclin dependent kinase 5	0.0091	0.0428	0.047
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.1158	1	1
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0054	0.0092	0.01
Entamoeba histolytica	protein kinase, putative	0.0103	0.053	1
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0099	0.0494	0.4377
Trichomonas vaginalis	STE family protein kinase	0.0103	0.053	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0091	0.0428	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0057	0.0119	0.2773
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0091	0.0428	0.0428
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0091	0.0428	0.047
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0054	0.0092	0.01
Schistosoma mansoni	protein kinase	0.0103	0.053	0.4702
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0392	0.0392
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0054	0.0092	0.2138
Trichomonas vaginalis	CMGC family protein kinase	0.0091	0.0428	0.808
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0099	0.0494	0.0542
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0078	0.0309	0.0339
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0078	0.0309	0.0339
Schistosoma mansoni	hypothetical protein	0.0099	0.0494	0.4377
Entamoeba histolytica	hypothetical protein	0.0099	0.0494	0.9308
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0099	0.0494	0.0494
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0119	0.2241
Echinococcus granulosus	cyclin dependent kinase	0.0091	0.0428	0.047
Entamoeba histolytica	hypothetical protein	0.0099	0.0494	0.9308
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0148	0.0148
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0054	0.0092	0.0092
Echinococcus granulosus	cyclin dependent kinase 1	0.0091	0.0428	0.047
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0057	0.0119	0.2773
Trichomonas vaginalis	CMGC family protein kinase	0.0091	0.0428	0.808
Echinococcus multilocularis	protein kinase shaggy	0.0054	0.0092	0.01
Echinococcus granulosus	protein kinase shaggy	0.0054	0.0092	0.01
Echinococcus granulosus	cyclin dependent kinase 5	0.0091	0.0428	0.047
Giardia lamblia	Kinase, STE STE20	0.0103	0.053	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0057	0.0119	0.2773
Trypanosoma brucei	protein kinase, putative	0.0054	0.0092	0.2138
Trypanosoma cruzi	cdc2-related kinase 1	0.0091	0.0428	1
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0103	0.053	0.0582
Trichomonas vaginalis	STE family protein kinase	0.0103	0.053	1
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0054	0.0092	0.0092
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0092	0.1727
Entamoeba histolytica	cell division protein kinase 2, putative	0.0091	0.0428	0.808
Echinococcus granulosus	PAK box P21 Rho binding	0.0099	0.0494	0.0542
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0119	0.2241
Echinococcus multilocularis	cyclin dependent kinase	0.0091	0.0428	0.047
Trichomonas vaginalis	STE family protein kinase	0.0103	0.053	1
Giardia lamblia	Kinase, CMGC CDK	0.0091	0.0428	0.7679
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0057	0.0119	0.2773
Trichomonas vaginalis	STE family protein kinase	0.0103	0.053	1
Schistosoma mansoni	protein kinase	0.0103	0.053	0.4702
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0078	0.0309	0.0339
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0091	0.0428	1
Schistosoma mansoni	serine/threonine protein kinase	0.0078	0.0309	0.2739
Brugia malayi	WH1 domain containing protein	0.0099	0.0494	0.0494
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0103	0.053	0.0582
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0054	0.0092	0.2138
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0057	0.0119	0.013
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1128	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0091	0.0428	0.0428
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0057	0.0119	0.0119
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.1374	0.1374
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0092	0.1727
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.1374	0.1507
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.1374	0.1374
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0054	0.0092	0.2138
Brugia malayi	cell division control protein 2 homolog	0.0091	0.0428	0.0428
Entamoeba histolytica	protein kinase, putative	0.0103	0.053	1
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0099	0.0494	0.0542
Trypanosoma cruzi	cdc2-related kinase 1	0.0091	0.0428	1
Echinococcus granulosus	serine:threonine protein kinase	0.0046	0.0024	0.0026
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0057	0.0119	0.2773
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0057	0.0119	0.2773
Plasmodium falciparum	protein kinase 5	0.0091	0.0428	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.1374	0.1507
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0428	0.0428
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0148	0.0148
Trichomonas vaginalis	STE family protein kinase	0.0103	0.053	1
Schistosoma mansoni	protein kinase	0.0099	0.0494	0.4377
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.0428	0.3799
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0494	0.4377
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.0428	0.3799
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0494	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0024	0.0024
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0103	0.053	0.0582
Brugia malayi	MAP kinase sur-1	0.0057	0.0119	0.0119
Giardia lamblia	Kinase, CMGC CDK	0.0091	0.0428	0.7679
Echinococcus multilocularis	serine:threonine protein kinase	0.0046	0.0024	0.0026
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0091	0.0428	1
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0119	0.2241
Echinococcus multilocularis	cyclin dependent kinase 1	0.0091	0.0428	0.047
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0054	0.0092	0.0812
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0119	0.1054
Plasmodium vivax	protein kinase Crk2	0.0091	0.0428	1
Entamoeba histolytica	p21-activated kinase	0.0103	0.053	1
Brugia malayi	intracellular kinase	0.0054	0.0092	0.0092
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0024	0.0024
Echinococcus granulosus	mitogen activated protein kinase	0.0057	0.0119	0.013
Trypanosoma brucei	protein kinase, putative	0.0057	0.0119	0.2773
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0091	0.0428	0.0428
Trypanosoma brucei	cdc2-related kinase 3	0.0091	0.0428	1
Entamoeba histolytica	protein kinase, putative	0.0103	0.053	1
Schistosoma mansoni	protein kinase	0.0103	0.053	0.4702
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0078	0.0309	0.0339
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0119	0.2241
Schistosoma mansoni	hypothetical protein	0.0099	0.0494	0.4377
Trypanosoma cruzi	cdc2-related kinase 3	0.0091	0.0428	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0057	0.0119	0.2773
Brugia malayi	P21-Rho-binding domain containing protein	0.0099	0.0494	0.0494
Entamoeba histolytica	cell division protein kinase 2, putative	0.0091	0.0428	0.808
Loa Loa (eye worm)	hypothetical protein	0.006	0.0148	0.0148
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0091	0.0428	1
Trypanosoma brucei	cdc2-related kinase 1	0.0091	0.0428	1
Echinococcus granulosus	serine:threonine protein kinase	0.0046	0.0024	0.0026
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1128	1
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0494	0.9308
Schistosoma mansoni	hypothetical protein	0.0099	0.0494	0.4377
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0092	0.1727
Trichomonas vaginalis	CMGC family protein kinase	0.0091	0.0428	0.808
Entamoeba histolytica	protein kinase, putative	0.0103	0.053	1
Brugia malayi	Protein kinase domain	0.0103	0.053	0.053
Brugia malayi	P21-Rho-binding domain containing protein	0.0099	0.0494	0.0494
Echinococcus multilocularis	mitogen activated protein kinase	0.0057	0.0119	0.013
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0099	0.0494	0.0542
Entamoeba histolytica	protein kinase, putative	0.0054	0.0092	0.1727
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0057	0.0119	0.2773
Echinococcus multilocularis	PAK box P21 Rho binding	0.0103	0.053	0.0582
Onchocerca volvulus		0.0114	0.0629	1
Schistosoma mansoni	serine/threonine protein kinase	0.0078	0.0309	0.2739

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1524239

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1393543