TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 317.426 | Formula: C16H15NO2S2
H donors: 1 H acceptors: 2 LogP: 4.53 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccccc1SC1=N[S+](=O)(c2c1cccc2)[O-])C
InChi: 1S/C16H15NO2S2/c1-11(2)12-7-3-5-9-14(12)20-16-13-8-4-6-10-15(13)21(18,19)17-16/h3-11H,1-2H3
InChiKey: SKTNCPGUEQTFMK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Leishmania mexicana	pyruvate kinase, putative	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium yoelii	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Giardia lamblia	Pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium leprae	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Theileria parva	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium berghei	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	ko:K00873 pyruvate kinase [EC2.7.1.40], putative	Get druggable targets OG5_126685	All targets in OG5_126685
Chlamydia trachomatis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma congolense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, M2 isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Entamoeba histolytica	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium parvum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, muscle isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Neospora caninum	Pyruvate kinase (EC 2.7.1.40), related	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium hominis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	Pyruvate kinase isozyme R, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium knowlesi	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium ulcerans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase-PB	Get druggable targets OG5_126685	All targets in OG5_126685
Babesia bovis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium falciparum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Toxoplasma gondii	pyruvate kinase PyK1	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania donovani	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium vivax	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyruvate kinase	pyruvate kinase, putative	498 aa	515 aa	27.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0217	0.2635
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0059	0.1223	0.3206
Echinococcus multilocularis	pyruvate kinase	0.004	0.0803	0.2089
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0803	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0715	0.8696
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0621	0.7548
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0715	0.8696
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0715	0.1081
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0006	0.0016	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0611	0.1582
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0217	0.0956
Leishmania major	pyruvate kinase	0.004	0.0803	0.9758
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0803	0.2089
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.019
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.2266	0.3424
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0534
Plasmodium vivax	pyruvate kinase, putative	0.004	0.0803	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0524	0.1349
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0333	0.4154
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0956
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0621	0.7548
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0059	0.1223	0.3206
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0388	0.483
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0534
Schistosoma mansoni	hypothetical protein	0.0019	0.0306	0.0771
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0006	0.0016	0.0194
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0956
Entamoeba histolytica	pyruvate kinase, putative	0.0028	0.0524	0.554
Leishmania major	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1629
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0621	0.7548
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0621	0.7548
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0612	0.0597
Leishmania major	basic transcription factor 3a, putative	0.0041	0.0823	1
Brugia malayi	major facilitator superfamily protein	0.0015	0.0217	0.0534
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Schistosoma mansoni	hypothetical protein	0.0104	0.2266	0.5973
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0956
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0217	0.2635
Schistosoma mansoni	glucose transport protein	0.0104	0.2266	0.5973
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0534
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0217	0.27
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0715	0.8696
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Echinococcus multilocularis	transcription factor btf3	0.0041	0.0823	0.2142
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0168	0.3734	0.5643
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0217	0.0534
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0597	0.1543
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0306	0.0771
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1629
Schistosoma mansoni	pyruvate kinase	0.0021	0.0354	0.0899
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0306	0.0771
Leishmania major	glucose transporter, lmgt1	0.0032	0.0621	0.7548
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1582
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0388	0.1017
Trichomonas vaginalis	pyruvate kinase, putative	0.004	0.0803	0.3543
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0534
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0217	0.0201
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2266	0.5973
Schistosoma mansoni	hypothetical protein	0.004	0.0799	0.2079
Brugia malayi	Pyruvate kinase, muscle isozyme	0.004	0.0803	0.2089
Leishmania major	glucose transporter, lmgt3	0.0032	0.0621	0.7548
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0286	0.3473
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0715	0.0701
Trichomonas vaginalis	pyruvate kinase, putative	0.004	0.0803	0.3543
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0006	0.0016	0.0194
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0414	0.5029
Chlamydia trachomatis	pyruvate kinase	0.004	0.0803	1
Toxoplasma gondii	pyruvate kinase PyKII	0.0021	0.0354	0.0535
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0621	0.274
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0612	0.0597
Plasmodium vivax	hexose transporter	0.0104	0.2266	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Echinococcus granulosus	pyruvate kinase	0.0021	0.0354	0.0926
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1223	0.3206
Leishmania major	protein kinase, putative	0.0032	0.0611	0.7434
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0414	0.5029
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Brugia malayi	Sugar transporter family protein	0.0015	0.0217	0.0534
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2266	0.6151
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0621	0.274
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0803	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Echinococcus granulosus	GPCR family 2	0.0019	0.0306	0.0794
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0956
Entamoeba histolytica	transcription factor BTF3, putative	0.0041	0.0823	0.8795
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0823	0.3631
Loa Loa (eye worm)	ICD-1 protein	0.0041	0.0823	0.2142
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0168	0.3734	0.3724
Plasmodium falciparum	protein kinase 7	0.0295	0.6617	0.6612
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0388	0.4713
Schistosoma mansoni	ap endonuclease	0.0022	0.0388	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.005	0.1029	0.1555
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0414	0.5029
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0217	0.2635
Brugia malayi	Sugar transporter family protein	0.0104	0.2266	0.5973
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0168	0.3734	0.3724
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0217	0.2635
Plasmodium falciparum	histone acetyltransferase GCN5	0.0046	0.0933	0.0919
Giardia lamblia	Pyruvate kinase	0.004	0.0803	0.8578
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Mycobacterium ulcerans	sugar transporter	0.0015	0.0217	0.27
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0217	0.27
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.1582
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0414	0.0625
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0388	0.1711
Plasmodium vivax	basic transcription factor 3b, putative	0.0041	0.0823	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0597	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0621	0.7548
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0534
Echinococcus granulosus	pyruvate kinase	0.004	0.0803	0.2152
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0217	0.0534
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.055
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.004	0.0803	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0799	0.2079
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2266	0.6151
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0612	0.0597
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0333	0.4154
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0414	0.5057
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1582
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0621	0.7548
Echinococcus granulosus	pyruvate kinase	0.0021	0.0354	0.0926
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0414	0.1088
Entamoeba histolytica	protein kinase, putative	0.0032	0.0611	0.6495
Giardia lamblia	Hexose transporter	0.0015	0.0217	0.2192
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0006	0.0016	0.0194
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0621	0.274
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0534
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0715	0.8696
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0566	0.1506
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0621	0.274
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1582
Plasmodium falciparum	pyruvate kinase 2	0.0021	0.0354	0.0339
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0612	0.0597
Schistosoma mansoni	hypothetical protein	0.0019	0.0306	0.0771
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0217	0.0327
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0217	0.27
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0612	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0621	0.274
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0621	0.7548
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0134	0.1671
Brugia malayi	Sugar transporter family protein	0.0015	0.0217	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Brugia malayi	beta-NAC-like protein	0.0041	0.0823	0.2142
Loa Loa (eye worm)	sugar transporter	0.0015	0.0217	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0597	0.1543
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0621	0.7548
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0306	0.0771
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0534
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.055
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0388	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0333	0.4154
Trypanosoma cruzi	transcription factor btf3, putative	0.0041	0.0823	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0597	0.1543
Entamoeba histolytica	hypothetical protein	0.0041	0.0823	0.8795
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0621	0.7548
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0217	0.0327
Echinococcus granulosus	transcription factor btf3	0.0041	0.0823	0.2206
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0414	0.1826
Plasmodium falciparum	hexose transporter	0.0104	0.2266	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Entamoeba histolytica	acetyltransferase, GNAT family	0.0046	0.0933	1
Echinococcus multilocularis	pyruvate kinase	0.0021	0.0354	0.0899
Trypanosoma cruzi	pyruvate kinase 2, putative	0.004	0.0803	0.9758
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0621	0.274
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0597	0.1543
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0388	0.4713
Entamoeba histolytica	hypothetical protein	0.0023	0.0414	0.4338
Trypanosoma brucei	pyruvate kinase 1, putative	0.004	0.0803	0.9758
Brugia malayi	Pyruvate kinase, M2 isozyme	0.004	0.0803	0.2089
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0621	0.7548
Schistosoma mansoni	hypothetical protein	0.0019	0.0306	0.0771
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0217	0.27
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0414	0.5153
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0414	0.0399
Giardia lamblia	Histone acetyltransferase GCN5	0.0046	0.0933	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0611	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0306	0.0771
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Echinococcus granulosus	histone acetyltransferase KAT2B	0.005	0.1029	0.277
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0388	0.4713
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0621	0.7548
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0217	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Entamoeba histolytica	protein kinase, putative	0.0032	0.0611	0.6495
Leishmania major	hypothetical protein, conserved	0.0015	0.0217	0.2635
Loa Loa (eye worm)	pyruvate kinase	0.0008	0.0076	0.0159
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0612	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1582
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0175	0.0423
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.005	0.1029	0.1015
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0621	0.7548
Plasmodium vivax	sugar transporter, putative	0.0015	0.0217	0.0201
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0823	0.3631
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.005	0.1029	0.1555
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0621	0.7548
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0597	0.6333
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.019
Schistosoma mansoni	ap endonuclease	0.0022	0.0388	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0059	0.1223	0.3206
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Mycobacterium leprae	Probable pyruvate kinase PykA	0.004	0.0803	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0597	0.7434
Loa Loa (eye worm)	hypothetical protein	0.004	0.0803	0.2089
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0612	0.0925
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0388	0.483
Trypanosoma cruzi	pyruvate kinase 2, putative	0.004	0.0803	0.9758
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.005	0.1029	0.4541
Trypanosoma brucei	transcription factor BTF3, putative	0.0041	0.0823	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0171	0.3783	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0611	0.7434
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.2266	0.5973
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Schistosoma mansoni	pyruvate kinase	0.004	0.0803	0.2089
Toxoplasma gondii	exonuclease III APE	0.0022	0.0388	0.0586
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0217	0.0956
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0217	0.0534
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0534
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0414	0.0399
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0621	0.7548
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0306	0.0794
Trichomonas vaginalis	bromodomain-containing protein, putative	0.005	0.1029	0.4541
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Leishmania major	pyruvate kinase	0.004	0.0803	0.9758
Loa Loa (eye worm)	acetyltransferase	0.0171	0.3783	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0217	0.0956
Brugia malayi	major facilitator superfamily protein	0.0015	0.0217	0.0534
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0803	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0597	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Toxoplasma gondii	glycyl-tRNA synthetase	0.0006	0.0016	0.0024
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0388	0.4055
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0611	0.1629
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0217	0.055
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0621	0.274
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0388	1
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0006	0.0016	0.019
Giardia lamblia	Sugar-proton symporter	0.0015	0.0217	0.2192
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0134	0.1506
Schistosoma mansoni	glucose transport protein	0.0104	0.2266	0.5973
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0388	0.4713
Brugia malayi	pyruvate kinase, muscle isozyme	0.0008	0.0076	0.0159
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0612	0.0925
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0012	0.016	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0414	0.1057
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0217	0.0534
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0715	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Plasmodium falciparum	pyruvate kinase	0.004	0.0803	0.0788
Echinococcus multilocularis	General substrate transporter	0.009	0.193	0.5083
Brugia malayi	acetyltransferase, GNAT family protein	0.0171	0.3783	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0166	0.3673	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0463	0.1187
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2266	0.6151
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0621	0.7548
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0612	0.0597
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0823	0.3631
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0217	0.055
Toxoplasma gondii	NAC domain-containing protein	0.0041	0.0823	0.1243
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0597	0.1589
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0414	0.5153
Schistosoma mansoni	glucose transporter	0.0015	0.0217	0.0534
Schistosoma mansoni	transcription factor btf3	0.0041	0.0823	0.2142
Brugia malayi	Cam kinase protein 1	0.0032	0.0611	0.1582
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0414	0.1057
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0069
Plasmodium vivax	pyruvate kinase 2, putative	0.0021	0.0354	0.0339
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.1582
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0414	0.1057
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0534
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0134	0.3185
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0956
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0609	0.1574
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.055
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.1582
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0803	0.2089
Schistosoma mansoni	pyruvate kinase	0.004	0.0803	0.2089
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0621	0.7548
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0414	0.1057
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0597	0.1543
Giardia lamblia	Pyruvate kinase	0.0021	0.0354	0.3691
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0715	0.8696
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0388	0.0373
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0803	0.2089
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0799	0.2079
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0611	0.2699
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.055
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0566	0.1462
Schistosoma mansoni	hypothetical protein	0.0019	0.0306	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0534
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0597	0.6333
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0414	0.1057
Trypanosoma brucei	pyruvate kinase 1	0.004	0.0803	0.9758
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0414	0.5153
Echinococcus multilocularis	pyruvate kinase	0.004	0.0803	0.2089
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0217	0.2635
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0388	0.0988
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2266	0.6151
Leishmania major	glucose transporter, lmgt2	0.0032	0.0621	0.7548
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2266	0.5973
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0388	0.1711
Echinococcus multilocularis	pyruvate kinase	0.0021	0.0354	0.0899
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0414	0.4338
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0612	0.0597
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0611	0.1582
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0217	0.27
Echinococcus multilocularis	pyruvate kinase	0.0021	0.0354	0.0899
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0171	0.3783	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0621	0.7548
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0217	0.2635
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0217	0.5405
Toxoplasma gondii	pyruvate kinase PyK1	0.004	0.0803	0.1213
Trypanosoma cruzi	hexose transporter	0.0032	0.0621	0.7548
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0306	0.0771
Plasmodium falciparum	basic transcription factor 3b, putative	0.0041	0.0823	0.0808
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0006	0.0016	0.0194
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Echinococcus granulosus	pyruvate kinase	0.004	0.0803	0.2152
Mycobacterium ulcerans	pyruvate kinase	0.004	0.0803	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0534
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0534
Loa Loa (eye worm)	sugar transporter	0.0104	0.2266	0.5973
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0217	0.0327
Loa Loa (eye worm)	pyruvate kinase-PB	0.0028	0.0524	0.1349
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0348	0.1536
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0306	0.0771
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.2266	1
Echinococcus granulosus	pyruvate kinase	0.0021	0.0354	0.0926
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0217	0.0534
Toxoplasma gondii	protein kinase, putative	0.0295	0.6617	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0597	0.1543
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0388	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0388	0.0988
Echinococcus granulosus	General substrate transporter	0.009	0.193	0.5235
Trypanosoma cruzi	transcription factor btf3, putative	0.0041	0.0823	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2266	0.5973
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0388	0.0373
Schistosoma mansoni	glucose transport protein	0.0104	0.2266	0.5973
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Brugia malayi	pyruvate kinase	0.0008	0.0076	0.0159
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0388	0.4055
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0534
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0306	0.0794
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0534
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0306	0.0771
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1629
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0611	0.1582

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.8338 uM	PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK): for Probe SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1721, AID2266]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1516061

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1397469