Detailed information for compound 1403351

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.489 | Formula: C21H22N4O4S
  • H donors: 1 H acceptors: 6 LogP: 3.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CN(S(=O)(=O)c1cccc2c1non2)Cc1cc2ccc(cc2nc1O)C)C
  • InChi: 1S/C21H22N4O4S/c1-13(2)11-25(30(27,28)19-6-4-5-17-20(19)24-29-23-17)12-16-10-15-8-7-14(3)9-18(15)22-21(16)26/h4-10,13H,11-12H2,1-3H3,(H,22,26)
  • InChiKey: URJCMQCIVZBQED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0008 0.0477 0.0172
Echinococcus granulosus NDR protein kinase 0.0012 0.1062 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.7133 0.868
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0799 0.0638
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0799 0.2455
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.004 0.5142 0.6864
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.2204 0.9086
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.8218 1
Trypanosoma brucei ABC transporter, putative 0.001 0.0799 0.058
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0505 0.0267
Giardia lamblia ABC transporter, putative 0.0007 0.0341 0.0208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0505 0.0267
Brugia malayi p70 ribosomal S6 kinase beta 0.0034 0.4265 0.5623
Leishmania major hypothetical protein, conserved 0.0008 0.0477 0.0172
Schistosoma mansoni cpg binding protein 0.0035 0.4393 0.4331
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Loa Loa (eye worm) hypothetical protein 0.0008 0.0505 0.03
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0505 0.0207
Trichomonas vaginalis AGC family protein kinase 0.0014 0.1383 0.1683
Plasmodium vivax hypothetical protein, conserved 0.0019 0.2204 0.388
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.3289 0.4002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0505 0.03
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0505 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0505 0.03
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0505 0.04
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0505 0.04
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0008 0.0477 0.0372
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0007 0.0341 0.0069
Echinococcus granulosus multidrug resistance associated protein 7 0.0007 0.0341 0.0061
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.2391 0.291
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.5142 0.6094
Brugia malayi nuclear receptor NHR-88 0.0008 0.0505 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.1062 0.0963
Toxoplasma gondii AGC kinase 0.0034 0.4265 0.4603
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0008 0.0477 0.0172
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0477 0.0261
Plasmodium vivax ABC transporter G family member 2, putative 0.001 0.0799 0.0952
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.2391 0.291
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.5142 0.6094
Entamoeba histolytica ABC transporter, putative 0.0007 0.0341 0.01
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0634 0.0431
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.002 0.2343 0.2586
Loa Loa (eye worm) hypothetical protein 0.0021 0.2391 0.297
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0293 0.0356
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0477 0.0172
Trichomonas vaginalis abcb9, putative 0.0021 0.2391 0.291
Echinococcus granulosus ATP binding cassette sub family B 0.0007 0.0341 0.0061
Brugia malayi ubiquitin conjugating enzyme protein 13 0.004 0.5142 0.6864
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.2391 0.291
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.2391 0.297
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.5406 0.6579
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.004 0.5142 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0008 0.0477 0.0372
Echinococcus multilocularis nervana 2 0.0022 0.2595 0.2862
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.3289 0.4002
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.2391 0.2648
Giardia lamblia Multidrug resistance-associated protein 1 0.0007 0.0341 0.0208
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0525 0.0639
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.5142 0.6257
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0008 0.0477 0.0232
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.2391 0.2648
Echinococcus multilocularis protein kinase c iota type 0.0012 0.1062 0.0915
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0034 0.4265 0.5623
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0008 0.0477 0.058
Toxoplasma gondii GAF domain-containing protein 0.0019 0.2204 0.2185
Trichomonas vaginalis AGC family protein kinase 0.0012 0.1062 0.1292
Brugia malayi protein kinase C II. 0.0012 0.1062 0.1089
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.2391 0.2602
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0008 0.0477 0.0261
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0477 0.0172
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.2391 0.291
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.8218 1
Loa Loa (eye worm) ABC transporter 0.0007 0.0341 0.0069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.2391 0.291
Brugia malayi ABC transporter transmembrane region family protein 0.0007 0.0341 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0477 0.0172
Loa Loa (eye worm) hypothetical protein 0.0012 0.1062 0.1089
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0505 0.0267
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0505 0.03
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.2391 0.2602
Loa Loa (eye worm) hypothetical protein 0.0021 0.2391 0.297
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0505 0.04
Giardia lamblia Multidrug resistance-associated protein 1 0.0007 0.0341 0.0208
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Schistosoma mansoni coup transcription factor 0.0008 0.0505 0.04
Brugia malayi nuclear hormone receptor 0.0008 0.0505 0.03
Loa Loa (eye worm) hypothetical protein 0.002 0.2343 0.2901
Entamoeba histolytica ATP-binding cassette protein, putative 0.0007 0.0341 0.01
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0008 0.0477 0.058
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.2391 0.291
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.3289 0.3742
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0505 0.03
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0505 0.03
Loa Loa (eye worm) hypothetical protein 0.0007 0.0341 0.0069
Echinococcus granulosus Protein kinase C brain isozyme 0.0012 0.1062 0.0971
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.2391 0.291
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.3289 0.3215
Schistosoma mansoni multidrug resistance protein 0.0007 0.0341 0.0235
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.2391 0.2648
Echinococcus granulosus protein kinase C gamma type 0.0012 0.1062 0.0971
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0012 0.1062 0.1089
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.2343 0.2541
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.149 0.1511
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.2391 0.291
Toxoplasma gondii hypothetical protein 0.0054 0.7133 0.7966
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0505 0.03
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0022 0.2631 0.2951
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.2391 0.297
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.2391 0.2648
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0505 0.03
Mycobacterium ulcerans putative regulatory protein 0.0019 0.2204 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0525 0.0639
Trichomonas vaginalis AGC family protein kinase 0.0036 0.4586 0.558
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.7357 0.7328
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0939 0.0915
Trichomonas vaginalis helicase, putative 0.0008 0.0525 0.0639
Loa Loa (eye worm) hypothetical protein 0.0008 0.0505 0.03
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.2391 0.2648
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0341 0.0415
Schistosoma mansoni multidrug resistance protein 0.0007 0.0341 0.0235
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0008 0.0477 0.0172
Brugia malayi ABC transporter family protein 0.0007 0.0341 0.0069
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.2391 0.2404
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.058
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0799 0.058
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.2952 0.2874
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0008 0.0477 0.0788
Loa Loa (eye worm) hypothetical protein 0.0019 0.2204 0.2705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0505 0.03
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.1062 0.0915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0505 0.03
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.8218 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0008 0.0477 0.0172
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.2391 0.291
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.2391 0.291
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0008 0.0477 0.0232
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.2391 0.2602
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.092 0.0887
Echinococcus granulosus serine threonine protein kinase nrc 0.0022 0.2631 0.2951
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.2391 0.291
Loa Loa (eye worm) hypothetical protein 0.0008 0.0505 0.03
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0505 0.03
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.3289 0.4002
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.2391 0.2602
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0505 0.0207
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0008 0.0477 0.0172
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0022 0.2631 0.477
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.0283
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0799 0.2455
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.2391 0.291
Entamoeba histolytica P-glycoprotein-2 0.0021 0.2391 0.4327
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0505 0.03
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0008 0.0477 0.0372
Loa Loa (eye worm) hypothetical protein 0.0008 0.0477 0.0261
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0505 0.03
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0505 0.03
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.0283
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.3289 0.378
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0505 0.03
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0634 0.0431
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0634 0.0372
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0012 0.1062 0.0915
Trichomonas vaginalis AGC family protein kinase 0.0036 0.4586 0.558
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0505 0.0207
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0505 0.0267
Schistosoma mansoni atypical protein kinase C 0.0012 0.1062 0.0963
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.5406 0.6579
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0008 0.0477 0.0372
Loa Loa (eye worm) hypothetical protein 0.0008 0.0477 0.0261
Entamoeba histolytica protein kinase, putative 0.0036 0.4586 0.8854
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.5406 0.643
Brugia malayi ABC transporter family protein 0.0008 0.059 0.042
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.2631 0.2907
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0799 0.0638
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0505 0.0267
Echinococcus granulosus nervana 2 0.0022 0.2595 0.2905
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0022 0.2631 0.477
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0012 0.1062 0.0915
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.3289 0.4241
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0008 0.0477 0.0372
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0012 0.1062 0.0915
Schistosoma mansoni multidrug resistance protein 0.0021 0.2391 0.2307
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0477 0.0172
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.1062 0.0963
Schistosoma mansoni multidrug resistance protein 0.0021 0.2391 0.2307
Loa Loa (eye worm) ABC transporter 0.0008 0.059 0.042
Leishmania major cAMP-specific phosphodiesterase, putative 0.0008 0.0477 0.0172
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.2391 0.427
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0008 0.0477 0.0172
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0505 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.1062 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0477 0.058
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0505 0.0207
Leishmania major hypothetical protein, conserved 0.0008 0.0477 0.0172
Schistosoma mansoni smdr1 0.0007 0.0341 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0505 0.03
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0505 0.0207
Trypanosoma cruzi ATP-binding cassette protein, putative 0.001 0.0799 0.058
Trichomonas vaginalis AGC family protein kinase 0.0012 0.1062 0.1292
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0008 0.0477 0.0283
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.004 0.5142 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.2391 0.2648
Brugia malayi Protein kinase domain containing protein 0.0036 0.4586 0.6077
Brugia malayi Hr1 repeat family protein 0.0012 0.1062 0.1089
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.2391 0.291
Entamoeba histolytica ATP-binding cassette protein, putative 0.0007 0.0341 0.01
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0939 0.0759
Toxoplasma gondii hypothetical protein 0.0019 0.2204 0.2185
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.004 0.5142 0.6094
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.0283
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.1062 0.0963
Entamoeba histolytica P-glycoprotein-5 0.0021 0.2391 0.4327
Giardia lamblia hypothetical protein 0.0008 0.0477 0.0788
Trichomonas vaginalis ABC transporter, putative 0.0021 0.2391 0.291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.7357 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.058
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0505 0.0267
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.5142 0.6864
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0011 0.1026 0.1249
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.2391 0.291
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0505 0.03
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0505 0.0267
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0008 0.0477 0.0172
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.2391 0.291
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0799 0.058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0505 0.03
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.2391 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0505 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Schistosoma mansoni hypothetical protein 0.0008 0.0541 0.0437
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0012 0.1062 0.1089
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0008 0.0477 0.058
Loa Loa (eye worm) hypothetical protein 0.0008 0.0505 0.03
Brugia malayi hypothetical protein 0.0007 0.0341 0.0069
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0008 0.0477 0.0172
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0012 0.1062 0.0915
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0505 0.0207
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.2391 0.291
Onchocerca volvulus 0.0021 0.2391 0.4851
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0008 0.0477 0.058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Loa Loa (eye worm) hypothetical protein 0.0008 0.0505 0.03
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.7357 0.8907
Loa Loa (eye worm) hypothetical protein 0.0008 0.0505 0.03
Echinococcus multilocularis serine:threonine protein kinase 38 0.0012 0.1062 0.0915
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Echinococcus granulosus serine/threonine protein kinase 0.0025 0.2952 0.3355
Toxoplasma gondii hypothetical protein 0.0019 0.2204 0.2185
Entamoeba histolytica P-glycoprotein 6, putative 0.0007 0.0341 0.01
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.2391 0.291
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0505 0.04
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.2204 0.388
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0008 0.0477 0.0261
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0505 0.04
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0505 0.04
Trypanosoma brucei ATP-binding cassette protein, putative 0.001 0.0799 0.058
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.001 0.0799 0.058
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0008 0.0477 0.0172
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0008 0.0477 0.0372
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0006 0.0293 0.0356
Loa Loa (eye worm) ABC transporter 0.0007 0.0341 0.0069
Trypanosoma cruzi ABC transporter, putative 0.001 0.0799 0.058
Loa Loa (eye worm) AGC/NDR protein kinase 0.0012 0.1062 0.1089
Schistosoma mansoni multidrug resistance protein 0.0007 0.0341 0.0235
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0006 0.0293 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.2204 0.2682
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0505 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Brugia malayi steroid hormone receptor 0.0008 0.0505 0.03
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.004 0.5142 0.6094
Schistosoma mansoni multidrug resistance protein 0.0007 0.0341 0.0235
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0022 0.2631 0.2907
Onchocerca volvulus 0.0035 0.4393 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.2952 0.3314
Brugia malayi CXXC zinc finger family protein 0.0035 0.4393 0.5804
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.7357 0.8914
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.8218 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.0172
Entamoeba histolytica ATP-binding cassette protein, putative 0.0007 0.0341 0.01
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.149 0.1511
Schistosoma mansoni multidrug resistance protein 0.0007 0.0341 0.0235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 0.8218 0.8198
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0012 0.1062 0.0971
Trichomonas vaginalis ABC transporter, putative 0.0021 0.2391 0.291
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0505 0.04
Entamoeba histolytica protein kinase, putative 0.0012 0.1062 0.1586
Schistosoma mansoni multidrug resistance protein 0.0006 0.0293 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0525 0.0639
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0799 0.2455
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0012 0.1062 0.0971
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 0.8218 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.7133 0.868
Brugia malayi P-glycoprotein-like protein 0.0007 0.0341 0.0069
Giardia lamblia Hypothetical protein 0.0008 0.0477 0.0788
Schistosoma mansoni cpg binding protein 0.0037 0.4678 0.4619
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.3289 0.4241
Echinococcus multilocularis nervana 2 0.0022 0.2595 0.2862
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0008 0.0477 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0505 0.03
Giardia lamblia ABC transporter 0.0009 0.075 0.1955
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0007 0.0341 0.5
Brugia malayi Protein kinase domain containing protein 0.0012 0.1062 0.1089
Echinococcus multilocularis rac serine:threonine kinase 0.0025 0.2952 0.3314
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0061 0.8218 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.7357 0.8914
Brugia malayi Protein kinase domain containing protein 0.0012 0.1062 0.1089
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0477 0.0172
Brugia malayi ABC transporter transmembrane region family protein 0.0007 0.0341 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.7357 0.7328
Echinococcus multilocularis cpg binding protein 0.0037 0.4678 0.5506
Loa Loa (eye worm) hypothetical protein 0.0008 0.0505 0.03
Trichomonas vaginalis ABC transporter, putative 0.0021 0.2391 0.291
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.1062 0.0963
Mycobacterium ulcerans putative regulatory protein 0.0019 0.2204 1
Trypanosoma brucei ubiquitin-protein ligase, putative 0.004 0.5142 0.6094
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0012 0.1062 0.1089
Entamoeba histolytica P-glycoprotein-2 0.0021 0.2391 0.4327
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0477 0.0172
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.0283
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0007 0.0341 0.0069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.2391 0.291
Echinococcus granulosus nervana 2 0.0022 0.2595 0.2905
Echinococcus multilocularis Glutaredoxin protein 5 0.0022 0.2595 0.2862
Entamoeba histolytica ATP-binding cassette protein, putative 0.0007 0.0341 0.01
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0799 0.0697
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.2391 0.2602
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.1062 0.0915
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0634 0.0372
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.7357 0.8907
Mycobacterium leprae conserved hypothetical protein 0.0019 0.2204 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.2391 0.2648
Brugia malayi ecdysteroid receptor 0.0008 0.0505 0.03
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.2952 0.5484
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0505 0.0207
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0505 0.0267
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.8218 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Trichomonas vaginalis AGC family protein kinase 0.0036 0.4586 0.558
Entamoeba histolytica protein kinase, putative 0.0034 0.4265 0.8193
Loa Loa (eye worm) AGC/AKT protein kinase 0.0036 0.4586 0.6077
Entamoeba histolytica P-glycoprotein-1 0.0021 0.2391 0.4327
Trypanosoma cruzi Protein kinase B 0.0025 0.2952 0.3314
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0799 0.058
Trichomonas vaginalis AGC family protein kinase 0.0012 0.1062 0.1292
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0007 0.0341 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0008 0.0477 0.0372
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0012 0.1062 0.1089
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0505 0.04
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.2391 0.4327
Loa Loa (eye worm) PDE1B protein 0.0008 0.0477 0.0261
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.8867 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0505 0.03
Brugia malayi ABC transporter family protein 0.0021 0.2391 0.297
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Trypanosoma brucei rac serine-threonine kinase, putative 0.0036 0.4586 0.5389
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0008 0.0477 0.0232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.7357 0.7328
Plasmodium vivax phosphodiesterase gamma, putative 0.0008 0.0477 0.0283
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.149 0.1459
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.8218 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0939 0.0816
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0525 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.8218 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0341 0.0069
Schistosoma mansoni multidrug resistance protein 0.0021 0.2391 0.2307
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0008 0.0477 0.0172
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.149 0.1814
Loa Loa (eye worm) AGC/PKN protein kinase 0.0012 0.1062 0.1089
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.001 0.0799 0.058
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.2391 0.427
Echinococcus granulosus multidrug resistance associated protein 1 0.0007 0.0341 0.0061
Loa Loa (eye worm) hypothetical protein 0.0007 0.0341 0.0069
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.2391 0.291
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0007 0.0341 0.0235
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0505 0.04
Echinococcus granulosus protein kinase c iota type 0.0012 0.1062 0.0971
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0505 0.03
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0008 0.0477 0.0232
Loa Loa (eye worm) ABC transporter 0.0007 0.0341 0.0069
Echinococcus multilocularis serine threonine protein kinase 0.0012 0.1062 0.0915
Entamoeba histolytica protein kinase, putative 0.0036 0.4586 0.8854
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.0283
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Brugia malayi ABC transporter family protein 0.0007 0.0341 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0525 0.0639
Trichomonas vaginalis ABC transporter, putative 0.0021 0.2391 0.291
Brugia malayi ABC transporter family protein 0.0007 0.0341 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0505 0.04
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.2391 0.2602
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0006 0.0293 0.0186
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Plasmodium falciparum phosphodiesterase gamma, putative 0.0008 0.0477 0.0283
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.2391 0.291
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.004 0.5142 0.5088
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.2391 0.291
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.004 0.5142 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.2391 0.2404
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0505 0.03
Giardia lamblia Kinase, AGC PKA 0.0022 0.2631 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.7357 1
Trichomonas vaginalis AGC family protein kinase 0.0036 0.4586 0.558
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0008 0.0477 0.0283
Trichomonas vaginalis abcb9, putative 0.0021 0.2391 0.291
Trichomonas vaginalis AGC family protein kinase 0.0036 0.4586 0.558
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.2391 0.291
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Entamoeba histolytica protein kinase 2, putative 0.0022 0.2631 0.4823
Echinococcus granulosus serine:threonine protein kinase N2 0.0012 0.1062 0.0971
Echinococcus granulosus cpg binding protein 0.0037 0.4678 0.5533
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0525 0.0639
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0505 0.0207
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.001 0.0799 0.0536
Trichomonas vaginalis AGC family protein kinase 0.0036 0.4586 0.558
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0525 0.0639
Schistosoma mansoni cpg binding protein 0.0037 0.4678 0.4619
Echinococcus granulosus Glutaredoxin protein 5 0.0022 0.2595 0.2905
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0008 0.0477 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0477 0.058
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0022 0.2595 0.2862
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.2952 0.2874
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0012 0.1062 0.0971
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.2391 0.4327
Trichomonas vaginalis AGC family protein kinase 0.0036 0.4586 0.558
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0008 0.0541 0.0974
Brugia malayi multidrug resistance protein 3 0.0021 0.2391 0.297
Schistosoma mansoni smdr2 0.0021 0.2391 0.2307
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.2391 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.1062 0.0963
Echinococcus granulosus protein kinase c epsilon type 0.0012 0.1062 0.0971
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.004 0.5142 0.6118
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0799 0.0638
Entamoeba histolytica ABC transporter, putative 0.001 0.0799 0.1043
Giardia lamblia MRP-like ABC transporter 0.0007 0.0341 0.0208
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Leishmania major p-glycoprotein 0.0021 0.2391 0.2602
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0006 0.0293 0.0356
Entamoeba histolytica P-glycoprotein 6, putative 0.0007 0.0341 0.01
Brugia malayi multidrug resistance related protein 1 0.0007 0.0341 0.0069
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.2204 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Brugia malayi ABC transporter 0.0007 0.0341 0.0069
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.2391 0.2602
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0008 0.0477 0.058
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.2391 0.2602
Schistosoma mansoni serine/threonine kinase 0.0012 0.1062 0.0963
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.4393 0.5804
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0505 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0477 0.0159
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.2204 0.9086
Trichomonas vaginalis abcb9, putative 0.0021 0.2391 0.291
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0008 0.0477 0.0372
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.1062 0.0963
Schistosoma mansoni ABC transporter 0.0008 0.059 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.7133 0.868
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0008 0.0477 0.0283
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0008 0.0477 0.0232
Entamoeba histolytica hypothetical protein 0.0007 0.0341 0.01
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0525 0.0639
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0008 0.0477 0.0172
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0008 0.0477 0.0172
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0022 0.2595 0.2905
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0505 0.03
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.004 0.5142 0.5631
Trypanosoma brucei hypothetical protein, conserved 0.0008 0.0477 0.0172
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.2391 0.4327
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0008 0.0477 0.0232
Echinococcus multilocularis protein kinase c epsilon type 0.0012 0.1062 0.0915
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.8218 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0008 0.0477 0.058
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0008 0.0477 0.0261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0505 0.0207
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0505 0.03
Echinococcus granulosus ATP binding cassette sub family B 0.0007 0.0341 0.0061
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0008 0.0477 0.058
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0008 0.0477 0.0372
Entamoeba histolytica multidrug resistance protein, putative 0.0007 0.0341 0.01
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.5142 0.6864
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0008 0.0477 0.0261
Loa Loa (eye worm) hypothetical protein 0.0027 0.3289 0.4241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0634 0.0531
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.8218 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.2952 0.5484
Plasmodium falciparum ABC transporter G family member 2 0.001 0.0799 0.0952
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0525 0.0639
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.5142 0.6257
Trichomonas vaginalis taga, putative 0.0021 0.2391 0.291
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.8218 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.