Detailed information for compound 1407266

Basic information

Technical information
  • TDR Targets ID: 1407266
  • Name: methyl 2-(benzoyl)-3-hydroxy-5-(2-methylpropy l)-4H-pyrazole-3-carboxylate
  • MW: 304.341 | Formula: C16H20N2O4
  • H donors: 1 H acceptors: 3 LogP: 2.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1(O)CC(=NN1C(=O)c1ccccc1)CC(C)C
  • InChi: 1S/C16H20N2O4/c1-11(2)9-13-10-16(21,15(20)22-3)18(17-13)14(19)12-7-5-4-6-8-12/h4-8,11,21H,9-10H2,1-3H3
  • InChiKey: YYYIYIREDMCDOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-(benzoyl)-3-hydroxy-5-isobutyl-4H-pyrazole-3-carboxylate
  • 3-hydroxy-5-isobutyl-2-(oxo-phenylmethyl)-4H-pyrazole-3-carboxylic acid methyl ester
  • 2-(benzoyl)-3-hydroxy-5-isobutyl-4H-pyrazole-3-carboxylic acid methyl ester
  • methyl 3-hydroxy-5-(2-methylpropyl)-2-phenylcarbonyl-4H-pyrazole-3-carboxylate
  • MLS000570506
  • SMR000186933
  • methyl 1-benzoyl-5-hydroxy-3-isobutyl-4,5-dihydro-1H-pyrazole-5-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Brugia malayi neuropeptide F receptor 0.0056 0.0536 0.0414
Schistosoma mansoni neuropeptide receptor 0.0056 0.0536 0.0629
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0536 0.0414
Trichomonas vaginalis tubulin gamma chain, putative 0.0045 0.0317 0.0879
Plasmodium falciparum cysteine repeat modular protein 1 0.0041 0.0252 0.6575
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0536 0.0414
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0536 0.0414
Leishmania major beta tubulin 0.0045 0.0317 0.131
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0154 0.2423 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Trypanosoma brucei glucosidase, putative 0.0044 0.0298 0.0743
Schistosoma mansoni tubulin subunit beta 0.0045 0.0317 0.0292
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0536 0.0629
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0536 0.0629
Toxoplasma gondii beta-1 tubulin, putative 0.0045 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Brugia malayi carbohydrate phosphorylase 0.0215 0.361 0.3528
Schistosoma mansoni hypothetical protein 0.0056 0.0536 0.0629
Schistosoma mansoni hypothetical protein 0.0056 0.0536 0.0629
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0317 0.0193
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0536 0.0414
Brugia malayi Tubulin beta-1 chain 0.0045 0.0317 0.0193
Trichomonas vaginalis tubulin alpha chain, putative 0.0045 0.0317 0.0879
Echinococcus granulosus tissue type plasminogen activator 0.0041 0.0252 0.0127
Onchocerca volvulus 0.0056 0.0536 0.0846
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0536 0.0629
Echinococcus granulosus tubulin subunit beta 0.0045 0.0317 0.0193
Echinococcus granulosus somatostatin receptor 0.0056 0.0536 0.0414
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0536 0.0414
Brugia malayi sulfakinin receptor protein 0.0056 0.0536 0.0414
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0298 0.0825
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0154 0.2423 1
Leishmania major beta tubulin 0.0045 0.0317 0.131
Leishmania major hypothetical protein, conserved 0.0041 0.0252 0.1041
Brugia malayi G-protein coupled receptor 0.0056 0.0536 0.0414
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0536 0.0629
Trichomonas vaginalis tubulin epsilon chain, putative 0.0045 0.0317 0.0879
Schistosoma mansoni opsin-like receptor 0.0056 0.0536 0.0629
Trypanosoma brucei beta tubulin 0.0045 0.0317 0.0828
Schistosoma mansoni tubulin subunit beta 0.0045 0.0317 0.0292
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Schistosoma mansoni alpha-glucosidase 0.0169 0.2725 0.3993
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis beta tubulin 0.0045 0.0317 0.0193
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.1462 0.2051
Loa Loa (eye worm) tubulin beta-4 chain 0.0045 0.0317 0.0193
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0536 0.0414
Echinococcus multilocularis sex peptide receptor 0.0056 0.0536 0.0414
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0536 0.0414
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0536 0.0629
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0536 0.0414
Trypanosoma brucei beta tubulin 0.0045 0.0317 0.0828
Leishmania major beta tubulin 0.0045 0.0317 0.131
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0536 0.0414
Schistosoma mansoni glycogen phosphorylase 0.0093 0.1252 0.1728
Leishmania major beta tubulin 0.0045 0.0317 0.131
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0536 0.0414
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0536 0.0414
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0317 0.0193
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.3254 0.3167
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0536 0.0414
Entamoeba histolytica glycogenphosphorylase, putative 0.0093 0.1252 0.3466
Loa Loa (eye worm) hypothetical protein 0.0104 0.1462 0.1352
Leishmania major beta tubulin 0.0045 0.0317 0.131
Echinococcus multilocularis glycogen phosphorylase 0.0215 0.361 0.3528
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0298 0.0825
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Brugia malayi Dopamine receptor protein 2 0.0056 0.0536 0.0414
Echinococcus granulosus snurportin 1 0.0372 0.6633 0.659
Onchocerca volvulus 0.0056 0.0536 0.0846
Giardia lamblia Glycogen phosphorylase 0.0215 0.361 1
Leishmania major beta tubulin 0.0045 0.0317 0.131
Echinococcus granulosus sex peptide receptor 0.0056 0.0536 0.0414
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0536 0.0629
Onchocerca volvulus 0.0056 0.0536 0.0846
Brugia malayi follicle stimulating hormone receptor 0.0056 0.0536 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3254 0.3167
Echinococcus multilocularis Glycosyl transferase, family 35 0.0215 0.361 0.3528
Schistosoma mansoni biogenic amine receptor 0.0056 0.0536 0.0629
Trichomonas vaginalis tubulin beta chain, putative 0.0045 0.0317 0.0879
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0536 0.0414
Brugia malayi beta-tubulin, identical 0.0045 0.0317 0.0193
Echinococcus granulosus tubulin beta 4A class IVa 0.0045 0.0317 0.0193
Entamoeba histolytica tubulin family protein 0.0045 0.0317 0.0879
Echinococcus granulosus allatostatin A receptor 0.0056 0.0536 0.0414
Schistosoma mansoni myosin xvIII 0.0056 0.0536 0.0629
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0298 0.0825
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0298 0.0825
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni alpha glucosidase 0.0044 0.0298 0.0262
Onchocerca volvulus 0.0056 0.0536 0.0846
Brugia malayi Protein kinase domain containing protein 0.0041 0.0252 0.0127
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0317 0.0193
Toxoplasma gondii kringle domain-containing protein 0.0041 0.0252 0.6575
Leishmania major beta tubulin 0.0045 0.0317 0.131
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.3254 0.3167
Loa Loa (eye worm) beta-tubulin 0.0045 0.0317 0.0193
Loa Loa (eye worm) tubulin beta-2A chain 0.0045 0.0317 0.0193
Schistosoma mansoni neuropeptide receptor 0.0056 0.0536 0.0629
Echinococcus multilocularis tubulin subunit beta 0.0045 0.0317 0.0193
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0536 0.0414
Echinococcus granulosus g protein coupled receptor 0.0056 0.0536 0.0414
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.3254 0.3167
Chlamydia trachomatis glycogen phosphorylase 0.0215 0.361 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0536 0.0414
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0298 0.1229
Echinococcus multilocularis tissue type plasminogen activator 0.0041 0.0252 0.0127
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Brugia malayi RNA, U transporter 1 0.0099 0.1367 0.1256
Trichomonas vaginalis tubulin epsilon chain, putative 0.0045 0.0317 0.0879
Loa Loa (eye worm) glycogen phosphorylase 0.0215 0.361 0.3528
Onchocerca volvulus 0.0056 0.0536 0.0846
Onchocerca volvulus 0.0056 0.0536 0.0846
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0536 0.0414
Echinococcus granulosus g protein coupled receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0298 0.8975
Leishmania major beta tubulin 0.0045 0.0317 0.131
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0536 0.0414
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0298 0.0825
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0536 0.0629
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Leishmania major beta tubulin 0.0045 0.0317 0.131
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0536 0.0629
Brugia malayi G protein-coupled receptor 0.0056 0.0536 0.0414
Toxoplasma gondii beta tubulin 0.0045 0.0317 1
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Brugia malayi Serotonin receptor 0.0056 0.0536 0.0414
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0317 0.0193
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0536 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0041 0.0252 0.6575
Onchocerca volvulus 0.0092 0.1227 0.2902
Echinococcus granulosus neuropeptide receptor 0.0056 0.0536 0.0414
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0317 0.0193
Brugia malayi Dopamine receptor 0.0056 0.0536 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0536 0.0846
Trypanosoma brucei beta tubulin 0.0045 0.0317 0.0828
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0298 0.0825
Schistosoma mansoni neuropeptide receptor 0.0056 0.0536 0.0629
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0536 0.0414
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0536 0.0846
Entamoeba histolytica glycogen phosphorylase, putative 0.0093 0.1252 0.3466
Leishmania major beta tubulin 0.0045 0.0317 0.131
Leishmania major beta tubulin 0.0045 0.0317 0.131
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0536 0.0414
Loa Loa (eye worm) TK/ROR protein kinase 0.0041 0.0252 0.0127
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Toxoplasma gondii beta-tubulin, putative 0.0045 0.0317 1
Loa Loa (eye worm) tubulin beta chain 0.0045 0.0317 0.0193
Echinococcus multilocularis snurportin 1 0.0372 0.6633 0.659
Trypanosoma cruzi beta tubulin, putative 0.0045 0.0317 0.131
Loa Loa (eye worm) tubulin beta-1 chain 0.0045 0.0317 0.0193
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0298 0.0173
Leishmania major beta tubulin 0.0045 0.0317 0.131
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0154 0.2423 1
Brugia malayi Dopamine receptor protein 1 0.0056 0.0536 0.0414
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0536 0.0414
Brugia malayi Trypsin family protein 0.0104 0.1462 0.1352
Echinococcus multilocularis beta tubulin 0.0045 0.0317 0.0193
Schistosoma mansoni hypothetical protein 0.0041 0.0252 0.0192
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0536 0.0629
Echinococcus granulosus serotonin receptor 0.0056 0.0536 0.0414
Schistosoma mansoni adenoreceptor 0.0056 0.0536 0.0629
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0536 0.0414
Onchocerca volvulus 0.0056 0.0536 0.0846
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0536 0.0629
Echinococcus multilocularis serotonin receptor 0.0056 0.0536 0.0414
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0154 0.2423 1
Onchocerca volvulus Glycogen phosphorylase homolog 0.0215 0.361 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0317 0.0193
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0536 0.0414
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0536 0.0414
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0536 0.0414
Leishmania major beta tubulin 0.0045 0.0317 0.131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0536 0.0629
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0536 0.0414
Onchocerca volvulus 0.0104 0.1462 0.3602
Loa Loa (eye worm) hypothetical protein 0.0104 0.1462 0.1352
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0536 0.0414
Schistosoma mansoni amine GPCR 0.0056 0.0536 0.0629
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Entamoeba histolytica glycogen phosphorylase, putative 0.0093 0.1252 0.3466
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0317 0.0193
Brugia malayi G-protein coupled receptor 0.0056 0.0536 0.0414
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0536 0.0629
Echinococcus granulosus beta tubulin 0.0045 0.0317 0.0193
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0536 0.0414
Brugia malayi Kringle domain containing protein 0.0041 0.0252 0.0127
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0536 0.0629
Echinococcus multilocularis serotonin receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0317 0.0193
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0536 0.0629
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0536 0.0414
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0154 0.2423 1
Schistosoma mansoni neuropeptide receptor 0.0056 0.0536 0.0629
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0536 0.0414
Plasmodium falciparum tubulin beta chain 0.0045 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Brugia malayi AKH receptor 0.0056 0.0536 0.0414
Schistosoma mansoni hypothetical protein 0.0056 0.0536 0.0629
Schistosoma mansoni tubulin subunit beta 0.0045 0.0317 0.0292
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0317 0.0193
Schistosoma mansoni alpha-glucosidase 0.0169 0.2725 0.3993
Loa Loa (eye worm) BEN-1 protein 0.0045 0.0317 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0536 0.0414
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0536 0.0629
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0298 0.0825
Schistosoma mansoni amine GPCR 0.0056 0.0536 0.0629
Onchocerca volvulus 0.0056 0.0536 0.0846
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0536 0.0414
Schistosoma mansoni glycogen phosphorylase 0.0215 0.361 0.5354
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0536 0.0414
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0252 0.1041
Echinococcus granulosus fmrfamide receptor 0.0056 0.0536 0.0414
Onchocerca volvulus 0.0056 0.0536 0.0846
Onchocerca volvulus 0.0056 0.0536 0.0846
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0298 0.0173
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0536 0.0414
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0536 0.0414
Schistosoma mansoni tubulin subunit beta 0.0045 0.0317 0.0292
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Onchocerca volvulus 0.0056 0.0536 0.0846
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0536 0.0414
Schistosoma mansoni hypothetical protein 0.0372 0.6633 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Schistosoma mansoni biogenic amine receptor 0.0056 0.0536 0.0629
Schistosoma mansoni amine GPCR 0.0056 0.0536 0.0629
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0045 0.0317 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0298 0.1229
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.6633 0.659
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0536 0.0414
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0536 0.0414
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0536 0.0414
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0536 0.0414
Trichomonas vaginalis tubulin, putative 0.0045 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0536 0.0414
Echinococcus granulosus neuropeptide receptor 0.0056 0.0536 0.0414
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0536 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.1462 0.2051
Schistosoma mansoni opsin-like receptor 0.0056 0.0536 0.0629
Onchocerca volvulus 0.0114 0.1652 0.4169
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0536 0.0414
Echinococcus granulosus Glycosyl transferase family 35 0.0215 0.361 0.3528
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0536 0.0414
Onchocerca volvulus 0.0056 0.0536 0.0846
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0298 0.0173
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0536 0.0414
Echinococcus multilocularis glycogen phosphorylase 0.0215 0.361 0.3528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0536 0.0629
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0536 0.0414
Brugia malayi GnHR receptor homolog 0.0056 0.0536 0.0414
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0536 0.0414
Schistosoma mansoni hypothetical protein 0.0056 0.0536 0.0629
Onchocerca volvulus 0.0056 0.0536 0.0846
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0298 0.1229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Schistosoma mansoni amine GPCR 0.0056 0.0536 0.0629
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0536 0.0629
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0536 0.0414
Schistosoma mansoni tubulin subunit beta 0.0045 0.0317 0.0292
Leishmania major beta tubulin 0.0045 0.0317 0.131
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0298 0.0825
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0536 0.0414
Schistosoma mansoni amine GPCR 0.0056 0.0536 0.0629
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Brugia malayi ORL1-like opioid receptor 0.0056 0.0536 0.0414
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0536 0.0629
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Trichomonas vaginalis glycogen phosphorylase, putative 0.0215 0.361 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni histamine h1 receptor 0.0056 0.0536 0.0629
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0536 0.0414
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0536 0.0629
Entamoeba histolytica glycogen phosphorylase, putative 0.0215 0.361 1
Brugia malayi larval opioid receptor 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Leishmania major beta tubulin 0.0045 0.0317 0.131
Leishmania major beta tubulin 0.0045 0.0317 0.131
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0298 0.0825
Echinococcus granulosus hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Entamoeba histolytica tubulin family protein 0.0045 0.0317 0.0879
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0536 0.0629
Trichomonas vaginalis glycogen phosphorylase, putative 0.0215 0.361 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0154 0.2423 1
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0536 0.0414
Plasmodium vivax tubulin beta chain, putative 0.0045 0.0317 1
Trypanosoma brucei beta tubulin 0.0045 0.0317 0.0828
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0536 0.0629
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0536 0.0414
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0041 0.0252 0.0127
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0536 0.0414
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0536 0.0414
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0298 0.0173
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0317 0.0193
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni tubulin subunit beta 0.0045 0.0317 0.0292
Onchocerca volvulus 0.0056 0.0536 0.0846
Brugia malayi neuropeptide F receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis somatostatin receptor 0.0056 0.0536 0.0414
Brugia malayi hypothetical protein 0.0056 0.0536 0.0414
Schistosoma mansoni biogenic amine receptor 0.0056 0.0536 0.0629
Schistosoma mansoni glycogen phosphorylase 0.0215 0.361 0.5354
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0536 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Loa Loa (eye worm) BEN-1 protein 0.0045 0.0317 0.0193
Leishmania major beta tubulin 0.0045 0.0317 0.131
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0536 0.0414
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0536 0.0414
Echinococcus granulosus orexin receptor type 2 0.0056 0.0536 0.0414
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0298 0.0825
Brugia malayi Serotonin receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0536 0.0414
Echinococcus granulosus glycogen phosphorylase 0.0215 0.361 0.3528
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0536 0.0414
Echinococcus granulosus glycogen phosphorylase 0.0215 0.361 0.3528
Onchocerca volvulus 0.0056 0.0536 0.0846
Echinococcus granulosus beta tubulin 0.0045 0.0317 0.0193
Echinococcus granulosus tubulin beta 1 chain 0.0045 0.0317 0.0193
Leishmania major beta tubulin 0.0045 0.0317 0.131
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Echinococcus granulosus g protein coupled receptor 0.0056 0.0536 0.0414
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.0536 0.0414
Onchocerca volvulus 0.0056 0.0536 0.0846
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0536 0.0414
Brugia malayi RE15519p 0.0056 0.0536 0.0414
Entamoeba histolytica glycogen phosphorylase, putative 0.0215 0.361 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0536 0.0414
Echinococcus multilocularis tubulin beta 1 chain 0.0045 0.0317 0.0193
Schistosoma mansoni opsin-like receptor 0.0056 0.0536 0.0629
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0536 0.0414
Brugia malayi putative neuropeptide receptor 0.0056 0.0536 0.0414
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3254 0.3167
Loa Loa (eye worm) hypothetical protein 0.0056 0.0536 0.0414
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0298 0.0825
Onchocerca volvulus 0.0056 0.0536 0.0846
Brugia malayi Melatonin receptor type 1A 0.0056 0.0536 0.0414

Activities

Activity type Activity value Assay description Source Reference
AbsAC40_uM (functional) = 20.28 uM PUBCHEM_BIOASSAY: Sustained Induction of HSF-1 Measured in Cell-Based System Using Plate Reader - 2038-07_Activator_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) > 260 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] ChEMBL. No reference
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 30.1313 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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