Detailed information for compound 1413781

Basic information

Technical information
  • TDR Targets ID: 1413781
  • Name: 1-[2-[(3-chlorophenyl)amino]-2-oxoethyl]-N-[( 2-chlorophenyl)methyl]-3-(4-methylphenyl)-2,4 -dioxoquinazoline-7-carboxamide
  • MW: 587.453 | Formula: C31H24Cl2N4O4
  • H donors: 2 H acceptors: 4 LogP: 5.66 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(cc1)n1c(=O)c2ccc(cc2n(c1=O)CC(=O)Nc1cccc(c1)Cl)C(=O)NCc1ccccc1Cl
  • InChi: 1S/C31H24Cl2N4O4/c1-19-9-12-24(13-10-19)37-30(40)25-14-11-20(29(39)34-17-21-5-2-3-8-26(21)33)15-27(25)36(31(37)41)18-28(38)35-23-7-4-6-22(32)16-23/h2-16H,17-18H2,1H3,(H,34,39)(H,35,38)
  • InChiKey: CZOOGPFLESIXHH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[2-[(3-chlorophenyl)amino]-2-oxo-ethyl]-N-[(2-chlorophenyl)methyl]-3-(4-methylphenyl)-2,4-dioxo-quinazoline-7-carboxamide
  • 1-[2-[(3-chlorophenyl)amino]-2-oxoethyl]-N-[(2-chlorophenyl)methyl]-3-(4-methylphenyl)-2,4-dioxo-7-quinazolinecarboxamide
  • N-(2-chlorobenzyl)-1-[2-[(3-chlorophenyl)amino]-2-keto-ethyl]-2,4-diketo-3-(4-methylphenyl)quinazoline-7-carboxamide
  • C487-0130
  • NCGC00108704-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0084 0.027 0.027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.057 0.1007
Echinococcus multilocularis g-protein coupled receptor 0.009 0.0312 0.0551
Loa Loa (eye worm) hypothetical protein 0.0084 0.027 0.027
Echinococcus granulosus orexin receptor type 2 0.009 0.0312 0.0419
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0565 0.3683 0.3683
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus multilocularis tumor protein p63 0.0408 0.2569 0.4539
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0312 0.0551
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus multilocularis serotonin receptor 0.009 0.0312 0.0551
Brugia malayi RE15519p 0.009 0.0312 0.0312
Brugia malayi ORL1-like opioid receptor 0.009 0.0312 0.0312
Loa Loa (eye worm) steroid hormone receptor 0.0084 0.027 0.027
Schistosoma mansoni neuropeptide receptor 0.009 0.0312 0.0591
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.0891 0.0839
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0312 0.0591
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Onchocerca volvulus Putative organic anion transporter 0.1454 1 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0177 0.0931 0.1645
Echinococcus granulosus ecdysone induced protein 78C 0.0084 0.027 0.0362
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0312 0.0551
Echinococcus multilocularis neuropeptide Y receptor 0.009 0.0312 0.0551
Schistosoma mansoni single-minded 0.0049 0.0018 0.0034
Schistosoma mansoni coup transcription factor 0.0084 0.027 0.0511
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0891 0.4257
Giardia lamblia Kinase, CMGC MAPK 0.0105 0.0417 0.5
Loa Loa (eye worm) hypothetical protein 0.0084 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Onchocerca volvulus 0.009 0.0312 0.0256
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0084 0.027 0.0362
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.009 0.0312 0.0419
Schistosoma mansoni hypothetical protein 0.0048 0.001 0.002
Echinococcus granulosus Solute carrier organic anion transporter family 0.0177 0.0931 0.1252
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0312 0.0419
Onchocerca volvulus 0.009 0.0312 0.0256
Toxoplasma gondii transporter, major facilitator family protein 0.0177 0.0931 1
Brugia malayi PAS domain containing protein 0.0049 0.0018 0.0018
Trypanosoma cruzi MFS transporter, putative 0.0177 0.0931 1
Echinococcus multilocularis g protein coupled receptor 0.009 0.0312 0.0551
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.027 0.0476
Schistosoma mansoni opsin-like receptor 0.009 0.0312 0.0591
Loa Loa (eye worm) hypothetical protein 0.0353 0.2175 0.2175
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Loa Loa (eye worm) hypothetical protein 0.0177 0.0931 0.0931
Echinococcus granulosus mitogen activated protein kinase 3 0.0105 0.0417 0.0561
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.009 0.0312 0.0312
Brugia malayi G protein-coupled receptor 0.009 0.0312 0.0312
Brugia malayi hypothetical protein 0.0365 0.2263 0.2263
Schistosoma mansoni hypothetical protein 0.0048 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0062 0.0108 0.0108
Brugia malayi putative neuropeptide receptor NPR1 0.009 0.0312 0.0312
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0084 0.027 0.0476
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Onchocerca volvulus Protein ultraspiracle homolog 0.0084 0.027 0.0213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1531 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0177 0.0931 0.1645
Schistosoma mansoni amine GPCR 0.009 0.0312 0.0591
Brugia malayi photoreceptor-specific nuclear receptor 0.0084 0.027 0.027
Onchocerca volvulus Putative organic anion transporter 0.0177 0.0931 0.0879
Schistosoma mansoni biogenic amine receptor 0.009 0.0312 0.0591
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus Solute carrier family 22 5 0.1094 0.744 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1531 1
Echinococcus granulosus g protein coupled receptor 0.009 0.0312 0.0419
Schistosoma mansoni neuropeptide receptor 0.009 0.0312 0.0591
Echinococcus granulosus neuropeptide receptor 0.009 0.0312 0.0419
Echinococcus granulosus lamin 0.0054 0.0057 0.0077
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0084 0.027 0.027
Echinococcus granulosus mitogen activated protein kinase 0.0105 0.0417 0.0561
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.057 0.5
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0312 0.0551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0084 0.027 0.027
Brugia malayi G-protein coupled receptor 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Brugia malayi MAP kinase sur-1 0.0105 0.0417 0.0417
Echinococcus multilocularis ecdysone induced protein 78C 0.0084 0.027 0.0476
Echinococcus multilocularis neuropeptides capa receptor 0.009 0.0312 0.0551
Brugia malayi nuclear hormone receptor 0.0084 0.027 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.027 0.0362
Schistosoma mansoni lamin 0.0054 0.0057 0.0109
Loa Loa (eye worm) runx1 0.006 0.0096 0.0096
Schistosoma mansoni retinoic acid receptor RXR 0.0084 0.027 0.0511
Onchocerca volvulus 0.0058 0.0084 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0084 0.027 0.027
Echinococcus granulosus biogenic amine 5HT receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0177 0.0931 0.0931
Schistosoma mansoni survival motor neuron protein 0.0058 0.0084 0.0159
Onchocerca volvulus 0.009 0.0312 0.0256
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.057 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.057 0.5
Onchocerca volvulus 0.009 0.0312 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0084 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0177 0.0931 0.0931
Schistosoma mansoni hypothetical protein 0.009 0.0312 0.0591
Echinococcus granulosus dro:myosuppressin receptor 0.009 0.0312 0.0419
Brugia malayi hypothetical protein 0.0478 0.3066 0.3066
Schistosoma mansoni RAR-like nuclear receptor 0.0084 0.027 0.0511
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1531 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.001 0.0014
Brugia malayi sodium-independent organic anion transporter family protein 0.0177 0.0931 0.0931
Brugia malayi Latrophilin receptor protein 2 0.0048 0.001 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.009 0.0312 0.0551
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.009 0.0312 0.0591
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus geminin 0.0342 0.2103 0.2826
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.009 0.0312 0.0591
Schistosoma mansoni hypothetical protein 0.0048 0.001 0.002
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0105 0.0417 0.3754
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.009 0.0312 0.0551
Schistosoma mansoni neuropeptide receptor 0.009 0.0312 0.0591
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.001 0.001
Onchocerca volvulus Neuropeptide F receptor homolog 0.009 0.0312 0.0256
Brugia malayi ecdysteroid receptor 0.0084 0.027 0.027
Echinococcus granulosus thyrotropin releasing hormone receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Brugia malayi Steroid receptor seven-up type 2 0.0084 0.027 0.027
Brugia malayi Dopamine receptor 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.1454 1 1
Onchocerca volvulus 0.009 0.0312 0.0256
Loa Loa (eye worm) G-protein coupled receptor 0.009 0.0312 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0084 0.027 0.027
Schistosoma mansoni organic anion transporter 0.0177 0.0931 0.1764
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0084 0.027 0.027
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0312 0.0551
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0084 0.027 0.0362
Echinococcus multilocularis somatostatin receptor 0.009 0.0312 0.0551
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Brugia malayi hypothetical protein 0.0164 0.0837 0.0837
Schistosoma mansoni intermediate filament proteins 0.0054 0.0057 0.0109
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0084 0.027 0.0511
Brugia malayi hypothetical protein 0.0177 0.0931 0.0931
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0312 0.0419
Echinococcus multilocularis orexin receptor type 2 0.009 0.0312 0.0551
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.057 0.561
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0312 0.0419
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0177 0.0931 0.0931
Brugia malayi follicle stimulating hormone receptor 0.0565 0.3683 0.3683
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Schistosoma mansoni hypothetical protein 0.009 0.0312 0.0591
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0108 0.0108
Brugia malayi Tachykinin-like peptides receptor 99D 0.009 0.0312 0.0312
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Brugia malayi hypothetical protein 0.0286 0.1699 0.1699
Onchocerca volvulus 0.009 0.0312 0.0256
Echinococcus multilocularis neuropeptide receptor A26 0.009 0.0312 0.0551
Echinococcus multilocularis follistatin 0.0062 0.0108 0.0191
Echinococcus granulosus serotonin receptor 0.009 0.0312 0.0419
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni myosin xvIII 0.009 0.0312 0.0591
Echinococcus multilocularis G-protein coupled receptor, putative 0.009 0.0312 0.0551
Schistosoma mansoni biogenic amine (5HT) receptor 0.009 0.0312 0.0591
Schistosoma mansoni peptide (allatostatin)-like receptor 0.009 0.0312 0.0591
Brugia malayi Serotonin/octopamine receptor family protein 7 0.009 0.0312 0.0312
Schistosoma mansoni hypothetical protein 0.0103 0.0405 0.0768
Echinococcus multilocularis biogenic amine (5HT) receptor 0.009 0.0312 0.0551
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.001 0.0018
Echinococcus granulosus lamin dm0 0.0054 0.0057 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0891 0.4257
Onchocerca volvulus 0.0177 0.0931 0.0879
Echinococcus granulosus alpha 1A adrenergic receptor 0.009 0.0312 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0891 0.4257
Schistosoma mansoni biogenic amine receptor 0.009 0.0312 0.0591
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0417 0.079
Brugia malayi Melatonin receptor type 1A 0.009 0.0312 0.0312
Schistosoma mansoni neuropeptide f receptor 76f 0.009 0.0312 0.0591
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus sex peptide receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.009 0.0312 0.0551
Echinococcus multilocularis neuropeptide s receptor 0.009 0.0312 0.0551
Schistosoma mansoni amine GPCR 0.009 0.0312 0.0591
Echinococcus granulosus agrin 0.0062 0.0108 0.0145
Echinococcus multilocularis musashi 0.0054 0.0057 0.0102
Echinococcus multilocularis g protein coupled receptor 0.009 0.0312 0.0551
Echinococcus granulosus allatostatin A receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.0177 0.0931 0.0931
Echinococcus multilocularis high affinity choline transporter 1 0.0353 0.2175 0.3843
Schistosoma mansoni biogenic amine receptor 0.009 0.0312 0.0591
Echinococcus granulosus g protein coupled receptor 0.009 0.0312 0.0419
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0312 0.0551
Schistosoma mansoni hypothetical protein 0.0058 0.0084 0.0159
Schistosoma mansoni histamine h1 receptor 0.009 0.0312 0.0591
Loa Loa (eye worm) neuropeptide F receptor 0.009 0.0312 0.0312
Onchocerca volvulus 0.009 0.0312 0.0256
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.001 0.0014
Echinococcus multilocularis lamin dm0 0.0054 0.0057 0.0102
Schistosoma mansoni steroid hormone receptor ad4bp 0.0084 0.027 0.0511
Echinococcus multilocularis G protein coupled receptor 139 0.009 0.0312 0.0551
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0312 0.0551
Echinococcus granulosus neuropeptides capa receptor 0.009 0.0312 0.0419
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0312 0.0551
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.001 0.001
Brugia malayi putative neuropeptide receptor 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0957 0.4847
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.027 0.0476
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.027 0.027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0084 0.027 0.027
Onchocerca volvulus 0.009 0.0312 0.0256
Onchocerca volvulus 0.006 0.0095 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1531 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0405 0.0405
Brugia malayi GH02984p 0.0353 0.2175 0.2175
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.0084 0.027 0.027
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0108 0.0108
Echinococcus multilocularis mitogen activated protein kinase 3 0.0105 0.0417 0.0737
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0312 0.0551
Brugia malayi secreted modular calcium-binding protein 1 0.0062 0.0108 0.0108
Echinococcus multilocularis dro:myosuppressin receptor 0.009 0.0312 0.0551
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.057 0.108
Loa Loa (eye worm) hypothetical protein 0.0365 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0478 0.3066 0.3066
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.057 1
Brugia malayi hypoxia-induced factor 1 0.0152 0.0747 0.0747
Echinococcus multilocularis FTZ F1 alpha 0.0084 0.027 0.0476
Echinococcus multilocularis fmrfamide receptor 0.009 0.0312 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0084 0.027 0.027
Echinococcus granulosus g-protein coupled receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0084 0.027 0.027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0084 0.027 0.0476
Onchocerca volvulus Bile acid receptor homolog 0.0084 0.027 0.0213
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.009 0.0312 0.0551
Onchocerca volvulus 0.009 0.0312 0.0256
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.009 0.0312 0.0312
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0745 0.0745
Onchocerca volvulus 0.0177 0.0931 0.0879
Brugia malayi intermediate filament protein 0.0054 0.0057 0.0057
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.057 0.108
Schistosoma mansoni amine GPCR 0.009 0.0312 0.0591
Echinococcus multilocularis allatostatin A receptor 0.009 0.0312 0.0551
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0084 0.027 0.0362
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0312 0.0419
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.057 0.0766
Schistosoma mansoni alpha-1 adrenergic receptor 0.009 0.0312 0.0591
Onchocerca volvulus 0.0177 0.0931 0.0879
Brugia malayi Serotonin receptor 0.009 0.0312 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Echinococcus granulosus peptide allatostatin:somatostatin 0.009 0.0312 0.0419
Echinococcus multilocularis neuropeptide FF receptor 2 0.009 0.0312 0.0551
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0084 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0891 0.4257
Loa Loa (eye worm) hypothetical protein 0.0164 0.0837 0.0837
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.009 0.0312 0.0591
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Echinococcus multilocularis neuropeptide receptor 0.009 0.0312 0.0551
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0084 0.027 0.0476
Echinococcus granulosus fmrfamide receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.0177 0.0931 0.0931
Onchocerca volvulus 0.0478 0.3066 0.3026
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1531 1
Schistosoma mansoni lamin 0.0054 0.0057 0.0109
Schistosoma mansoni biogenic amine (5HT) receptor 0.009 0.0312 0.0591
Onchocerca volvulus 0.009 0.0312 0.0256
Schistosoma mansoni hypothetical protein 0.0342 0.2103 0.3984
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Brugia malayi Serotonin receptor 0.009 0.0312 0.0312
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0891 0.4257
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0105 0.0417 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1531 1
Brugia malayi GnHR receptor homolog 0.009 0.0312 0.0312
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0084 0.027 0.0511
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0312 0.0591
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus 7TM GPCR rhodopsin 0.009 0.0312 0.0419
Schistosoma mansoni lozenge 0.006 0.0096 0.0182
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.009 0.0312 0.0551
Echinococcus multilocularis neuropeptide receptor 0.009 0.0312 0.0551
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.009 0.0312 0.0591
Echinococcus granulosus biogenic amine 5HT receptor 0.009 0.0312 0.0419
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.009 0.0312 0.0256
Schistosoma mansoni nuclear hormone receptor 0.0084 0.027 0.0511
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.009 0.0312 0.0591
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0405 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0084 0.027 0.027
Echinococcus granulosus intermediate filament protein 0.0054 0.0057 0.0077
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0084 0.027 0.0511
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0745 0.0745
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.009 0.0312 0.0551
Schistosoma mansoni hypothetical protein 0.009 0.0312 0.0591
Echinococcus granulosus 7tm_1 domain containing protein 0.009 0.0312 0.0419
Echinococcus multilocularis expressed protein 0.0062 0.0108 0.0191
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Brugia malayi larval opioid receptor 0.009 0.0312 0.0312
Onchocerca volvulus 0.009 0.0312 0.0256
Echinococcus multilocularis alpha 1A adrenergic receptor 0.009 0.0312 0.0551
Loa Loa (eye worm) TYRA-2 protein 0.009 0.0312 0.0312
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0084 0.027 0.0476
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.009 0.0312 0.0312
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0084 0.027 0.0511
Echinococcus multilocularis sex peptide receptor 0.009 0.0312 0.0551
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0312 0.0591
Schistosoma mansoni neuropeptide F-like receptor 0.009 0.0312 0.0591
Echinococcus granulosus tumor protein p63 0.0408 0.2569 0.3453
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus G protein coupled receptor 139 0.009 0.0312 0.0419
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0084 0.027 0.0511
Brugia malayi SPARC precursor 0.0062 0.0108 0.0108
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.1531 0.1531
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0084 0.027 0.027
Onchocerca volvulus 0.009 0.0312 0.0256
Onchocerca volvulus 0.009 0.0312 0.0256
Echinococcus multilocularis lamin 0.0054 0.0057 0.0102
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Onchocerca volvulus 0.0084 0.027 0.0213
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.009 0.0312 0.0551
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0057 0.0057
Echinococcus multilocularis fmrfamide receptor 0.009 0.0312 0.0551
Echinococcus granulosus g protein coupled receptor 0.009 0.0312 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0084 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni hypothetical protein 0.009 0.0312 0.0591
Schistosoma mansoni neuropeptide receptor 0.009 0.0312 0.0591
Echinococcus multilocularis expressed protein 0.0843 0.5659 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0745 0.0745
Schistosoma mansoni agrin 0.0062 0.0108 0.0205
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0312 0.0419
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0105 0.0417 0.0417
Echinococcus multilocularis g protein coupled receptor 0.009 0.0312 0.0551
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Onchocerca volvulus 0.009 0.0312 0.0256
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0084 0.027 0.0476
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0312 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0084 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0312 0.0551
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.009 0.0312 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0084 0.027 0.027
Brugia malayi neuropeptide F receptor 0.009 0.0312 0.0312
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.009 0.0312 0.0312
Echinococcus granulosus follistatin 0.0062 0.0108 0.0145
Loa Loa (eye worm) hypothetical protein 0.0084 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0286 0.1699 0.1699
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0084 0.027 0.027
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0312 0.0551
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0084 0.027 0.0213
Schistosoma mansoni follistatin 0.0062 0.0108 0.0205
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.009 0.0312 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0084 0.027 0.027
Brugia malayi Dopamine receptor protein 2 0.009 0.0312 0.0312
Brugia malayi steroid hormone receptor 0.0084 0.027 0.027
Brugia malayi sodium-independent organic anion transporter family protein 0.0177 0.0931 0.0931
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0084 0.027 0.0362
Echinococcus granulosus neuropeptide Y receptor 0.009 0.0312 0.0419
Onchocerca volvulus 0.0177 0.0931 0.0879
Trypanosoma brucei protein kinase, putative 0.0105 0.0417 0.5
Echinococcus multilocularis GPCR, family 2 0.0048 0.001 0.0018
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.1531 0.1531
Loa Loa (eye worm) hypothetical protein 0.0084 0.027 0.027
Schistosoma mansoni thyroid hormone receptor 0.0084 0.027 0.0511
Echinococcus granulosus neuropeptide receptor 0.009 0.0312 0.0419
Echinococcus granulosus neuropeptide FF receptor 2 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Onchocerca volvulus 0.0177 0.0931 0.0879
Loa Loa (eye worm) hypothetical protein 0.0062 0.0108 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.027 0.0362
Schistosoma mansoni opsin-like receptor 0.009 0.0312 0.0591
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0084 0.027 0.027
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.009 0.0312 0.0312
Echinococcus granulosus somatostatin receptor 0.009 0.0312 0.0419
Echinococcus granulosus neuropeptide s receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.0478 0.3066 0.3066
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0062 0.0108 0.0108
Echinococcus granulosus neuropeptides capa receptor 0.009 0.0312 0.0419
Loa Loa (eye worm) G-protein coupled receptor 0.009 0.0312 0.0312
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0789 0.5278 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0084 0.027 0.027
Brugia malayi neuropeptide F receptor 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0053 0.005 0.005
Echinococcus granulosus FTZ F1 alpha 0.0084 0.027 0.0362
Loa Loa (eye worm) hypothetical protein 0.0062 0.0108 0.0108
Echinococcus granulosus expressed protein 0.0843 0.5659 0.7607
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.009 0.0312 0.0419
Schistosoma mansoni neuropeptide F-like receptor 0.009 0.0312 0.0591
Schistosoma mansoni opsin-like receptor 0.009 0.0312 0.0591
Echinococcus multilocularis serotonin receptor 0.009 0.0312 0.0551
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Brugia malayi nuclear receptor NHR-88 0.0084 0.027 0.027
Brugia malayi Dopamine receptor protein 1 0.009 0.0312 0.0312
Echinococcus granulosus tachykinin peptides receptor 99D 0.009 0.0312 0.0419
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0108 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0957 0.4847
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0312 0.0419
Brugia malayi AKH receptor 0.009 0.0312 0.0312
Onchocerca volvulus Putative organic anion transporter 0.0177 0.0931 0.0879
Schistosoma mansoni amine GPCR 0.009 0.0312 0.0591
Echinococcus granulosus GPCR family 2 0.0048 0.001 0.0014
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.009 0.0312 0.0591
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0084 0.027 0.027
Brugia malayi G-protein coupled receptor 0.009 0.0312 0.0312
Echinococcus granulosus high affinity choline transporter 1 0.0353 0.2175 0.2924
Echinococcus multilocularis mitogen activated protein kinase 0.0105 0.0417 0.0737
Loa Loa (eye worm) neuropeptide F receptor 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni high-affinity choline transporter 0.0353 0.2175 0.4121
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Brugia malayi sulfakinin receptor protein 0.009 0.0312 0.0312
Brugia malayi sodium-independent organic anion transporter family protein 0.0177 0.0931 0.0931
Onchocerca volvulus 0.0062 0.0108 0.0051
Echinococcus multilocularis geminin 0.0342 0.2103 0.3716
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.009 0.0312 0.0551
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0312 0.0419
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0312 0.0551
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0095 0.0179
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1699 0.3002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.009 0.0312 0.0591
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0891 0.4257
Brugia malayi gonadotropin-releasing hormone receptor 2 0.009 0.0312 0.0312
Brugia malayi G protein-coupled receptor F59B2.13 0.009 0.0312 0.0312
Schistosoma mansoni hypothetical protein 0.0342 0.2103 0.3984
Brugia malayi hypothetical protein 0.0177 0.0931 0.0931
Loa Loa (eye worm) agrin synaptic family protein 0.0062 0.0108 0.0108
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0084 0.027 0.0511
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Onchocerca volvulus 0.009 0.0312 0.0256
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.0747 0.0747
Echinococcus multilocularis tachykinin peptides receptor 99D 0.009 0.0312 0.0551
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.009 0.0312 0.0591
Schistosoma mansoni hypothetical protein 0.0048 0.001 0.002
Onchocerca volvulus 0.009 0.0312 0.0256
Onchocerca volvulus 0.0365 0.2263 0.2218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0312 0.0591
Echinococcus granulosus neuropeptide Y receptor 0.009 0.0312 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0891 0.4257
Schistosoma mansoni adenoreceptor 0.009 0.0312 0.0591
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.001 0.0018
Echinococcus multilocularis neuropeptides capa receptor 0.009 0.0312 0.0551
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni amine GPCR 0.009 0.0312 0.0591
Echinococcus granulosus neuropeptide receptor A26 0.009 0.0312 0.0419
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.057 0.5
Schistosoma mansoni thyroid hormone receptor 0.0084 0.027 0.0511
Echinococcus multilocularis Protein lozenge 0.006 0.0096 0.017
Echinococcus granulosus hypothetical protein 0.009 0.0312 0.0419
Echinococcus multilocularis agrin 0.0062 0.0108 0.0191
Onchocerca volvulus 0.009 0.0312 0.0256
Loa Loa (eye worm) hypothetical protein 0.0084 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1699 0.2283
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0312 0.0419
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0108 0.0108
Brugia malayi hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.009 0.0312 0.0591
Schistosoma mansoni organic anion transporter 0.0177 0.0931 0.1764
Loa Loa (eye worm) hypothetical protein 0.0177 0.0931 0.0931
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0084 0.027 0.0362
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0177 0.0931 0.1252
Loa Loa (eye worm) hypothetical protein 0.009 0.0312 0.0312
Schistosoma mansoni growth hormone secretagogue receptor 0.009 0.0312 0.0591
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0084 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.006 0.0095 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0084 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0057 0.0057

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.