Detailed information for compound 14153

Basic information

Technical information
  • TDR Targets ID: 14153
  • Name: 4-cyclopropyl-1-(2,3-dihydro-1-benzofuran-5-y l)butan-1-one
  • MW: 230.302 | Formula: C15H18O2
  • H donors: 0 H acceptors: 1 LogP: 3.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)CCO2)CCCC1CC1
  • InChi: 1S/C15H18O2/c16-14(3-1-2-11-4-5-11)12-6-7-15-13(10-12)8-9-17-15/h6-7,10-11H,1-5,8-9H2
  • InChiKey: WSIZFTULXCTIHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-cyclopropyl-1-(2,3-dihydrobenzofuran-5-yl)butan-1-one
  • 4-cyclopropyl-1-(2,3-dihydrobenzofuran-5-yl)-1-butanone
  • 1-coumaran-5-yl-4-cyclopropyl-butan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0064 0.0795 0.0684
Toxoplasma gondii hypothetical protein 0.0068 0.0908 0.5
Entamoeba histolytica hypothetical protein 0.0038 0.0083 0.5
Brugia malayi ecdysone receptor 0.0057 0.0608 0.0605
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0121 0.2354 0.2352
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0608 0.0605
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Brugia malayi hypothetical protein 0.0064 0.0795 0.0792
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.012 0.2347 1
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0086 0.1397 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0057 0.0608 0.0605
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0121 0.2354 0.2352
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0061 0.073 0.3111
Loa Loa (eye worm) RNA binding protein 0.0065 0.0843 0.0732
Brugia malayi hypothetical protein 0.0133 0.2691 0.2689
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0068 0.0908 0.0905
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0068 0.0908 0.0905
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0843 0.0766
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0121 0.2354 0.2352
Schistosoma mansoni steroid hormone receptor ad4bp 0.0121 0.2354 0.229
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0843 0.0732
Loa Loa (eye worm) fli-1 protein 0.0227 0.5275 0.5217
Brugia malayi tailless protein 0.0057 0.0608 0.0605
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0068 0.0908 0.0832
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0843 0.0766
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0338 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0121 0.2354 0.2262
Schistosoma mansoni thyroid hormone receptor 0.0121 0.2354 0.229
Onchocerca volvulus Bile acid receptor homolog 0.0121 0.2354 0.2352
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.11 0.1097
Brugia malayi hypothetical protein 0.0057 0.0608 0.0605
Brugia malayi nuclear receptor RXR 0.0057 0.0608 0.0605
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0054 0.0525 0.2238
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0068 0.0908 0.0905
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0064 0.0795 0.0718
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0068 0.0908 0.0832
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0003 0.0014
Echinococcus granulosus sodium and chloride dependent glycine 0.0068 0.0908 0.0905
Brugia malayi Ets-domain containing protein 0.0075 0.11 0.1097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0121 0.2354 0.2262
Plasmodium vivax amine transporter, putative 0.0068 0.0908 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0121 0.2354 0.2352
Schistosoma mansoni sodium/chloride dependent transporter 0.0399 1 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.3373 0.3293
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0795 0.0792
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0068 0.0908 0.0905
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0608 0.0605
Brugia malayi hypothetical protein 0.0064 0.0795 0.0792
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0843 0.0766
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0068 0.0908 0.0832
Brugia malayi nuclear hormone receptor 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0399 1 1
Onchocerca volvulus 0.0121 0.2354 0.2352
Brugia malayi Fli-1 protein 0.0227 0.5275 0.5273
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0843 0.084
Schistosoma mansoni lipoxygenase 0.0058 0.0636 0.0557
Loa Loa (eye worm) hypothetical protein 0.0064 0.0803 0.0691
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0083 0.008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0399 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0795 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0121 0.2354 0.2262
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0608 0.0605
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0068 0.0908 0.0905
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0061 0.073 0.3111
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0182 0.4028 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0795 0.0718
Echinococcus multilocularis jun protein 0.0169 0.3687 0.3685
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0843 0.0732
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0608 0.053
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0908 0.5
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.11 0.1097
Loa Loa (eye worm) nuclear hormone receptor 0.0057 0.0608 0.0495
Echinococcus granulosus ecdysone induced protein 78C 0.0121 0.2354 0.2352
Loa Loa (eye worm) nuclear receptor NHR-67 0.0057 0.0608 0.0495
Schistosoma mansoni sodium/chloride dependent transporter 0.0068 0.0908 0.0832
Echinococcus multilocularis FTZ F1 alpha 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Schistosoma mansoni ets-related 0.0227 0.5275 0.5235
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0608 0.0605
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0068 0.0908 0.0905
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0121 0.2354 0.2352
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121 0.2354 0.229
Loa Loa (eye worm) steroid hormone receptor 0.0121 0.2354 0.2262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0345 0.0264
Brugia malayi bZIP transcription factor family protein 0.0169 0.3687 0.3685
Loa Loa (eye worm) hypothetical protein 0.0068 0.0908 0.0798
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0121 0.2354 0.229
Brugia malayi RNA binding protein 0.0065 0.0843 0.084
Brugia malayi steroid hormone receptor 0.0121 0.2354 0.2352
Echinococcus multilocularis ecdysone induced protein 78C 0.0121 0.2354 0.2352
Schistosoma mansoni single-minded 0.0047 0.0338 0.0257
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0064 0.0795 0.0792
Brugia malayi Ets-domain containing protein 0.0075 0.11 0.1097
Onchocerca volvulus 0.0068 0.0908 0.0905
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0068 0.0908 0.0832
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0068 0.0908 0.5
Echinococcus granulosus sodium and chloride dependent glycine 0.0068 0.0908 0.0905
Schistosoma mansoni nuclear receptor 0.0057 0.0608 0.053
Echinococcus granulosus nuclear receptor nhr 48 0.0057 0.0608 0.0605
Brugia malayi Cytochrome P450 family protein 0.008 0.1238 0.1235
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0121 0.2354 0.2352
Loa Loa (eye worm) serotonin transporter b 0.0399 1 1
Plasmodium falciparum amino acid transporter, putative 0.0068 0.0908 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0608 0.0605
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0064 0.0795 0.0792
Schistosoma mansoni retinoic acid receptor RXR 0.0121 0.2354 0.229
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0068 0.0908 0.0905
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145 0.3038 0.2954
Brugia malayi nuclear hormone receptor family member nhr-6 0.0057 0.0608 0.0605
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.012 0.5
Entamoeba histolytica hypothetical protein 0.0038 0.0083 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0345 0.0264
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0121 0.2354 0.2262
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0068 0.0908 0.0832
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.012 0.051
Schistosoma mansoni thyroid hormone receptor 0.0121 0.2354 0.229
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0057 0.0608 0.0605
Echinococcus granulosus tar DNA binding protein 0.0065 0.0843 0.084
Brugia malayi hypothetical protein 0.0057 0.0608 0.0605
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0843 0.0766
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0121 0.2354 0.2352
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0121 0.2354 0.2352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0121 0.2354 0.2262
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0843 0.084
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Schistosoma mansoni zinc finger protein 0.0057 0.0608 0.053
Echinococcus granulosus serotonin transporter 0.0399 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0795 0.0792
Echinococcus multilocularis sodium and chloride dependent glycine 0.0068 0.0908 0.0905
Onchocerca volvulus 0.0068 0.0908 0.0905
Treponema pallidum sodium- and chloride- dependent transporter 0.0399 1 0.5
Brugia malayi orphan nuclear receptor NR2E1 0.0057 0.0608 0.0605
Loa Loa (eye worm) solute carrier family 6 member 4 0.0399 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0121 0.2354 0.229
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0121 0.2354 0.2262
Onchocerca volvulus 0.0133 0.2691 0.2689
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0068 0.0908 0.5
Brugia malayi conserved hypotetical protein 0.0057 0.0608 0.0605
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0068 0.0908 0.0798
Echinococcus granulosus FTZ F1 alpha 0.0121 0.2354 0.2352
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0068 0.0908 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0121 0.2354 0.2352
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0121 0.2354 0.229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0345 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0068 0.0908 0.0798
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0608 0.053
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0121 0.2354 0.2352
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0064 0.0795 0.0684
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0345 0.0264
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0121 0.2354 0.229
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.2354 0.2352
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0121 0.2354 0.2352
Schistosoma mansoni sodium-dependent amino acid transporter 0.0068 0.0908 0.0832
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0068 0.0908 0.0798
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0169 0.3687 0.3685
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Brugia malayi hypothetical protein 0.0038 0.0083 0.008
Brugia malayi ecdysteroid receptor 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0164 0.356 0.3482
Echinococcus granulosus jun protein 0.0169 0.3687 0.3685
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Loa Loa (eye worm) hypothetical protein 0.0068 0.0908 0.0798
Loa Loa (eye worm) hypothetical protein 0.0068 0.0908 0.0798
Loa Loa (eye worm) hypothetical protein 0.0399 1 1
Onchocerca volvulus 0.0068 0.0908 0.0905
Loa Loa (eye worm) hypothetical protein 0.0068 0.0908 0.0798
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.2354 0.2352
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.2354 0.2352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0345 0.0341
Onchocerca volvulus 0.0399 1 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0068 0.0908 0.0905
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0057 0.0608 0.053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Entamoeba histolytica hypothetical protein 0.0038 0.0083 0.5
Schistosoma mansoni sodium/chloride dependent transporter 0.0068 0.0908 0.0832
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0057 0.0608 0.053
Entamoeba histolytica hypothetical protein 0.0038 0.0083 0.5
Schistosoma mansoni nuclear receptor 0.0057 0.0608 0.053
Plasmodium falciparum transporter, putative 0.0068 0.0908 0.5
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0068 0.0908 0.0905
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0083 0.008
Schistosoma mansoni jun-related protein 0.0137 0.2818 0.2758
Loa Loa (eye worm) hypothetical protein 0.0068 0.0908 0.0798
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0068 0.0908 0.0905
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0636 0.0633
Brugia malayi Cytochrome P450 family protein 0.0039 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0064 0.0795 0.0684
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.2354 0.2352
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0121 0.2354 0.229
Schistosoma mansoni gabp alpha 0.0075 0.11 0.1025
Loa Loa (eye worm) hypothetical protein 0.0121 0.2354 0.2262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.2354 0.2352
Onchocerca volvulus 0.0057 0.0608 0.0605
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0057 0.0608 0.0605
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.11 0.0992
Schistosoma mansoni nuclear hormone receptor 0.0121 0.2354 0.229
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.2354 0.2352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0345 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0121 0.2354 0.2352
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.012 0.5
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0086 0.1397 0.5951
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Loa Loa (eye worm) hypothetical protein 0.0064 0.0795 0.0684
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0057 0.0608 0.0605
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0121 0.2354 0.2352
Brugia malayi nuclear receptor NHR-88 0.0121 0.2354 0.2352
Onchocerca volvulus 0.0057 0.0608 0.0605
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0068 0.0908 0.5
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0843 0.0766
Brugia malayi hypothetical protein 0.0068 0.0908 0.0905
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0068 0.0908 0.0905
Loa Loa (eye worm) DR-78 0.0057 0.0608 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0121 0.2354 0.2352
Brugia malayi hypoxia-induced factor 1 0.0145 0.3038 0.3036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0121 0.2354 0.2262
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0057 0.0608 0.0495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0121 0.2354 0.2262
Echinococcus multilocularis thyroid hormone receptor alpha 0.0121 0.2354 0.2352
Brugia malayi nuclear hormone receptor family member odr-7 0.0057 0.0608 0.0605
Loa Loa (eye worm) hypothetical protein 0.0064 0.0795 0.0684
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0086 0.1397 0.5951
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0636 0.0633
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Loa Loa (eye worm) norepinephrine transporter 0.0399 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0608 0.0605
Trypanosoma brucei cytochrome P450, putative 0.0039 0.012 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0345 0.0228
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0608 0.0605
Brugia malayi nuclear receptor RXR 0.0064 0.0795 0.0792
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0068 0.0908 0.0832
Loa Loa (eye worm) hypothetical protein 0.0068 0.0908 0.0798
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0345 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0121 0.2354 0.2262
Brugia malayi nuclear receptor NHR-67 0.0057 0.0608 0.0605
Leishmania major cytochrome p450-like protein 0.0039 0.012 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0121 0.2354 0.2262
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0169 0.3687 0.3685
Echinococcus multilocularis sodium and chloride dependent glycine 0.0068 0.0908 0.0905
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0068 0.0908 0.0832
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0345 0.0341
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0068 0.0908 0.0832
Brugia malayi PAS domain containing protein 0.0047 0.0338 0.0335
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Schistosoma mansoni hypothetical protein 0.0137 0.2818 0.2758
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.1238 0.1132
Loa Loa (eye worm) hypothetical protein 0.0121 0.2354 0.2262
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0061 0.073 0.5229
Schistosoma mansoni nuclear receptor nhr-48 0.0057 0.0608 0.053
Loa Loa (eye worm) hypothetical protein 0.0399 1 1
Trichomonas vaginalis aldehyde oxidase, putative 0.0182 0.4028 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0121 0.2354 0.229
Loa Loa (eye worm) hypothetical protein 0.0057 0.0608 0.0495
Schistosoma mansoni coup transcription factor 0.0121 0.2354 0.229
Brugia malayi Steroid receptor seven-up type 2 0.0121 0.2354 0.2352
Echinococcus granulosus thyroid hormone receptor alpha 0.0057 0.0608 0.0605
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0121 0.2354 0.2262
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0608 0.0605
Brugia malayi nuclear hormone receptor 0.0057 0.0608 0.0605
Toxoplasma gondii hypothetical protein 0.0068 0.0908 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0121 0.2354 0.2262
Brugia malayi TAR-binding protein 0.0065 0.0843 0.084
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0057 0.0608 0.0605
Brugia malayi hypothetical protein 0.0158 0.3373 0.3371
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0608 0.0605
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.2354 0.2352
Loa Loa (eye worm) hypothetical protein 0.0121 0.2354 0.2262
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0608 0.0605
Brugia malayi nuclear receptor NHR-88 0.0057 0.0608 0.0605
Brugia malayi Cytochrome P450 family protein 0.0039 0.012 0.0116
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0182 0.4028 0.5
Echinococcus multilocularis serotonin transporter 0.0399 1 1

Activities

Activity type Activity value Assay description Source Reference
CPE index (functional) = 0.13 Carrageenan paw edema index (CPE index) as ratio of the reduction in paw volume of tested compound relative to the compound tebufelone at peroral dose of 50 mg/kg. ChEMBL. 9544212

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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