Detailed information for compound 1419283

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 458.509 | Formula: C26H26N4O4
  • H donors: 2 H acceptors: 4 LogP: 3.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc2c1cccc2)CN(C(=O)CN1C(=O)NC(C1=O)(C)c1ccc(cc1)C)C
  • InChi: 1S/C26H26N4O4/c1-17-11-13-19(14-12-17)26(2)24(33)30(25(34)28-26)16-23(32)29(3)15-22(31)27-21-10-6-8-18-7-4-5-9-20(18)21/h4-14H,15-16H2,1-3H3,(H,27,31)(H,28,34)
  • InChiKey: HUUBFJRTPKLKOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0328 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0105 0.2629 0.2132
Plasmodium falciparum ABC transporter B family member 3, putative 0.0105 0.2629 0.2629
Brugia malayi RE11181p 0.0045 0.0632 0.0632
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1271 0.0792
Plasmodium falciparum multidrug resistance-associated protein 2 0.0105 0.2629 0.2629
Loa Loa (eye worm) hypothetical protein 0.0321 0.977 0.977
Echinococcus multilocularis multidrug resistance associated protein 1 0.0105 0.2629 0.1557
Schistosoma mansoni smdr2 0.0328 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0105 0.2629 0.1557
Leishmania major p-glycoprotein 0.0328 1 1
Toxoplasma gondii ABC transporter, putative 0.0105 0.2629 0.2629
Trichomonas vaginalis abcb9, putative 0.0328 1 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0105 0.2629 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0328 1 1
Brugia malayi hypothetical protein 0.0045 0.0632 0.0632
Loa Loa (eye worm) ABC transporter 0.0105 0.2629 0.2629
Echinococcus granulosus ATP binding cassette sub family B 0.0105 0.2629 0.1557
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0328 1 1
Entamoeba histolytica P-glycoprotein-2 0.0328 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0863 0.0962
Plasmodium falciparum ABC transporter G family member 2 0.0297 0.8963 0.8963
Echinococcus multilocularis ATP binding cassette sub family G 0.0297 0.8963 0.8812
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0105 0.2629 0.2629
Brugia malayi RNA binding protein 0.0064 0.1271 0.1271
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0105 0.2629 0.2629
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0245 0.726 0.7075
Trichomonas vaginalis ABC transporter, putative 0.0328 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0328 1 1
Onchocerca volvulus 0.0328 1 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0328 1 1
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0105 0.2629 0.2934
Toxoplasma gondii ABC transporter family protein 0.0105 0.2629 0.2629
Echinococcus multilocularis geminin 0.0205 0.5923 0.5329
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0328 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0328 1 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.1271 0.1271
Echinococcus granulosus multidrug resistance protein 1 0.0328 1 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG87 0.0052 0.0863 0.0863
Echinococcus multilocularis ATP binding cassette sub family G 0.0297 0.8963 0.8812
Brugia malayi ABC transporter family protein 0.0105 0.2629 0.2629
Schistosoma mansoni multidrug resistance protein 0.0328 1 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0328 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0328 1 1
Echinococcus granulosus ATP binding cassette sub family G 0.0297 0.8963 0.8812
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1271 0.0792
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0328 1 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.2399 0.2399
Trypanosoma brucei ATP-binding cassette protein subfamily G 0.0052 0.0863 0.0962
Entamoeba histolytica P-glycoprotein-5 0.0328 1 1
Brugia malayi multidrug resistance related protein 1 0.0105 0.2629 0.2629
Plasmodium vivax multidrug resistance protein 2, putative 0.0105 0.2629 0.2629
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0328 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0105 0.2629 0.2629
Brugia malayi ABC transporter transmembrane region family protein 0.0105 0.2629 0.2629
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.3138 0.3138
Entamoeba histolytica ABC transporter, putative 0.0297 0.8963 0.8893
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0297 0.8963 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0328 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0297 0.8963 1
Echinococcus granulosus ATP binding cassette sub family G 0.0297 0.8963 0.8812
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0328 1 1
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0052 0.0863 0.0962
Trichomonas vaginalis ABC transporter, putative 0.0328 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0105 0.2629 0.1557
Entamoeba histolytica ATP-binding cassette protein, putative 0.0105 0.2629 0.2132
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0105 0.2629 0.2397
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0328 1 1
Schistosoma mansoni multidrug resistance protein 0.0105 0.2629 0.2225
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0297 0.8963 1
Leishmania major ATP-binding cassette protein subfamily G, member 1, putative 0.0052 0.0863 0.0863
Schistosoma mansoni hypothetical protein 0.0205 0.5923 0.5699
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0105 0.2629 0.2629
Plasmodium vivax ABC transporter B family member 3, putative 0.0105 0.2629 0.2629
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0328 1 1
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0105 0.2629 0.2629
Loa Loa (eye worm) hypothetical protein 0.006 0.115 0.115
Echinococcus multilocularis multidrug resistance associated protein 7 0.0105 0.2629 0.1557
Loa Loa (eye worm) hypothetical protein 0.0105 0.2629 0.2629
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0328 1 1
Trypanosoma cruzi ABC transporter, putative 0.0045 0.0632 0.0706
Entamoeba histolytica P-glycoprotein-2 0.0328 1 1
Loa Loa (eye worm) ABC transporter 0.0252 0.749 0.749
Echinococcus multilocularis ATP binding cassette sub family B 0.0321 0.977 0.9736
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0328 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.3138 0.3138
Trichomonas vaginalis abcb9, putative 0.0328 1 1
Plasmodium vivax ABC transporter B family member 6, putative 0.0105 0.2629 0.2629
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0105 0.2629 0.2934
Brugia malayi MH2 domain containing protein 0.012 0.3138 0.3138
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2629 0.0303
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0105 0.2629 0.2397
Entamoeba histolytica ATP-binding cassette protein, putative 0.0105 0.2629 0.2132
Giardia lamblia ABC transporter 0.029 0.8732 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0105 0.2629 0.2934
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0328 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0105 0.2629 0.2629
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0105 0.2629 0.2934
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0105 0.2629 0.2132
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0105 0.2629 0.2225
Brugia malayi ABC transporter family protein 0.0252 0.749 0.749
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0105 0.2629 0.2629
Plasmodium vivax ABC transporter B family member 4, putative 0.0105 0.2629 0.2629
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0105 0.2629 0.2629
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0098 0.2399 0.1982
Echinococcus multilocularis ATP binding cassette sub family B 0.0105 0.2629 0.1557
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0105 0.2629 0.2397
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0328 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0105 0.2629 0.2629
Loa Loa (eye worm) hypothetical protein 0.0105 0.2629 0.2629
Entamoeba histolytica P-glycoprotein-1 0.0328 1 1
Loa Loa (eye worm) hypothetical protein 0.0328 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0297 0.8963 0.8963
Entamoeba histolytica multidrug resistance protein, putative 0.0105 0.2629 0.2132
Trypanosoma cruzi ABC transporter, putative 0.0297 0.8963 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0328 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0098 0.2399 0.2399
Trichomonas vaginalis abcb9, putative 0.0328 1 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0328 1 1
Plasmodium falciparum multidrug resistance protein 1 0.0328 1 1
Brugia malayi ABC transporter 0.0105 0.2629 0.2629
Entamoeba histolytica P-glycoprotein 5, putative 0.0328 1 1
Schistosoma mansoni multidrug resistance protein 0.0105 0.2629 0.2225
Trypanosoma brucei p-glycoprotein 0.0105 0.2629 0.2934
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1271 0.0792
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0328 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1271 0.1271
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0105 0.2629 0.2629
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0328 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1271 0.0792
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0105 0.2629 0.5
Trypanosoma brucei multidrug resistance protein E 0.0105 0.2629 0.2934
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0328 1 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0297 0.8963 0.8812
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1271 0.0792
Echinococcus granulosus ATP binding cassette sub family B 0.0098 0.2399 0.1293
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.115 0.115
Trichomonas vaginalis taga, putative 0.0328 1 1
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0105 0.2629 0.2132
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0105 0.2629 0.2934
Echinococcus multilocularis multidrug resistance protein 1 0.023 0.6761 0.629
Trypanosoma cruzi ABC transporter, putative 0.0052 0.0863 0.0962
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0328 1 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0321 0.977 0.9736
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0297 0.8963 0.8906
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0105 0.2629 0.2629
Leishmania major ATP-binding cassette protein subfamily G, member 5, putative 0.0052 0.0863 0.0863
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0328 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.052 0.052
Trypanosoma brucei ABC transporter, putative 0.0297 0.8963 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0105 0.2629 0.2629
Entamoeba histolytica P-glycoprotein 6, putative 0.0105 0.2629 0.2132
Echinococcus multilocularis ATP binding cassette sub family B 0.0105 0.2629 0.1557
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0105 0.2629 0.2629
Giardia lamblia MRP-like ABC transporter 0.0105 0.2629 0.0363
Plasmodium falciparum multidrug resistance protein 2 0.0105 0.2629 0.2629
Loa Loa (eye worm) ABC transporter 0.0105 0.2629 0.2629
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0328 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 2, putative 0.0052 0.0863 0.0863
Entamoeba histolytica P-glycoprotein 5, putative 0.0098 0.2399 0.1886
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0105 0.2629 0.2629
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0052 0.0863 0.0962
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.023 0.6761 0.5739
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0328 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0632 0.0632
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0328 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0632 0.0632
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0632 0.0706
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0105 0.2629 0.5
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0105 0.2629 0.2629
Schistosoma mansoni multidrug resistance protein 0.0105 0.2629 0.2225
Echinococcus granulosus multidrug resistance associated protein 7 0.0105 0.2629 0.1557
Giardia lamblia Multidrug resistance-associated protein 1 0.0105 0.2629 0.0363
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0105 0.2629 0.2934
Plasmodium falciparum ABC transporter B family member 6, putative 0.0105 0.2629 0.2629
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0105 0.2629 0.2934
Leishmania major ABC-thiol transporter 0.0105 0.2629 0.2629
Echinococcus granulosus multidrug resistance protein 1 0.023 0.6761 0.629
Brugia malayi P-glycoprotein-like protein 0.0105 0.2629 0.2629
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0328 1 1
Schistosoma mansoni multidrug resistance protein 0.0098 0.2399 0.1982
Entamoeba histolytica hypothetical protein 0.0105 0.2629 0.2132
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0105 0.2629 0.2934
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0328 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0328 1 1
Trichomonas vaginalis ABC transporter, putative 0.0328 1 1
Trypanosoma cruzi ABC transporter, putative 0.0045 0.0632 0.0706
Echinococcus granulosus multidrug resistance protein 1 0.0328 1 1
Brugia malayi TAR-binding protein 0.0064 0.1271 0.1271
Echinococcus granulosus geminin 0.0205 0.5923 0.5329
Brugia malayi ABC transporter family protein 0.0328 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0105 0.2629 0.2629
Echinococcus multilocularis multidrug resistance protein 1 0.0328 1 1
Brugia malayi ABC transporter family protein 0.0105 0.2629 0.2629
Brugia malayi ABC transporter 0.0098 0.2399 0.2399
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0297 0.8963 0.8963
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0328 1 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0098 0.2399 0.1886
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1271 0.1271
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0328 1 0.5
Entamoeba histolytica P-glycoprotein-2, putative 0.0328 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0863 0.0962
Schistosoma mansoni ABC transporter 0.0045 0.0632 0.0118
Echinococcus multilocularis ATP binding cassette sub family B 0.0105 0.2629 0.1557
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0328 1 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0328 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0297 0.8963 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0105 0.2629 0.0363
Entamoeba histolytica ABC transporter, putative 0.0105 0.2629 0.2132
Schistosoma mansoni hypothetical protein 0.0245 0.726 0.711
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0297 0.8963 0.8963
Plasmodium vivax ABC transporter G family member 2, putative 0.0297 0.8963 0.8963
Plasmodium falciparum ABC transporter B family member 7, putative 0.0105 0.2629 0.2629
Leishmania major pentamidine resistance protein 1 0.0105 0.2629 0.2629
Toxoplasma gondii ATP-binding cassette G family transporter ABCG89 0.0052 0.0863 0.0863
Schistosoma mansoni ABC transporter 0.0252 0.749 0.7353
Trypanosoma brucei ABC transporter, putative 0.0052 0.0863 0.0962
Toxoplasma gondii ATP-binding cassette G family transporter ABCG107 0.0052 0.0863 0.0863
Loa Loa (eye worm) hypothetical protein 0.0105 0.2629 0.2629
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0105 0.2629 0.2397
Echinococcus granulosus ATP binding cassette sub family G 0.0297 0.8963 0.8812
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0105 0.2629 1
Schistosoma mansoni multidrug resistance protein 0.0328 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1271 0.1271
Echinococcus multilocularis multidrug resistance protein 1 0.0328 1 1
Entamoeba histolytica P-glyco protein 6, putative 0.0328 1 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0105 0.2629 0.1557
Echinococcus granulosus multidrug resistance protein 1 0.023 0.6761 0.629
Entamoeba histolytica P-glycoprotein 6, putative 0.0105 0.2629 0.2132
Schistosoma mansoni smdr1 0.0105 0.2629 0.2225
Brugia malayi ABC transporter family protein 0.0105 0.2629 0.2629
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0105 0.2629 0.2629
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0105 0.2629 0.2629
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.115 0.115
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.052 0.052
Schistosoma mansoni multidrug resistance protein 0.0105 0.2629 0.2225
Schistosoma mansoni multidrug resistance protein 0.0328 1 1
Trypanosoma brucei ATP-binding cassette protein, putative 0.0297 0.8963 1
Schistosoma mansoni multidrug resistance protein 0.0105 0.2629 0.2225
Plasmodium falciparum ABC transporter B family member 4, putative 0.0105 0.2629 0.2629
Plasmodium falciparum multidrug resistance-associated protein 1 0.0105 0.2629 0.2629
Schistosoma mansoni hypothetical protein 0.0205 0.5923 0.5699
Giardia lamblia ABC transporter, putative 0.0105 0.2629 0.0363
Loa Loa (eye worm) hypothetical protein 0.0045 0.0632 0.0632
Trypanosoma cruzi multidrug resistance protein E, putative 0.0105 0.2629 0.2934
Trichomonas vaginalis ABC transporter, putative 0.0328 1 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0328 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0105 0.2629 0.2132
Loa Loa (eye worm) hypothetical protein 0.0328 1 1
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0105 0.2629 0.2397
Plasmodium falciparum ABC transporter B family member 5, putative 0.0105 0.2629 0.2629
Echinococcus multilocularis 0.0105 0.2629 0.1557
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0328 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0328 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0098 0.2399 0.2399
Toxoplasma gondii ATP-binding cassette G family transporter ABCG96 0.0052 0.0863 0.0863
Brugia malayi hypothetical protein 0.0105 0.2629 0.2629
Plasmodium vivax ABC transporter B family member 5, putative 0.0105 0.2629 0.2629
Leishmania major p-glycoprotein e 0.0105 0.2629 0.2629
Plasmodium vivax ABC transporter B family member 7, putative 0.0105 0.2629 0.2629
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0328 1 1
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0105 0.2629 0.2629
Loa Loa (eye worm) ABC transporter 0.0105 0.2629 0.2629

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.