Detailed information for compound 1419789

Basic information

Technical information
  • TDR Targets ID: 1419789
  • Name: N-[2,5-dioxo-1-(3-phenylpropyl)-4-(trifluorom ethyl)imidazolidin-4-yl]-3,4,5-trimethoxybenz amide
  • MW: 495.448 | Formula: C23H24F3N3O6
  • H donors: 2 H acceptors: 3 LogP: 3.4 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)NC1(NC(=O)N(C1=O)CCCc1ccccc1)C(F)(F)F
  • InChi: 1S/C23H24F3N3O6/c1-33-16-12-15(13-17(34-2)18(16)35-3)19(30)27-22(23(24,25)26)20(31)29(21(32)28-22)11-7-10-14-8-5-4-6-9-14/h4-6,8-9,12-13H,7,10-11H2,1-3H3,(H,27,30)(H,28,32)
  • InChiKey: WFRGFZCSVQXURV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2,5-dioxo-1-(3-phenylpropyl)-4-(trifluoromethyl)imidazolidin-4-yl]-3,4,5-trimethoxy-benzamide
  • N-[2,5-dioxo-1-(3-phenylpropyl)-4-(trifluoromethyl)-4-imidazolidinyl]-3,4,5-trimethoxybenzamide
  • N-[2,5-diketo-1-(3-phenylpropyl)-4-(trifluoromethyl)imidazolidin-4-yl]-3,4,5-trimethoxy-benzamide
  • SMR000220001
  • STOCK4S-35770
  • MLS000588572
  • N-[2,5-Dioxo-1-(3-phenyl-propyl)-4-trifluoromethyl-imidazolidin-4-yl]-3,4,5-trimethoxy-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.011 0.2652 0.2652
Plasmodium vivax ABC transporter B family member 4, putative 0.011 0.2652 0.2652
Brugia malayi P-glycoprotein-like protein 0.011 0.2652 0.2652
Plasmodium falciparum ABC transporter B family member 6, putative 0.011 0.2652 0.2652
Echinococcus granulosus multidrug resistance protein 1 0.0241 0.6771 0.6582
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0344 1 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.1225 0.1225
Schistosoma mansoni multidrug resistance protein 0.0344 1 1
Trichomonas vaginalis ABC transporter, putative 0.0344 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0322 0.929 0.929
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.011 0.2652 0.2652
Entamoeba histolytica hypothetical protein 0.011 0.2652 0.2221
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.011 0.2652 0.2652
Trypanosoma brucei ATP-binding cassette protein subfamily G 0.0056 0.0941 0.1013
Trypanosoma brucei ABC transporter, putative 0.0056 0.0941 0.1013
Brugia malayi ABC transporter family protein 0.0273 0.7773 0.7773
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0941 0.1013
Brugia malayi ABC transporter transmembrane region family protein 0.011 0.2652 0.2652
Plasmodium vivax ABC transporter B family member 6, putative 0.011 0.2652 0.2652
Trypanosoma cruzi ABC transporter, putative 0.0322 0.929 1
Entamoeba histolytica ABC transporter, putative 0.0322 0.929 0.9248
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.011 0.2652 0.5
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0266 0.7539 0.7352
Trypanosoma brucei ABC transporter, putative 0.0322 0.929 1
Giardia lamblia ABC transporter, putative 0.011 0.2652 0.0351
Leishmania major p-glycoprotein 0.0344 1 1
Plasmodium falciparum multidrug resistance protein 1 0.0344 1 1
Plasmodium vivax ABC transporter B family member 7, putative 0.011 0.2652 0.2652
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0482 0.0482
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0344 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0344 1 1
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0056 0.0941 0.1013
Schistosoma mansoni hypothetical protein 0.0043 0.0554 0.0076
Echinococcus granulosus ATP binding cassette sub family B 0.0103 0.2419 0.1974
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1081 0.1081
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0344 1 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0322 0.929 0.9248
Trypanosoma brucei multidrug resistance-associated protein, putative 0.011 0.2652 0.2855
Loa Loa (eye worm) ABC transporter 0.011 0.2652 0.2652
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0344 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.011 0.2652 0.2652
Brugia malayi ABC transporter family protein 0.011 0.2652 0.2652
Trypanosoma brucei multidrug resistance protein E 0.011 0.2652 0.2855
Trypanosoma cruzi ABC transporter, putative 0.0056 0.0941 0.1013
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.011 0.2652 0.2652
Loa Loa (eye worm) hypothetical protein 0.0344 1 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0103 0.2419 0.1974
Echinococcus multilocularis multidrug resistance associated protein 1 0.011 0.2652 0.2221
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0344 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.011 0.2652 0.2221
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.011 0.2652 0.0308
Loa Loa (eye worm) hypothetical protein 0.011 0.2652 0.2652
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0344 1 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.0344 1 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0344 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.011 0.2652 0.2652
Brugia malayi RE11181p 0.0048 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.011 0.2652 0.2652
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.3026 0.3026
Schistosoma mansoni smdr1 0.011 0.2652 0.228
Loa Loa (eye worm) hypothetical protein 0.0103 0.2419 0.2419
Schistosoma mansoni multidrug resistance protein 0.011 0.2652 0.228
Echinococcus multilocularis ATP binding cassette sub family G 0.0322 0.929 0.9248
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0344 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0554 0.0076
Toxoplasma gondii ATP-binding cassette G family transporter ABCG87 0.0056 0.0941 0.0941
Plasmodium falciparum multidrug resistance protein 2 0.011 0.2652 0.2652
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.011 0.2652 0.2652
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.011 0.2652 0.2652
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0941 0.1013
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0103 0.2419 0.2035
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.011 0.2652 0.5
Toxoplasma gondii ATP-binding cassette G family transporter ABCG96 0.0056 0.0941 0.0941
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0344 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.011 0.2652 0.2221
Schistosoma mansoni multidrug resistance protein 0.011 0.2652 0.228
Entamoeba histolytica P-glycoprotein 6, putative 0.011 0.2652 0.2221
Giardia lamblia Multidrug resistance-associated protein 1 0.011 0.2652 0.0351
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.011 0.2652 0.2652
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.011 0.2652 0.2652
Echinococcus multilocularis ATP binding cassette sub family B 0.011 0.2652 0.2221
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0322 0.929 1
Brugia malayi hypothetical protein 0.0043 0.0554 0.0554
Leishmania major ATP-binding cassette protein subfamily G, member 2, putative 0.0056 0.0941 0.0941
Trichomonas vaginalis ABC transporter, putative 0.0344 1 1
Plasmodium falciparum ABC transporter B family member 7, putative 0.011 0.2652 0.2652
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0322 0.929 1
Entamoeba histolytica P-glycoprotein-2 0.0344 1 1
Loa Loa (eye worm) hypothetical protein 0.0337 0.9767 0.9767
Toxoplasma gondii ATP-binding cassette G family transporter ABCG89 0.0056 0.0941 0.0941
Echinococcus granulosus multidrug resistance protein 1 0.0241 0.6771 0.6582
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.011 0.2652 0.2652
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0344 1 1
Brugia malayi ABC transporter 0.0103 0.2419 0.2419
Brugia malayi RNA binding protein 0.0065 0.1225 0.1225
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.011 0.2652 0.2652
Entamoeba histolytica P-glycoprotein-5 0.0344 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0344 1 1
Trypanosoma cruzi multidrug resistance protein E, putative 0.011 0.2652 0.2855
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1225 0.078
Echinococcus granulosus multidrug resistance protein 1 0.0344 1 1
Entamoeba histolytica P-glycoprotein 6, putative 0.011 0.2652 0.2221
Trypanosoma cruzi ABC transporter, putative 0.0048 0.0708 0.0762
Schistosoma mansoni smdr2 0.0344 1 1
Entamoeba histolytica multidrug resistance protein, putative 0.011 0.2652 0.2221
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.011 0.2652 0.228
Trichomonas vaginalis abcb9, putative 0.0344 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0344 1 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0344 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1225 0.1225
Plasmodium vivax multidrug resistance protein 2, putative 0.011 0.2652 0.2652
Echinococcus multilocularis multidrug resistance protein 1 0.0241 0.6771 0.6582
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.011 0.2652 0.2652
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.011 0.2652 0.2855
Plasmodium falciparum ABC transporter B family member 3, putative 0.011 0.2652 0.2652
Giardia lamblia Multidrug resistance-associated protein 1 0.011 0.2652 0.0351
Brugia malayi ABC transporter 0.011 0.2652 0.2652
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.011 0.2652 0.2855
Brugia malayi ABC transporter transmembrane region family protein 0.0103 0.2419 0.2419
Brugia malayi ABC transporter family protein 0.011 0.2652 0.2652
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.011 0.2652 0.2855
Brugia malayi hypothetical protein 0.0048 0.0708 0.0708
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0344 1 1
Schistosoma mansoni ABC transporter 0.0048 0.0708 0.0237
Trichomonas vaginalis taga, putative 0.0344 1 1
Trypanosoma cruzi ABC transporter, putative 0.0048 0.0708 0.0762
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0241 0.6771 0.5741
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1225 0.078
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.011 0.2652 0.2266
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.011 0.2652 0.2093
Plasmodium falciparum multidrug resistance-associated protein 1 0.011 0.2652 0.2652
Schistosoma mansoni ABC transporter 0.0273 0.7773 0.766
Schistosoma mansoni multidrug resistance protein 0.011 0.2652 0.228
Leishmania major p-glycoprotein e 0.011 0.2652 0.2652
Loa Loa (eye worm) hypothetical protein 0.0103 0.2419 0.2419
Plasmodium vivax ABC transporter B family member 3, putative 0.011 0.2652 0.2652
Echinococcus multilocularis 0.011 0.2652 0.2221
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0344 1 1
Giardia lamblia ABC transporter 0.0314 0.9057 1
Echinococcus multilocularis ATP binding cassette sub family B 0.011 0.2652 0.2221
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.011 0.2652 0.2266
Brugia malayi hypothetical protein 0.011 0.2652 0.2652
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.011 0.2652 0.2266
Schistosoma mansoni multidrug resistance protein 0.011 0.2652 0.228
Schistosoma mansoni multidrug resistance protein 0.011 0.2652 0.228
Loa Loa (eye worm) multidrug resistance protein 3 0.0344 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.011 0.2652 0.2266
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0344 1 1
Loa Loa (eye worm) ABC transporter 0.0273 0.7773 0.7773
Echinococcus multilocularis ATP binding cassette sub family B 0.0337 0.9767 0.9753
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0344 1 1
Entamoeba histolytica P-glycoprotein-1 0.0344 1 1
Entamoeba histolytica ATP-binding cassette sub-family G1, putative 0.0048 0.0708 0.0162
Loa Loa (eye worm) ABC transporter 0.011 0.2652 0.2652
Toxoplasma gondii ATP-binding cassette G family transporter ABCG107 0.0056 0.0941 0.0941
Loa Loa (eye worm) ABC transporter 0.011 0.2652 0.2652
Echinococcus granulosus multidrug resistance associated protein 1 0.011 0.2652 0.2221
Entamoeba histolytica P-glycoprotein-2 0.0344 1 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.011 0.2652 0.2855
Loa Loa (eye worm) hypothetical protein 0.006 0.1081 0.1081
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1225 0.078
Echinococcus granulosus tar DNA binding protein 0.0065 0.1225 0.071
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0344 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0322 0.929 1
Trypanosoma brucei p-glycoprotein 0.011 0.2652 0.2855
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.011 0.2652 0.2855
Echinococcus granulosus multidrug resistance protein 1 0.0344 1 1
Brugia malayi TAR-binding protein 0.0065 0.1225 0.1225
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1225 0.078
Leishmania major ABC-thiol transporter 0.011 0.2652 0.2652
Brugia malayi ABC transporter family protein 0.0344 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1225 0.1225
Brugia malayi multidrug resistance related protein 1 0.011 0.2652 0.2652
Plasmodium falciparum ABC transporter B family member 5, putative 0.011 0.2652 0.2652
Toxoplasma gondii ABC transporter family protein 0.011 0.2652 0.2652
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0344 1 1
Loa Loa (eye worm) hypothetical protein 0.0344 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0344 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0344 1 1
Schistosoma mansoni multidrug resistance protein 0.0103 0.2419 0.2035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1081 0.1081
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0344 1 1
Echinococcus granulosus ATP binding cassette sub family G 0.0322 0.929 0.9248
Echinococcus multilocularis ATP binding cassette sub family G 0.0322 0.929 0.9248
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.011 0.2652 0.2652
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0344 1 1
Trichomonas vaginalis ABC transporter, putative 0.0344 1 1
Giardia lamblia MRP-like ABC transporter 0.011 0.2652 0.0351
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.011 0.2652 0.2652
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0344 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.011 0.2652 0.2221
Echinococcus multilocularis multidrug resistance associated protein 7 0.011 0.2652 0.2221
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1225 0.078
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0344 1 1
Entamoeba histolytica P-glyco protein 6, putative 0.0344 1 1
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.011 0.2652 0.2652
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.3026 0.3026
Brugia malayi ABC transporter family protein 0.011 0.2652 0.2652
Trichomonas vaginalis abcb9, putative 0.0344 1 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0344 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0344 1 1
Schistosoma mansoni hypothetical protein 0.0266 0.7539 0.7415
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0344 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.011 0.2652 0.2652
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1225 0.1225
Plasmodium falciparum ABC transporter B family member 4, putative 0.011 0.2652 0.2652
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0322 0.929 0.9254
Plasmodium vivax ABC transporter G family member 2, putative 0.0322 0.929 0.929
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0056 0.0941 0.1013
Onchocerca volvulus 0.0344 1 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0344 1 1
Plasmodium falciparum multidrug resistance-associated protein 2 0.011 0.2652 0.2652
Echinococcus multilocularis ATP binding cassette sub family B 0.011 0.2652 0.2221
Loa Loa (eye worm) hypothetical protein 0.0048 0.0708 0.0708
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0344 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0344 1 1
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.011 0.2652 0.2652
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.011 0.2652 0.2652
Schistosoma mansoni multidrug resistance protein 0.0344 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.011 0.2652 0.2266
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0344 1 1
Toxoplasma gondii ABC transporter, putative 0.011 0.2652 0.2652
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0337 0.9767 0.9753
Loa Loa (eye worm) hypothetical protein 0.0048 0.0708 0.0708
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1225 0.071
Plasmodium vivax ABC transporter B family member 5, putative 0.011 0.2652 0.2652
Entamoeba histolytica ATP-binding cassette protein, putative 0.011 0.2652 0.2221
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.011 0.2652 0.2093
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0344 1 1
Brugia malayi MH2 domain containing protein 0.0122 0.3026 0.3026
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.011 0.2652 0.2855
Loa Loa (eye worm) hypothetical protein 0.0048 0.0708 0.0708
Trypanosoma brucei ATP-binding cassette protein, putative 0.0322 0.929 1
Echinococcus multilocularis ATP binding cassette sub family B 0.011 0.2652 0.2221
Entamoeba histolytica ABC transporter, putative 0.011 0.2652 0.2221
Echinococcus granulosus ATP binding cassette sub family B 0.011 0.2652 0.2221
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0344 1 1
Echinococcus granulosus multidrug resistance associated protein 7 0.011 0.2652 0.2221
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0708 0.0762
Trichomonas vaginalis ABC transporter, putative 0.0344 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0344 1 1
Echinococcus granulosus ATP binding cassette sub family G 0.0322 0.929 0.9248
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0322 0.929 0.929
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0344 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0322 0.929 0.929
Echinococcus granulosus ATP binding cassette sub family G 0.0322 0.929 0.9248
Entamoeba histolytica ATP-binding cassette protein, putative 0.011 0.2652 0.2221
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.011 0.2652 1
Leishmania major pentamidine resistance protein 1 0.011 0.2652 0.2652
Loa Loa (eye worm) hypothetical protein 0.0041 0.0482 0.0482
Echinococcus granulosus multidrug resistance protein 1 0.0344 1 1
Trichomonas vaginalis abcb9, putative 0.0344 1 1
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.011 0.2652 0.2855
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.011 0.2652 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0103 0.2419 0.1974
Leishmania major ATP-binding cassette protein subfamily G, member 5, putative 0.0056 0.0941 0.0941
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0344 1 1
Schistosoma mansoni multidrug resistance protein 0.0344 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0344 1 1
Plasmodium falciparum ABC transporter G family member 2 0.0322 0.929 0.929
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1081 0.1081
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0344 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.011 0.2652 0.2652
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0322 0.929 1
Leishmania major ATP-binding cassette protein subfamily G, member 1, putative 0.0056 0.0941 0.0941
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0344 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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