Detailed information for compound 1423864

Basic information

Technical information
  • TDR Targets ID: 1423864
  • Name: [2-(furan-2-ylmethylamino)-2-oxoethyl] 3,5-di chlorobenzoate
  • MW: 328.147 | Formula: C14H11Cl2NO4
  • H donors: 1 H acceptors: 2 LogP: 2.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccco1)COC(=O)c1cc(Cl)cc(c1)Cl
  • InChi: 1S/C14H11Cl2NO4/c15-10-4-9(5-11(16)6-10)14(19)21-8-13(18)17-7-12-2-1-3-20-12/h1-6H,7-8H2,(H,17,18)
  • InChiKey: HDHILLYXHBKSLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(2-furylmethylamino)-2-oxo-ethyl] 3,5-dichlorobenzoate
  • 3,5-dichlorobenzoic acid [2-(2-furylmethylamino)-2-oxoethyl] ester
  • 3,5-dichlorobenzoic acid [2-(2-furylmethylamino)-2-keto-ethyl] ester
  • [2-(furan-2-ylmethylamino)-2-oxo-ethyl] 3,5-dichlorobenzoate
  • T0506-9094
  • ZINC03275831

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0957 0.7695 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0117 0.069 0.1024
Loa Loa (eye worm) MH2 domain-containing protein 0.1233 1 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0957 0.7695 1
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0171 0.0609
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0414 0.0976
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0957 0.7695 1
Brugia malayi MH1 domain containing protein 0.0046 0.0097 0.0097
Echinococcus granulosus mothers against decapentaplegic 2 0.0038 0.0023 0.0081
Loa Loa (eye worm) hypothetical protein 0.0794 0.6337 0.6337
Schistosoma mansoni smad1 5 8 and 0.0084 0.0411 0.0968
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0251 0.1806 0.6425
Loa Loa (eye worm) hypothetical protein 0.0251 0.1806 0.1806
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0957 0.7695 0.7695
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0117 0.069 0.3177
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0414 0.5
Schistosoma mansoni Smad4 0.0084 0.0411 0.0968
Trypanosoma cruzi hypothetical protein, conserved 0.0295 0.2171 1
Brugia malayi hypothetical protein 0.014 0.0875 0.0875
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0251 0.1806 0.6425
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0414 1
Schistosoma mansoni hypothetical protein 0.0251 0.1806 0.426
Loa Loa (eye worm) hypothetical protein 0.0543 0.424 0.424
Onchocerca volvulus 0.0957 0.7695 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0662 0.5233 1
Brugia malayi MH2 domain containing protein 0.0084 0.0411 0.0411
Schistosoma mansoni Smad4 0.0038 0.0023 0.0054
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0097 0.0519 0.1848
Leishmania major hypothetical protein, conserved 0.0216 0.1515 0.5575
Echinococcus multilocularis snurportin 1 0.0372 0.2812 1
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0957 0.7695 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0794 0.6337 0.6337
Brugia malayi latrophilin 2 splice variant baaae 0.0543 0.424 0.424
Brugia malayi hypothetical protein 0.0216 0.1515 0.1515
Echinococcus multilocularis Smad4 0.0084 0.0411 0.146
Brugia malayi mothers against decapentaplegic homolog 3 0.0038 0.0023 0.0023
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0171 0.0609
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0957 0.7695 1
Brugia malayi MH2 domain containing protein 0.0038 0.0023 0.0023
Schistosoma mansoni smad 0.0038 0.0023 0.0054
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0117 0.069 0.2453
Echinococcus multilocularis mothers against decapentaplegic 6 0.0038 0.0023 0.0081
Plasmodium vivax ataxin-2 like protein, putative 0.0216 0.1515 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0117 0.069 0.069
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0117 0.069 0.3177
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0117 0.069 0.4551
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0794 0.6337 0.6337
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0251 0.1806 0.1806
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0553 0.432 0.5602
Schistosoma mansoni hypothetical protein 0.0251 0.1806 0.426
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0117 0.069 0.2453
Loa Loa (eye worm) transcription factor SMAD2 0.1233 1 1
Loa Loa (eye worm) hypothetical protein 0.0216 0.1515 0.1515
Loa Loa (eye worm) hypothetical protein 0.0553 0.432 0.432
Echinococcus multilocularis GPCR, family 2 0.0251 0.1806 0.6425
Brugia malayi N-terminal motif family protein 0.0553 0.432 0.432
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0117 0.069 0.2453
Echinococcus granulosus GPCR family 2 0.0251 0.1806 0.6425
Schistosoma mansoni smad 0.0084 0.0411 0.0968
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0414 0.2732
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2812 0.2812
Echinococcus granulosus Smad4 0.0084 0.0411 0.146
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0251 0.1806 0.6425
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0117 0.069 0.4551
Brugia malayi MH1 domain containing protein 0.0084 0.0411 0.0411
Brugia malayi MH1 domain containing protein 0.0046 0.0097 0.0097
Brugia malayi RNA, U transporter 1 0.0099 0.0536 0.0536
Brugia malayi isocitrate dehydrogenase 0.0117 0.069 0.069
Schistosoma mansoni Smad4 0.0038 0.0023 0.0054
Loa Loa (eye worm) hypothetical protein 0.0046 0.0097 0.0097
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0414 0.2732
Trypanosoma cruzi hypothetical protein, conserved 0.0295 0.2171 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0216 0.1515 0.5575
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0117 0.069 0.1627
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0957 0.7695 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0084 0.0411 0.0411
Trypanosoma cruzi PAB1-binding protein , putative 0.0216 0.1515 0.5575
Echinococcus granulosus snurportin 1 0.0372 0.2812 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0414 0.5
Echinococcus multilocularis smad 0.0084 0.0411 0.146
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0251 0.1806 0.6425
Echinococcus granulosus mothers against decapentaplegic 6 0.0038 0.0023 0.0081
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0117 0.069 0.2453
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0414 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0117 0.069 0.4551
Loa Loa (eye worm) latrophilin receptor protein 2 0.0251 0.1806 0.1806
Echinococcus multilocularis isocitrate dehydrogenase 0.0117 0.069 0.2453
Brugia malayi MH1 domain containing protein 0.0084 0.0411 0.0411
Schistosoma mansoni hypothetical protein 0.0097 0.0519 0.1225
Echinococcus granulosus smad 0.0084 0.0411 0.146
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0957 0.7695 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0084 0.0411 0.0968
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0084 0.0411 0.146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0794 0.6337 0.6337
Plasmodium falciparum ataxin-2 like protein, putative 0.0216 0.1515 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0414 0.5
Brugia malayi Smad1 0.0084 0.0411 0.0411
Leishmania major hypothetical protein, conserved 0.0295 0.2171 1
Schistosoma mansoni hypothetical protein 0.0251 0.1806 0.426
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0117 0.069 0.2453
Trypanosoma brucei PAB1-binding protein , putative 0.0216 0.1515 0.698
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0414 0.2732
Loa Loa (eye worm) hypothetical protein 0.0084 0.0414 0.0414
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0957 0.7695 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0038 0.0023 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0251 0.1806 0.1806
Echinococcus granulosus TGF beta signal transducer SmadC 0.0084 0.0411 0.146
Schistosoma mansoni smad1 5 8 and 0.0084 0.0411 0.0968
Loa Loa (eye worm) nuclear factor I 0.0046 0.0097 0.0097
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0414 0.1472
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0957 0.7695 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0251 0.1806 0.426
Echinococcus granulosus mothers against decapentaplegic 5 0.0084 0.0411 0.146
Loa Loa (eye worm) MH1 domain-containing protein 0.0038 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0372 0.2812 0.6631
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0097 0.0519 0.1848
Plasmodium falciparum ataxin-2 like protein, putative 0.0216 0.1515 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0414 0.2732
Loa Loa (eye worm) MH2 domain-containing protein 0.0084 0.0411 0.0411
Brugia malayi Isocitrate dehydrogenase 0.0117 0.069 0.069
Toxoplasma gondii LsmAD domain-containing protein 0.0216 0.1515 1
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0295 0.2171 1
Loa Loa (eye worm) Smad1 0.0084 0.0411 0.0411
Echinococcus multilocularis mothers against decapentaplegic 2 0.0038 0.0023 0.0081
Brugia malayi Probable ClpP-like protease 0.0084 0.0414 0.0414
Schistosoma mansoni hypothetical protein 0.0543 0.424 1
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0957 0.7695 0.7695
Brugia malayi MH2 domain containing protein 0.0084 0.0411 0.0411
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0414 0.1472
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0957 0.7695 0.5
Schistosoma mansoni smad1 5 8 and 0.0084 0.0411 0.0968
Echinococcus multilocularis mothers against decapentaplegic 5 0.0084 0.0411 0.146
Toxoplasma gondii isocitrate dehydrogenase 0.0117 0.069 0.4551

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.