Detailed information for compound 1432474

Basic information

Technical information
  • TDR Targets ID: 1432474
  • Name: N-[(3-chlorophenyl)methyl]-5-methyl-3-phenyl- 1,2-oxazole-4-carboxamide
  • MW: 326.777 | Formula: C18H15ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)CNC(=O)c1c(C)onc1c1ccccc1
  • InChi: 1S/C18H15ClN2O2/c1-12-16(17(21-23-12)14-7-3-2-4-8-14)18(22)20-11-13-6-5-9-15(19)10-13/h2-10H,11H2,1H3,(H,20,22)
  • InChiKey: YFLVWRMGAAHSNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(3-chlorophenyl)methyl]-5-methyl-3-phenyl-isoxazole-4-carboxamide
  • N-[(3-chlorophenyl)methyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide
  • N-(3-chlorobenzyl)-5-methyl-3-phenyl-isoxazole-4-carboxamide
  • ZINC02644845
  • T5238673

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0043 0.0244 0.2821
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0053 0.0331 0.097
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0244 0.1843
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0244 0.0716
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0244 0.0716
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.1843
Schistosoma mansoni hypothetical protein 0.0034 0.0158 0.0463
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0062 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0244 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0318 0.264 0.2594
Brugia malayi Protein kinase domain containing protein 0.0053 0.0331 0.2497
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0244 0.0183
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0053 0.0331 0.097
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0082 0.0578 0.1999
Schistosoma mansoni ap endonuclease 0.0023 0.0062 0.0183
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.041 0.3098
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0228 0.067
Echinococcus granulosus epidermal growth factor receptor 0.009 0.0649 0.1902
Brugia malayi beta-lactamase family protein 0.0043 0.0244 0.1843
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0244 0.0197
Plasmodium falciparum protoporphyrinogen oxidase 0.0082 0.0578 0.1999
Loa Loa (eye worm) hypothetical protein 0.0051 0.031 0.2343
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0244 1
Mycobacterium ulcerans monoamine oxidase 0.0082 0.0578 0.0519
Echinococcus multilocularis epidermal growth factor receptor 0.009 0.0649 0.1902
Schistosoma mansoni tyrosine kinase 0.0167 0.1324 0.3884
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.041 0.3098
Schistosoma mansoni amine oxidase 0.0082 0.0578 0.1694
Leishmania major UDP-galactopyranose mutase 0.0082 0.0578 1
Leishmania major hypothetical protein, conserved 0.0043 0.0244 0.3524
Mycobacterium tuberculosis Possible oxidoreductase 0.0082 0.0578 0.0559
Echinococcus multilocularis epidermal growth factor receptor 0.0167 0.1324 0.3884
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0244 0.0716
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0244 0.0716
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0082 0.0578 0.0519
Schistosoma mansoni tyrosine kinase 0.0053 0.0331 0.097
Echinococcus granulosus insulin receptor 0.0053 0.0331 0.097
Loa Loa (eye worm) hypothetical protein 0.0097 0.0713 0.5384
Mycobacterium tuberculosis Conserved protein 0.0043 0.0244 0.0197
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0336 0.515
Echinococcus granulosus expressed conserved protein 0.0091 0.0662 0.194
Schistosoma mansoni tyrosine kinase 0.0053 0.0331 0.097
Loa Loa (eye worm) beta-lactamase 0.0043 0.0244 0.1843
Loa Loa (eye worm) TK/EGFR protein kinase 0.0167 0.1324 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0158 0.1192
Echinococcus multilocularis tar DNA binding protein 0.0062 0.041 0.1203
Brugia malayi beta-lactamase 0.0043 0.0244 0.1843
Mycobacterium ulcerans oxidoreductase 0.0082 0.0578 0.0519
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0244 0.0197
Brugia malayi Furin-like cysteine rich region family protein 0.0167 0.1324 1
Onchocerca volvulus 0.0043 0.0244 0.2821
Schistosoma mansoni tyrosine kinase 0.0089 0.064 0.1878
Loa Loa (eye worm) hypothetical protein 0.0082 0.0578 0.4362
Schistosoma mansoni cpg binding protein 0.0028 0.0113 0.0331
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0713 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.1724
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0082 0.0578 0.1694
Schistosoma mansoni hypothetical protein 0.004 0.0215 0.0631
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0228 0.067
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0373
Toxoplasma gondii histone lysine-specific demethylase 0.0082 0.0578 0.9714
Mycobacterium ulcerans beta-lactamase 0.0043 0.0244 0.0183
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0082 0.0578 0.1999
Schistosoma mansoni tar DNA-binding protein 0.0062 0.041 0.1203
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0713 0.2091
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0244 0.0197
Echinococcus multilocularis cpg binding protein 0.003 0.0127 0.0373
Loa Loa (eye worm) hypothetical protein 0.0082 0.0578 0.4362
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0228 0.9136
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0244 0.0197
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0373
Toxoplasma gondii ABC1 family protein 0.0043 0.0244 0.3423
Onchocerca volvulus 0.0043 0.0244 0.2821
Echinococcus multilocularis protein patched 0.0042 0.0228 0.067
Loa Loa (eye worm) RNA binding protein 0.0062 0.041 0.3098
Trypanosoma cruzi UDP-galactopyranose mutase 0.0082 0.0578 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0082 0.0578 0.1999
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1078 0.316
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0082 0.0578 0.1694
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0113 0.0853
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0244 0.0197
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0062 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0294 0.2219
Schistosoma mansoni tar DNA-binding protein 0.0062 0.041 0.1203
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.1843
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0062 0.0183
Schistosoma mansoni amine oxidase 0.0082 0.0578 0.1694
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0318 0.264 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0244 0.0197
Loa Loa (eye worm) hypothetical protein 0.0082 0.0578 0.4362
Echinococcus granulosus epidermal growth factor receptor 0.0167 0.1324 0.3884
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0244 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0318 0.264 0.2795
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0244 0.0197
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0244 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0244 0.0197
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0713 0.2091
Loa Loa (eye worm) TK/INSR protein kinase 0.0053 0.0331 0.2497
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0244 0.3524
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0062 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0228 0.1724
Loa Loa (eye worm) TAR-binding protein 0.0062 0.041 0.3098
Schistosoma mansoni patched 1 0.0042 0.0228 0.067
Mycobacterium ulcerans hypothetical protein 0.0043 0.0244 0.0183
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0318 0.264 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0062 0.0472
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.0578 0.1999
Loa Loa (eye worm) hypothetical protein 0.0082 0.0578 0.4362
Loa Loa (eye worm) hypothetical protein 0.0034 0.0158 0.1192
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0294 0.2219
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1078 0.316
Echinococcus multilocularis expressed conserved protein 0.0091 0.0662 0.194
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0318 0.264 1
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0225 0.249
Brugia malayi CHE-14 protein 0.0042 0.0228 0.1724
Echinococcus multilocularis 0.0052 0.0316 0.0927
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.1843
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0318 0.264 0.2594
Brugia malayi hypothetical protein 0.0082 0.0578 0.4362
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0578 0.1999
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0228 0.067
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0578 0.1999
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0062 0.0472
Schistosoma mansoni tyrosine kinase 0.0089 0.064 0.1878
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0082 0.0578 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0082 0.0578 0.4362
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1159 1 1
Brugia malayi RNA binding protein 0.0062 0.041 0.3098
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.0578 0.0559
Mycobacterium ulcerans lipase LipD 0.0043 0.0244 0.0183
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0244 0.0183
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0713 0.5384
Schistosoma mansoni tar DNA-binding protein 0.0062 0.041 0.1203
Schistosoma mansoni tar DNA-binding protein 0.0062 0.041 0.1203
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.009 0.0649 0.1902
Brugia malayi SWIRM domain containing protein 0.0082 0.0578 0.4362
Schistosoma mansoni hypothetical protein 0.004 0.0215 0.0631
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0294 0.2219
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.1843
Brugia malayi beta-lactamase family protein 0.0043 0.0244 0.1843
Brugia malayi CXXC zinc finger family protein 0.0028 0.0113 0.0853
Schistosoma mansoni hypothetical protein 0.004 0.0215 0.0631
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0244 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0083 0.0593 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0082 0.0578 0.1694
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0244 0.3524
Schistosoma mansoni ap endonuclease 0.0023 0.0062 0.0183
Loa Loa (eye worm) hypothetical protein 0.0082 0.0578 0.4362
Echinococcus multilocularis protoporphyrinogen oxidase 0.0082 0.0578 0.1694
Echinococcus multilocularis insulin receptor 0.0053 0.0331 0.097
Brugia malayi TAR-binding protein 0.0062 0.041 0.3098
Echinococcus multilocularis 0.0082 0.0578 0.1694
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1078 0.9286 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0244 0.0704
Echinococcus granulosus lysine specific histone demethylase 1A 0.0082 0.0578 0.1694
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0244 1
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0225 0.249
Schistosoma mansoni hypothetical protein 0.0406 0.341 1
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.341 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0082 0.0578 0.1694
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0318 0.264 0.2594
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0225 0.249
Echinococcus multilocularis protein dispatched 1 0.0048 0.028 0.0821
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0244 0.0197
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2292 0.2418
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0244 0.1843
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0392 0.115
Mycobacterium ulcerans dehydrogenase 0.0082 0.0578 0.0519
Trichomonas vaginalis esterase, putative 0.0043 0.0244 1
Schistosoma mansoni tyrosine kinase 0.0089 0.064 0.1878
Onchocerca volvulus 0.0082 0.0578 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0294 0.2219
Trypanosoma cruzi UDP-galactopyranose mutase 0.0082 0.0578 1
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0225 0.249
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0726 0.213
Echinococcus granulosus tar DNA binding protein 0.0062 0.041 0.1203
Loa Loa (eye worm) hypothetical protein 0.0082 0.0578 0.4362
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0318 0.264 1
Schistosoma mansoni tyrosine kinase 0.009 0.0649 0.1902
Schistosoma mansoni tar DNA-binding protein 0.0062 0.041 0.1203
Echinococcus granulosus cpg binding protein 0.003 0.0127 0.0373
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0225 0.249
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.1843
Schistosoma mansoni tyrosine kinase 0.009 0.0649 0.1902
Schistosoma mansoni hypothetical protein 0.004 0.0215 0.0631
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.1843
Echinococcus granulosus dnaJ subfamily B 0.0406 0.341 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0067 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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