Detailed information for compound 1433119

Basic information

Technical information
  • TDR Targets ID: 1433119
  • Name: [2-(phenylmethoxy)phenyl]phosphonic acid
  • MW: 264.214 | Formula: C13H13O4P
  • H donors: 2 H acceptors: 3 LogP: 1.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OP(=O)(c1ccccc1OCc1ccccc1)O
  • InChi: 1S/C13H13O4P/c14-18(15,16)13-9-5-4-8-12(13)17-10-11-6-2-1-3-7-11/h1-9H,10H2,(H2,14,15,16)
  • InChiKey: HCGRZKQJKAPKMJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(benzyloxy)phenyl]phosphonic acid
  • SMR000046935
  • MLS000041815
  • NSC129454

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine kinase 2 beta Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens alkaline phosphatase, placental-like 2 Starlite/ChEMBL No references
Pseudomonas aeruginosa Beta Lactamase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium ulcerans class a beta-lactamase, BlaC Get druggable targets OG5_143180 All targets in OG5_143180
Loa Loa (eye worm) TK/FAK protein kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Mycobacterium tuberculosis Class a beta-lactamase BlaC Get druggable targets OG5_143180 All targets in OG5_143180
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum Protein tyrosine kinase 2 beta, putative Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130513 All targets in OG5_130513
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0027 0.001 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0298 0.0292
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0404 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0298 0.0292
Brugia malayi Inositol-1 0.0037 0.0127 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0277 0.0272
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0298 0.0292
Schistosoma mansoni inositol monophosphatase 0.0037 0.0127 0.0121
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0298 0.0292
Brugia malayi nuclear receptor NHR-88 0.0051 0.0298 0.0292
Schistosoma mansoni alkaline phosphatase 0.0196 0.2009 0.2004
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0006 0.0001
Schistosoma mansoni hypothetical protein 0.0102 0.0898 0.0893
Echinococcus multilocularis voltage dependent calcium channel 0.0875 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0447 0.0442
Echinococcus multilocularis SAM and MBT domain containing protein 0.0374 0.4106 0.4103
Brugia malayi RNA binding protein 0.0064 0.0447 0.0441
Loa Loa (eye worm) hypothetical protein 0.0051 0.0298 0.0293
Loa Loa (eye worm) TK/FAK protein kinase 0.0309 0.3333 0.333
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0404 0.1904
Schistosoma mansoni hypothetical protein 0.0034 0.0093 0.0088
Echinococcus granulosus chromobox protein 2 0.0192 0.1954 0.195
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0298 0.0292
Echinococcus granulosus histone acetyltransferase MYST2 0.0093 0.0794 0.0789
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0127 0.5
Mycobacterium ulcerans lipoprotein LpqF 0.0077 0.0602 0.3263
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0009
Loa Loa (eye worm) calcium channel 0.0875 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0447 0.0441
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0404 0.1904
Schistosoma mansoni jumonji/arid domain-containing protein 0.0091 0.0762 0.0757
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0298 0.0292
Onchocerca volvulus 0.0294 0.3154 0.6383
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0447 0.0442
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0277 0.0273
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0009
Echinococcus multilocularis voltage dependent calcium channel 0.0875 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0298 0.0293
Brugia malayi ecdysteroid receptor 0.0051 0.0298 0.0292
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0875 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0298 0.0292
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0404 0.1904
Schistosoma mansoni lamin 0.0027 0.001 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0298 0.0293
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0298 0.0292
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0404 0.2147
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0298 0.0292
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0127 0.5
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0196 0.2009 0.2004
Echinococcus granulosus lysine specific demethylase 5A 0.0091 0.0762 0.0757
Plasmodium falciparum importin beta, putative 0.0028 0.0032 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0093 0.0794 0.0789
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0298 0.0292
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0371 0.4067 0.4064
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0298 0.0292
Brugia malayi nuclear hormone receptor 0.0051 0.0298 0.0292
Loa Loa (eye worm) hypothetical protein 0.0051 0.0298 0.0293
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0298 0.0583
Echinococcus granulosus snurportin 1 0.0304 0.3278 0.3274
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0404 0.0399
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0298 0.0292
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0111 0.1004 0.0999
Schistosoma mansoni phd finger protein 0.004 0.0163 0.0157
Schistosoma mansoni hypothetical protein 0.0304 0.3278 0.3274
Schistosoma mansoni myelin transcription factor 1 myt1 0.0093 0.0794 0.0789
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0447 0.0441
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0298 0.0292
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0447 0.0441
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0298 0.0292
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0298 0.0292
Echinococcus multilocularis alkaline phosphatase 0.0196 0.2009 0.2004
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0298 0.0292
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0014 0.0008
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0532 0.5964 1
Brugia malayi TAR-binding protein 0.0064 0.0447 0.0441
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0127 0.5
Echinococcus granulosus intermediate filament protein 0.0027 0.001 0.0005
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0067 0.0194
Loa Loa (eye worm) RNA binding protein 0.0064 0.0447 0.0442
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0875 1 1
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0196 0.2009 0.2004
Brugia malayi jmjC domain containing protein 0.0133 0.1266 0.1261
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0127 0.0522
Schistosoma mansoni alkaline phosphatase 0.0196 0.2009 0.2004
Schistosoma mansoni inositol monophosphatase 0.0037 0.0127 0.0121
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0298 0.0292
Brugia malayi Protein kinase domain containing protein 0.0309 0.3333 0.3329
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0014 0.0008
Plasmodium vivax JmjC domain containing protein 0.0028 0.0029 0.926
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0093 0.0794 0.079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0298 0.0293
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0404 0.2044
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0298 0.0292
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0111 0.1004 0.0999
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0298 0.0292
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0196 0.2009 0.2004
Echinococcus granulosus histone acetyltransferase myst3 0.004 0.0163 0.0157
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0404 0.0399
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0127 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0298 0.0292
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0318 0.3446 0.3442
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0404 1
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0196 0.2009 0.2004
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0875 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0298 0.0292
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0298 0.0292
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0298 0.0292
Echinococcus multilocularis snurportin 1 0.0304 0.3278 0.3274
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.0584 0.0579
Plasmodium vivax importin-beta 2, putative 0.0028 0.0032 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0093 0.0794 0.0789
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0298 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0298 0.0292
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0404 0.0399
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.1266 0.1262
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0298 0.0292
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0298 0.0292
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0298 0.0292
Schistosoma mansoni hypothetical protein 0.0318 0.3446 0.3442
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0298 0.0583
Schistosoma mansoni jumonji/arid domain-containing protein 0.0091 0.0762 0.0757
Onchocerca volvulus 0.0051 0.0298 0.0583
Brugia malayi hypothetical protein 0.0027 0.0014 0.0008
Echinococcus granulosus lamin 0.0027 0.001 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0447 0.0441
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0093 0.0794 0.0789
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0277 0.0272
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0127 0.5
Brugia malayi mbt repeat family protein 0.0269 0.2865 0.2861
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0014 0.0008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0127 0.016
Loa Loa (eye worm) hypothetical protein 0.0051 0.0298 0.0293
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0009
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.016 0.1583 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0093 0.0794 0.0789
Schistosoma mansoni intermediate filament proteins 0.0027 0.001 0.0005
Schistosoma mansoni lamin 0.0027 0.001 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0298 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0298 0.0292
Echinococcus multilocularis protein tyrosine kinase 0.0305 0.329 0.3287
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0447 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0298 0.0293
Schistosoma mansoni coup transcription factor 0.0051 0.0298 0.0292
Brugia malayi nuclear receptor RXR 0.0027 0.0014 0.0008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0298 0.0292
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0298 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0298 0.0293
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0298 0.0292
Echinococcus multilocularis lamin dm0 0.0027 0.001 0.0005
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0875 1 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.1853 0.185
Toxoplasma gondii transporter, cation channel family protein 0.0183 0.1853 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0032 0.0026
Echinococcus granulosus intestinal type alkaline phosphatase 0.0196 0.2009 0.2004
Loa Loa (eye worm) hypothetical protein 0.0051 0.0298 0.0293
Toxoplasma gondii hypothetical protein 0.0161 0.1593 0.8572
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0445 0.4935 1
Echinococcus granulosus polycomb protein SCMH1 0.0259 0.2741 0.2737
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.016 0.1583 1
Echinococcus multilocularis polycomb protein SCMH1 0.0259 0.2741 0.2737
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0298 0.0292
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.001 0.0005
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0507 0.5669 0.5667
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0298 0.0292
Echinococcus granulosus lamin dm0 0.0027 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0161 0.1593 0.1589
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.3278 0.3275
Echinococcus multilocularis musashi 0.0027 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0161 0.1593 0.1589
Loa Loa (eye worm) mbt repeat family protein 0.0269 0.2865 0.2861
Brugia malayi mbt repeat family protein 0.0445 0.4935 0.4932
Echinococcus granulosus importin subunit beta 1 0.0028 0.0032 0.0026
Loa Loa (eye worm) hypothetical protein 0.0445 0.4935 0.4932
Loa Loa (eye worm) hypothetical protein 0.0051 0.0298 0.0293
Schistosoma mansoni chromobox protein 0.0192 0.1954 0.195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0298 0.0292
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0875 1 1
Echinococcus granulosus alkaline phosphatase 0.0196 0.2009 0.2004
Loa Loa (eye worm) MBCTL1 0.0093 0.0794 0.079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0298 0.0293
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0077 0.0602 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0298 0.0292
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0507 0.5669 0.5667
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0014 0.0008
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0532 0.5964 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0298 0.0292
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0298 0.0293
Loa Loa (eye worm) inositol-1 0.0037 0.0127 0.0122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0875 1 1
Echinococcus multilocularis sodium channel protein 0.0371 0.4067 0.4064
Brugia malayi hypothetical protein 0.0027 0.0014 0.0008
Echinococcus granulosus tar DNA binding protein 0.0064 0.0447 0.0441
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0127 0.0121
Echinococcus multilocularis histone acetyltransferase myst3 0.004 0.0163 0.0157
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0014 0.0008
Schistosoma mansoni importin beta-1 0.0028 0.0032 0.0026
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0196 0.2009 0.2004
Brugia malayi steroid hormone receptor 0.0051 0.0298 0.0292
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0298 0.0292
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0374 0.4106 0.4103
Toxoplasma gondii PLU-1 family protein 0.0043 0.0199 0.0921
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0298 0.0292
Loa Loa (eye worm) hypothetical protein 0.0051 0.0298 0.0293
Loa Loa (eye worm) hypothetical protein 0.0051 0.0298 0.0293
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0298 0.0292
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0027
Brugia malayi Importin beta-1 subunit 0.0028 0.0032 0.0026
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0127 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0093 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0298 0.0292
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0298 0.0292
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0875 1 1
Schistosoma mansoni voltage-gated cation channel 0.0875 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0875 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0183 0.1853 0.185
Loa Loa (eye worm) hypothetical protein 0.0034 0.0093 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0298 0.0292
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.0834 0.9523 0.9523
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0298 0.0292
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0298 0.0293
Loa Loa (eye worm) hypothetical protein 0.0051 0.0298 0.0293
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0009
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0875 1 1
Brugia malayi intermediate filament protein 0.0027 0.001 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0447 0.0441
Loa Loa (eye worm) hypothetical protein 0.0049 0.0277 0.0273
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0447 0.0441
Echinococcus multilocularis lamin 0.0027 0.001 0.0005
Echinococcus granulosus voltage dependent calcium channel 0.0183 0.1853 0.1849
Schistosoma mansoni sex comb on midleg homolog 0.0259 0.2741 0.2737
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0875 1 1
Echinococcus granulosus protein tyrosine kinase 0.0305 0.329 0.3287
Trypanosoma brucei beta lactamase 0.0077 0.0602 0.0962
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0875 1 1
Schistosoma mansoni tyrosine kinase 0.0305 0.329 0.3287
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0077 0.0602 0.3465
Echinococcus granulosus SAM and MBT domain containing protein 0.0374 0.4106 0.4103
Schistosoma mansoni sex comb on midleg homolog 0.0259 0.2741 0.2737
Echinococcus multilocularis chromobox protein 2 0.0192 0.1954 0.195
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0298 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0298 0.0292
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0318 0.3446 0.3442
Brugia malayi RNA, U transporter 1 0.0081 0.065 0.0645

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 999 um PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase. (Class of assay: confirmatory) [Related pubchem assays: 518 ] ChEMBL. No reference
IC50 (binding) = 0.689 uM PubChem BioAssay. FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify epi-absorbance assay artifacts. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 2.212 um PUBCHEM_BIOASSAY: TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2). (Class of assay: confirmatory) [Related pubchem assays: 794, 727, 810 ] ChEMBL. No reference
IC50 (binding) = 2.44 uM PubChem BioAssay. Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 8.43 um PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase. (Class of assay: confirmatory) [Related pubchem assays: 1512, 518 ] ChEMBL. No reference
IC50 (binding) > 59.64 uM PubChem BioAssay. Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of TEM-1 serine-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 59.64 uM PubChem BioAssay. FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 59.64 uM PubChem BioAssay. Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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