Detailed information for compound 1436861

Basic information

Technical information
  • TDR Targets ID: 1436861
  • Name: N-(4-tert-butyl-1,3-thiazol-2-yl)-2-(2-oxo-1, 3-benzoxazol-3-yl)acetamide
  • MW: 331.389 | Formula: C16H17N3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1c(=O)oc2c1cccc2)Nc1scc(n1)C(C)(C)C
  • InChi: 1S/C16H17N3O3S/c1-16(2,3)12-9-23-14(17-12)18-13(20)8-19-10-6-4-5-7-11(10)22-15(19)21/h4-7,9H,8H2,1-3H3,(H,17,18,20)
  • InChiKey: PQMQFSAVXGKIQE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(4-tert-butylthiazol-2-yl)-2-(2-oxo-1,3-benzoxazol-3-yl)acetamide
  • N-(4-tert-butyl-2-thiazolyl)-2-(2-oxo-1,3-benzoxazol-3-yl)acetamide
  • N-(4-tert-butylthiazol-2-yl)-2-(2-keto-1,3-benzoxazol-3-yl)acetamide
  • N-(4-tert-butyl-1,3-thiazol-2-yl)-2-(2-oxo-1,3-benzoxazol-3-yl)ethanamide
  • SMR000079096
  • ZINC02867154
  • MLS000065358
  • N-(4-tert-butyl-1,3-thiazol-2-yl)-2-(2-oxo-1,3-benzoxazol-3(2H)-yl)acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog Get druggable targets OG5_129328 All targets in OG5_129328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0057
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0065 0.0045
Trichomonas vaginalis transmembrane protein nessy, putative 0.013 0.0798 0.4351
Onchocerca volvulus 0.013 0.0798 0.4286
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0065 0.0065
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0065 0.0045
Echinococcus granulosus GPCR family 2 0.0019 0.0057 0.0057
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.013 0.0798 0.0798
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Echinococcus granulosus cathepsin l1 0.002 0.0065 0.0065
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.013 0.0798 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Leishmania major cathepsin L-like protease 0.0077 0.0444 0.516
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.1357 0.1357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1318 0.718
Loa Loa (eye worm) diacylglycerol acyltransferase 0.013 0.0798 0.0779
Brugia malayi Pre-SET motif family protein 0.0036 0.0171 0.0171
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0444 0.5555
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0392 0.5
Schistosoma mansoni sterol O-acyltransferase 1 0.013 0.0798 0.0798
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0057
Onchocerca volvulus 0.002 0.0065 0.0245
Leishmania major cathepsin L-like protease 0.0077 0.0444 0.516
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.013 0.0798 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0214 0.1357 0.1339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0392 0.4455
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.013 0.0798 0.0798
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.013 0.0798 0.0798
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0057 0.0057
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.013 0.0798 0.0798
Onchocerca volvulus 0.002 0.0065 0.0245
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0065 0.0065
Loa Loa (eye worm) MBOAT family protein 0.013 0.0798 0.0779
Brugia malayi MBOAT family protein 0.013 0.0798 0.0798
Brugia malayi Cathepsin L-like precursor 0.002 0.0065 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0171 0.0171
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.013 0.0798 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0392 0.0392
Plasmodium vivax vivapain-2 0.002 0.0065 0.0817
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1604 0.1586
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0171 0.0171
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0392 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.0205 0.0205
Brugia malayi Cathepsin L-like precursor 0.002 0.0065 0.0065
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0334 0.418
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0399 0.4998
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.013 0.0798 0.0798
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Echinococcus multilocularis cysteine protease 0.002 0.0065 0.0065
Loa Loa (eye worm) fibroinase 0.002 0.0065 0.0045
Onchocerca volvulus Cathepsin L homolog 0.002 0.0065 0.0245
Plasmodium falciparum diacylglycerol O-acyltransferase 0.013 0.0798 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0065 0.0817
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.013 0.0798 0.0798
Leishmania major glycerol uptake protein, putative 0.013 0.0798 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.013 0.0798 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0798 0.4351
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0065 0.0065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0057 0.0057
Echinococcus granulosus lysophospholipid acyltransferase 7 0.013 0.0798 0.0798
Loa Loa (eye worm) cysteine protease 0.002 0.0065 0.0045
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0021 0.0113
Brugia malayi MBOAT family protein 0.013 0.0798 0.0798
Onchocerca volvulus 0.002 0.0065 0.0245
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.013 0.0798 0.0798
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Echinococcus multilocularis cysteine protease 0.002 0.0065 0.0065
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0021 0.0021
Loa Loa (eye worm) hhat protein 0.013 0.0798 0.0779
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0444 0.5555
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0444 0.5555
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0057 0.0037
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.645 0.645
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0065 0.0065
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0392 0.0392
Loa Loa (eye worm) MBOAT family protein 0.013 0.0798 0.0779
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0065 0.0356
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0057 0.0057
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0361 0.0341
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.013 0.0798 0.0798
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0065 0.0817
Loa Loa (eye worm) hypothetical protein 0.013 0.0798 0.0779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Trypanosoma cruzi glycerol uptake protein, putative 0.013 0.0798 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.0065 0.0245
Echinococcus granulosus membrane bound acyltransferase:hhat 0.013 0.0798 0.0798
Brugia malayi Cathepsin L-like precursor 0.0014 0.0021 0.0021
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.013 0.0798 0.0798
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0392 0.5
Onchocerca volvulus Cathepsin L homolog 0.002 0.0065 0.0245
Leishmania major glycerol uptake protein, putative 0.013 0.0798 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Brugia malayi Cathepsin L-like precursor 0.002 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.013 0.0798 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0444 0.5555
Brugia malayi diacylglycerol acyltransferase 0.013 0.0798 0.0798
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.013 0.0798 1
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.013 0.0798 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0331 0.0311
Echinococcus multilocularis sterol O acyltransferase 1 0.013 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.006 0.0331 0.0311
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0021 0.0021
Entamoeba histolytica hypothetical protein, conserved 0.013 0.0798 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0205 0.0205
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0171 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0021 0.0113
Leishmania major hypothetical protein, conserved 0.013 0.0798 1
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.013 0.0798 0.0798
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0171 0.0171
Onchocerca volvulus 0.002 0.0065 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0798 0.4351
Trypanosoma cruzi glycerol uptake protein, putative 0.013 0.0798 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0037
Echinococcus granulosus o acyltransferase membrane bound domain 0.013 0.0798 0.0798
Onchocerca volvulus 0.0036 0.0171 0.0826
Leishmania major glycerol uptake protein, putative 0.013 0.0798 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0065 0.0817
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0065 0.0817
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0065 0.0356
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0162 0.0162
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0171 0.1437
Echinococcus granulosus zinc finger protein 0.1382 0.9132 0.9132
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.013 0.0798 0.0798
Brugia malayi Cathepsin L-like precursor 0.0014 0.0021 0.0021
Leishmania major glycerol uptake protein, putative 0.013 0.0798 1
Onchocerca volvulus 0.002 0.0065 0.0245
Entamoeba histolytica vacuolar protein sorting 26 0.013 0.0798 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0057 0.0057
Toxoplasma gondii hypothetical protein 0.013 0.0798 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0798 0.0779
Brugia malayi MBOAT family protein 0.013 0.0798 0.0798
Brugia malayi Cathepsin L-like precursor 0.002 0.0065 0.0065
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.1513 1 1
Leishmania major glycerol uptake protein, putative 0.013 0.0798 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0798 0.0779
Trypanosoma brucei glycerol uptake protein, putative 0.013 0.0798 1
Plasmodium vivax vivapain-2 0.002 0.0065 0.0817
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.013 0.0798 0.0798
Loa Loa (eye worm) ctsf protein 0.002 0.0065 0.0045
Brugia malayi cathepsin L-like precursor 0.0014 0.0021 0.0021
Loa Loa (eye worm) hhat protein 0.013 0.0798 0.0779
Trypanosoma cruzi glycerol uptake protein, putative 0.013 0.0798 1
Onchocerca volvulus 0.002 0.0065 0.0245
Loa Loa (eye worm) hypothetical protein 0.013 0.0798 0.0779
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Brugia malayi Pre-SET motif family protein 0.0251 0.1604 0.1604
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.013 0.0798 1
Trichomonas vaginalis porcupine, putative 0.013 0.0798 0.4351
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.013 0.0798 0.0798
Plasmodium vivax SET domain protein, putative 0.0036 0.0171 0.2137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Brugia malayi Cathepsin L-like precursor 0.002 0.0065 0.0065
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.013 0.0798 0.0798
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0331 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0171 0.0171
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0021 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0065 0.0817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0065 0.0356
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.013 0.0798 0.0798
Echinococcus multilocularis GPCR, family 2 0.0019 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Onchocerca volvulus 0.002 0.0065 0.0245
Brugia malayi MBOAT family protein 0.013 0.0798 0.0798
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0065 0.0817
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.013 0.0798 0.0798
Echinococcus granulosus cathepsin l1 0.0014 0.0021 0.0021
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0065 0.0065
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0041 0.0205 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1835 1
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0331 0.0331
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0065 0.0817
Onchocerca volvulus 0.0286 0.1835 1
Loa Loa (eye worm) MBOAT family protein 0.1513 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0057
Trypanosoma cruzi GUP1, putative 0.013 0.0798 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0065 0.0065
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.1513 1 1
Schistosoma mansoni zinc finger protein 0.1513 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Echinococcus granulosus o acyltransferase membrane bound domain 0.013 0.0798 0.0798
Brugia malayi Hhat protein 0.013 0.0798 0.0798
Treponema pallidum alginate O-acetylation protein (algI) 0.013 0.0798 0.5
Trypanosoma cruzi GUP1, putative 0.013 0.0798 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.013 0.0798 0.0779
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0065 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0444 0.5555
Trypanosoma brucei glycerol uptake protein, putative 0.013 0.0798 1
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0798 0.4351
Echinococcus granulosus sterol O acyltransferase 1 0.013 0.0798 0.0798
Echinococcus multilocularis zinc finger protein 0.1382 0.9132 0.9132
Leishmania major cathepsin L-like protease 0.0077 0.0444 0.516

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 100 uM PubChem BioAssay. Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 1.5 uM PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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