Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0127 | 0.3739 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0127 | 0.3739 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0127 | 0.3739 | 0.3633 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0114 | 0.3178 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0046 | 0.0166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.027 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.027 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0092 | 0.2207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.063 | 0.0472 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0.0166 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1905 | 0.1769 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0127 | 0.3739 | 0.3633 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0114 | 0.3178 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0042 | 0 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0127 | 0.3739 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0127 | 0.3739 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0.0166 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.027 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0069 | 0.1191 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0127 | 0.3739 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.063 | 0.0472 |
Schistosoma mansoni | DNA topoisomerase II | 0.0127 | 0.3739 | 0.3633 |
Echinococcus granulosus | acetylcholinesterase | 0.027 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0114 | 0.3178 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0042 | 0 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0127 | 0.3739 | 0.3633 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0127 | 0.3739 | 0.3633 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0046 | 0.0166 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0114 | 0.3178 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0092 | 0.2207 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1905 | 0.1769 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0092 | 0.2207 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0127 | 0.3739 | 0.3633 |
Giardia lamblia | DNA topoisomerase II | 0.0122 | 0.3493 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.027 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0127 | 0.3739 | 0.3633 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0114 | 0.3178 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.9 uM | Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]-PIA as radioligand | ChEMBL. | 8410976 |
Ki (binding) | = 4.9 uM | Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]-PIA as radioligand | ChEMBL. | 8410976 |
Ki (binding) | = 7.6 uM | Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]-CGS-21,680 | ChEMBL. | 8410976 |
Ki (binding) | = 7.6 uM | Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]-CGS-21,680 | ChEMBL. | 8410976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.