Detailed information for compound 1439445

Basic information

Technical information
  • TDR Targets ID: 1439445
  • Name: 3-nitro-N'-[3-(1,2,3,4-tetrahydrocarbazol-9-y l)propanoyl]benzohydrazide
  • MW: 406.434 | Formula: C22H22N4O4
  • H donors: 2 H acceptors: 4 LogP: 3.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCn1c2ccccc2c2c1CCCC2)NNC(=O)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C22H22N4O4/c27-21(23-24-22(28)15-6-5-7-16(14-15)26(29)30)12-13-25-19-10-3-1-8-17(19)18-9-2-4-11-20(18)25/h1,3,5-8,10,14H,2,4,9,11-13H2,(H,23,27)(H,24,28)
  • InChiKey: ZRDMDBIXDAOAPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-nitro-N'-[1-oxo-3-(1,2,3,4-tetrahydrocarbazol-9-yl)propyl]benzohydrazide
  • 3-Nitro-benzoic acid N'-(3-1,2,3,4-tetrahydro-carbazol-9-yl-propionyl)-hydrazide
  • MLS000590905
  • SMR000217642
  • ZINC04311633
  • STOCK2S-40972

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Matrixin family protein 0.0055 0.035 0.035
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.0981 0.0981
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0499 0.0487
Echinococcus granulosus lamin dm0 0.0026 0.0123 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0393 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0013 0.0013
Schistosoma mansoni intermediate filament proteins 0.0026 0.0123 0.011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0013 0.0012
Echinococcus multilocularis musashi 0.0026 0.0123 0.0122
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1271 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.035 0.0349
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.0981 0.0981
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0013 0.0012
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0981 0.098
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0377 0.2905 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0013 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0067 0.0066
Echinococcus granulosus carbonic anhydrase 0.0134 0.0981 0.098
Schistosoma mansoni hypothetical protein 0.0494 0.3834 0.3826
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0393 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0013 0.0013
Brugia malayi Matrixin family protein 0.0055 0.035 0.035
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0377 0.2905 0.145
Echinococcus multilocularis lamin dm0 0.0026 0.0123 0.0122
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0124 0.0902 0.089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0013 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0013 0.0012
Echinococcus multilocularis carbonic anhydrase II 0.0225 0.1702 0.1701
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0456 0.3534 0.3233
Giardia lamblia Farnesyl diphosphate synthase 0.1271 1 0.5
Leishmania major solanesyl-diphosphate synthase, putative 0.0377 0.2905 0.145
Echinococcus multilocularis muscleblind protein 0.018 0.1347 0.1346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0013 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0013 0.0012
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0377 0.2905 0.145
Brugia malayi CXXC zinc finger family protein 0.0035 0.0191 0.0191
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0377 0.2905 0.2134
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.6526 0.6525
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0013 0.0013
Schistosoma mansoni lamin 0.0026 0.0123 0.011
Schistosoma mansoni cpg binding protein 0.0037 0.0207 0.0194
Loa Loa (eye worm) matrixin family protein 0.0202 0.1517 0.1517
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0981 0.0981
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0981 0.098
Treponema pallidum octaprenyl-diphosphate synthase 0.0531 0.4126 0.5
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0233 0.0221
Loa Loa (eye worm) hypothetical protein 0.0134 0.0981 0.098
Trypanosoma cruzi polyprenyl synthase, putative 0.0531 0.4126 0.2921
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0981 0.0969
Schistosoma mansoni lamin 0.0026 0.0123 0.011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0013 0.0012
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1271 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0013 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0013 0.0013
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0013 0.0012
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0981 0.0969
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0067 0.0445 0.0445
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1271 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0225 0.1702 0.1691
Brugia malayi Matrixin family protein 0.0055 0.035 0.035
Echinococcus multilocularis cpg binding protein 0.0037 0.0207 0.0206
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0456 0.3534 0.3233
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0013 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0013 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0013 0.0013
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0377 0.2905 0.2575
Schistosoma mansoni hypothetical protein 0.0019 0.0067 0.0054
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0531 0.4126 0.4125
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0269 0.2046 0.2045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0013 0.0013
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0027 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0067 0.0067
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0377 0.2905 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0013 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0055 0.035 0.0349
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0225 0.1702 0.1702
Schistosoma mansoni carbonic anhydrase 0.0134 0.0981 0.0969
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0531 0.4126 0.4125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0013 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0013 0.0012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0191 0.019
Brugia malayi ecdysteroid receptor 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0067 0.0066
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0377 0.2905 0.145
Echinococcus granulosus cpg binding protein 0.0037 0.0207 0.0206
Brugia malayi Matrixin family protein 0.0055 0.035 0.035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.0241
Echinococcus multilocularis GPCR, family 2 0.0019 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.018 0.1347 0.1346
Brugia malayi Polyprenyl synthetase family protein 0.0377 0.2905 0.2905
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0225 0.1702 0.1702
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.6526 0.6521
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0013 0.0012
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0377 0.2905 0.2905
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0242 0.0242
Brugia malayi nuclear receptor NHR-88 0.0012 0.0013 0.0013
Onchocerca volvulus Matrix metalloproteinase homolog 0.0121 0.0879 0.6109
Toxoplasma gondii hypothetical protein 0.0134 0.0981 0.0568
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0118
Brugia malayi nuclear hormone receptor 0.0012 0.0013 0.0013
Brugia malayi steroid hormone receptor 0.0012 0.0013 0.0013
Brugia malayi Muscleblind-like protein 0.018 0.1347 0.1347
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1271 1 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0123 0.0122
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0377 0.2905 0.2575
Leishmania major farnesyl pyrophosphate synthase 0.1271 1 1
Onchocerca volvulus 0.0035 0.0191 0.1257
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1271 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0122
Schistosoma mansoni hypothetical protein 0.0041 0.0242 0.023
Schistosoma mansoni cpg binding protein 0.0035 0.0191 0.0179
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0531 0.4126 0.4125
Loa Loa (eye worm) hypothetical protein 0.0134 0.0981 0.098
Onchocerca volvulus Matrilysin homolog 0.0055 0.035 0.2379
Schistosoma mansoni hypothetical protein 0.0019 0.0067 0.0054
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0013 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0134 0.0981 0.0969
Loa Loa (eye worm) hypothetical protein 0.0019 0.0067 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0393 0.0393
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1271 1 0.5
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0377 0.2905 0.2905
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0013 0.0013
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0269 0.2046 0.2045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0013 0.0013
Onchocerca volvulus 0.0078 0.0532 0.3659
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0013 0.0012
Echinococcus granulosus microtubule associated protein 2 0.0833 0.6526 0.6525
Trypanosoma cruzi polyprenyl synthase, putative 0.0531 0.4126 0.2921
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1271 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0067 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0067 0.0066
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0134 0.0981 0.098
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0123 0.0122
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1271 1 1
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0377 0.2905 0.2581
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0377 0.2905 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0067 0.0067
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0013 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0013 0.0012
Echinococcus granulosus carbonic anhydrase II 0.0225 0.1702 0.1701
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0456 0.3534 0.3233
Onchocerca volvulus Matrilysin homolog 0.0191 0.1431 1
Brugia malayi Matrixin family protein 0.0202 0.1517 0.1517
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1271 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Echinococcus granulosus carbonic anhydrase 0.0134 0.0981 0.098
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0377 0.2905 0.5
Onchocerca volvulus 0.0055 0.035 0.2379
Loa Loa (eye worm) matrix metalloproteinase 0.0055 0.035 0.0349
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0531 0.4126 0.4126
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0981 0.0981
Echinococcus granulosus carbonic anhydrase 0.0134 0.0981 0.098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Schistosoma mansoni trans-prenyltransferase 0.0377 0.2905 0.2896
Leishmania major polyprenyl synthase, putative 0.0531 0.4126 0.2921
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0016 0.0015
Echinococcus granulosus lamin 0.0026 0.0123 0.0122
Loa Loa (eye worm) matrixin family protein 0.0121 0.0879 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0067 0.0445 0.0444
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0013 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0027 0.0027
Onchocerca volvulus 0.0026 0.0123 0.0775
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0456 0.3534 0.5
Schistosoma mansoni glutathione synthetase 0.0377 0.2905 0.2896
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0123 0.0123
Echinococcus granulosus muscleblind protein 0.018 0.1347 0.1346
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.018 0.1347 0.1346
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0981 0.0981
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0981 0.0969
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0225 0.1702 0.1691
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0013 0.0013
Loa Loa (eye worm) polyprenyl synthetase 0.1271 1 1
Schistosoma mansoni hypothetical protein 0.0078 0.0532 0.0519
Echinococcus multilocularis lamin 0.0026 0.0123 0.0122
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0377 0.2905 0.2905
Echinococcus granulosus GPCR family 2 0.0019 0.0067 0.0066
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1271 1 1
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1271 1 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0225 0.1702 0.1701
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1271 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0019 0.0067 0.0054
Brugia malayi Hemopexin family protein 0.0078 0.0532 0.0532
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1271 1 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.0037 0.0207 0.0194
Loa Loa (eye worm) hypothetical protein 0.006 0.0393 0.0392
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0981 0.098
Brugia malayi intermediate filament protein 0.0026 0.0123 0.0123
Loa Loa (eye worm) carbonic anhydrase 3 0.0225 0.1702 0.1701
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0456 0.3534 1
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0377 0.2905 0.145
Loa Loa (eye worm) hypothetical protein 0.0124 0.0902 0.0901
Loa Loa (eye worm) polyprenyl synthetase 0.0377 0.2905 0.2905
Schistosoma mansoni hypothetical protein 0.0019 0.0067 0.0054
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0531 0.4126 0.4118
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3834 0.3833
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1271 1 0.5
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0377 0.2905 0.2905
Echinococcus multilocularis muscleblind protein 1 0.018 0.1347 0.1346
Loa Loa (eye worm) hypothetical protein 0.0134 0.0981 0.098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0013 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0067 0.0066
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0013 0.0012
Onchocerca volvulus 0.0026 0.0123 0.0775
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3834 0.3833
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0016 0.0015
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0123 0.0122
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1271 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0013

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0447 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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