Detailed information for compound 1440101

Basic information

Technical information
  • TDR Targets ID: 1440101
  • Name: ASN 04455513
  • MW: 363.435 | Formula: C16H21N5O3S
  • H donors: 1 H acceptors: 4 LogP: 2.62 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc(c1)n1nnnc1SCC(=O)NC1CCCC1
  • InChi: 1S/C16H21N5O3S/c1-23-13-7-12(8-14(9-13)24-2)21-16(18-19-20-21)25-10-15(22)17-11-5-3-4-6-11/h7-9,11H,3-6,10H2,1-2H3,(H,17,22)
  • InChiKey: NMRROUKLGJQSLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000527024
  • N-cyclopentyl-2-[1-(3,5-dimethoxyphenyl)tetrazol-5-yl]sulfanylacetamide
  • N-cyclopentyl-2-[1-(3,5-dimethoxyphenyl)tetrazol-5-yl]sulfanyl-acetamide
  • N-cyclopentyl-2-[[1-(3,5-dimethoxyphenyl)-5-tetrazolyl]thio]acetamide
  • N-cyclopentyl-2-[[1-(3,5-dimethoxyphenyl)tetrazol-5-yl]thio]acetamide
  • N-cyclopentyl-2-[[1-(3,5-dimethoxyphenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]ethanamide
  • N-Cyclopentyl-2-[1-(3,5-dimethoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-acetamide
  • Oprea1_421068
  • Oprea1_547988
  • SMR000117498
  • ZINC00932285

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0432 0.0713 0.0583
Loa Loa (eye worm) phosphatidylinositol kinase 0.0372 0.0605 0.0605
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5604 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0392 0.0641 0.051
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0112 0.0138 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0372 0.0605 0.0605
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2339 0.4137 0.4055
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0502 0.0838 0.071
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0392 0.0641 0.0641
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0829 0.1426 0.1426
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1089 0.1893 0.178
Trichomonas vaginalis PIKK family atypical protein kinase 0.1908 0.3363 0.327
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0112 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0104 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0372 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.1206 0.1083
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1908 0.3363 0.327
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0392 0.0641 0.0641
Echinococcus multilocularis 0.0372 0.0605 0.0605
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0112 0.0138 0.0093
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0392 0.0641 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.4179 0.7441 0.7405
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1078 0.1874 0.1836
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.063 0.1069 0.1069
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0392 0.0641 0.0641
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1078 0.1874 0.1874
Echinococcus multilocularis fk506 binding protein 0.0112 0.0138 0.0138
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0112 0.0138 0.0138
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0494 0.0825 0.0825
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0153 0.0153
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0564 0.095 0.0908
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0461 0.0766 0.0636
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0372 0.0605 0.0605
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0372 0.0605 0.9288
Trichomonas vaginalis PIKK family atypical protein kinase 0.3041 0.5398 0.5333
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5604 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0372 0.0605 0.0605
Leishmania major phosphatidylinositol 4-kinase, putative 0.0372 0.0605 0.0473
Loa Loa (eye worm) hypothetical protein 0.0707 0.1206 0.1206
Trichomonas vaginalis PIKK family atypical protein kinase 0.3045 0.5406 0.5342
Leishmania major phosphatidylinositol kinase, putative 0.0372 0.0605 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.4466 0.7957 0.7928
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0112 0.0138 0.0138
Leishmania major phosphatidylinositol 3-kinase, putative 0.1908 0.3363 0.327
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0372 0.0605 0.0473
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0372 0.0605 0.0562
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0372 0.0605 0.0605
Echinococcus granulosus serine protein kinase ATM 0.1078 0.1874 0.1874
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1918 0.3382 0.3289
Trichomonas vaginalis PIKK family atypical protein kinase 0.1078 0.1874 0.176
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0372 0.0605 0.9288
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0494 0.0825 0.0825
Loa Loa (eye worm) phosphatidylinositol 3 0.0372 0.0605 0.0605
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0432 0.0713 0.0583
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0112 0.0138 0.0093
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5604 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5604 1 1
Loa Loa (eye worm) FKBP5 protein 0.0112 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.1201 0.2094 0.2094
Schistosoma mansoni hypothetical protein 0.0829 0.1426 0.1426
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0372 0.0605 0.0562
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0372 0.0605 0.0562
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0372 0.0605 0.9288
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0564 0.095 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.1089 0.1893 0.178
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4471 0.7965 0.7936
Trichomonas vaginalis conserved hypothetical protein 0.0829 0.1426 0.1306
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0112 0.0139 0.0001
Leishmania major phosphatidylinositol kinase related protein, putative 0.0372 0.0605 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.4179 0.7441 0.7405
Trichomonas vaginalis PIKK family atypical protein kinase 0.3759 0.6688 0.6641
Giardia lamblia Hypothetical protein 0.0372 0.0605 0.0473
Loa Loa (eye worm) hypothetical protein 0.1078 0.1874 0.1874
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0112 0.0138 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.4179 0.7441 0.7405
Entamoeba histolytica hypothetical protein 0.0372 0.0605 0.0473
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0372 0.0605 0.0605
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0372 0.0605 0.0562
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0392 0.0641 0.051
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0392 0.0641 0.051
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0392 0.0641 0.0052
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5604 1 1
Mycobacterium leprae conserved hypothetical protein 0.0372 0.0605 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1958 0.3454 0.3424
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0392 0.0641 0.0641
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1078 0.1874 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.4179 0.7441 0.7405
Onchocerca volvulus 0.0372 0.0605 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0372 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.335 0.5952 0.5895
Trichomonas vaginalis PIKK family atypical protein kinase 0.4179 0.7441 0.7405
Trichomonas vaginalis PIKK family atypical protein kinase 0.3041 0.5398 0.5333
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0372 0.0605 0.0605
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0372 0.0605 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.4179 0.7441 0.7405
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0112 0.0139 0.0001
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0112 0.0138 0.5
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4471 0.7965 0.7936
Giardia lamblia GTOR 0.5604 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1201 0.2094 0.1983
Trichomonas vaginalis PIKK family atypical protein kinase 0.1078 0.1874 0.176
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.095 0.0823
Entamoeba histolytica hypothetical protein 0.0372 0.0605 0.0473
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0372 0.0605 0.9288
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0738 0.1263 0.1263
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0564 0.095 0.0823
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0096 0.0111 0.0111
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0174 0.025 0.025
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1958 0.3454 0.3454
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0112 0.0138 0.0093
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0153 0.0153
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1958 0.3454 0.3424
Trichomonas vaginalis PIKK family atypical protein kinase 0.1908 0.3363 0.327
Trichomonas vaginalis PIKK family atypical protein kinase 0.335 0.5952 0.5895
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1078 0.1874 0.1836
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0432 0.0713 0.0583
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0432 0.0713 0.0713
Loa Loa (eye worm) phosphatidylinositol 3 0.5604 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0494 0.0825 0.0825
Loa Loa (eye worm) hypothetical protein 0.007 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0372 0.0605 0.0473
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0153 0.0153
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0454 0.0752 0.0622
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5604 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0192 0.0282 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0102 0.0057
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1201 0.2094 0.2178
Plasmodium vivax hypothetical protein 0.0372 0.0605 0.9288
Loa Loa (eye worm) hypothetical protein 0.0096 0.0111 0.0111
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1958 0.3454 0.3454
Leishmania major hypothetical protein, conserved 0.0463 0.077 0.064
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0392 0.0641 0.051
Loa Loa (eye worm) hypothetical protein 0.0829 0.1426 0.1426
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1958 0.3454 0.3454
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1908 0.3363 0.327
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5604 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1078 0.1874 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.4466 0.7957 0.7928
Onchocerca volvulus 0.0372 0.0605 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0096 0.0111 0.0111
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0372 0.0605 0.0473
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1958 0.3454 0.3454
Entamoeba histolytica hypothetical protein 0.1078 0.1874 0.176
Toxoplasma gondii FATC domain-containing protein 0.1078 0.1874 0.1856
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0372 0.0605 0.0473
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.063 0.1069 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.3045 0.5406 0.5342
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0392 0.0641 0.0641
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5604 1 1
Entamoeba histolytica hypothetical protein 0.0523 0.0877 0.0749
Toxoplasma gondii target of rapamycin (TOR), putative 0.4179 0.7441 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0372 0.0605 0.0473
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0112 0.0138 0.0138
Loa Loa (eye worm) phosphatidylinositol 3 0.006 0.0046 0.0046
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0372 0.0605 0.0605
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1078 0.1874 0.1874
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0372 0.0605 0.0605
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0564 0.095 0.0908
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0432 0.0713 0.0583
Entamoeba histolytica protein kinase rad3, putative 0.1078 0.1874 0.176
Schistosoma mansoni immunophilin 0.0096 0.0111 0.0111
Entamoeba histolytica hypothetical protein 0.0372 0.0605 0.0473
Schistosoma mansoni hypothetical protein 0.0372 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.4466 0.7957 0.7928
Trichomonas vaginalis PIKK family atypical protein kinase 0.335 0.5952 0.5895
Brugia malayi FAT domain containing protein 0.0829 0.1426 0.1426
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0392 0.0641 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0392 0.0641 0.0598
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0738 0.1263 0.1263
Trypanosoma cruzi target of rapamycin kinase 3 0.4471 0.7965 0.7956
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0564 0.095 0.095
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0432 0.0713 0.0713
Plasmodium vivax hypothetical protein, conserved 0.0372 0.0605 0.9288
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0372 0.0605 0.9288
Trichomonas vaginalis PIKK family atypical protein kinase 0.3333 0.5922 0.5864
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0112 0.0138 0.0138
Schistosoma mansoni immunophilin 0.0112 0.0138 0.0138
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0173 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.3041 0.5398 0.5333
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0112 0.0138 0.0093
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0523 0.0877 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0707 0.1206 0.1083
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2643 0.4683 0.4609
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0392 0.0641 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.4466 0.7957 0.7928
Mycobacterium tuberculosis Conserved hypothetical protein 0.0372 0.0605 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0564 0.095 0.0823
Loa Loa (eye worm) hypothetical protein 0.0494 0.0825 0.0825
Loa Loa (eye worm) phosphatidylinositol 3 0.0372 0.0605 0.0605
Leishmania major phosphatidylinositol 3-kinase, putative 0.0392 0.0641 0.051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5604 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0392 0.0641 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.1918 0.3382 0.3289
Trichomonas vaginalis PIKK family atypical protein kinase 0.4775 0.8511 0.849
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0392 0.0641 0.0641
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0392 0.0641 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0112 0.0138 0.0138
Leishmania major hypothetical protein, unknown function 0.0372 0.0605 0.0473
Loa Loa (eye worm) phosphatidylinositol 3 0.1918 0.3382 0.3382
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0372 0.0605 0.0605
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1078 0.1874 0.176
Giardia lamblia Phosphatidylinositol 4-kinase 0.0372 0.0605 0.0473
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0829 0.1426 0.1426
Trichomonas vaginalis PIKK family atypical protein kinase 0.3045 0.5406 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.4466 0.7957 0.7928
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0392 0.0641 0.051
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0432 0.0713 0.0671
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0372 0.0605 0.0605
Echinococcus multilocularis serine protein kinase ATM 0.1078 0.1874 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0372 0.0605 0.0473
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1078 0.1874 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.4179 0.7441 0.7405
Trichomonas vaginalis PIKK family atypical protein kinase 0.3045 0.5406 0.5342
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0707 0.1206 0.1166
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0432 0.0713 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.5604 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0372 0.0605 0.0473
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0392 0.0641 0.051
Loa Loa (eye worm) hypothetical protein 0.1133 0.1973 0.1973
Trichomonas vaginalis PIKK family atypical protein kinase 0.3637 0.6468 0.6418
Loa Loa (eye worm) phosphatidylinositol 3 0.0698 0.119 0.119
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0392 0.0641 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0153 0.0153
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0372 0.0605 0.0605
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0738 0.1263 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.1908 0.3363 0.327
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0173 0.0173
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0502 0.0838 0.071
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0392 0.0641 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.1505 0.264 0.2537
Loa Loa (eye worm) phosphatidylinositol 3 0.0372 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.3333 0.5922 0.5864
Schistosoma mansoni immunophilin 0.0112 0.0138 0.0138
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5604 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0412 0.0678 0.0547
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1918 0.3382 0.3289
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0432 0.0713 0.0583
Schistosoma mansoni fkbp-rapamycin associated protein 0.1078 0.1874 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.5604 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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