Detailed information for compound 1442656

Basic information

Technical information
  • TDR Targets ID: 1442656
  • Name: 8-[(4-fluorophenyl)methoxy]-2-methylquinoline
  • MW: 267.298 | Formula: C17H14FNO
  • H donors: 0 H acceptors: 1 LogP: 4.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)COc1cccc2c1nc(C)cc2
  • InChi: 1S/C17H14FNO/c1-12-5-8-14-3-2-4-16(17(14)19-12)20-11-13-6-9-15(18)10-7-13/h2-10H,11H2,1H3
  • InChiKey: MLSNZAWSVHJGOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[(4-fluorophenyl)methoxy]-2-methyl-quinoline
  • 8-(4-fluorobenzyl)oxy-2-methyl-quinoline
  • ZINC06703240
  • 8-[(4-fluorobenzyl)oxy]-2-methylquinoline
  • MLS000999709
  • SMR000498829

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.1221 0.1795 0.1767
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0421 0.0515 0.0482
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0421 0.0515 0.0507
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1221 0.1795 0.1767
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2172 0.3316 0.3292
Giardia lamblia Phosphatidylinositol 4-kinase 0.0421 0.0515 0.0482
Leishmania major phosphatidylinositol 3-kinase, putative 0.2161 0.3297 0.3274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0801 0.1123 0.11
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0421 0.0515 0.0492
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.012 0.0035 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5062 0.7937 0.7931
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0421 0.0515 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.3451 0.5361 0.5349
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6353 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0421 0.0515 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.3446 0.5352 0.5341
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0421 0.0515 0.0492
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0552 0.0725 0.0693
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.012 0.0035 0.0027
Loa Loa (eye worm) FKBP5 protein 0.012 0.0035 0.0027
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0517 0.0669 0.0636
Entamoeba histolytica hypothetical protein 0.0421 0.0515 0.0482
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0627 0.0845 0.0822
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0122 0.0038 0.0029
Loa Loa (eye worm) hypothetical protein 0.1221 0.1795 0.1788
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0698 0.0959 0.0951
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0442 0.055 0.0516
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0442 0.055 0.0541
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.012 0.0035 0.0035
Toxoplasma gondii FATC domain-containing protein 0.1221 0.1795 0.1855
Trichomonas vaginalis PIKK family atypical protein kinase 0.4737 0.7416 0.7409
Trichomonas vaginalis PIKK family atypical protein kinase 0.2161 0.3297 0.328
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6353 1 1
Onchocerca volvulus 0.0421 0.0515 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0442 0.055 0.0541
Trichomonas vaginalis conserved hypothetical protein 0.0801 0.1123 0.11
Loa Loa (eye worm) hypothetical protein 0.0106 0.0012 0.0004
Leishmania major phosphatidylinositol 4-kinase, putative 0.0421 0.0515 0.0482
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.012 0.0035 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.1233 0.1814 0.1793
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2161 0.3297 0.3274
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0442 0.055 0.055
Brugia malayi FAT domain containing protein 0.0939 0.1345 0.1314
Schistosoma mansoni immunophilin 0.012 0.0035 0.0027
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2651 0.4081 0.406
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.056 0.0739 0.0715
Leishmania major hypothetical protein, unknown function 0.0421 0.0515 0.0482
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6353 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0442 0.055 0.0541
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0486 0.0619 0.0586
Loa Loa (eye worm) phosphatidylinositol kinase 0.0421 0.0515 0.0507
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0627 0.0845 0.0813
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0187 0.0142 0.0107
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0421 0.0515 0.9336
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0814 0.1144 0.1136
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0627 0.0845 0.0822
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1221 0.1795 0.1795
Plasmodium vivax hypothetical protein 0.0421 0.0515 0.9336
Trichomonas vaginalis PIKK family atypical protein kinase 0.6353 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5067 0.7945 0.7938
Toxoplasma gondii non-specific serine/threonine protein kinase 0.136 0.2017 0.2177
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.012 0.0035 0.0027
Trichomonas vaginalis fk506-binding protein, putative 0.012 0.0035 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.0515 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.4737 0.7416 0.7409
Trichomonas vaginalis PIKK family atypical protein kinase 0.3797 0.5914 0.5904
Mycobacterium tuberculosis Conserved hypothetical protein 0.0421 0.0515 0.5
Toxoplasma gondii target of rapamycin (TOR), putative 0.4737 0.7416 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3446 0.5352 0.5341
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0421 0.0515 0.0482
Leishmania major phosphatidylinositol 3-kinase, putative 0.0442 0.055 0.0516
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6353 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0421 0.0515 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.4737 0.7416 0.7409
Trichomonas vaginalis PIKK family atypical protein kinase 0.1221 0.1795 0.1775
Echinococcus multilocularis 0.0421 0.0515 0.0507
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0442 0.055 0.0526
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2215 0.3384 0.3379
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0442 0.055 0.055
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0442 0.055 0.0516
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0421 0.0515 0.0507
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0421 0.0515 0.9336
Entamoeba histolytica hypothetical protein 0.0421 0.0515 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.4737 0.7416 0.7409
Trichomonas vaginalis PIKK family atypical protein kinase 0.4737 0.7416 0.7409
Trichomonas vaginalis PIKK family atypical protein kinase 0.4262 0.6657 0.6648
Giardia lamblia Hypothetical protein 0.0421 0.0515 0.0482
Schistosoma mansoni fkbp-rapamycin associated protein 0.1221 0.1795 0.1788
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.012 0.0035 0.0035
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.012 0.0035 0.0035
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0939 0.1345 0.1337
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5067 0.7945 0.7938
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0421 0.0515 0.0507
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0421 0.0515 0.0482
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0627 0.0845 0.0845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0421 0.0515 0.0482
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1233 0.1814 0.1785
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.012 0.0035 0.001
Trichomonas vaginalis conserved hypothetical protein 0.136 0.2017 0.1997
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6353 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0421 0.0515 0.0507
Loa Loa (eye worm) hypothetical protein 0.0939 0.1345 0.1337
Loa Loa (eye worm) phosphatidylinositol 3 0.6353 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6353 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0421 0.0515 0.0507
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0486 0.0619 0.0595
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0421 0.0515 0.0515
Schistosoma mansoni immunophilin 0.012 0.0035 0.0027
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0552 0.0725 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.3446 0.5352 0.5341
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0056 0.0047
Entamoeba histolytica hypothetical protein 0.0583 0.0775 0.0743
Loa Loa (eye worm) hypothetical protein 0.0801 0.1123 0.1115
Trichomonas vaginalis immunophilin, putative 0.012 0.0035 0.001
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0486 0.0619 0.0611
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.012 0.0035 0.001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0421 0.0515 0.0482
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.012 0.0035 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.3777 0.5881 0.5871
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0421 0.0515 0.0507
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0627 0.0845 0.0845
Trypanosoma cruzi target of rapamycin kinase 3 0.5067 0.7945 0.7945
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0442 0.055 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3797 0.5914 0.5904
Trichomonas vaginalis conserved hypothetical protein 0.0939 0.1345 0.1323
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0814 0.1144 0.1136
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0442 0.055 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0486 0.0619 0.0595
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1221 0.1795 0.1767
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0627 0.0845 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.5062 0.7937 0.7931
Loa Loa (eye worm) hypothetical protein 0.0421 0.0515 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.0515 0.0492
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1221 0.1795 0.1788
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0421 0.0515 0.0515
Loa Loa (eye worm) phosphatidylinositol 3 0.0421 0.0515 0.0507
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0442 0.055 0.0516
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0421 0.0515 0.9336
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0583 0.0775 0.0743
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.012 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.4737 0.7416 0.7409
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6353 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1221 0.1795 0.1775
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0421 0.0515 0.9336
Trichomonas vaginalis PIKK family atypical protein kinase 0.3451 0.5361 0.5349
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0698 0.0959 0.0951
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0421 0.0515 0.9336
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2215 0.3384 0.3379
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1221 0.1795 0.1795
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6353 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2161 0.3297 0.328
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0421 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.5062 0.7937 0.7931
Echinococcus granulosus serine protein kinase ATM 0.1221 0.1795 0.1788
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0939 0.1345 0.1337
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2215 0.3384 0.3384
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0442 0.055 0.0541
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2215 0.3384 0.3379
Leishmania major phosphatidylinositol kinase related protein, putative 0.0421 0.0515 0.0482
Leishmania major hypothetical protein, conserved 0.0519 0.0673 0.064
Loa Loa (eye worm) hypothetical protein 0.136 0.2017 0.201
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6353 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0206 0.0172 0.0137
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0552 0.0725 0.0717
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0509 0.0656 0.0623
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0122 0.0038 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0421 0.0515 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.0619 0.0586
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1221 0.1795 0.1767
Giardia lamblia GTOR 0.6353 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0486 0.0619 0.0619
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0122 0.0038 0.0029
Echinococcus multilocularis fk506 binding protein 0.012 0.0035 0.0027
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2215 0.3384 0.3384
Trichomonas vaginalis PIKK family atypical protein kinase 0.3797 0.5914 0.5904
Trichomonas vaginalis PIKK family atypical protein kinase 0.2161 0.3297 0.328
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2215 0.3384 0.3361
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6353 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1221 0.1795 0.1788
Trichomonas vaginalis PIKK family atypical protein kinase 0.2172 0.3316 0.3299
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.0619 0.0595
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6353 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0464 0.0585 0.0552
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.012 0.0035 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.1706 0.2571 0.2552
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0442 0.055 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.3777 0.5881 0.5871
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0421 0.0515 0.0482
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0056 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.2161 0.3297 0.328
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.056 0.0739 0.0715
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0442 0.055 0.0516
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0421 0.0515 0.0507
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0122 0.0038 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.4123 0.6435 0.6426
Loa Loa (eye worm) phosphatidylinositol 3 0.077 0.1074 0.1067
Loa Loa (eye worm) hypothetical protein 0.1285 0.1898 0.1891
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0814 0.1144 0.1136
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0801 0.1123 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.4737 0.7416 0.7409
Trichomonas vaginalis PIKK family atypical protein kinase 0.3451 0.5361 0.5349
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0442 0.055 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.6353 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0486 0.0619 0.0586
Onchocerca volvulus 0.0421 0.0515 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0421 0.0515 0.0507
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0421 0.0515 0.0515
Entamoeba histolytica protein kinase rad3, putative 0.1221 0.1795 0.1767
Echinococcus multilocularis serine protein kinase ATM 0.1221 0.1795 0.1788
Echinococcus multilocularis Zinc finger, PHD finger 0.0442 0.055 0.0541
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.0619 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.5062 0.7937 0.7931
Schistosoma mansoni hypothetical protein 0.0939 0.1345 0.1337
Trichomonas vaginalis PIKK family atypical protein kinase 0.3451 0.5361 0.5349
Plasmodium vivax hypothetical protein, conserved 0.0421 0.0515 0.9336
Loa Loa (eye worm) phosphatidylinositol 3 0.2172 0.3316 0.331
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1221 0.1795 0.1788
Entamoeba histolytica hypothetical protein 0.0421 0.0515 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.5413 0.8498 0.8494
Schistosoma mansoni hypothetical protein 0.0421 0.0515 0.0507
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.012 0.0035 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0442 0.055 0.0526
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0442 0.055 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.6353 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0442 0.055 0.0526
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2172 0.3316 0.3292
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0442 0.055 0.0516
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0627 0.0845 0.0822
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0421 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0552 0.0725 0.0717
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0442 0.055 0.0541
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2997 0.4634 0.4615
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0421 0.0515 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.5062 0.7937 0.7931

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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