Detailed information for compound 1443724

Basic information

Technical information
  • TDR Targets ID: 1443724
  • Name: N-[5-(3,3-diethoxypropyl)-4-methyl-6-oxo-3H-p yrimidin-2-yl]acetamide
  • MW: 297.35 | Formula: C14H23N3O4
  • H donors: 2 H acceptors: 4 LogP: 1.31 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(CCc1c(C)nc(nc1O)NC(=O)C)OCC
  • InChi: 1S/C14H23N3O4/c1-5-20-12(21-6-2)8-7-11-9(3)15-14(16-10(4)18)17-13(11)19/h12H,5-8H2,1-4H3,(H2,15,16,17,18,19)
  • InChiKey: YNWTXNHRPVVSIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[5-(3,3-diethoxypropyl)-4-keto-6-methyl-1H-pyrimidin-2-yl]acetamide
  • N-[5-(3,3-diethoxypropyl)-4-methyl-6-oxo-3H-pyrimidin-2-yl]ethanamide
  • 92431-27-1
  • NCIOpen2_003357
  • NSC 70308
  • AIDS-125362
  • AIDS125362
  • N-(5-(3,3-Diethoxypropyl)-4-hydroxy-6-methyl-2-pyrimidinyl)acetamide
  • MLS000736770
  • SMR000528317
  • NSC70308

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi orphan nuclear receptor NR2E1 0.0063 0.1017 0.3474
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0063 0.1017 0.1017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0135 0.2926 0.3147
Loa Loa (eye worm) hypothetical protein 0.0135 0.2926 0.3147
Loa Loa (eye worm) DR-78 0.0063 0.1017 0.1093
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.1221 0.4173
Brugia malayi RNA, U transporter 1 0.0099 0.1972 0.6738
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.1221 0.1221
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0135 0.2926 1
Brugia malayi Steroid receptor seven-up type 2 0.0135 0.2926 1
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.1221 0.4173
Brugia malayi hypothetical protein 0.0063 0.1017 0.3474
Onchocerca volvulus Protein ultraspiracle homolog 0.0135 0.2926 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0063 0.1017 0.1093
Loa Loa (eye worm) steroid hormone receptor 0.0135 0.2926 0.3147
Brugia malayi steroid hormone receptor 0.0135 0.2926 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.007 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.2926 0.3147
Schistosoma mansoni zinc finger protein 0.0063 0.1017 0.1017
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0247 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0063 0.1017 0.3474
Brugia malayi tailless protein 0.0063 0.1017 0.3474
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0135 0.2926 0.3147
Brugia malayi Importin beta-1 subunit 0.0035 0.0247 0.0844
Loa Loa (eye worm) hypothetical protein 0.0135 0.2926 0.3147
Brugia malayi nuclear hormone receptor 0.0135 0.2926 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0135 0.2926 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0796 0.0796
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0796 0.2718
Brugia malayi nuclear receptor RXR 0.0063 0.1017 0.3474
Loa Loa (eye worm) nuclear receptor NHR-67 0.0063 0.1017 0.1093
Onchocerca volvulus 0.0135 0.2926 1
Echinococcus granulosus nuclear receptor nhr 48 0.0063 0.1017 0.1093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0063 0.1017 0.1093
Schistosoma mansoni RAR-like nuclear receptor 0.0135 0.2926 0.2926
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0796 0.0856
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0135 0.2926 0.3147
Onchocerca volvulus Bile acid receptor homolog 0.0135 0.2926 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Brugia malayi Nuclear hormone receptor E75 0.0063 0.1017 0.3474
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0135 0.2926 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0796 0.0796
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0071 0.1221 0.1313
Echinococcus multilocularis nuclear receptor nhr 48 0.0063 0.1017 0.1093
Loa Loa (eye worm) hypothetical protein 0.0071 0.1221 0.1313
Loa Loa (eye worm) hypothetical protein 0.0135 0.2926 0.3147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0796 0.0796
Brugia malayi nuclear receptor NHR-88 0.0063 0.1017 0.3474
Brugia malayi hypothetical protein 0.0071 0.1221 0.4173
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0071 0.1221 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0135 0.2926 0.3147
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0135 0.2926 0.3147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0135 0.2926 0.3147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0135 0.2926 0.3147
Echinococcus granulosus snurportin 1 0.0372 0.9299 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0135 0.2926 0.2926
Echinococcus granulosus ecdysone induced protein 78C 0.0135 0.2926 0.3147
Loa Loa (eye worm) hypothetical protein 0.0071 0.1221 0.1313
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Loa Loa (eye worm) hypothetical protein 0.0071 0.1221 0.1313
Schistosoma mansoni nuclear receptor 0.0063 0.1017 0.1017
Loa Loa (eye worm) nuclear hormone receptor 0.0063 0.1017 0.1093
Schistosoma mansoni importin beta-1 0.0035 0.0247 0.0247
Echinococcus granulosus Nuclear hormone receptor HR96 0.0063 0.1017 0.1093
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0135 0.2926 0.3147
Brugia malayi ecdysone receptor 0.0063 0.1017 0.3474
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0135 0.2926 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Brugia malayi hypothetical protein 0.0063 0.1017 0.3474
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0796 0.0856
Schistosoma mansoni nuclear hormone receptor 0.0063 0.1017 0.1017
Echinococcus multilocularis snurportin 1 0.0372 0.9299 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0135 0.2926 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0135 0.2926 0.2926
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0247 0.0266
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0135 0.2926 0.3147
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0135 0.2926 0.2926
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0135 0.2926 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0063 0.1017 0.1093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0796 0.0856
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0135 0.2926 0.3147
Loa Loa (eye worm) hypothetical protein 0.0071 0.1221 0.1313
Entamoeba histolytica hypothetical protein 0.0028 0.007 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0135 0.2926 0.3147
Brugia malayi Nuclear hormone receptor E75 0.0063 0.1017 0.3474
Echinococcus granulosus Nuclear hormone receptor HR96 0.0063 0.1017 0.1093
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0135 0.2926 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0135 0.2926 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0135 0.2926 0.3147
Trichomonas vaginalis importin beta-1, putative 0.0028 0.007 1
Schistosoma mansoni hypothetical protein 0.0372 0.9299 0.9299
Schistosoma mansoni coup transcription factor 0.0135 0.2926 0.2926
Leishmania major importin beta-1 subunit, putative 0.0028 0.007 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0135 0.2926 0.3147
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0135 0.2926 0.2926
Schistosoma mansoni thyroid hormone receptor 0.0135 0.2926 0.2926
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0063 0.1017 0.3474
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0135 0.2926 0.3147
Brugia malayi conserved hypotetical protein 0.0063 0.1017 0.3474
Echinococcus multilocularis FTZ F1 alpha 0.0135 0.2926 0.3147
Brugia malayi nuclear receptor NHR-67 0.0063 0.1017 0.3474
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0135 0.2926 1
Schistosoma mansoni nuclear hormone receptor 0.0135 0.2926 0.2926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0135 0.2926 0.3147
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0135 0.2926 0.3147
Brugia malayi hypothetical protein 0.0071 0.1221 0.4173
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Schistosoma mansoni nuclear receptor nhr-48 0.0063 0.1017 0.1017
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0 0.5
Schistosoma mansoni nuclear receptor 0.0063 0.1017 0.1017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0135 0.2926 0.3147
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0063 0.1017 0.1093
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0063 0.1017 0.1093
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0135 0.2926 0.2926
Loa Loa (eye worm) hypothetical protein 0.0071 0.1221 0.1313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0135 0.2926 0.3147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.1017 0.1093
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0071 0.1221 0.1313
Schistosoma mansoni retinoic acid receptor RXR 0.0135 0.2926 0.2926
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0247 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0135 0.2926 0.3147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0135 0.2926 1
Plasmodium falciparum importin beta, putative 0.0035 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0266
Loa Loa (eye worm) hypothetical protein 0.0135 0.2926 0.3147
Brugia malayi nuclear receptor RXR 0.0071 0.1221 0.4173
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0063 0.1017 0.1093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0135 0.2926 0.3147
Echinococcus granulosus importin subunit beta 1 0.0035 0.0247 0.0266
Brugia malayi nuclear hormone receptor family member odr-7 0.0063 0.1017 0.3474
Loa Loa (eye worm) hypothetical protein 0.0135 0.2926 0.3147
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0063 0.1017 0.1093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0135 0.2926 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0135 0.2926 0.2926
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.007 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.2926 0.3147
Brugia malayi ecdysteroid receptor 0.0135 0.2926 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0247 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.1017 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0135 0.2926 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0135 0.2926 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0796 0.0856
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0796 0.0856
Schistosoma mansoni thyroid hormone receptor 0.0135 0.2926 0.2926
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0135 0.2926 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.2926 0.3147
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0071 0.1221 0.1221
Schistosoma mansoni nuclear hormone receptor 0.0063 0.1017 0.1017
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.007 1
Brugia malayi nuclear receptor NHR-88 0.0135 0.2926 1
Brugia malayi nuclear hormone receptor 0.0063 0.1017 0.3474
Schistosoma mansoni steroid hormone receptor ad4bp 0.0135 0.2926 0.2926
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0135 0.2926 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.2926 0.3147
Loa Loa (eye worm) hypothetical protein 0.0063 0.1017 0.1093
Brugia malayi Nuclear hormone receptor-like 1 0.0135 0.2926 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0135 0.2926 0.3147
Echinococcus granulosus FTZ F1 alpha 0.0135 0.2926 0.3147
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.9299 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0047 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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