Detailed information for compound 1443967

Basic information

Technical information
  • TDR Targets ID: 1443967
  • Name: 3-(3-nitrophenyl)imidazo[1,5-a]pyridine
  • MW: 239.229 | Formula: C13H9N3O2
  • H donors: 0 H acceptors: 3 LogP: 3.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc(c1)c1ncc2n1cccc2
  • InChi: 1S/C13H9N3O2/c17-16(18)11-6-3-4-10(8-11)13-14-9-12-5-1-2-7-15(12)13/h1-9H
  • InChiKey: JOTGZHHDHITSSG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ZINC00126044
  • T5467984
  • MLS000624581
  • SMR000323523
  • Oprea1_694262

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0111 0.0943 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.2504 0.3001
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0701 0.8345 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.1818 0.1792
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0103 0.0842 0.0814
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0701 0.8345 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0419 0.4808 0.5762
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0045 0.0124 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.2504 0.3001
Brugia malayi Cytochrome P450 family protein 0.0077 0.0516 0.0584
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0133 0.122 0.1332
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0045 0.0124 0.0149
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0312 0.0338
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0124 0.0112
Loa Loa (eye worm) hypothetical protein 0.018 0.1818 0.2149
Trichomonas vaginalis immunophilin, putative 0.0111 0.0943 0.1129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.6093 0.7302
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0111 0.0943 0.0995
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0045 0.0124 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.2504 0.3001
Echinococcus multilocularis muscleblind protein 0.018 0.1818 0.1792
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0045 0.0124 0.0149
Loa Loa (eye worm) hypothetical protein 0.0148 0.1409 0.1658
Onchocerca volvulus 0.0045 0.0124 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0653 0.0782
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0045 0.0124 0.0149
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0111 0.0943 0.1129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.8345 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0111 0.0943 0.1129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0419 0.4808 0.5762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0558 0.6547 0.7845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.122 0.1461
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0045 0.0124 0.0052
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0235 0.2504 0.2449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0558 0.6547 0.7845
Leishmania major cytochrome p450-like protein 0.0077 0.0516 0.0477
Brugia malayi FAT domain containing protein 0.0103 0.0842 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.4302 0.5156
Loa Loa (eye worm) hypothetical protein 0.0133 0.122 0.1429
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0124 0.0112
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.2504 0.2975
Loa Loa (eye worm) hypothetical protein 0.0095 0.0752 0.0867
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0095 0.0752 0.0723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.8345 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0045 0.0124 0.0052
Loa Loa (eye worm) hypothetical protein 0.006 0.0312 0.0338
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0516 0.0584
Loa Loa (eye worm) phosphatidylinositol 3 0.0701 0.8345 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0241 0.0252
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0558 0.6554 0.7822
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0087 0.0653 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.4295 0.5147
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0045 0.0124 0.0149
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0111 0.0943 0.1096
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0111 0.0943 0.0995
Loa Loa (eye worm) hypothetical protein 0.0045 0.0124 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0419 0.4808 0.5762
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0045 0.0124 0.0052
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0124 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 0.0842 0.0976
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0111 0.0943 0.0995
Echinococcus multilocularis fk506 binding protein 0.0111 0.0943 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.4302 0.5156
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0124 0.0112
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0133 0.122 0.1332
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0312 0.0338
Loa Loa (eye worm) CYP4Cod1 0.0077 0.0516 0.0584
Echinococcus multilocularis serine protein kinase ATM 0.0133 0.122 0.1192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.5262 0.6306
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0111 0.0943 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.706 0.846
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0045 0.0124 0.0094
Entamoeba histolytica protein kinase rad3, putative 0.0133 0.122 0.1332
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0045 0.0124 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0558 0.6547 0.7845
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0045 0.0124 0.0149
Echinococcus multilocularis Zinc finger, PHD finger 0.0045 0.0124 0.0094
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0133 0.122 0.1332
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0111 0.0943 0.0995
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0111 0.0943 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0045 0.0124 0.0149
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0111 0.0943 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.4756 0.5699
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0133 0.122 0.1429
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0045 0.0124 0.0149
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0111 0.0943 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.6093 0.7302
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0701 0.8345 0.834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0653 0.0782
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0045 0.0124 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.1409 0.1689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0558 0.6547 0.7845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0701 0.8345 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0235 0.2504 0.2895
Entamoeba histolytica hypothetical protein 0.0133 0.122 0.1332
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0045 0.0124 0.0094
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0235 0.2504 0.2895
Trypanosoma cruzi cytochrome P450, putative 0.0077 0.0516 0.0477
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0111 0.0943 0.0995
Loa Loa (eye worm) phosphatidylinositol 3 0.0235 0.2504 0.2975
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0045 0.0124 0.0149
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0291 0.3207 0.375
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0133 0.122 0.1192
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0124 0.0112
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0111 0.0943 0.0995
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0045 0.0124 0.0094
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0111 0.0943 0.1096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.1915 0.2295
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0045 0.0124 0.0112
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0235 0.2504 0.2481
Trichomonas vaginalis PIKK family atypical protein kinase 0.047 0.5452 0.6533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.2504 0.3001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0124 0.0149
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0332 0.3713 0.4366
Giardia lamblia GTOR 0.0701 0.8345 1
Leishmania major fk506-binding protein 1-like protein 0.0111 0.0943 0.0995
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0111 0.0943 0.0995
Loa Loa (eye worm) hypothetical protein 0.0143 0.1348 0.1584
Schistosoma mansoni fkbp-rapamycin associated protein 0.0133 0.122 0.1155
Echinococcus multilocularis 0.0045 0.0124 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0124 0.0112
Brugia malayi Muscleblind-like protein 0.018 0.1818 0.2149
Trichomonas vaginalis fk506-binding protein, putative 0.0111 0.0943 0.1129
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0124 0.0112
Leishmania major peptidylprolyl isomerase-like protein 0.0111 0.0943 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.2504 0.3001
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0701 0.8345 0.834
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0701 0.8345 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0124 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.4302 0.5156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.6093 0.7302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.6093 0.7302
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0045 0.0124 0.0094
Toxoplasma gondii target of rapamycin (TOR), putative 0.0522 0.6093 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0045 0.0124 0.0094
Trypanosoma cruzi cytochrome P450, putative 0.0077 0.0516 0.0477
Loa Loa (eye worm) hypothetical protein 0.0087 0.0653 0.0747
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0124 0.0112
Trypanosoma cruzi target of rapamycin kinase 3 0.0558 0.6554 0.7822
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0045 0.0124 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0133 0.122 0.1429
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0842 0.1009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.4295 0.5147
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0045 0.0124 0.0094
Schistosoma mansoni immunophilin 0.0095 0.0752 0.0684
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0701 0.8345 0.8333
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0558 0.6554 0.7822
Schistosoma mansoni hypothetical protein 0.0045 0.0124 0.0052
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0045 0.0124 0.0112
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0045 0.0124 0.0052
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0701 0.8345 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0133 0.122 0.1332
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0045 0.0124 0.0052
Toxoplasma gondii FATC domain-containing protein 0.0133 0.122 0.1835
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0045 0.0124 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.6093 0.7302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.6093 0.7302
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0124 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.122 0.1461
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0075 0.0002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0235 0.2504 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.8345 1
Echinococcus granulosus muscleblind protein 0.018 0.1818 0.1792
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0111 0.0943 0.0914
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0045 0.0124 0.0094
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0045 0.0124 0.0094
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0111 0.0943 0.0995
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0312 0.0338
Schistosoma mansoni immunophilin 0.0111 0.0943 0.0876
Mycobacterium leprae conserved hypothetical protein 0.0045 0.0124 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0701 0.8345 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0701 0.8345 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0045 0.0124 0.0094
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0235 0.2504 0.2895
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0133 0.122 0.1192
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0235 0.2504 0.2895
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0045 0.0124 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.122 0.1461
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0124 0.0112
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0045 0.0124 0.0052
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0701 0.8345 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.4302 0.5156
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0045 0.0124 0.0094
Loa Loa (eye worm) hypothetical protein 0.0041 0.0073 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0558 0.6547 0.7845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.4756 0.5699
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0045 0.0124 0.0052
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0111 0.0943 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0124 0.0112
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0148 0.1409 0.2153
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0045 0.0124 0.0149
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0111 0.0943 0.5
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0045 0.0124 0.0149
Loa Loa (eye worm) FKBP5 protein 0.0111 0.0943 0.1096
Schistosoma mansoni immunophilin 0.0111 0.0943 0.0876
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0073 0.005
Echinococcus granulosus serine protein kinase ATM 0.0133 0.122 0.1192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.6093 0.7302
Trypanosoma brucei cytochrome P450, putative 0.0077 0.0516 0.0477
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0075 0.0002
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0095 0.0752 0.0723
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0111 0.0943 0.0914
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0111 0.0943 0.1096
Loa Loa (eye worm) hypothetical protein 0.0045 0.0124 0.0112
Schistosoma mansoni hypothetical protein 0.0103 0.0842 0.0775
Leishmania major phosphatidylinositol 3-kinase, putative 0.0235 0.2504 0.2895
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0701 0.8345 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0124 0.0112
Onchocerca volvulus 0.0045 0.0124 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.4295 0.5147
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0111 0.0943 0.0876
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0235 0.2504 0.2481
Loa Loa (eye worm) hypothetical protein 0.018 0.1818 0.2149
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0133 0.122 0.1155
Brugia malayi Cytochrome P450 family protein 0.0077 0.0516 0.0584
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0103 0.0842 0.0814
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0045 0.0124 0.0094
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0516 0.0584
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 260 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] ChEMBL. No reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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