Detailed information for compound 14444

Basic information

Technical information
  • TDR Targets ID: 14444
  • Name: phenyl-(4-propoxy-1H-pyrazolo[3,4-b]pyridin-5 -yl)methanone
  • MW: 281.309 | Formula: C16H15N3O2
  • H donors: 1 H acceptors: 3 LogP: 2.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1c(c[nH]c2c1cnn2)C(=O)c1ccccc1
  • InChi: 1S/C16H15N3O2/c1-2-8-21-15-12(9-17-16-13(15)10-18-19-16)14(20)11-6-4-3-5-7-11/h3-7,9-10H,2,8H2,1H3,(H,17,18,19)
  • InChiKey: PSYXCQFSMTXEPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • phenyl-(4-propoxy-1H-pyrazolo[4,3-e]pyridin-5-yl)methanone
  • SQ-67563 Analog 11c

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin E2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.2999 0.7924
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0176 0.3238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Giardia lamblia G2/mitotic-specific cyclin B 0.0094 0.129 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.129 0.129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0597 0.0597
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0032 0.0247
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0835 0.6477
Trichomonas vaginalis cyclins, putative 0.0064 0.0799 0.6193
Entamoeba histolytica cyclin family protein 0.0064 0.0799 0.6193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Echinococcus multilocularis cyclins 0.0064 0.0799 0.2111
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0015
Leishmania major cyclin 0.0094 0.129 1
Trichomonas vaginalis cyclins, putative 0.0094 0.129 1
Trichomonas vaginalis cyclin A, putative 0.0094 0.129 1
Schistosoma mansoni hypothetical protein 0.005 0.057 0.19
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0015 0.004
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.2999 0.2999
Echinococcus granulosus cyclin B3 1 0.0064 0.0799 0.2111
Echinococcus multilocularis GPCR, family 2 0.0016 0.0015 0.004
Brugia malayi MH2 domain containing protein 0.0125 0.1785 0.1785
Trichomonas vaginalis cyclins, putative 0.0045 0.0491 0.3807
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.036 0.0952
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Schistosoma mansoni hypothetical protein 0.0177 0.264 0.8803
Loa Loa (eye worm) ctsf protein 0.0017 0.0032 0.0032
Loa Loa (eye worm) STAT protein 0.0137 0.1992 0.1992
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0361 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Plasmodium vivax vivapain-2 0.0017 0.0032 0.1807
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0015 0.0015
Leishmania major cathepsin L-like protease 0.0067 0.0835 0.6477
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0051
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0016 0.0052
Brugia malayi Cathepsin L-like precursor 0.0017 0.0032 0.0032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.057 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0799 0.6193
Brugia malayi hypothetical protein 0.0038 0.036 0.036
Schistosoma mansoni hypothetical protein 0.0036 0.0328 0.1094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Trichomonas vaginalis cyclin D, putative 0.0064 0.0799 0.6193
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0016 0.0122
Brugia malayi PAS domain containing protein 0.0051 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0026 0.0176 0.0176
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.2999 0.7924
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0176 0.2208
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0032 0.0084
Entamoeba histolytica hypothetical protein 0.0038 0.036 0.2794
Onchocerca volvulus 0.0017 0.0032 0.0083
Toxoplasma gondii cathepsin CPL 0.0017 0.0032 0.0585
Onchocerca volvulus 0.0017 0.0032 0.0083
Trypanosoma brucei mitotic cyclin 6 0.0094 0.129 1
Brugia malayi hypoxia-induced factor 1 0.0157 0.2317 0.2317
Entamoeba histolytica cyclin family protein 0.0064 0.0799 0.6193
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0032 0.0084
Leishmania major cathepsin L-like protease 0.0017 0.0032 0.0247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0032 0.0084
Echinococcus multilocularis cyclins 0.0064 0.0799 0.2111
Schistosoma mansoni cyclin B3 0.0199 0.2999 1
Echinococcus granulosus cathepsin l1 0.0017 0.0032 0.0084
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0032 0.0247
Echinococcus multilocularis cyclins 0.0064 0.0799 0.2111
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0032 0.0083
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.129 0.129
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0032 0.0084
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0016 0.0892
Brugia malayi hypothetical protein 0.0247 0.3785 0.3785
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0602 0.4669
Schistosoma mansoni cyclins 0.0064 0.0799 0.2664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Echinococcus granulosus geminin 0.0177 0.264 0.6976
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0016 0.0197
Leishmania major hypothetical protein, conserved 0.0026 0.0176 0.1368
Trichomonas vaginalis cyclin B, putative 0.0094 0.129 1
Leishmania major cathepsin L-like protease 0.0017 0.0032 0.0247
Echinococcus granulosus cyclins 0.0064 0.0799 0.2111
Brugia malayi hypothetical protein 0.0026 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0051
Schistosoma mansoni survival motor neuron protein 0.005 0.057 0.19
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0835 0.6477
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0577 0.1923
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Echinococcus multilocularis cysteine protease 0.0017 0.0032 0.0084
Trichomonas vaginalis cyclins, putative 0.0094 0.129 1
Echinococcus granulosus GPCR family 2 0.0016 0.0015 0.004
Echinococcus granulosus cyclins 0.0064 0.0799 0.2111
Brugia malayi isocitrate dehydrogenase 0.0016 0.0016 0.0016
Trichomonas vaginalis cyclin B, putative 0.0094 0.129 1
Echinococcus granulosus cyclins 0.0064 0.0799 0.2111
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0032 0.0032
Loa Loa (eye worm) pax transcription factor protein 2 0.0251 0.3856 0.3856
Loa Loa (eye worm) hypothetical protein 0.0247 0.3785 0.3785
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0176 0.2208
Echinococcus multilocularis cyclins 0.0064 0.0799 0.2111
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.2999 0.2999
Plasmodium vivax vivapain-2 0.0017 0.0032 0.1807
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0597 0.0597
Onchocerca volvulus 0.0017 0.0032 0.0083
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0051
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0032 0.0247
Onchocerca volvulus 0.0017 0.0032 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0016 0.0016
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0016 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0176 0.1368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0042
Trypanosoma cruzi CYC2-like cyclin, putative 0.0094 0.129 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0137 0.1992 0.1992
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0042
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0361 0.0953
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0016 0.0042
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.3785 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0032 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0176 0.1368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Schistosoma mansoni single-minded 0.0051 0.0577 0.1923
Schistosoma mansoni cyclin B 0.0094 0.129 0.4301
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0835 0.6477
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0835 0.6477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Echinococcus multilocularis geminin 0.0177 0.264 0.6976
Echinococcus granulosus cyclins 0.0064 0.0799 0.2111
Entamoeba histolytica cyclin, putative 0.0094 0.129 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0032 0.0106
Loa Loa (eye worm) hypothetical protein 0.003 0.0237 0.0237
Schistosoma mansoni hypothetical protein 0.0038 0.036 0.1202
Brugia malayi Cathepsin L-like precursor 0.0017 0.0032 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0032 0.0247
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0015 0.0015
Trichomonas vaginalis cyclins, putative 0.0094 0.129 1
Toxoplasma gondii hypothetical protein 0.0049 0.0545 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0016 0.0042
Entamoeba histolytica hypothetical protein 0.0038 0.036 0.2794
Loa Loa (eye worm) hypothetical protein 0.017 0.2533 0.2533
Brugia malayi Cathepsin L-like precursor 0.0017 0.0032 0.0032
Trichomonas vaginalis cyclins, putative 0.0094 0.129 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0122
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0042
Echinococcus multilocularis cyclin B3 1 0.0064 0.0799 0.2111
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0032 0.0084
Onchocerca volvulus 0.0017 0.0032 0.0083
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0032 0.0247
Brugia malayi hypothetical protein 0.0017 0.0024 0.0024
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0016 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0032
Loa Loa (eye worm) cysteine protease 0.0017 0.0032 0.0032
Plasmodium falciparum cyclin 0.0064 0.0799 1
Echinococcus multilocularis cyclins 0.0064 0.0799 0.2111
Trichomonas vaginalis cyclin D, putative 0.0064 0.0799 0.6193
Trichomonas vaginalis cyclin B, putative 0.0094 0.129 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Leishmania major cathepsin L-like protease 0.0067 0.0835 0.6477
Trichomonas vaginalis cyclin B3, putative 0.0064 0.0799 0.6193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Echinococcus multilocularis cyclins 0.0064 0.0799 0.2111
Trichomonas vaginalis cyclin B, putative 0.0094 0.129 1
Onchocerca volvulus 0.0094 0.129 0.3345
Leishmania major cathepsin L-like protease 0.0017 0.0032 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Echinococcus multilocularis cyclin B 0.0094 0.129 0.3408
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.036 0.1202
Leishmania major cathepsin L-like protease 0.0067 0.0835 0.6477
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0016 0.0289
Entamoeba histolytica cysteine protease, putative 0.0017 0.0032 0.0247
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0032 0.0106
Echinococcus granulosus cyclin B 0.0094 0.129 0.3408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Entamoeba histolytica hypothetical protein 0.0038 0.036 0.2794
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0361 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0015 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0032 0.0247
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0741 0.5744
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0042
Trypanosoma cruzi cyclin, putative 0.0094 0.129 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0015 0.004
Giardia lamblia Hypothetical protein 0.0064 0.0799 0.6193
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0051
Giardia lamblia Cyclin A 0.0064 0.0799 0.6193
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0016 0.0122
Entamoeba histolytica cyclin, putative 0.0064 0.0799 0.6193
Onchocerca volvulus 0.005 0.057 0.1477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Trypanosoma cruzi cyclin 6, putative 0.0094 0.129 1
Echinococcus multilocularis cysteine protease 0.0017 0.0032 0.0084
Trypanosoma cruzi cyclin, putative 0.0094 0.129 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0032 0.0032
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0032 0.0084
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0032 0.0399
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0032 0.0399
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0835 0.6477
Onchocerca volvulus 0.0038 0.0361 0.0936
Echinococcus multilocularis cyclin b3 0.0064 0.0799 0.2111
Loa Loa (eye worm) hypothetical protein 0.0094 0.129 0.129
Brugia malayi hypothetical protein 0.017 0.2533 0.2533
Entamoeba histolytica hypothetical protein 0.0038 0.036 0.2794
Loa Loa (eye worm) fibroinase 0.0017 0.0032 0.0032
Echinococcus granulosus cyclins 0.0064 0.0799 0.2111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0032 0.0083
Brugia malayi Cathepsin L-like precursor 0.0017 0.0032 0.0032
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0176 1
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.3785 1
Onchocerca volvulus 0.0251 0.3856 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0176 0.1368
Loa Loa (eye worm) hypothetical protein 0.0052 0.0597 0.0597
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0015 0.0015
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.2317 0.2317
Leishmania major cathepsin L-like protease 0.0017 0.0032 0.0247
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0032 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0094 0.129 0.129
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1785 0.1785
Onchocerca volvulus 0.0017 0.0032 0.0083
Echinococcus multilocularis cyclins 0.0064 0.0799 0.2111
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0094 0.129 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.036 0.0952
Brugia malayi Cathepsin L-like precursor 0.0017 0.0032 0.0032
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0032 0.0399
Echinococcus granulosus single minded 2 0.0038 0.0361 0.0953
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0032 0.0247
Leishmania major cathepsin L-like protease 0.0017 0.0032 0.0247
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0015 0.004
Schistosoma mansoni hypothetical protein 0.0177 0.264 0.8803
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1785 0.1785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0032 0.0247
Brugia malayi Pax transcription factor protein 2 0.0251 0.3856 0.3856
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0122
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0016 0.5
Brugia malayi Cathepsin L-like precursor 0.0017 0.0032 0.0032
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0626 1 1
Onchocerca volvulus 0.0017 0.0032 0.0083
Trichomonas vaginalis cyclin B, putative 0.0064 0.0799 0.6193
Echinococcus granulosus cyclin b3 0.0064 0.0799 0.2111

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.18 uM In vitro inhibition of human CDK2/cyclin E. ChEMBL. 12643928
IC50 (binding) = 0.18 uM In vitro inhibition of human CDK2/cyclin E. ChEMBL. 12643928
IC50 (binding) = 0.22 uM Inhibitory concentration of the compound against CDK1/cyclin B was determined ChEMBL. 12643928
IC50 (binding) = 0.22 uM Inhibitory concentration of the compound against CDK1/cyclin B was determined ChEMBL. 12643928

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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