Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0217 | 0.0546 | 1 | |
Echinococcus multilocularis | carbonic anhydrase | 0.1549 | 0.4718 | 0.4715 |
Schistosoma mansoni | carbonic anhydrase | 0.154 | 0.4691 | 0.4688 |
Schistosoma mansoni | carbonic anhydrase | 0.1549 | 0.4718 | 0.4715 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3235 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1549 | 0.4718 | 0.4715 |
Entamoeba histolytica | ankyrin, putative | 0.0075 | 0.01 | 0.0213 |
Echinococcus granulosus | carbonic anhydrase | 0.1549 | 0.4718 | 0.4715 |
Echinococcus granulosus | dynactin 5 p25 | 0.0075 | 0.01 | 0.0095 |
Echinococcus multilocularis | carbonic anhydrase | 0.1549 | 0.4718 | 0.4715 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.3235 | 1 | 1 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0075 | 0.01 | 0.0322 |
Onchocerca volvulus | Putative sulfate transporter | 0.0217 | 0.0546 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.1549 | 0.4718 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.3235 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0075 | 0.01 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.3235 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3235 | 1 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.0005 | 0.0011 |
Echinococcus granulosus | carbonic anhydrase | 0.1549 | 0.4718 | 0.4715 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1549 | 0.4718 | 0.4715 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0075 | 0.01 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.3235 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1612 | 0.4915 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.154 | 0.4691 | 0.9545 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0005 | 0.0005 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0828 | 0.2459 | 0.7912 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3235 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1549 | 0.4718 | 0.4715 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.3235 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1549 | 0.4718 | 0.4715 |
Echinococcus multilocularis | carbonic anhydrase | 0.1549 | 0.4718 | 0.4715 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0964 | 0.2884 | 0.928 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0005 | 0.0005 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1549 | 0.4718 | 0.4715 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1549 | 0.4718 | 0.4715 |
Trichomonas vaginalis | maltose O-acetyltransferase, putative | 0.0072 | 0.0091 | 0.0175 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.2933 | 0.293 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1612 | 0.4915 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1549 | 0.4718 | 0.4715 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1549 | 0.4718 | 0.4715 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0005 | 0.0005 |
Toxoplasma gondii | hypothetical protein | 0.1549 | 0.4718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2807 | 0.866 | 0.8659 |
Echinococcus multilocularis | carbonic anhydrase II | 0.3235 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0005 | 0.0005 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.0005 | 0.0011 |
Mycobacterium ulcerans | transferase | 0.0072 | 0.0091 | 0.0185 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.154 | 0.4691 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1612 | 0.4915 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3235 | 1 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0251 | 0.0652 | 0.1219 |
Loa Loa (eye worm) | hypothetical protein | 0.1549 | 0.4718 | 0.4715 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0251 | 0.0652 | 0.2097 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1549 | 0.4718 | 0.4715 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.0005 | 0.053 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.154 | 0.4691 | 1 |
Entamoeba histolytica | acetyltransferase, putative | 0.0075 | 0.01 | 0.0213 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1035 | 0.3108 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1549 | 0.4718 | 0.4715 |
Echinococcus granulosus | carbonic anhydrase | 0.1549 | 0.4718 | 0.4715 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1549 | 0.4718 | 0.4715 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.0091 | 0.0175 |
Leishmania major | carbonic anhydrase family protein, putative | 0.154 | 0.4691 | 0.4691 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.3235 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (binding) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.