Detailed information for compound 1445020

Basic information

Technical information
  • TDR Targets ID: 1445020
  • Name: SMR000127773
  • MW: 400.448 | Formula: C20H20N2O5S
  • H donors: 0 H acceptors: 4 LogP: 1.27 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1C(=O)c2ccccc2S(=O)(=O)c2c1cc(cc2)C(=O)N1CCOCC1
  • InChi: 1S/C20H20N2O5S/c1-2-22-16-13-14(19(23)21-9-11-27-12-10-21)7-8-18(16)28(25,26)17-6-4-3-5-15(17)20(22)24/h3-8,13H,2,9-12H2,1H3
  • InChiKey: YFNMXLNPMDZMJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000522506

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0134 0.0123
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2339 0.2331
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0134 0.0402
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0129 0.0061
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0342 0.0721
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0342 0.0721
Plasmodium vivax cell division cycle ATPase, putative 0.0149 0.1307 0.3266
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0411 0.4083 0.7998
Loa Loa (eye worm) hypothetical protein 0.0054 0.03 0.1283
Onchocerca volvulus 0.0102 0.081 0.1722
Brugia malayi beta-lactamase 0.0038 0.0129 0.038
Echinococcus multilocularis dna polymerase eta 0.0044 0.0194 0.0183
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1223 0.1214
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.043 0.1689
Loa Loa (eye worm) hypothetical protein 0.0049 0.0246 0.1052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0342 0.0751
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0134 0.0073
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0105 0.0094
Onchocerca volvulus 0.005 0.0263 0.0339
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0311 0.1172
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.081 0.1477
Loa Loa (eye worm) hypothetical protein 0.0241 0.2283 0.9761
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0134 0.0123
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0134 0.0172
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0364 0.0809
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0364 0.1302
Brugia malayi beta-lactamase family protein 0.0038 0.0129 0.038
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0194 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0066 0.043 0.0719
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0342 0.1461
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0246 0.1052
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.2273 0.9725
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0097 0.076 0.1647
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0134 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0045
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.055
Loa Loa (eye worm) hypothetical protein 0.0102 0.081 0.3461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1223 0.23
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.1415 0.5979
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.055
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0263 0.0964
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0342 0.0965
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0194 0.0663
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2339 0.2331
Schistosoma mansoni tar DNA-binding protein 0.0066 0.043 0.0719
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0105 0.0275
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0083 0.0182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1223 0.1214
Loa Loa (eye worm) beta-lactamase 0.0038 0.0129 0.055
Echinococcus granulosus dna polymerase eta 0.0044 0.0194 0.0183
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0068 0.0031
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0068 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0105 0.0127
Schistosoma mansoni ap endonuclease 0.0058 0.0342 0.0544
Echinococcus granulosus geminin 0.0506 0.5088 0.5083
Schistosoma mansoni cell division control protein 48 aaa family protein 0.039 0.3859 0.7552
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0068 0.0058
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0342 0.0331
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0129 0.0266
Loa Loa (eye worm) VCP protein 0.017 0.1531 0.6543
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0364 0.0353
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0134 0.0123
Schistosoma mansoni lamin 0.0055 0.0311 0.0483
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0411 0.4083 0.4077
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0129 0.0159
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0068 0.0058
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0129 0.0061
Echinococcus granulosus tar DNA binding protein 0.0066 0.043 0.0419
Toxoplasma gondii exonuclease III APE 0.0058 0.0342 0.0709
Schistosoma mansoni tar DNA-binding protein 0.0066 0.043 0.0719
Loa Loa (eye worm) hypothetical protein 0.0044 0.0194 0.0828
Brugia malayi follicle stimulating hormone receptor 0.0246 0.2338 0.9996
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0134 0.0204
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1223 0.5227
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0105 0.0447
Loa Loa (eye worm) TAR-binding protein 0.0066 0.043 0.1836
Echinococcus multilocularis musashi 0.0055 0.0311 0.03
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0342 0.0751
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0246 0.0891
Brugia malayi vesicle-fusing ATPase 0.0241 0.2283 0.9756
Schistosoma mansoni DNA polymerase eta 0.0044 0.0194 0.025
Onchocerca volvulus 0.0055 0.0311 0.046
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0129 0.055
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0311 0.1328
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0411 0.4083 0.4077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0342 0.5
Trichomonas vaginalis esterase, putative 0.0038 0.0129 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0342 0.0751
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1223 0.1214
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.055
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0129 0.0266
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0134 0.0073
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0194 0.0362
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0097 0.076 0.1647
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0129 0.0266
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0129 0.0266
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.055
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0342 0.1307
Leishmania major DNA polymerase eta, putative 0.0044 0.0194 0.0362
Schistosoma mansoni alpha-glucosidase 0.0137 0.1181 0.2216
Echinococcus multilocularis tar DNA binding protein 0.0066 0.043 0.0419
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0364 0.1064
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0411 0.4083 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0129 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0066 0.043 0.0719
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0129 0.0159
Echinococcus granulosus lamin 0.0055 0.0311 0.03
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0342 0.0596
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0411 0.4083 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0364 0.1064
Toxoplasma gondii cell division protein CDC48AP 0.0246 0.2336 0.566
Mycobacterium tuberculosis Conserved protein 0.0038 0.0129 0.0266
Giardia lamblia AAA family ATPase 0.0246 0.2336 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0342 0.0331
Toxoplasma gondii cell division protein CDC48CY 0.0411 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0355
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0129 0.0191
Schistosoma mansoni hypothetical protein 0.0506 0.5088 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0342 0.0632
Brugia malayi intermediate filament protein 0.0055 0.0311 0.1172
Onchocerca volvulus 0.0055 0.0311 0.046
Schistosoma mansoni ap endonuclease 0.0058 0.0342 0.0544
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0129 0.0266
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0129 0.0118
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0134 0.013
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.8115 0.8113
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0134 0.0123
Loa Loa (eye worm) hypothetical protein 0.0125 0.1052 0.4497
Echinococcus multilocularis geminin 0.0506 0.5088 0.5083
Echinococcus multilocularis neuropeptide s receptor 0.097 1 1
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.017 0.1531 0.1522
Echinococcus granulosus neuropeptide receptor A26 0.097 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0364 0.1402
Trypanosoma cruzi Valosin-containing protein, putative 0.039 0.3859 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.2339 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0129 0.0191
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0246 0.2336 0.566
Brugia malayi RNA binding protein 0.0066 0.043 0.1689
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1223 0.5141
Mycobacterium leprae Probable lipase LipE 0.0038 0.0129 0.5
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0068 0.0292
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0342 0.5
Brugia malayi hypothetical protein 0.0125 0.1052 0.4398
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0129 0.0061
Brugia malayi TAR-binding protein 0.0066 0.043 0.1689
Brugia malayi valosin containing protein 0.0241 0.2283 0.9756
Echinococcus multilocularis tumor protein p63 0.0696 0.7102 0.7099
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.1415 0.605
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0134 0.013
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.039 0.3859 1
Schistosoma mansoni hypothetical protein 0.0506 0.5088 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0068 0.0058
Mycobacterium ulcerans ATPase 0.0246 0.2336 1
Schistosoma mansoni hypothetical protein 0.005 0.0263 0.0387
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0129 0.0061
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1415 0.1406
Schistosoma mansoni tar DNA-binding protein 0.0066 0.043 0.0719
Loa Loa (eye worm) hypothetical protein 0.0055 0.0311 0.1328
Brugia malayi beta-lactamase family protein 0.0038 0.0129 0.038
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0364 0.0588
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.039 0.3859 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0105 0.012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0134 0.0073
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0134 0.0204
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0321 0.1372
Echinococcus multilocularis lamin dm0 0.0055 0.0311 0.03
Mycobacterium tuberculosis Conserved protein 0.0038 0.0129 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0105 0.0127
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0129 0.012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0068 0.0032
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0364 0.0353
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0129 0.0061
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.2338 0.9996
Trypanosoma brucei glucosidase, putative 0.0035 0.0105 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1223 0.23
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0129 0.0266
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0129 0.038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1223 0.1214
Schistosoma mansoni alpha-glucosidase 0.0137 0.1181 0.2216
Loa Loa (eye worm) hypothetical protein 0.0125 0.1052 0.4497
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0105 0.0127
Onchocerca volvulus Huntingtin homolog 0.0125 0.1052 0.2335
Echinococcus granulosus intermediate filament protein 0.0055 0.0311 0.03
Schistosoma mansoni survival motor neuron protein 0.005 0.0263 0.0387
Loa Loa (eye worm) hypothetical protein 0.0038 0.0134 0.0572
Mycobacterium tuberculosis Conserved protein 0.0038 0.0129 0.0266
Brugia malayi isocitrate dehydrogenase 0.0032 0.0068 0.0117
Echinococcus granulosus tumor protein p63 0.0696 0.7102 0.7099
Schistosoma mansoni lamin 0.0055 0.0311 0.0483
Schistosoma mansoni intermediate filament proteins 0.0055 0.0311 0.0483
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.039 0.3859 1
Trypanosoma brucei Valosin-containing protein 0.039 0.3859 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0105 0.0094
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.017 0.1531 0.6481
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0246 0.0891
Loa Loa (eye worm) vesicle-fusing ATPase 0.0241 0.2283 0.9761
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1023 0.4371
Toxoplasma gondii ABC1 family protein 0.0038 0.0129 0.018
Echinococcus multilocularis neuropeptide receptor A26 0.097 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1223 0.23
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0134 0.0204
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1415 0.1406
Schistosoma mansoni alpha glucosidase 0.0035 0.0105 0.0072
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.039 0.3859 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0129 0.0118
Entamoeba histolytica cdc48-like protein, putative 0.039 0.3859 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.1415 0.1406
Brugia malayi MH2 domain containing protein 0.0122 0.1023 0.427
Onchocerca volvulus Huntingtin homolog 0.0125 0.1052 0.2335
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0068 0.0058
Onchocerca volvulus 0.0092 0.0705 0.1457
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0134 0.0123
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0134 0.0123
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0342 0.0596
Schistosoma mansoni cell division control protein 48 aaa family protein 0.017 0.1531 0.2913
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.043 0.1836
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0342 0.1205
Brugia malayi hypothetical protein 0.0246 0.2339 1
Leishmania major hypothetical protein, conserved 0.0038 0.0129 0.0191
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0068 0.0032
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0342 0.0721
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0068 0.0031
Mycobacterium tuberculosis Putative conserved ATPase 0.0246 0.2336 1
Echinococcus granulosus lamin dm0 0.0055 0.0311 0.03
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0342 0.0944
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0129 0.012
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0068 0.0117
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0311 0.1328
Echinococcus multilocularis lamin 0.0055 0.0311 0.03
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0129 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0068 0.0058
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1023 0.4371
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0068 0.0058
Loa Loa (eye worm) RNA binding protein 0.0066 0.043 0.1836
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0041 0.0177

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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