Detailed information for compound 1445265

Basic information

Technical information
  • TDR Targets ID: 1445265
  • Name: N-[(2-ethoxyphenyl)carbamothioyl]-3-phenylpro panamide
  • MW: 328.429 | Formula: C18H20N2O2S
  • H donors: 2 H acceptors: 1 LogP: 4.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=S)NC(=O)CCc1ccccc1
  • InChi: 1S/C18H20N2O2S/c1-2-22-16-11-7-6-10-15(16)19-18(23)20-17(21)13-12-14-8-4-3-5-9-14/h3-11H,2,12-13H2,1H3,(H2,19,20,21,23)
  • InChiKey: AZRPWXHFTWJKFA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-ethoxyphenyl)carbamothioyl]-3-phenyl-propanamide
  • N-[[(2-ethoxyphenyl)amino]-thioxomethyl]-3-phenylpropanamide
  • N-[(2-ethoxyphenyl)thiocarbamoyl]-3-phenyl-propionamide
  • NSC205933
  • AN-329/42667818
  • ZINC01004116
  • ALD-N009449
  • ARONIS008436

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose transporter 0.0014 0.0217 0.0503
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Loa Loa (eye worm) hypothetical protein 0.0041 0.0853 0.2095
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2617 1
Trypanosoma brucei trypanothione reductase 0.0046 0.096 1
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0621 0.274
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0566 0.1377
Trypanosoma brucei sugar transporter, putative 0.0014 0.0217 0.2257
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0255 0.024
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0597 0.1453
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0255 0.2659
Loa Loa (eye worm) trypsin family protein 0.0008 0.0072 0.0142
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0715 0.1081
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0611 0.2699
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0331 0.0789
Plasmodium vivax glutathione reductase, putative 0.0046 0.096 0.0946
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0255 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0008 0.0072 0.0142
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0163
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0621 0.6466
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2617 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0072 0.0142
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0566 0.1418
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0217 0.839
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0612 0.0597
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0163
Echinococcus multilocularis glycoprotein Antigen 5 0.0008 0.0072 0.0142
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.096 0.2362
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2617 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0621 0.6466
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.096 0.0946
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0503
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0072 0.0142
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0255 0.0599
Onchocerca volvulus 0.0014 0.0217 1
Leishmania major glucose transporter, lmgt1 0.0031 0.0621 0.6466
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2266 0.5794
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis GPCR, family 2 0.0019 0.0331 0.0789
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2266 1
Schistosoma mansoni hypothetical protein 0.0019 0.0331 0.0789
Toxoplasma gondii thioredoxin reductase 0.0046 0.096 0.1451
Echinococcus multilocularis General substrate transporter 0.0087 0.193 0.4788
Brugia malayi hypothetical protein 0.0014 0.0217 0.0503
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0163 0.3734 0.5643
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.2342 0.8951
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0503
Brugia malayi hypothetical protein 0.0014 0.0217 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0069
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0996 1
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0503
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1303 0.3219
Plasmodium falciparum protein kinase 7 0.0285 0.6617 0.6612
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.3899 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1097 0.4842
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0255 0.024
Plasmodium vivax sugar transporter, putative 0.0014 0.0217 0.0201
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0255 0.2659
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0611 0.6369
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Schistosoma mansoni protein kinase 0.0031 0.0611 0.149
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0611 0.149
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.096 1
Schistosoma mansoni glucose transport protein 0.0101 0.2266 0.5626
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.1535
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0621 0.6466
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0715 0.7449
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0333 0.1274
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0612 0.0597
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0503
Onchocerca volvulus Putative transporter 0.0014 0.0217 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0255 0.2659
Schistosoma mansoni glucose transport protein 0.0101 0.2266 0.5626
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi Trypsin-like protease protein 5 0.0008 0.0072 0.0142
Entamoeba histolytica protein kinase, putative 0.0031 0.0611 0.608
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0008 0.0072 0.0142
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.1535
Brugia malayi Trypsin family protein 0.0008 0.0072 0.0142
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0503
Brugia malayi glutathione reductase 0.0046 0.096 0.2362
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium vivax hexose transporter 0.0101 0.2266 0.2253
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1097 0.4842
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0414 0.0995
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0621 0.6466
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.2257
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0217 0.0503
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.2342 0.8951
Giardia lamblia Hexose transporter 0.0014 0.0217 0.2052
Mycobacterium tuberculosis Probable reductase 0.0104 0.2342 0.8951
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0016 0.0377
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0217 0.0828
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0072 0.0142
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0518
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0331 0.0789
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0621 0.274
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.149
Onchocerca volvulus 0.0014 0.0217 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0414 0.4308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Echinococcus granulosus enteropeptidase 0.0008 0.0072 0.0146
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0503
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.149
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0217 0.0956
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.4014 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1303 0.3219
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0255 0.6172
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0217 0.2257
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0217 0.5239
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Onchocerca volvulus 0.0014 0.0217 1
Brugia malayi Thioredoxin reductase 0.0046 0.096 0.2362
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0414 0.4308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0255 0.2659
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0414 1
Onchocerca volvulus 0.0014 0.0217 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0503
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0621 0.6466
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0597 0.1453
Trypanosoma brucei glucose transporter, putative 0.0031 0.0621 0.6466
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0255 0.1127
Trypanosoma brucei glucose transporter, putative 0.0031 0.0621 0.6466
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0414 0.0995
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0414 0.4061
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0217 0.0518
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Treponema pallidum NADH oxidase 0.0016 0.0255 1
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0503
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0612 0.0597
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0996 0.0982
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0331 0.0789
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1097 0.1658
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi Sugar transporter family protein 0.0101 0.2266 0.5626
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1303 0.3219
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 1
Echinococcus granulosus General substrate transporter 0.0087 0.193 0.4931
Loa Loa (eye worm) hypothetical protein 0.0031 0.0611 0.149
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0255 0.0386
Schistosoma mansoni hypothetical protein 0.0019 0.0331 0.0789
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0217 0.0503
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0503
Schistosoma mansoni hypothetical protein 0.0041 0.0853 0.2095
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0255 0.1127
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0975 0.247
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0611 0.149
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0518
Trypanosoma brucei glucose transporter, putative 0.0031 0.0621 0.6466
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0217 0.0201
Trypanosoma brucei glucose transporter 1E 0.0031 0.0621 0.6466
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0134 0.4945
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0255 0.0599
Loa Loa (eye worm) sugar transporter 0.0101 0.2266 0.5626
Onchocerca volvulus 0.0014 0.0217 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1303 0.3219
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0518
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0597 0.593
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Brugia malayi Trypsin family protein 0.0008 0.0072 0.0142
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0975 0.2398
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0163
Onchocerca volvulus 0.0014 0.0217 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0612 0.0597
Echinococcus multilocularis Mastin 0.0008 0.0072 0.0142
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0255 0.0617
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0255 0.2659
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0597 0.593
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0255 0.024
Loa Loa (eye worm) hypothetical protein 0.003 0.0597 0.1453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0255 0.2659
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0333 0.1274
Leishmania major hypothetical protein, conserved 0.0014 0.0217 0.2257
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0611 0.1535
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0217 0.0503
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0072 0.0142
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.2342 0.8951
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0715 0.7449
Trypanosoma brucei glucose transporter, putative 0.0031 0.0621 0.6466
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0255 0.2659
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0414 0.0995
Loa Loa (eye worm) hypothetical protein 0.0008 0.0072 0.0142
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0611 0.149
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.149
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.149
Brugia malayi hypothetical protein 0.0008 0.0072 0.0142
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.0019 0.0331 0.0789
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0621 0.274
Brugia malayi Cam kinase protein 1 0.0031 0.0611 0.149
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0016 0.0024
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0134 0.2978
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0503
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0016 0.0377
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0072 0.0142
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0612 0.0597
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0255 0.2659
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni protein kinase 0.0031 0.0611 0.149
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0621 0.6466
Toxoplasma gondii sugar transporter ST3 0.0014 0.0217 0.0327
Toxoplasma gondii protein kinase, putative 0.0285 0.6617 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni hypothetical protein 0.0019 0.0331 0.0789
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0597 0.1453
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2266 0.5794
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0715 0.0701
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0217 0.0327
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0503
Loa Loa (eye worm) hypothetical protein 0.0023 0.0414 0.0995
Echinococcus multilocularis enteropeptidase 0.0008 0.0072 0.0142
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0255 0.2659
Echinococcus multilocularis transmembrane protease serine 3 0.0008 0.0072 0.0142
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0503
Loa Loa (eye worm) hypothetical protein 0.0008 0.0072 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0255 0.2659
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0134 0.3243
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.2342 0.8951
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0175 0.0399
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0597 0.1453
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0008 0.0072 0.0146
Trypanosoma cruzi hexose transporter 0.0031 0.0621 0.6466
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0255 0.2659
Brugia malayi Trypsin family protein 0.0008 0.0072 0.0142
Loa Loa (eye worm) hypothetical protein 0.0008 0.0072 0.0142
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0217 0.2257
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0597 0.2281
Trypanosoma brucei glucose transporter, putative 0.0031 0.0621 0.6466
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0331 0.0813
Plasmodium falciparum mitogen-activated protein kinase 2 0.0163 0.3734 0.3724
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2266 0.5626
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0597 0.2634
Entamoeba histolytica hypothetical protein 0.0023 0.0414 0.4061
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0331 0.0813
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0217 0.0828
Trypanosoma brucei glucose transporter, putative 0.0031 0.0621 0.6466
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2266 0.5626
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0853 0.2095
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0503
Loa Loa (eye worm) acetyltransferase 0.0175 0.4014 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0611 0.149
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2266 0.5794
Loa Loa (eye worm) sugar transporter 0.0014 0.0217 0.0503
Plasmodium falciparum hexose transporter 0.0101 0.2266 0.2253
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.096 0.3669
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0217 0.0518
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0621 0.274
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0621 0.274
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0156 0.0351
Echinococcus granulosus glycoprotein Antigen 5 0.0008 0.0072 0.0146
Schistosoma mansoni hypothetical protein 0.0101 0.2266 0.5626
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0503
Onchocerca volvulus 0.0014 0.0217 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0072 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0612 0.0597
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0414 0.0399
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0072 0.0142
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0255 0.6172
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0414 0.0995
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0016 0.006
Leishmania major protein kinase, putative 0.0031 0.0611 0.6369
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1097 0.1658
Schistosoma mansoni glucose transport protein 0.0101 0.2266 0.5626
Plasmodium falciparum glutathione reductase 0.0016 0.0255 0.024
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.4014 1
Toxoplasma gondii sugar transporter ST1 0.0014 0.0217 0.0327
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0414 1
Echinococcus granulosus Mastin 0.0008 0.0072 0.0146
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0715 0.7449
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Schistosoma mansoni protein kinase 0.0031 0.0611 0.149
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0715 0.0701
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0255 0.2659
Onchocerca volvulus 0.0014 0.0217 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0518
Onchocerca volvulus 0.0014 0.0217 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0597 0.1453
Onchocerca volvulus 0.0014 0.0217 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.2342 0.8951
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.4014 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0255 0.0976
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0597 0.1453
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0255 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Toxoplasma gondii sugar transporter ST2 0.0014 0.0217 0.0327
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0255 0.2659
Schistosoma mansoni hypothetical protein 0.0008 0.0072 0.0142
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0255 0.0599
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0025 0.0463 0.1118
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0414 0.1025
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.2342 0.8951
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0331 0.0789
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0503
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0217 0.2257
Giardia lamblia Sugar-proton symporter 0.0014 0.0217 0.2052
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0715 0.7449
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0414 0.1826
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0008 0.0072 0.0146
Loa Loa (eye worm) hypothetical protein 0.0008 0.0072 0.0142
Plasmodium falciparum glutathione reductase 0.0046 0.096 0.0946
Onchocerca volvulus 0.0014 0.0217 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0612 0.0925
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0715 0.7449
Schistosoma mansoni hypothetical protein 0.0008 0.0072 0.0142
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0255 0.024
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2266 0.5626
Loa Loa (eye worm) glutathione reductase 0.0046 0.096 0.2362
Mycobacterium ulcerans hypothetical protein 0.0008 0.0072 0.1751
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0255 0.6172
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2617 1
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0217 0.5239
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0414 0.0399
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0255 0.2659
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2266 0.3424
Plasmodium falciparum thioredoxin reductase 0.0016 0.0255 0.024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0072 0.0142
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.1535
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0621 0.6466
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0163 0.3734 0.3724
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0072 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0255 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major glucose transporter, lmgt3 0.0031 0.0621 0.6466
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0255 0.2659
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0255 0.2659
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0156 0.0351
Brugia malayi hypothetical protein 0.0014 0.0217 0.0503
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0621 0.274
Brugia malayi Trypsin family protein 0.0008 0.0072 0.0142
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1097 0.1083
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1097 0.2785
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0414 0.0625
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0503
Schistosoma mansoni hypothetical protein 0.0019 0.0331 0.0789
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0217 0.5239
Echinococcus granulosus transmembrane protease serine 3 0.0008 0.0072 0.0146
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0333 0.1274
Plasmodium falciparum thioredoxin reductase 0.0046 0.096 0.0946
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0597 0.1497
Leishmania major trypanothione reductase 0.0046 0.096 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0016 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0621 0.274
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0016 0.0163
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0255 0.6022
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0414 0.4308
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0286 0.2975
Loa Loa (eye worm) hypothetical protein 0.0008 0.0072 0.0142
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.2257
Schistosoma mansoni cercarial elastase (S01 family) 0.0008 0.0072 0.0142
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0612 0.0925
Trypanosoma brucei glucose transporter, putative 0.0031 0.0621 0.6466
Trypanosoma brucei glucose transporter 2A 0.0031 0.0621 0.6466
Entamoeba histolytica protein kinase, putative 0.0031 0.0611 0.608
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0612 0.0597
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0008 0.0072 0.0142
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0348 0.1536
Mycobacterium ulcerans sugar transporter 0.0014 0.0217 0.5239
Leishmania major glucose transporter, lmgt2 0.0031 0.0621 0.6466
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0255 0.2446
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0008 0.0072 0.0142
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0612 0.0597
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0016 0.006
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2266 0.5626
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0414 0.1581
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0612 0.0925
Echinococcus granulosus GPCR family 2 0.0019 0.0331 0.0813
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0503
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0621 0.6466
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0331 0.0789
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2266 0.5794
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0255 0.2659
Onchocerca volvulus 0.0014 0.0217 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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