Detailed information for compound 1447261

Basic information

Technical information
  • TDR Targets ID: 1447261
  • Name: N-cyclohexyl-N-methyl-2-thieno[3,2-e]pyrimidi n-4-yloxyacetamide
  • MW: 305.395 | Formula: C15H19N3O2S
  • H donors: 0 H acceptors: 3 LogP: 3.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C1CCCCC1)C)COc1ncnc2c1ccs2
  • InChi: 1S/C15H19N3O2S/c1-18(11-5-3-2-4-6-11)13(19)9-20-14-12-7-8-21-15(12)17-10-16-14/h7-8,10-11H,2-6,9H2,1H3
  • InChiKey: BXHCYRCPBCIUKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclohexyl-N-methyl-2-thieno[3,2-e]pyrimidin-4-yloxy-acetamide
  • N-cyclohexyl-N-methyl-2-(4-thieno[3,2-e]pyrimidinyloxy)acetamide
  • N-cyclohexyl-N-methyl-2-thieno[3,2-e]pyrimidin-4-yloxy-ethanamide
  • T5252272

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0124 0.1186 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0172 0.0996
Mycobacterium ulcerans lipase LipD 0.0043 0.0351 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0351 0.2589
Loa Loa (eye worm) hypothetical protein 0.0043 0.0343 0.0802
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0445 0.0445
Loa Loa (eye worm) tumor suppressor 0.0358 0.3589 1
Trypanosoma brucei Metacaspase-4 0.0046 0.0375 0.2801
Leishmania major importin beta-1 subunit, putative 0.0026 0.0172 0.0996
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0131
Mycobacterium tuberculosis Conserved protein 0.0043 0.0351 0.1269
Brugia malayi Temporarily assigned gene name protein 44 0.003 0.0215 0.044
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0175 0.4972
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0351 0.9365
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.259 0.7169
Onchocerca volvulus 0.0043 0.0351 0.2177
Schistosoma mansoni hypothetical protein 0.0077 0.0699 0.2031
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0351 0.1269
Brugia malayi mbt repeat family protein 0.0046 0.0379 0.0906
Entamoeba histolytica hypothetical protein 0.0077 0.0699 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0379 0.1102
Schistosoma mansoni hypothetical protein 0.0041 0.0327 0.095
Plasmodium vivax metacaspase 1, putative 0.0046 0.0375 1
Onchocerca volvulus 0.0043 0.0343 0.212
Onchocerca volvulus 0.0043 0.0351 0.2177
Schistosoma mansoni jumonji domain containing protein 0.0015 0.006 0.0173
Mycobacterium ulcerans beta-lactamase 0.0043 0.0351 1
Schistosoma mansoni hypothetical protein 0.0043 0.0343 0.0995
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0124 0.1186 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0491 0.1425
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0491 0.108
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0099 0.0112
Schistosoma mansoni caspase-7 (C14 family) 0.0088 0.0815 0.2366
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2767 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0124 0.1186 1
Trypanosoma brucei metacaspase 0.0046 0.0375 0.2801
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0095 0.0343
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0445 0.0981
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0375 1
Onchocerca volvulus 0.0156 0.1516 1
Trypanosoma brucei hypothetical protein 0.0124 0.1186 1
Onchocerca volvulus 0.0046 0.0379 0.2368
Brugia malayi jmjC domain containing protein 0.0057 0.0491 0.1221
Echinococcus granulosus phd:f box containing protein 0.0015 0.006 0.0131
Echinococcus granulosus caspase 8 0.0046 0.0375 0.0825
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0201 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0327 0.0758
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0445 0.0445
Echinococcus multilocularis phd:f box containing protein 0.0015 0.006 0.006
Echinococcus multilocularis caspase 0.0121 0.1151 0.1151
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0445 0.1294
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0175 0.0326
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.006 0.0131
Schistosoma mansoni phd/f-box containing protein 0.0015 0.006 0.0173
Onchocerca volvulus 0.0026 0.0175 0.0991
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0445 0.0981
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0351 0.9365
Mycobacterium leprae Probable lipase LipE 0.0043 0.0351 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0379 0.1102
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0172 0.4579
Schistosoma mansoni protein phosphatase 2C 0.0015 0.006 0.0173
Echinococcus granulosus caspase 2 0.0088 0.0815 0.1794
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0351 0.0351
Toxoplasma gondii ABC1 family protein 0.0043 0.0351 0.9245
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0351 0.0826
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0175 0.4972
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0175 0.4972
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.006 0.006
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0379 0.1102
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0106 0.0383
Plasmodium falciparum metacaspase 1 0.0046 0.0375 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0379 0.0835
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0351 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0131
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0234 0.0234
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0175 0.0055
Brugia malayi beta-lactamase family protein 0.0043 0.0351 0.0826
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0326
Mycobacterium ulcerans hypothetical protein 0.0043 0.0351 1
Loa Loa (eye worm) MBCTL1 0.0053 0.0445 0.1093
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0491 0.1425
Echinococcus granulosus protein quaking 0.003 0.0215 0.0473
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0326
Schistosoma mansoni hypothetical protein 0.0205 0.2013 0.5846
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0351 0.2589
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0491 0.1221
Schistosoma mansoni hypothetical protein 0.0019 0.0099 0.0288
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0175 0.4972
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0124 0.1186 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0124 0.1186 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0099 0.0099
Echinococcus granulosus GPCR family 2 0.0019 0.0099 0.0218
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0524 0.1315
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0351 0.2589
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0375 0.1089
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0121 0.1151 0.1151
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0175 0.1022
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0124 0.1186 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0351 0.1269
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0106 0.147
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0351 0.1269
Brugia malayi Cell death protein 3 precursor 0.0088 0.0815 0.2139
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0699 0.1539
Loa Loa (eye worm) hypothetical protein 0.0032 0.0234 0.0495
Brugia malayi hypothetical protein 0.003 0.0215 0.044
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0524 0.1315
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0131
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0201 0.537
Loa Loa (eye worm) hypothetical protein 0.0043 0.0351 0.0826
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0106 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0351 0.9365
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0379 0.2368
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.044
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0351 0.9365
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Echinococcus granulosus snurportin 1 0.0343 0.3443 0.758
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Brugia malayi tumor suppressor. 0.0358 0.3589 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.006 0.006
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0201 0.1259
Echinococcus multilocularis neuropeptide s receptor 0.045 0.4542 0.4542
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0201 0.1259
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0124 0.1186 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0699 0.0699
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0375 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0351 0.0826
Schistosoma mansoni hypothetical protein 0.0019 0.0099 0.0288
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0175 0.0631
Entamoeba histolytica hypothetical protein 0.0077 0.0699 1
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0379 0.0835
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.006 0.0173
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.1781 0.1781
Loa Loa (eye worm) hypothetical protein 0.006 0.0524 0.1315
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0379 0.0379
Brugia malayi hypothetical protein 0.0156 0.1516 0.4125
Echinococcus multilocularis GPCR, family 2 0.0019 0.0099 0.0099
Trypanosoma cruzi metacaspase, putative 0.0046 0.0375 0.2801
Brugia malayi Importin beta-1 subunit 0.0032 0.0234 0.0495
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0234 0.1553
Brugia malayi hypothetical protein 0.0043 0.0343 0.0802
Loa Loa (eye worm) hypothetical protein 0.0043 0.0351 0.0826
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0124 0.1186 1
Onchocerca volvulus 0.0043 0.0351 0.2177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0351 0.0826
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0175 0.4972
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0124 0.1186 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0375 1
Plasmodium falciparum flap endonuclease 1 0.0029 0.0201 0.4496
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0099 0.0112
Brugia malayi mbt repeat family protein 0.0046 0.0379 0.0906
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0201 0.1259
Plasmodium vivax importin-beta 2, putative 0.0032 0.0234 0.5545
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0201 0.0402
Treponema pallidum bacterioferrin (TpF1) 0.0009 0 0.5
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0106 0.3016
Echinococcus multilocularis caspase 2 0.0088 0.0815 0.0815
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0099 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0124 0.1186 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0099 0.0218
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0095 0.0343
Entamoeba histolytica hypothetical protein 0.0077 0.0699 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0095 0.0343
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0124 0.1186 1
Echinococcus granulosus neuropeptide s receptor 0.045 0.4542 1
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0234 0.5545
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0375 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0351 0.9365
Trypanosoma cruzi metacaspase, putative 0.0046 0.0375 0.2801
Trypanosoma cruzi metacaspase, putative 0.0046 0.0375 0.2801
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0124 0.1186 1
Schistosoma mansoni hypothetical protein 0.0281 0.28 0.8134
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0121 0.1151 0.2534
Brugia malayi Flap endonuclease-1 0.0029 0.0201 0.0402
Echinococcus multilocularis caspase 3 0.0075 0.0679 0.0679
Echinococcus granulosus importin subunit beta 1 0.0032 0.0234 0.0516
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0379 0.0379
Echinococcus granulosus caspase 3 0.0075 0.0679 0.1495
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0491 0.108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0095 0.0343
Schistosoma mansoni flap endonuclease-1 0.0026 0.0173 0.0502
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.006 0.0131
Onchocerca volvulus Cell death protein 3 homolog 0.0088 0.0815 0.5291
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.4542 0.4542
Brugia malayi jmjC domain containing protein 0.0057 0.0491 0.1221
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0234 0.1553
Brugia malayi beta-lactamase 0.0043 0.0351 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0375 1
Mycobacterium ulcerans hypothetical protein 0.0026 0.0175 0.4972
Echinococcus multilocularis snurportin 1 0.0343 0.3443 0.3443
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0099 0.0218
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0351 0.0826
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0343 0.0754
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0201 0.4496
Brugia malayi follicle stimulating hormone receptor 0.0261 0.259 0.7169
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0175 0.4972
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.006 0.006
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0106 0.147
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0351 0.0773
Loa Loa (eye worm) hypothetical protein 0.0088 0.0815 0.2139
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0699 0.2031
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0375 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0379 0.0906
Echinococcus multilocularis geminin 0.0205 0.2013 0.2013
Trypanosoma cruzi metacaspase, putative 0.0046 0.0375 0.2801
Schistosoma mansoni caspase-7 (C14 family) 0.0121 0.1151 0.3344
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0175 0.1022
Echinococcus granulosus geminin 0.0205 0.2013 0.4431
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0375 0.2801
Echinococcus multilocularis caspase 8 0.0046 0.0375 0.0375
Trypanosoma brucei metacaspase MCA2 0.0046 0.0375 0.2801
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0351 0.102
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.006 0.0131
Entamoeba histolytica hypothetical protein 0.0077 0.0699 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0351 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0175 0.4972
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0351 0.9245
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0375 1
Leishmania major hypothetical protein, conserved 0.0043 0.0351 0.2589
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0172 0.4579
Mycobacterium tuberculosis Conserved protein 0.0043 0.0351 0.1269
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0524 0.1315
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0124 0.1186 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0175 0.1022
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0491 0.0491
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0175 0.4972
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0175 0.0055
Schistosoma mansoni hypothetical protein 0.003 0.0215 0.0624
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0351 0.0826
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0351 0.102
Loa Loa (eye worm) hypothetical protein 0.0156 0.1516 0.4125
Brugia malayi hypothetical protein 0.0077 0.0699 0.1812
Loa Loa (eye worm) hypothetical protein 0.0043 0.0351 0.0826
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0175 0.0631
Schistosoma mansoni hypothetical protein 0.003 0.0215 0.0624
Plasmodium falciparum importin beta, putative 0.0032 0.0234 0.5545
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0351 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0375 1
Trypanosoma brucei metacaspase MCA3 0.0046 0.0375 0.2801
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 0.3443 0.9585
Schistosoma mansoni hypothetical protein 0.0205 0.2013 0.5846
Loa Loa (eye worm) hypothetical protein 0.0053 0.0445 0.1093
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0491 0.1425
Brugia malayi beta-lactamase family protein 0.0043 0.0351 0.0826
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0351 0.1269
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0351 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.006 0.0131
Echinococcus multilocularis protein quaking 0.003 0.0215 0.0215
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0175 0.4972
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0124 0.1186 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0351 0.1269
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0099 0.0099
Leishmania major metacaspase, putative 0.0046 0.0375 0.2801
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.1781 0.3922
Trypanosoma brucei calpain-like protein, putative 0.0124 0.1186 1
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0379 0.0906
Brugia malayi RNA, U transporter 1 0.0091 0.0846 0.2227
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0201 0.0201
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0343 0.0343
Echinococcus granulosus neuropeptide receptor A26 0.045 0.4542 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0491 0.0491
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0351 0.1269
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0351 0.1269
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0375 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0375 1
Echinococcus granulosus caspase 0.0121 0.1151 0.2534
Echinococcus granulosus hypothetical protein 0.003 0.0215 0.0473
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0112
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0172 0.4579
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0375 0.2801
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0326
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0124 0.1186 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0375 0.0894
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0175 0.0326
Trichomonas vaginalis esterase, putative 0.0043 0.0351 0.9365
Plasmodium falciparum metacaspase-like protein 0.0046 0.0375 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0175 0.0055
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0201 0.0562
Schistosoma mansoni importin beta-1 0.0032 0.0234 0.0681
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0375 0.2801
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0201 0.4496
Schistosoma mansoni hypothetical protein 0.0019 0.0099 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0327 0.0758
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0175 0.0326
Mycobacterium tuberculosis Conserved protein 0.0043 0.0351 0.1269
Loa Loa (eye worm) hypothetical protein 0.0046 0.0375 0.0894
Schistosoma mansoni hypothetical protein 0.0019 0.0099 0.0288
Schistosoma mansoni hypothetical protein 0.0343 0.3443 1
Schistosoma mansoni caspase-3 (C14 family) 0.0121 0.1151 0.3344
Echinococcus granulosus flap endonuclease 1 0.0029 0.0201 0.0443
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0445 0.1093
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0131
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.006 0.0173
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0375 1
Trypanosoma brucei calpain, putative 0.0124 0.1186 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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