TDR Targets

Basic information

Technical information

TDR Targets ID: 1449751
Name: 5-(2-chlorophenyl)-2-[[4-(2-hydroxyphenyl)pip erazin-1-yl]methyl]-3H-thieno[3,2-e]pyrimidin -4-one
MW: 452.956 | Formula: C23H21ClN4O2S
H donors: 2 H acceptors: 4 LogP: 4.9 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccccc1N1CCN(CC1)Cc1nc(O)c2c(n1)scc2c1ccccc1Cl
InChi: 1S/C23H21ClN4O2S/c24-17-6-2-1-5-15(17)16-14-31-23-21(16)22(30)25-20(26-23)13-27-9-11-28(12-10-27)18-7-3-4-8-19(18)29/h1-8,14,29H,9-13H2,(H,25,26,30)
InChiKey: CLOWJYGSYZQMOQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

5-(2-chlorophenyl)-2-[[4-(2-hydroxyphenyl)-1-piperazinyl]methyl]-3H-thieno[3,2-e]pyrimidin-4-one
T5305075
MLS001002723
SMR000369180

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	l(3)mbt-like 1 (Drosophila)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130415	All targets in OG5_130415
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 4 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 3 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0414	0.4511	0.4511
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1321	0.1583
Brugia malayi	jmjC domain containing protein	0.0043	0.0165	0.0165
Trypanosoma cruzi	cardiolipin synthetase, putative	0.0308	0.327	1
Echinococcus granulosus	sorting nexin	0.0038	0.0115	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0115	0.0138
Onchocerca volvulus		0.0038	0.0115	0.0221
Trypanosoma brucei	PX domain containing protein, putative	0.0038	0.0115	0.0353
Echinococcus granulosus	sorting nexin 13	0.0038	0.0115	0.0085
Echinococcus granulosus	GPCR family 2	0.0131	0.12	0.1173
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.0141	0.1321	0.5
Giardia lamblia	Hypothetical protein	0.0038	0.0115	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0131	0.12	0.1173
Echinococcus granulosus	histone acetyltransferase MYST2	0.0066	0.0434	0.0405
Toxoplasma gondii	hypothetical protein	0.0038	0.0115	0.0353
Leishmania major	hypothetical protein, conserved	0.0038	0.0115	0.0714
Plasmodium vivax	WD domain, G-beta repeat domain containing protein	0.0038	0.0115	0.0873
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0079	0.0048
Plasmodium falciparum	phosphoinositide-binding protein, putative	0.0038	0.0115	0.0873
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0165	0.0198
Echinococcus multilocularis	sorting nexin 4	0.0038	0.0115	0.0085
Echinococcus multilocularis		0.0038	0.0115	0.0085
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0165	0.0135
Echinococcus multilocularis	ribosomal protein S6 kinase delta 1	0.0038	0.0115	0.0085
Loa Loa (eye worm)	PX domain-containing protein	0.0038	0.0115	0.0138
Giardia lamblia	hypothetical protein	0.0038	0.0115	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0079	0.024
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0517	0.062
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0165	0.0135
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0738	0.071
Onchocerca volvulus	Putative phospholipase D	0.0167	0.1616	0.922
Trypanosoma cruzi	cardiolipin synthetase, putative	0.0308	0.327	1
Brugia malayi	Sorting nexin 12	0.0038	0.0115	0.0115
Schistosoma mansoni	phospholipase D	0.0883	1	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0066	0.0434	0.0405
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.0141	0.1321	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0038	0.0115	0.0138
Schistosoma mansoni	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	0.0141	0.1321	0.1295
Loa Loa (eye worm)	hypothetical protein	0.0575	0.6396	0.7664
Leishmania major	phosphatidylglycerophosphate synthase, putative	0.0167	0.1616	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0066	0.0434	0.0405
Loa Loa (eye worm)	MBCTL1	0.0066	0.0434	0.052
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.1016	0.0988
Leishmania major	cardiolipin synthetase, putative	0.0141	0.1321	0.8176
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0414	0.4511	0.4511
Echinococcus granulosus	ribosomal protein S6 kinase delta 1	0.0038	0.0115	0.0085
Brugia malayi	mbt repeat family protein	0.0058	0.0341	0.0341
Brugia malayi	isocitrate dehydrogenase	0.0031	0.003	0.003
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0038	0.0115	0.0085
Brugia malayi	PX domain containing protein	0.0038	0.0115	0.0115
Schistosoma mansoni	sorting nexin	0.0038	0.0115	0.0085
Trypanosoma brucei	phosphatidylglycerolphosphate synthase, mitochondrial	0.0141	0.1321	0.404
Loa Loa (eye worm)	hypothetical protein	0.006	0.0373	0.0447
Echinococcus multilocularis	phospholipase D	0.078	0.8794	0.8791
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0341	0.0311
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0079	0.0048
Echinococcus granulosus	SAM and MBT domain containing protein	0.0058	0.0341	0.0311
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.024	0.021
Schistosoma mansoni	hypothetical protein	0.0131	0.12	0.1173
Loa Loa (eye worm)	hypothetical protein	0.0131	0.12	0.1437
Brugia malayi	Isocitrate dehydrogenase	0.0031	0.003	0.003
Plasmodium falciparum	mitochondrial cardiolipin synthase, putative	0.0141	0.1321	1
Schistosoma mansoni	hypothetical protein	0.0131	0.12	0.1173
Brugia malayi	PXA domain containing protein	0.0038	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0575	0.6396	0.7664
Echinococcus multilocularis	phospholipase d3	0.0167	0.1616	0.159
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Onchocerca volvulus		0.0058	0.0341	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0341	0.0408
Brugia malayi	PXA domain containing protein	0.0038	0.0115	0.0115
Echinococcus multilocularis	Phox	0.0038	0.0115	0.0085
Trypanosoma cruzi	hypothetical protein	0.0038	0.0115	0.0353
Brugia malayi	N-terminal motif family protein	0.0178	0.1746	0.1746
Trypanosoma cruzi	PX domain containing protein, putative	0.0038	0.0115	0.0353
Trypanosoma cruzi	Autophagy-related protein 24	0.0038	0.0115	0.0353
Trypanosoma cruzi	PX domain containing protein, putative	0.0038	0.0115	0.0353
Echinococcus multilocularis	GPCR, family 2	0.0131	0.12	0.1173
Trypanosoma brucei	PX domain containing protein, putative	0.0038	0.0115	0.0353
Echinococcus multilocularis	sorting nexin	0.0038	0.0115	0.0085
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0058	0.0341	0.1571
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0079	0.0595
Entamoeba histolytica	hypothetical protein	0.0055	0.0312	0.0199
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0079	0.0595
Schistosoma mansoni	sorting nexin	0.0038	0.0115	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0079	0.0094
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0031	0.003	0.0093
Echinococcus multilocularis	phospholipase D1	0.0883	1	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0066	0.0434	0.0434
Brugia malayi	mbt repeat family protein	0.0058	0.0341	0.0341
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.003	0.0093
Giardia lamblia	Hypothetical protein	0.0038	0.0115	1
Leishmania major	zinc finger protein kinase-like	0.0038	0.0115	0.0714
Leishmania major	phosphoinositide-binding protein, putative	0.0038	0.0115	0.0714
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0341	0.0311
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0178	0.1746	1
Entamoeba histolytica	phospholipase D, putative	0.0883	1	1
Brugia malayi	Bromodomain containing protein	0.0035	0.0079	0.0079
Echinococcus granulosus	phospholipase d3	0.0167	0.1616	0.159
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0414	0.4511	0.5406
Schistosoma mansoni	hypothetical protein	0.0131	0.12	0.1173
Trypanosoma cruzi	PX domain containing protein, putative	0.0038	0.0115	0.0353
Loa Loa (eye worm)	phospholipase D	0.0167	0.1616	0.1936
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.0141	0.1321	0.5
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0079	0.0094
Echinococcus multilocularis	sorting nexin 2	0.0038	0.0115	0.0085
Schistosoma mansoni	hypothetical protein	0.0283	0.2978	0.2957
Echinococcus granulosus	sorting nexin	0.0038	0.0115	0.0085
Plasmodium falciparum	phosphoinositide-binding protein, putative	0.0038	0.0115	0.0873
Schistosoma mansoni	sorting nexin	0.0038	0.0115	0.0085
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0079	0.024
Schistosoma mansoni	hypothetical protein	0.0035	0.0079	0.0048
Trypanosoma brucei	cardiolipin synthetase, putative	0.0308	0.327	1
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0038	0.0115	0.0138
Echinococcus granulosus	sorting nexin 6	0.0038	0.0115	0.0085
Loa Loa (eye worm)	sorting nexin 12	0.0038	0.0115	0.0138
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0131	0.12	0.12
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0165	0.0135
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.003	0.0188
Brugia malayi	Phospholipase D. Active site motif family protein	0.0308	0.327	0.327
Schistosoma mansoni	hypothetical protein	0.0131	0.12	0.1173
Loa Loa (eye worm)	TRAF4-associated factor 2	0.0038	0.0115	0.0138
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0227	0.2322	0.2299
Echinococcus multilocularis	nischarin	0.0038	0.0115	0.0085
Wolbachia endosymbiont of Brugia malayi	cardiolipin synthase	0.0141	0.1321	0.5
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0058	0.0341	0.0311
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.003	0.0093
Schistosoma mansoni	sorting nexin	0.0038	0.0115	0.0085
Plasmodium vivax	cardiolipin synthetase, putative	0.0141	0.1321	1
Trypanosoma cruzi	hypothetical protein	0.0038	0.0115	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0742	0.8346	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0031	0.003	0.5
Echinococcus granulosus	phospholipase D1	0.0883	1	1
Echinococcus granulosus	phospholipase D	0.078	0.8794	0.8791
Brugia malayi	hypothetical protein	0.0141	0.1321	0.1321
Loa Loa (eye worm)	PXA domain-containing protein	0.0038	0.0115	0.0138
Echinococcus multilocularis	sorting nexin 14	0.0038	0.0115	0.0085
Entamoeba histolytica	phospholipase D active site domain-containing protein	0.0742	0.8346	0.8326
Echinococcus granulosus	sorting nexin 4	0.0038	0.0115	0.0085
Loa Loa (eye worm)	PX domain-containing protein	0.0038	0.0115	0.0138
Giardia lamblia	Hypothetical protein	0.0038	0.0115	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0066	0.0434	0.0405
Echinococcus multilocularis	sorting nexin	0.0038	0.0115	0.0085
Entamoeba histolytica	phospholipase D, putative	0.0883	1	1
Trypanosoma brucei	differentiation inhibitory kinase	0.0038	0.0115	0.0353
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.003	0.0093
Chlamydia trachomatis	phospholipase D superfamily protein	0.0141	0.1321	0.5
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0079	0.0048
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0038	0.0115	0.0353
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0115	0.0138
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0038	0.0115	0.0115
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0131	0.12	0.1437
Echinococcus multilocularis	sorting nexin 6	0.0038	0.0115	0.0085
Brugia malayi	latrophilin 2 splice variant baaae	0.0283	0.2978	0.2978
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0165	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0115	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1616	0.1936
Trypanosoma cruzi	zinc finger protein kinase, putative	0.0038	0.0115	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0434	0.052
Echinococcus granulosus	polycomb protein SCMH1	0.0058	0.0341	0.0311
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.0141	0.1321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0742	0.8346	1
Schistosoma mansoni	hypothetical protein	0.035	0.3763	0.3744
Chlamydia trachomatis	phospholipase D superfamily protein	0.0141	0.1321	0.5
Echinococcus multilocularis	polycomb protein SCMH1	0.0058	0.0341	0.0311
Brugia malayi	PX domain containing protein	0.0038	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1746	0.2092
Brugia malayi	PX domain containing protein	0.0038	0.0115	0.0115
Echinococcus granulosus	nischarin	0.0038	0.0115	0.0085
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.024	0.021
Plasmodium falciparum	phosphatidylglycerophosphate synthase	0.0141	0.1321	1
Brugia malayi	PHD-finger family protein	0.0035	0.0079	0.0079
Trypanosoma brucei	Autophagy-related protein 24	0.0038	0.0115	0.0353
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.003	0.0093
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0058	0.0341	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0115	0.0138
Brugia malayi	Phospholipase D. Active site motif family protein	0.0167	0.1616	0.1616
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Brugia malayi	PX domain containing protein	0.0038	0.0115	0.0115
Trypanosoma brucei	cardiolipin synthetase	0.0308	0.327	1
Echinococcus granulosus	sorting nexin 2	0.0038	0.0115	0.0085
Brugia malayi	PX domain containing protein	0.0038	0.0115	0.0115
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0031	0.003	0.023
Plasmodium vivax	phosphatidylglycerophosphate synthase, putative	0.0141	0.1321	1
Giardia lamblia	Hypothetical protein	0.0038	0.0115	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0131	0.12	0.1173
Loa Loa (eye worm)	PX domain-containing protein	0.0038	0.0115	0.0138
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0031	0.003	0.0093
Echinococcus granulosus	Phox	0.0038	0.0115	0.0085
Echinococcus granulosus	peregrin	0.0035	0.0079	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0414	0.4511	0.5406
Trypanosoma cruzi	hypothetical protein	0.0038	0.0115	0.0353
Echinococcus granulosus	sorting nexin 14	0.0038	0.0115	0.0085
Onchocerca volvulus		0.0038	0.0115	0.0221
Echinococcus multilocularis	peregrin	0.0035	0.0079	0.0048
Schistosoma mansoni	sortingnexin-related	0.0038	0.0115	0.0085
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0066	0.0434	0.0405
Trypanosoma cruzi	Autophagy-related protein 24	0.0038	0.0115	0.0353
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0031	0.003	0.023
Giardia lamblia	Liver stage antigen-like protein	0.0038	0.0115	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0115	0.5
Toxoplasma gondii	phospholipase D active site domain-containing protein	0.0308	0.327	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0131	0.12	0.1173
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0115	0.0873
Brugia malayi	TRAF4-associated factor 2	0.0038	0.0115	0.0115
Brugia malayi	Variant SH3 domain containing protein	0.0038	0.0115	0.0115
Loa Loa (eye worm)	mbt repeat family protein	0.0058	0.0341	0.0408
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0131	0.12	0.1173
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0031	0.003	0.0036
Brugia malayi	jmjC domain containing protein	0.0115	0.1016	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0283	0.2978	0.3569
Brugia malayi	PX domain containing protein	0.0038	0.0115	0.0115
Brugia malayi	Latrophilin receptor protein 2	0.0131	0.12	0.12
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0227	0.2322	0.2299
Brugia malayi	Protein K4	0.0141	0.1321	0.1321
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.1016	0.0988

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.2213 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	20.5878 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (binding)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1589087

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1449751