Detailed information for compound 1451383

Basic information

Technical information
  • TDR Targets ID: 1451383
  • Name: 2-(dipropylamino)-N-[(1-phenylcyclopentyl)met hyl]propanamide hydrochloride
  • MW: 366.968 | Formula: C21H35ClN2O
  • H donors: 1 H acceptors: 1 LogP: 5.93 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(C(=O)NCC1(CCCC1)c1ccccc1)C)CCC.Cl
  • InChi: 1S/C21H34N2O.ClH/c1-4-15-23(16-5-2)18(3)20(24)22-17-21(13-9-10-14-21)19-11-7-6-8-12-19;/h6-8,11-12,18H,4-5,9-10,13-17H2,1-3H3,(H,22,24);1H
  • InChiKey: WBDGRCCIHSGSML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(dipropylamino)-N-[(1-phenylcyclopentyl)methyl]propionamide hydrochloride
  • MLS000709863
  • SMR000287026

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0163 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0106
Entamoeba histolytica hypothetical protein 0.0028 0.0125 1
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0028 0.0119 0.0157
Trichomonas vaginalis ran, putative 0.0026 0.009 0.6905
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0051 0.2567
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0163 0.6938
Onchocerca volvulus 0.0028 0.0119 0.0146
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.009 0.2408
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0163 0.6938
Schistosoma mansoni dishevelled 0.0028 0.0119 0.0157
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0125 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0163 0.0198
Echinococcus granulosus tar DNA binding protein 0.059 0.7581 1
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0163 0.6938
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1665 0.1654
Schistosoma mansoni ap endonuclease 0.0023 0.0051 0.0068
Schistosoma mansoni hypothetical protein 0.0244 0.2993 0.3948
Leishmania major GTP-binding protein, putative 0.0026 0.009 0.3471
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0244 0.2993 0.3937
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0051 0.3444
Echinococcus granulosus importin subunit beta 1 0.0035 0.0212 0.0263
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0163 0.0198
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0051 0.3444
Schistosoma mansoni tar DNA-binding protein 0.059 0.7581 1
Brugia malayi hypothetical protein 0.0028 0.0119 0.0106
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0051 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0527 0.6757 0.6753
Loa Loa (eye worm) hypothetical protein 0.0244 0.2993 0.2984
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0119 0.014
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0013 0.0017
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0013 0.0017
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0163 1
Brugia malayi DIX domain containing protein 0.0028 0.0119 0.0106
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.009 0.2408
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0163 1
Echinococcus multilocularis GPCR, family 2 0.0244 0.2993 0.3937
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0106
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0119 0.014
Schistosoma mansoni hypothetical protein 0.0244 0.2993 0.3948
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.002 0.0013 0.0017
Entamoeba histolytica Ran family GTPase 0.0026 0.009 0.6905
Loa Loa (eye worm) DIX domain-containing protein 0.0028 0.0119 0.0106
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0051 0.0039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0244 0.2993 0.3937
Brugia malayi RNA binding protein 0.059 0.7581 0.7578
Schistosoma mansoni dep domain containing protein 0.0028 0.0119 0.0157
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0028 0.0119 0.0146
Loa Loa (eye worm) latrophilin receptor protein 2 0.0244 0.2993 0.2984
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0125 1
Echinococcus granulosus GPCR family 2 0.0244 0.2993 0.3937
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.059 0.7581 0.7578
Loa Loa (eye worm) hypothetical protein 0.0772 1 1
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0119 0.0157
Leishmania major importin beta-1 subunit, putative 0.0028 0.0125 0.6575
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0119 0.014
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0119 0.014
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.009 0.0102
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0051 0.0039
Schistosoma mansoni hypothetical protein 0.0244 0.2993 0.3948
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0212 1
Schistosoma mansoni ran 0.0026 0.009 0.0119
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0125 0.7454
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.009 0.5147
Brugia malayi Latrophilin receptor protein 2 0.0244 0.2993 0.2984
Schistosoma mansoni ras GTP exchange factor 0.002 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0527 0.6757 0.6753
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.009 0.0102
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0013 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0772 1 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0212 1
Schistosoma mansoni dishevelled 0.0028 0.0119 0.0157
Schistosoma mansoni tar DNA-binding protein 0.059 0.7581 1
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0163 0.6938
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0119 0.014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0051 0.0051
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0212 1
Schistosoma mansoni tar DNA-binding protein 0.059 0.7581 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.009 0.2408
Schistosoma mansoni hypothetical protein 0.0244 0.2993 0.3948
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0051 0.5
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0119 0.0106
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0163 0.0198
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0212 1
Plasmodium falciparum importin beta, putative 0.0035 0.0212 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0163 0.6938
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0051 0.0051
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.009 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0772 1 1
Schistosoma mansoni hypothetical protein 0.0372 0.4688 0.6183
Echinococcus multilocularis snurportin 1 0.0372 0.4688 0.6177
Brugia malayi TAR-binding protein 0.059 0.7581 0.7578
Loa Loa (eye worm) hypothetical protein 0.0565 0.725 0.7246
Schistosoma mansoni ran 0.0026 0.009 0.0119
Toxoplasma gondii hypothetical protein 0.0028 0.0119 0.4191
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.009 0.5147
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.009 0.2408
Schistosoma mansoni importin beta-1 0.0035 0.0212 0.028
Schistosoma mansoni tar DNA-binding protein 0.059 0.7581 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0212 0.02
Echinococcus granulosus Pleckstrin G protein interacting region 0.0028 0.0119 0.014
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1665 0.1654
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0119 0.014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0163 0.0198
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0119 0.014
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4688 0.4681
Brugia malayi hypothetical protein 0.0028 0.0119 0.0106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0051 0.2567
Schistosoma mansoni ap endonuclease 0.0023 0.0051 0.0068
Schistosoma mansoni hypothetical protein 0.0527 0.6757 0.8912
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0119 0.0106
Loa Loa (eye worm) TAR-binding protein 0.059 0.7581 0.7578
Loa Loa (eye worm) RNA binding protein 0.059 0.7581 0.7578
Brugia malayi isocitrate dehydrogenase 0.0031 0.0163 0.015
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0163 0.6938
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0244 0.2993 0.3937
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.009 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0028 0.0119 0.014
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0119 0.0106
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0163 0.0215
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0119 0.014
Brugia malayi RNA recognition motif domain containing protein 0.059 0.7581 0.7578
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0565 0.725 1
Brugia malayi MH2 domain containing protein 0.0144 0.1665 0.1654
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0163 1
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0163 0.015
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0119 0.0106
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0163 0.0198
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0051 0.5
Echinococcus multilocularis tar DNA binding protein 0.059 0.7581 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0163 0.0198
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0244 0.2993 0.2984
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.02
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0051 0.3444
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0125 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.009 0.0077
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0212 0.0263
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0119 0.0157
Brugia malayi N-terminal motif family protein 0.0565 0.725 0.7246
Brugia malayi RNA, U transporter 1 0.0099 0.1065 0.1054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0244 0.2993 0.3937
Schistosoma mansoni tar DNA-binding protein 0.059 0.7581 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0163 0.015
Echinococcus granulosus snurportin 1 0.0372 0.4688 0.6177

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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