Detailed information for compound 1451956

Basic information

Technical information
  • TDR Targets ID: 1451956
  • Name: N-[(4-ethylphenyl)methyl]-5-methyl-3-(4-methy lphenyl)-4-oxopyridazino[5,4-b]indole-1-carbo xamide
  • MW: 450.532 | Formula: C28H26N4O2
  • H donors: 1 H acceptors: 2 LogP: 5.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)CNC(=O)c1nn(c2ccc(cc2)C)c(=O)c2c1c1ccccc1n2C
  • InChi: 1S/C28H26N4O2/c1-4-19-11-13-20(14-12-19)17-29-27(33)25-24-22-7-5-6-8-23(22)31(3)26(24)28(34)32(30-25)21-15-9-18(2)10-16-21/h5-16H,4,17H2,1-3H3,(H,29,33)
  • InChiKey: ARXUBAKYMMOYSC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(4-ethylphenyl)methyl]-5-methyl-3-(4-methylphenyl)-4-oxo-pyridazino[5,4-b]indole-1-carboxamide
  • N-[(4-ethylphenyl)methyl]-5-methyl-3-(4-methylphenyl)-4-oxo-1-pyridazino[5,4-b]indolecarboxamide
  • N-(4-ethylbenzyl)-4-keto-5-methyl-3-(4-methylphenyl)pyridazino[5,4-b]indole-1-carboxamide
  • C448-1616
  • NCGC00108641-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens galactosylceramidase No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Onchocerca volvulus Alhambra homolog 0.0035 0.028 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.063 0.0728
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.1124 0.0224
Brugia malayi eukaryotic initiation factor 4A 0.0337 0.7159 1
Treponema pallidum ATP-dependent RNA helicase 0.0337 0.7159 0.5
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.1124 0.0224
Mycobacterium ulcerans hypothetical protein 0.0072 0.1124 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1235 0.1383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.063 0.088
Brugia malayi Heterochromatin protein 1 0.0071 0.1089 0.124
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2108 0.2944
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.063 0.0728
Loa Loa (eye worm) beta-lactamase 0.0072 0.1124 0.1346
Brugia malayi hypothetical protein 0.0051 0.0643 0.0596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.1124 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0283 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1124 0.1223
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0449 0.0628
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0643 0.0527
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1124 0.1431
Echinococcus granulosus chromobox protein 1 0.0071 0.1089 0.1521
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1235 0.1383
Brugia malayi jmjC domain containing protein 0.0043 0.0449 0.0317
Brugia malayi chromobox protein homolog 3 0.004 0.0381 0.0218
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.1124 0.1291
Loa Loa (eye worm) hypothetical protein 0.0072 0.1124 0.1346
Echinococcus multilocularis chromobox protein 1 0.0071 0.1089 0.1521
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.063 0.0504
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.028 0.0392
Loa Loa (eye worm) hypothetical protein 0.0051 0.0643 0.0656
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0643 0.002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.1124 0.157
Mycobacterium ulcerans beta-lactamase 0.0072 0.1124 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0386 0.0288
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.063 0.0728
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1136 0.1362
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0386 0.0226
Schistosoma mansoni hypothetical protein 0.0164 0.3221 0.3535
Brugia malayi Protein kinase domain containing protein 0.0035 0.0283 0.0078
Echinococcus granulosus chromobox protein 1 0.0071 0.1089 0.1521
Trichomonas vaginalis chromobox protein, putative 0.0071 0.1089 0.138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0643 0.0522
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0337 0.7159 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0807 0.0892
Mycobacterium tuberculosis Conserved protein 0.0072 0.1124 0.0224
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0337 0.7159 1
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.1124 0.0757
Schistosoma mansoni hypothetical protein 0.0164 0.3221 0.3535
Onchocerca volvulus 0.0146 0.2807 0.376
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.1089 0.1295
Onchocerca volvulus 0.0072 0.1124 0.1346
Plasmodium vivax hypothetical protein, conserved 0.0072 0.1124 0.1227
Brugia malayi beta-lactamase family protein 0.0072 0.1124 0.1291
Leishmania major eukaryotic initiation factor 4a, putative 0.0337 0.7159 1
Schistosoma mansoni hypothetical protein 0.0035 0.0283 0.0311
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0283 0.0396
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1124 0.1431
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0283 0.0004
Brugia malayi Kringle domain containing protein 0.0035 0.0283 0.0078
Schistosoma mansoni chromobox protein 0.0071 0.1089 0.1195
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.063 0.0728
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1124 0.1234
Onchocerca volvulus 0.0035 0.0283 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.028 0.0136
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.063 0.0508
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.1124 0.1346
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0921 0.1287
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0643 0.0527
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0337 0.7159 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.063 0.0504
Schistosoma mansoni chromobox protein 0.0071 0.1089 0.1195
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0283 0.014
Schistosoma mansoni hypothetical protein 0.0035 0.028 0.0308
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1082 0.1162
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0449 0.0472
Echinococcus multilocularis geminin 0.0164 0.3221 0.4499
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1124 0.1431
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0643 0.0527
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.1124 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0807 0.0892
Echinococcus multilocularis chromobox protein 1 0.0071 0.1089 0.1521
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1235 0.1383
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.063 0.0691
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.063 0.0508
Loa Loa (eye worm) hypothetical protein 0.0072 0.1124 0.1346
Trichomonas vaginalis chromobox protein, putative 0.0071 0.1089 0.138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Mycobacterium leprae conserved hypothetical protein 0.0072 0.1124 0.5
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0381 0.0374
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0337 0.7159 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.063 0.0637
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.028 0.0136
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.028 0.0392
Echinococcus granulosus peregrin 0.0035 0.028 0.0392
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1124 0.1223
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0337 0.7159 1
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0283 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0449 0.0378
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0449 0.0628
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0283 0.0004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0381 0.028
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0921 0.1011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0807 0.0833
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.1124 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Leishmania major hypothetical protein, conserved 0.0051 0.0643 0.0522
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0595 0.0831
Toxoplasma gondii ABC1 family protein 0.0072 0.1124 0.1227
Plasmodium vivax RNA helicase-1, putative 0.0337 0.7159 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0337 0.7159 0.7857
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0449 0.0472
Loa Loa (eye worm) hypothetical protein 0.0337 0.7159 1
Echinococcus granulosus geminin 0.0164 0.3221 0.4499
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.063 0.0504
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.1124 0.0224
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.1124 0.157
Brugia malayi PHD-finger family protein 0.0035 0.028 0.0073
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.1124 0.0224
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0337 0.7159 1
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1567 0.172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Leishmania major cathepsin L-like protease 0.0077 0.1235 0.1383
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0337 0.7159 1
Mycobacterium leprae Probable lipase LipE 0.0072 0.1124 0.5
Brugia malayi jmjC domain containing protein 0.0115 0.2108 0.271
Plasmodium falciparum eukaryotic initiation factor 4A 0.0337 0.7159 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0381 0.0374
Brugia malayi hypothetical protein 0.0146 0.2807 0.372
Mycobacterium ulcerans lipase LipD 0.0072 0.1124 1
Onchocerca volvulus 0.0072 0.1124 0.1346
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0449 0.0493
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0643 0.0527
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0921 0.1011
Leishmania major hypothetical protein, conserved 0.0072 0.1124 0.1223
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0337 0.7159 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0381 0.028
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0337 0.7159 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0337 0.7159 1
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0337 0.7159 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0449 0.0378
Mycobacterium tuberculosis Conserved protein 0.0072 0.1124 0.0224
Leishmania major eukaryotic initiation factor 4a, putative 0.0337 0.7159 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0921 0.0927
Brugia malayi MAP kinase sur-1 0.0051 0.063 0.0577
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.063 0.0504
Loa Loa (eye worm) hypothetical protein 0.006 0.0854 0.0959
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0449 0.0493
Loa Loa (eye worm) hypothetical protein 0.0072 0.1124 0.1346
Loa Loa (eye worm) hypothetical protein 0.0072 0.1124 0.1346
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2108 0.2944
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0859 0.0836
Brugia malayi beta-lactamase family protein 0.0072 0.1124 0.1291
Loa Loa (eye worm) hypothetical protein 0.0072 0.1124 0.1346
Brugia malayi Bromodomain containing protein 0.0035 0.028 0.0073
Loa Loa (eye worm) hypothetical protein 0.0146 0.2807 0.376
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0921 0.0931
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0921 0.1287
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.1124 1
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0283 0.0396
Echinococcus multilocularis peregrin 0.0035 0.028 0.0392
Brugia malayi beta-lactamase 0.0072 0.1124 0.1291
Leishmania major cathepsin L-like protease 0.0077 0.1235 0.1383
Schistosoma mansoni hypothetical protein 0.004 0.0386 0.0424
Leishmania major cathepsin L-like protease 0.0077 0.1235 0.1383
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0337 0.7159 0.7857
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.063 0.088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0337 0.7159 0.6871
Loa Loa (eye worm) hypothetical protein 0.0072 0.1124 0.1346
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1124 0.1431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1235 0.0926
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0337 0.7159 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.063 0.0504
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0337 0.7159 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1235 0.1383
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1124 0.1431
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0595 0.0831
Schistosoma mansoni memapsin-2 (A01 family) 0.0422 0.9112 1
Onchocerca volvulus 0.0072 0.1124 0.1346
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.063 0.0504
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.028 0.0308
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.063 0.088
Echinococcus granulosus eukaryotic initiation factor 4A 0.0337 0.7159 1
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.063 0.088
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0643 0.0522
Trichomonas vaginalis esterase, putative 0.0072 0.1124 0.1431
Mycobacterium tuberculosis Conserved protein 0.0072 0.1124 0.0224
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.1124 0.0224
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1124 0.1234
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0807 0.0833

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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