Detailed information for compound 1454093

Basic information

Technical information
  • TDR Targets ID: 1454093
  • Name: 3-methoxy-N-(1-morpholin-4-yl-1-thiophen-2-yl propan-2-yl)benzamide
  • MW: 360.47 | Formula: C19H24N2O3S
  • H donors: 1 H acceptors: 1 LogP: 2.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)NC(C(c1cccs1)N1CCOCC1)C
  • InChi: 1S/C19H24N2O3S/c1-14(20-19(22)15-5-3-6-16(13-15)23-2)18(17-7-4-12-25-17)21-8-10-24-11-9-21/h3-7,12-14,18H,8-11H2,1-2H3,(H,20,22)
  • InChiKey: SENKLYNXEAKKAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-methoxy-N-[1-methyl-2-morpholino-2-(2-thienyl)ethyl]benzamide
  • 3-methoxy-N-(1-morpholin-4-yl-1-thiophen-2-yl-propan-2-yl)benzamide
  • MLS000529992
  • IDI1_009444
  • SMR000126999
  • IFLab1_002985

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.007 0.0602 0.0573
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0258 0.3315 0.3315
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0187 0.2291 0.2266
Loa Loa (eye worm) hypothetical protein 0.0722 1 1
Leishmania major farnesyltransferase beta subunit 0.0258 0.3315 1
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0258 0.3315 0.3251
Trypanosoma cruzi protein farnesyltransferase, putative 0.0258 0.3315 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0389 0.0297
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.2291 0.6912
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0258 0.3315 0.3293
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0722 1 1
Giardia lamblia Rab geranylgeranyltransferase 0.0722 1 1
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.007 0.0602 0.0573
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0187 0.2291 0.6882
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0389 0.0297
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0032 0.0096
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0187 0.2291 0.6912
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0722 1 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0722 1 1
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.007 0.0602 0.0602
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0602 0.1818
Trypanosoma cruzi lanosterol synthase, putative 0.007 0.0602 0.1818
Echinococcus multilocularis snurportin 1 0.0372 0.4953 0.4904
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0187 0.2291 0.6912
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0187 0.2291 0.2291
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.007 0.0602 0.0512
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0187 0.2291 0.2217
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0187 0.2291 0.2291
Plasmodium vivax geranylgeranyltransferase, putative 0.007 0.0602 0.0573
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0188 0.2305 0.228
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0187 0.2291 0.2217
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0258 0.3315 0.3315
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0389 0.0297
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0389 0.0297
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.007 0.0602 0.5
Trypanosoma cruzi lanosterol synthase, putative 0.007 0.0602 0.1818
Leishmania major hypothetical protein, conserved 0.003 0.0032 0.0096
Onchocerca volvulus 0.0187 0.2291 0.5
Toxoplasma gondii hypothetical protein 0.0535 0.7302 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0095 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.2291 0.6882
Plasmodium vivax importin-beta 2, putative 0.0035 0.0095 0.0063
Echinococcus granulosus snurportin 1 0.0372 0.4953 0.4904
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0187 0.2291 0.6912
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.007 0.0602 0.0602
Plasmodium falciparum geranylgeranyltransferase, putative 0.007 0.0602 0.0573
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0187 0.2291 0.2266
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0722 1 1
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.007 0.0602 0.0785
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.007 0.0602 0.0602
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0535 0.7302 0.7302
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0187 0.2291 0.2217
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0032 0.0096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0095 0.0063
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.007 0.0602 0.1738
Schistosoma mansoni hypothetical protein 0.0372 0.4953 0.4904
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0095 0.0192
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0258 0.3315 0.3293
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4953 0.4937
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.007 0.0602 0.0573
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.007 0.0602 0.0512
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0187 0.2291 0.2217
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0258 0.3315 0.3315
Loa Loa (eye worm) hypothetical protein 0.007 0.0602 0.0573
Trypanosoma cruzi protein farnesyltransferase, putative 0.0258 0.3315 1
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0258 0.3315 0.4516
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0722 1 1
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0722 1 1
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0258 0.3315 1
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0258 0.3315 0.3293
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.007 0.0602 0.0512
Loa Loa (eye worm) hypothetical protein 0.007 0.0602 0.0573
Plasmodium falciparum importin beta, putative 0.0035 0.0095 0.0063
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0722 1 1
Giardia lamblia Rab geranylgeranyltransferase 0.0187 0.2291 0.1797
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0722 1 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0187 0.2291 0.2266
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.007 0.0602 0.0573
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.007 0.0602 0.0573
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.2291 0.6912
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0389 0.0297
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.007 0.0602 0.0602
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.007 0.0602 0.0785
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0187 0.2291 0.6912
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0187 0.2291 0.2266
Toxoplasma gondii hypothetical protein 0.0187 0.2291 0.3108
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.007 0.0602 0.0512
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.007 0.0602 0.0512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0389 0.0297
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0389 0.0359
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.007 0.0602 0.1818
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0722 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0389 0.0359
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0722 1 1
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0258 0.3315 0.3293
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0258 0.3315 0.3315
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.007 0.0602 0.0512
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0258 0.3315 0.3251
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0095 0.0192
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0187 0.2291 0.6882
Giardia lamblia Prenyltransferase 0.0258 0.3315 0.2886
Trypanosoma brucei lanosterol synthase 0.007 0.0602 0.1738
Brugia malayi Importin beta-1 subunit 0.0035 0.0095 0.0063
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0187 0.2291 0.2217
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0602 0.1818
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0258 0.3315 0.3315
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0258 0.3315 0.3251
Brugia malayi RNA, U transporter 1 0.0099 0.1021 0.0992
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0389 0.0297
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0187 0.2291 0.6882
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.007 0.0602 0.0602
Leishmania major geranylgeranyltransferase, putative 0.007 0.0602 0.1818
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0258 0.3315 0.3315
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0258 0.3315 0.3315

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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