Detailed information for compound 145514

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 694.323 | Formula: C22H36Br2FN4O8P
  • H donors: 3 H acceptors: 4 LogP: 1.24 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: BrCCN(P(=O)(OCC1OC(CC1O)n1cc(F)c(=O)[nH]c1=O)OCCC1OC(C)CC(N1)(C)C)CCBr
  • InChi: 1S/C22H36Br2FN4O8P/c1-14-11-22(2,3)27-18(36-14)4-9-34-38(33,28(7-5-23)8-6-24)35-13-17-16(30)10-19(37-17)29-12-15(25)20(31)26-21(29)32/h12,14,16-19,27,30H,4-11,13H2,1-3H3,(H,26,31,32)
  • InChiKey: HINZFAZKWQIKGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.0274
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0365 0.3873 0.3835
Loa Loa (eye worm) hypothetical protein 0.007 0.0642 0.0638
Brugia malayi Heterochromatin protein 1 0.0068 0.0621 0.0617
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0019
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0117 0.1155 0.1155
Brugia malayi hypothetical protein 0.0235 0.2444 0.2441
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0029 0.0194 0.0133
Echinococcus multilocularis cpg binding protein 0.0032 0.0228 0.0228
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.7364 0.7364
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0926 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0215 0.0196
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0029 0.0194 0.0315
Brugia malayi CXXC zinc finger family protein 0.003 0.0209 0.0205
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0322 0.0458
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2992 0.5858
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0642 0.1203
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.106 0.106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0541 0.0541
Mycobacterium tuberculosis Conserved protein 0.007 0.0642 0.1237
Brugia malayi SET domain containing protein 0.0014 0.0031 0.0028
Echinococcus multilocularis transient receptor potential ion channel A 0.0304 0.3196 0.3196
Loa Loa (eye worm) hypothetical protein 0.0117 0.1155 0.115
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0642 0.2973
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0061 0.0061
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0621 0.0616
Toxoplasma gondii exonuclease III APE 0.0041 0.0322 0.4485
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0642 0.0585
Loa Loa (eye worm) hypothetical protein 0.0314 0.331 0.3307
Echinococcus multilocularis chromobox protein 1 0.0068 0.0621 0.0621
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0835 0.9 0.9
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0326 0.0577
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.0106 0.104 0.1036
Loa Loa (eye worm) hypothetical protein 0.007 0.0642 0.0638
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0662 0.0645
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0075 0.008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0215 0.0215
Mycobacterium ulcerans hypothetical protein 0.007 0.0642 0.2973
Entamoeba histolytica hypothetical protein 0.0108 0.106 0.3095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0603 0.0586
Echinococcus granulosus chromobox protein 1 0.0068 0.0621 0.0621
Schistosoma mansoni hypothetical protein 0.0031 0.0215 0.0196
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0322 0.0569
Plasmodium falciparum T-complex protein 1 subunit beta 0.0029 0.0194 0.5076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0061 0.0061
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0541 0.8254
Schistosoma mansoni chromobox protein 0.0068 0.0621 0.0603
Echinococcus multilocularis GPCR, family 2 0.0031 0.0215 0.0215
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0942 0.0939
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.2444 0.2444
Brugia malayi Pre-SET motif family protein 0.0419 0.4453 0.4451
Brugia malayi hypothetical protein 0.0108 0.106 0.1057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0295 0.029
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0642 0.1203
Brugia malayi beta-lactamase 0.007 0.0642 0.0639
Toxoplasma gondii t-complex protein beta subunit 0.0029 0.0194 0.2277
Onchocerca volvulus 0.007 0.0642 0.0642
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0942 0.0939
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0642 0.2973
Schistosoma mansoni hypothetical protein 0.0048 0.0402 0.0384
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0642 0.0638
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0215 0.0215
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0075 0.008
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0194 0.0175
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0326 0.0577
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0061 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0295 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.004 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.4453 0.445
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0194 0.0175
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0488 0.1539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0541 0.0523
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0642 0.1237
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0061 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.106 0.1043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0529 0.8045
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0365 0.3873 0.3871
Trichomonas vaginalis set domain proteins, putative 0.0476 0.5084 1
Echinococcus granulosus transient receptor potential gamma protein 0.0314 0.331 0.331
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0926 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2992 0.5858
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2992 0.5858
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0926 1 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0314 0.331 0.331
Onchocerca volvulus 0.0072 0.0662 0.0662
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0194 0.019
Plasmodium vivax hypothetical protein, conserved 0.007 0.0642 1
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0926 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0075 0.008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0642 0.1237
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0075 0.008
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0835 0.9 0.9
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0488 0.0488
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0926 1 1
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0926 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0061 0.0061
Brugia malayi CHD4 protein 0.0013 0.0019 0.0015
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0926 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0208 0.2148 0.2148
Schistosoma mansoni hypothetical protein 0.0031 0.0215 0.0196
Loa Loa (eye worm) beta-lactamase 0.007 0.0642 0.0638
Schistosoma mansoni transient receptor potential channel 4 0.0314 0.331 0.3297
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0061 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.02
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0075 0.008
Leishmania major hypothetical protein, conserved 0.007 0.0642 0.0585
Schistosoma mansoni ap endonuclease 0.0041 0.0322 0.0304
Trichomonas vaginalis chaperonin, putative 0.0029 0.0194 0.0315
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0365 0.3873 0.387
Schistosoma mansoni transient receptor potential channel 0.0208 0.2148 0.2133
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.14 1
Echinococcus granulosus transient receptor potential ion channel A 0.0304 0.3196 0.3196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2992 0.5858
Echinococcus multilocularis geminin 0.0549 0.5882 0.5882
Echinococcus multilocularis chromobox protein 1 0.0068 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0031 0.0215 0.021
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.14 1
Plasmodium vivax SET domain protein, putative 0.0061 0.0541 0.8254
Onchocerca volvulus 0.003 0.0205 0.0205
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.7364 0.7359
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2992 0.5858
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0447 0.0442
Mycobacterium ulcerans beta-lactamase 0.007 0.0642 0.2973
Schistosoma mansoni transient receptor potential channel 0.0208 0.2148 0.2133
Loa Loa (eye worm) hypothetical protein 0.0187 0.192 0.1916
Echinococcus multilocularis short transient receptor potential channel 6 0.0208 0.2148 0.2148
Echinococcus granulosus lysosomal protective protein 0.0926 1 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0194 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0075 0.008
Echinococcus granulosus chromobox protein 1 0.0068 0.0621 0.0621
Schistosoma mansoni cpg binding protein 0.003 0.0209 0.019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0215 0.0215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0942 0.0937
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0541 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0295 0.0515
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.2992 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0215 0.0211
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0642 0.1203
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0029 0.0194 0.2277
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0005 0.0005
Trichomonas vaginalis esterase, putative 0.007 0.0642 0.1203
Schistosoma mansoni hypothetical protein 0.0067 0.0605 0.0588
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0488 0.1539
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0322 0.0262
Entamoeba histolytica hypothetical protein 0.0108 0.106 0.3095
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0621 0.1161
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0621 0.1161
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0215 0.021
Mycobacterium tuberculosis Conserved protein 0.007 0.0642 0.1237
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0075 0.008
Schistosoma mansoni hypothetical protein 0.0108 0.106 0.1043
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0019 0.0014
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0322 0.0322
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.007 0.0642 0.0638
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.2992 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0642 0.1237
Echinococcus granulosus cpg binding protein 0.0032 0.0228 0.0228
Trypanosoma brucei C-8 sterol isomerase, putative 0.0365 0.3873 0.3835
Onchocerca volvulus 0.0048 0.0402 0.0402
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.2444 0.2444
Brugia malayi isocitrate dehydrogenase 0.0017 0.0061 0.0058
Schistosoma mansoni survival motor neuron protein 0.0048 0.0402 0.0384
Entamoeba histolytica hypothetical protein 0.0108 0.106 0.3095
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0322 0.4485
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0322 0.0317
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0926 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0208 0.2148 0.2148
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0061 0.0058
Leishmania major C-8 sterol isomerase-like protein 0.0365 0.3873 0.3835
Mycobacterium tuberculosis Conserved protein 0.007 0.0642 0.1237
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0446 0.4758 1
Onchocerca volvulus 0.007 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0926 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0642 0.0585
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0075 0.008
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0322 0.0458
Schistosoma mansoni cpg binding protein 0.0032 0.0228 0.0209
Schistosoma mansoni ap endonuclease 0.0041 0.0322 0.0304
Loa Loa (eye worm) hypothetical protein 0.0235 0.2444 0.244
Loa Loa (eye worm) hypothetical protein 0.007 0.0642 0.0638
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0322 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0642 0.1203
Schistosoma mansoni transient receptor potential channel 0.0314 0.331 0.3297
Mycobacterium ulcerans lipase LipD 0.007 0.0642 0.2973
Loa Loa (eye worm) hypothetical protein 0.0067 0.0605 0.0601
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0488 0.0429
Onchocerca volvulus 0.007 0.0642 0.0642
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0322 0.0318
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.004 0.0011
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0926 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0061 0.0541 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.0274
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0322 0.0555
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0322 0.0569
Brugia malayi beta-lactamase family protein 0.007 0.0642 0.0639
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0926 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0488 0.0488
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2992 0.5858
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0642 0.1203
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0215 0.0211
Brugia malayi chromobox protein homolog 3 0.0038 0.0295 0.0291
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0322 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0488 0.047
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0488 0.0908
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2992 0.5858
Echinococcus granulosus GPCR family 2 0.0031 0.0215 0.0215
Onchocerca volvulus 0.0476 0.5084 0.5084
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0322 0.0262
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0642 0.1237
Schistosoma mansoni cpg binding protein 0.0032 0.0228 0.0209
Schistosoma mansoni chromobox protein 0.0068 0.0621 0.0603
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0926 1 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0029 0.0194 0.0194
Echinococcus granulosus microtubule associated protein 2 0.0685 0.7364 0.7364
Schistosoma mansoni hypothetical protein 0.0549 0.5882 0.5874
Brugia malayi beta-lactamase family protein 0.007 0.0642 0.0639
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2992 0.5858
Echinococcus multilocularis short transient receptor potential channel 6 0.0208 0.2148 0.2148
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0092 0.0879 0.0862
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0402 0.0398
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0642 0.1237
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0061 0.0061
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0322 0.5
Loa Loa (eye worm) hypothetical protein 0.0197 0.2034 0.203
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0642 0.1237
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0642 0.0642
Onchocerca volvulus 0.003 0.0209 0.0209
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0215 0.0215
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0488 0.0484
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0541 0.0541
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0642 0.1237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0642 0.0625
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0029 0.0194 0.0194
Leishmania major T-complex protein 1, beta subunit, putative 0.0029 0.0194 0.0133
Entamoeba histolytica hypothetical protein 0.0108 0.106 0.3095
Brugia malayi Transient-receptor-potential like protein 0.0117 0.1155 0.1152
Brugia malayi Pre-SET motif family protein 0.0061 0.0541 0.0537
Loa Loa (eye worm) hypothetical protein 0.007 0.0642 0.0638
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0642 0.0639
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0194 0.019
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0295 0.0295
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.2992 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0322 0.0322
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.106 0.106
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0642 0.0585
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0029 0.0194 0.0133
Loa Loa (eye worm) hypothetical protein 0.007 0.0642 0.0638
Loa Loa (eye worm) hypothetical protein 0.0097 0.0942 0.0937
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0061 0.0061
Echinococcus multilocularis lysosomal protective protein 0.0926 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0541 0.0541
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0005 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0209 0.0204
Echinococcus granulosus geminin 0.0549 0.5882 0.5882
Loa Loa (eye worm) T-complex protein 1 0.0029 0.0194 0.0189
Echinococcus granulosus TRP transient receptor potential channel 0.0117 0.1155 0.1155
Schistosoma mansoni hypothetical protein 0.0549 0.5882 0.5874
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.2992 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.14 0.285
Schistosoma mansoni hypothetical protein 0.0031 0.0215 0.0196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0642 0.0625
Toxoplasma gondii ABC1 family protein 0.007 0.0642 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0541 0.0523
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0322 0.0262

Activities

Activity type Activity value Assay description Source Reference
LC99 (ADMET) = 100 uM In vitro cytotoxicity (LC99) of the compound was measured against B16 Melanoma cells ChEMBL. 7629806

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.