Detailed information for compound 1458785

Basic information

Technical information
  • TDR Targets ID: 1458785
  • Name: ethyl 1-[3-[(4-bromo-3-methylphenyl)amino]-3- oxopropyl]piperidine-3-carboxylate
  • MW: 397.307 | Formula: C18H25BrN2O3
  • H donors: 1 H acceptors: 2 LogP: 2.84 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1CCCN(C1)CCC(=O)Nc1ccc(c(c1)C)Br
  • InChi: 1S/C18H25BrN2O3/c1-3-24-18(23)14-5-4-9-21(12-14)10-8-17(22)20-15-6-7-16(19)13(2)11-15/h6-7,11,14H,3-5,8-10,12H2,1-2H3,(H,20,22)
  • InChiKey: OPXBVBURIYYMJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 1-[3-[(4-bromo-3-methyl-phenyl)amino]-3-oxo-propyl]piperidine-3-carboxylate
  • 1-[3-[(4-bromo-3-methylphenyl)amino]-3-oxopropyl]-3-piperidinecarboxylic acid ethyl ester
  • 1-[3-[(4-bromo-3-methyl-phenyl)amino]-3-keto-propyl]nipecotic acid ethyl ester
  • Oprea1_185759
  • ST5015726
  • BAS 03086218
  • Oprea1_270785

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major trypanothione reductase 0.0039 0.0153 0.0153
Plasmodium vivax malate dehydrogenase, putative 0.0448 0.7102 1
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0215 0.3147 0.3147
Chlamydia trachomatis malate dehydrogenase 0.0222 0.3264 1
Brugia malayi Flap endonuclease-1 0.003 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0062 0.0551 0.0551
Toxoplasma gondii malate dehydrogenase MDH 0.0448 0.7102 1
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.1205 0.1205
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0992 0.3037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Trypanosoma cruzi malate dehydrogenase, putative 0.0215 0.3147 0.3147
Echinococcus granulosus cathepsin l1 0.0041 0.0203 0.0203
Plasmodium falciparum L-lactate dehydrogenase 0.0448 0.7102 1
Plasmodium falciparum lactate dehydrogenase, putative 0.0197 0.2835 0.3992
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0222 0.3264 0.3264
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0041 0.0058
Plasmodium vivax vivapain-3 0.0032 0.0041 0.0058
Echinococcus granulosus cathepsin L 0.0032 0.0041 0.0041
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0062 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0075 0.0774 0.0774
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.1205 0.1205
Trypanosoma brucei trypanothione reductase 0.0039 0.0153 0.0153
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Schistosoma mansoni carbonic anhydrase 0.0335 0.5186 0.5186
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0041 0.0041
Plasmodium vivax vivapain-1 0.0032 0.0041 0.0058
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0144 0.1935 0.1935
Leishmania major carbonic anhydrase-like protein 0.0619 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0619 1 1
Echinococcus multilocularis carbonic anhydrase II 0.0619 1 1
Plasmodium vivax glutathione reductase, putative 0.0039 0.0153 0.0216
Plasmodium vivax unspecified product 0.0032 0.0041 0.0058
Onchocerca volvulus Cathepsin L homolog 0.0062 0.0551 0.4576
Toxoplasma gondii lactate dehydrogenase LDH2 0.0448 0.7102 1
Schistosoma mansoni intermediate filament proteins 0.0059 0.0503 0.0503
Entamoeba histolytica acyl-coA synthetase, putative 0.01 0.1205 0.1696
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0164 0.2283 0.2283
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Echinococcus granulosus L lactate dehydrogenase 0.0251 0.3766 0.3766
Plasmodium falciparum carbonic anhydrase 0.0335 0.5186 0.7302
Echinococcus multilocularis carbonic anhydrase 0.0335 0.5186 0.5186
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.1205 0.1205
Echinococcus granulosus lamin dm0 0.0059 0.0503 0.0503
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.1205 0.369
Echinococcus granulosus lactate dehydrogenase a 0.0448 0.7102 0.7102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0041 0.0041
Schistosoma mansoni carbonic anhydrase-related 0.0335 0.5186 0.5186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0551 0.0551
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.1205 0.369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Loa Loa (eye worm) hypothetical protein 0.0059 0.0503 0.0503
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0007 0.0007
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0222 0.3264 0.3264
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0062 0.0551 0.0551
Leishmania major cathepsin L-like protease 0.0062 0.0551 0.0551
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.1205 0.369
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0062 0.0551 0.0776
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1205 0.1205
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0222 0.3264 1
Brugia malayi AMP-binding enzyme family protein 0.01 0.1205 0.1205
Echinococcus granulosus lactate dehydrogenase protein 0.0448 0.7102 0.7102
Echinococcus multilocularis cathepsin L cysteine protease 0.0062 0.0551 0.0551
Echinococcus granulosus cathepsin L cysteine proteinase 0.0062 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0041 0.0203 0.0203
Plasmodium falciparum malate dehydrogenase 0.0448 0.7102 1
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0203 0.0286
Echinococcus multilocularis lactate dehydrogenase a 0.0448 0.7102 0.7102
Echinococcus granulosus cathepsin l1 0.0062 0.0551 0.0551
Onchocerca volvulus 0.0059 0.0503 0.4172
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0222 0.3264 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.01 0.1205 0.369
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.01 0.1205 0.369
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0222 0.3264 0.4596
Loa Loa (eye worm) hypothetical protein 0.0075 0.0774 0.0774
Brugia malayi Thioredoxin reductase 0.0039 0.0153 0.0153
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.1205 0.1696
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0704 0.2156
Plasmodium falciparum thioredoxin reductase 0.0039 0.0153 0.0216
Schistosoma mansoni cathepsin F (C01 family) 0.0062 0.0551 0.0551
Plasmodium vivax vivapain-2 0.0062 0.0551 0.0776
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0041 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Trypanosoma brucei malate dehydrogenase-related 0.0197 0.2835 0.2835
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0992 0.3037
Leishmania major cytosolic malate dehydrogenase 0.0222 0.3264 0.3264
Echinococcus granulosus cathepsin l cysteine peptidase 0.0062 0.0551 0.0551
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Onchocerca volvulus Cathepsin F homolog 0.0062 0.0551 0.4576
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0041 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0551 0.0776
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.1205 0.1696
Brugia malayi Cathepsin L-like precursor 0.0062 0.0551 0.0551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0215 0.3147 0.3147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Schistosoma mansoni lamin 0.0059 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0448 0.7102 0.7102
Loa Loa (eye worm) hypothetical protein 0.0335 0.5186 0.5186
Echinococcus multilocularis carbonic anhydrase 0.0335 0.5186 0.5186
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0041 0.0041
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0503 0.0503
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0222 0.3264 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Echinococcus granulosus cysteine protease 0.0032 0.0041 0.0041
Echinococcus multilocularis cysteine protease 0.0062 0.0551 0.0551
Leishmania major cathepsin L-like protease 0.0164 0.2283 0.2283
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0153 0.0153
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Leishmania major mitochondrial malate dehydrogenase 0.0215 0.3147 0.3147
Echinococcus granulosus carbonic anhydrase 0.0335 0.5186 0.5186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Toxoplasma gondii lactate dehydrogenase LDH1 0.0448 0.7102 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Entamoeba histolytica cysteine protease, putative 0.0062 0.0551 0.0776
Brugia malayi cathepsin L-like precursor 0.0041 0.0203 0.0203
Toxoplasma gondii thioredoxin reductase 0.0039 0.0153 0.0216
Schistosoma mansoni hypothetical protein 0.0335 0.5186 0.5186
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0222 0.3264 1
Brugia malayi glutathione reductase 0.0039 0.0153 0.0153
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0222 0.3264 0.3264
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0041 0.0058
Plasmodium falciparum flap endonuclease 1 0.003 0.0007 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0062 0.0551 0.1689
Trypanosoma cruzi cruzipain precursor, putative 0.0164 0.2283 0.2283
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0335 0.5186 0.5186
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0153 0.047
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Brugia malayi Cathepsin L-like precursor 0.0062 0.0551 0.0551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Loa Loa (eye worm) hypothetical protein 0.0075 0.0774 0.0774
Mycobacterium ulcerans hypothetical protein 0.01 0.1205 0.369
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Plasmodium vivax vivapain-2 0.0062 0.0551 0.0776
Entamoeba histolytica Flap nuclease, putative 0.003 0.0007 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0041 0.0126
Trichomonas vaginalis malate dehydrogenase, putative 0.0096 0.1125 0.3445
Echinococcus granulosus malate dehydrogenase 0.0215 0.3147 0.3147
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0222 0.3264 0.3264
Loa Loa (eye worm) hypothetical protein 0.0335 0.5186 0.5186
Loa Loa (eye worm) hypothetical protein 0.01 0.1205 0.1205
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.01 0.1205 0.369
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0041 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Echinococcus granulosus malate dehydrogenase 0.0215 0.3147 0.3147
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0041 0.0058
Entamoeba histolytica malate dehydrogenase, putative 0.0448 0.7102 1
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0007 0.001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0992 0.3037
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0992 0.3037
Brugia malayi Cathepsin L-like precursor 0.0041 0.0203 0.0203
Brugia malayi AMP-binding enzyme family protein 0.01 0.1205 0.1205
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1158 0.3547
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1158 0.3547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Leishmania major malate dehydrogenase, putative 0.0448 0.7102 0.7102
Loa Loa (eye worm) hypothetical protein 0.0075 0.0774 0.0774
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0037 0.0037
Echinococcus multilocularis lamin dm0 0.0059 0.0503 0.0503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Trypanosoma cruzi cysteine peptidase, putative 0.0164 0.2283 0.2283
Echinococcus granulosus carbonic anhydrase II 0.0619 1 1
Entamoeba histolytica malate dehydrogenase, putative 0.0222 0.3264 0.4596
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0551 0.0776
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0041 0.0058
Schistosoma mansoni malate dehydrogenase 0.0448 0.7102 0.7102
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0162 0.0162
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.01 0.1205 0.369
Echinococcus multilocularis cathepsin L 0.0032 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0062 0.0551 0.0551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0203 0.0623
Leishmania major glycosomal malate dehydrogenase 0.0215 0.3147 0.3147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0041 0.0058
Leishmania major cathepsin L-like protease 0.0062 0.0551 0.0551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Brugia malayi intermediate filament protein 0.0059 0.0503 0.0503
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0503 0.0503
Echinococcus multilocularis musashi 0.0059 0.0503 0.0503
Trypanosoma brucei cytosolic malate dehydrogenase 0.0222 0.3264 0.3264
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0041 0.0041
Onchocerca volvulus 0.0062 0.0551 0.4576
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0335 0.5186 0.5186
Trypanosoma brucei carbonic anhydrase-like protein 0.0619 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0041 0.0041
Plasmodium falciparum glutathione reductase 0.0039 0.0153 0.0216
Trypanosoma cruzi major cysteine proteinase, putative 0.0113 0.1425 0.1425
Echinococcus granulosus lactate dehydrogenase a 0.0448 0.7102 0.7102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0704 0.2156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0619 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0062 0.0551 0.0551
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.1205 0.369
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0335 0.5186 0.5186
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0062 0.0551 0.0551
Schistosoma mansoni carbonic anhydrase-related 0.0335 0.5186 0.5186
Echinococcus multilocularis flap endonuclease 1 0.003 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Schistosoma mansoni L-lactate dehydrogenase 0.0448 0.7102 0.7102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0215 0.3147 0.3147
Brugia malayi Cathepsin L-like precursor 0.0062 0.0551 0.0551
Schistosoma mansoni L-lactate dehydrogenase 0.0197 0.2835 0.2835
Echinococcus granulosus intermediate filament protein 0.0059 0.0503 0.0503
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Onchocerca volvulus 0.0062 0.0551 0.4576
Brugia malayi Cathepsin L-like precursor 0.0062 0.0551 0.0551
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.1205 0.369
Loa Loa (eye worm) hypothetical protein 0.01 0.1205 0.1205
Brugia malayi Cathepsin L-like precursor 0.0062 0.0551 0.0551
Echinococcus granulosus cytosolic malate dehydrogenase 0.0222 0.3264 0.3264
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0619 1 1
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0448 0.7102 0.5
Echinococcus multilocularis malate dehydrogenase 0.0215 0.3147 0.3147
Loa Loa (eye worm) malate dehydrogenase 0.0215 0.3147 0.3147
Plasmodium falciparum acyl-CoA synthetase 0.0075 0.0774 0.1089
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0062 0.0551 0.0551
Mycobacterium tuberculosis Probable reductase 0.0088 0.0992 0.3037
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0041 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0704 0.2156
Loa Loa (eye worm) hypothetical protein 0.0041 0.0203 0.0203
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0203 0.0203
Echinococcus multilocularis cysteine protease 0.0062 0.0551 0.0551
Toxoplasma gondii hypothetical protein 0.0335 0.5186 0.7302
Toxoplasma gondii cathepsin CPL 0.0062 0.0551 0.0776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0704 0.2156
Trypanosoma cruzi cysteine peptidase, putative 0.0164 0.2283 0.2283
Loa Loa (eye worm) hypothetical protein 0.0075 0.0774 0.0774
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0041 0.0058
Trichomonas vaginalis malate dehydrogenase, putative 0.0121 0.1554 0.4759
Echinococcus granulosus carbonic anhydrase 0.0335 0.5186 0.5186
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0215 0.3147 0.3147
Echinococcus multilocularis lactate dehydrogenase a 0.0448 0.7102 0.7102
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0075 0.0774 0.237
Echinococcus granulosus flap endonuclease 1 0.003 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1158 0.3547
Leishmania major cathepsin L-like protease 0.0062 0.0551 0.0551
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0774 0.237
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0197 0.2835 0.3992
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Schistosoma mansoni cathepsin F (C01 family) 0.0062 0.0551 0.0551
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0335 0.5186 0.5186
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0222 0.3264 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.01 0.1205 0.369
Loa Loa (eye worm) cysteine protease 0.0062 0.0551 0.0551
Onchocerca volvulus 0.0062 0.0551 0.4576
Onchocerca volvulus Cathepsin L homolog 0.0062 0.0551 0.4576
Brugia malayi lactate dehydrogenase. 0.0448 0.7102 0.7102
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0007 0.001
Loa Loa (eye worm) malate dehydrogenase 0.0222 0.3264 0.3264
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0992 0.3037
Brugia malayi AMP-binding enzyme family protein 0.01 0.1205 0.1205
Loa Loa (eye worm) glutathione reductase 0.0039 0.0153 0.0153
Schistosoma mansoni malate dehydrogenase 0.0215 0.3147 0.3147
Plasmodium falciparum cysteine proteinase falcipain 3 0.0062 0.0551 0.0776
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0551 0.0551
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0041 0.0041
Brugia malayi Cathepsin L-like precursor 0.0062 0.0551 0.0551
Plasmodium vivax lactate dehydrogenase 0.0448 0.7102 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0197 0.2835 0.8686
Leishmania major malate dehydrogenase, putative 0.0197 0.2835 0.2835
Echinococcus multilocularis L lactate dehydrogenase 0.0251 0.3766 0.3766
Loa Loa (eye worm) hypothetical protein 0.0335 0.5186 0.5186
Onchocerca volvulus 0.0062 0.0551 0.4576
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0503 0.0503
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.1205 0.369
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Echinococcus multilocularis lactate dehydrogenase protein 0.0448 0.7102 0.7102
Schistosoma mansoni carbonic anhydrase-related 0.0335 0.5186 0.5186
Leishmania major cysteine peptidase A (CPA) 0.0062 0.0551 0.0551
Leishmania major malate dehydrogenase 0.0215 0.3147 0.3147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.2283 0.2283
Leishmania major cathepsin L-like protease 0.0164 0.2283 0.2283
Trypanosoma brucei glycosomal malate dehydrogenase 0.0215 0.3147 0.3147
Schistosoma mansoni malate dehydrogenase 0.0222 0.3264 0.3264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0203 0.0623
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1158 0.3547
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Onchocerca volvulus 0.0041 0.0203 0.1689
Onchocerca volvulus 0.0059 0.0503 0.4172
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0222 0.3264 0.3264
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0062 0.0551 0.1689
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0619 1 1
Echinococcus multilocularis carbonic anhydrase 0.0335 0.5186 0.5186
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0619 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Giardia lamblia Malate dehydrogenase 0.0222 0.3264 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0162 0.0162
Loa Loa (eye worm) fibroinase 0.0062 0.0551 0.0551
Echinococcus granulosus L lactate dehydrogenase B chain 0.0448 0.7102 0.7102
Plasmodium vivax acyl-CoA synthetase, putative 0.0075 0.0774 0.1089
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0062 0.0551 0.0776
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0007 0.0023
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0992 0.3037
Brugia malayi Cathepsin L-like cysteine proteinase 0.0041 0.0203 0.0203
Trypanosoma cruzi malate dehydrogenase, putative 0.0197 0.2835 0.2835
Echinococcus granulosus cytosolic malate dehydrogenase 0.0222 0.3264 0.3264
Onchocerca volvulus 0.01 0.1205 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Trypanosoma cruzi cysteine peptidase, putative 0.0164 0.2283 0.2283
Mycobacterium ulcerans malate dehydrogenase 0.0222 0.3264 1
Loa Loa (eye worm) ctsf protein 0.0062 0.0551 0.0551
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0335 0.5186 0.5186
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0037 0.0037
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0619 1 1
Echinococcus multilocularis lactate dehydrogenase a 0.0448 0.7102 0.7102
Echinococcus multilocularis malate dehydrogenase 0.0215 0.3147 0.3147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0551 0.1689
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Schistosoma mansoni malate dehydrogenase 0.0222 0.3264 0.3264
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0215 0.3147 0.3147
Entamoeba histolytica cysteine protease, putative 0.0032 0.0041 0.0058
Echinococcus multilocularis cathepsin L cysteine protease 0.0062 0.0551 0.0551
Onchocerca volvulus 0.0062 0.0551 0.4576
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0041 0.0041
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0222 0.3264 1
Brugia malayi Cathepsin L-like precursor 0.0041 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0551 0.1689
Echinococcus granulosus carbonic anhydrase 0.0335 0.5186 0.5186
Loa Loa (eye worm) hypothetical protein 0.0058 0.0484 0.0484
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0335 0.5186 0.5186
Echinococcus multilocularis lamin 0.0059 0.0503 0.0503
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0153 0.0216
Onchocerca volvulus 0.0062 0.0551 0.4576
Onchocerca volvulus 0.0062 0.0551 0.4576
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0619 1 1
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0448 0.7102 0.7102
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0041 0.0041
Echinococcus granulosus lamin 0.0059 0.0503 0.0503
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0007 0.0007
Trichomonas vaginalis malate dehydrogenase, putative 0.0222 0.3264 1
Schistosoma mansoni lamin 0.0059 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0041 0.0203 0.0203

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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