Detailed information for compound 1460772

Basic information

Technical information
  • TDR Targets ID: 1460772
  • Name: 2-[[2-(4-chlorophenoxy)acetyl]amino]-N-(4-met hoxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[ d]thiophene-3-carboxamide
  • MW: 484.995 | Formula: C25H25ClN2O4S
  • H donors: 2 H acceptors: 2 LogP: 6.57 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)c1c(NC(=O)COc2ccc(cc2)Cl)sc2c1CCCCC2
  • InChi: 1S/C25H25ClN2O4S/c1-31-18-13-9-17(10-14-18)27-24(30)23-20-5-3-2-4-6-21(20)33-25(23)28-22(29)15-32-19-11-7-16(26)8-12-19/h7-14H,2-6,15H2,1H3,(H,27,30)(H,28,29)
  • InChiKey: YMVBMJOUZJDZHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]-N-(4-methoxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophene-3-carboxamide
  • 2-[2-(4-chlorophenoxy)ethanoylamino]-N-(4-methoxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophene-3-carboxamide
  • Oprea1_145323
  • NCGC00098569-01
  • A2077/0087297
  • ZINC02186029
  • AG-205/12835133

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0793 0.0816
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Loa Loa (eye worm) hypothetical protein 0.2742 0.9453 0.9734
Brugia malayi Steroid receptor seven-up type 2 0.0159 0.0534 0.055
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0284
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0075 0.0245 0.1735
Echinococcus granulosus tar DNA binding protein 0.0076 0.0251 0.1777
Brugia malayi hypothetical protein 0.0084 0.0276 0.0284
Loa Loa (eye worm) hypothetical protein 0.0159 0.0534 0.055
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.0276 0.0284
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0115 1
Brugia malayi hypothetical protein 0.0075 0.0245 0.0252
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0159 0.0534 0.3785
Schistosoma mansoni nuclear receptor 0.0075 0.0245 0.1735
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0037 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797
Brugia malayi Nuclear hormone receptor E75 0.0075 0.0245 0.0252
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0087 0.0089
Brugia malayi CXXC zinc finger family protein 0.0029 0.0087 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0251 0.1777
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0159 0.0534 0.055
Echinococcus granulosus dnaJ subfamily B 0.0412 0.1411 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0115 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0075 0.0245 0.1735
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Brugia malayi nuclear hormone receptor 0.2816 0.9711 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.0534 0.055
Loa Loa (eye worm) hypothetical protein 0.0159 0.0534 0.055
Brugia malayi nuclear hormone receptor family member nhr-6 0.0075 0.0245 0.0252
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0075 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0159 0.0534 0.055
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0198 0.1403
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0284
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0011 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0797
Echinococcus granulosus Nuclear hormone receptor HR96 0.0075 0.0245 0.1735
Echinococcus granulosus ecdysone induced protein 78C 0.0159 0.0534 0.3785
Echinococcus granulosus Nuclear hormone receptor HR96 0.0075 0.0245 0.1735
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0065 0.0067
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0037 0.0259
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0159 0.0534 0.3785
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.1411 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0797
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0159 0.0534 0.055
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0075 0.0245 0.1735
Echinococcus granulosus cpg binding protein 0.0031 0.0092 0.0654
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0037 0.0262
Schistosoma mansoni thyroid hormone receptor 0.0159 0.0534 0.3785
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Brugia malayi hypothetical protein 0.0075 0.0245 0.0252
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0159 0.0534 0.3785
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0251 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0159 0.0534 0.055
Echinococcus granulosus death domain containing protein 0.0014 0.0037 0.0259
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0011 0.0081
Loa Loa (eye worm) hypothetical protein 0.0159 0.0534 0.055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797
Echinococcus multilocularis Ankyrin 0.0015 0.0037 0.0262
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0075 0.0245 0.1735
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0198 0.1403
Brugia malayi tailless protein 0.0075 0.0245 0.0252
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0159 0.0534 0.3785
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0258 0.0877 0.6218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0159 0.0534 0.055
Echinococcus granulosus Ankyrin 0.0015 0.0037 0.0262
Schistosoma mansoni nuclear hormone receptor 0.0075 0.0245 0.1735
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0259
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0124
Schistosoma mansoni retinoic acid receptor RXR 0.0258 0.0877 0.6218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.0245 0.1735
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0159 0.0534 0.055
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0198 0.1403
Brugia malayi nuclear receptor RXR 0.0075 0.0245 0.0252
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0251 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0159 0.0534 0.3785
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0037 0.0037
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0075 0.0245 0.1735
Brugia malayi photoreceptor-specific nuclear receptor 0.0159 0.0534 0.055
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0037 0.0259
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0159 0.0534 0.3785
Brugia malayi TAR-binding protein 0.0076 0.0251 0.0258
Echinococcus multilocularis FTZ F1 alpha 0.0159 0.0534 0.3785
Onchocerca volvulus 0.0159 0.0534 0.0534
Schistosoma mansoni cpg binding protein 0.0031 0.0092 0.0654
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0251 0.1777
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0159 0.0534 0.055
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0243 0.1722
Schistosoma mansoni coup transcription factor 0.0159 0.0534 0.3785
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0159 0.0534 0.055
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0075 0.0245 0.1735
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Loa Loa (eye worm) hypothetical protein 0.0159 0.0534 0.055
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0115 1
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0793 0.0816
Loa Loa (eye worm) hypothetical protein 0.0159 0.0534 0.055
Brugia malayi Protein kinase domain containing protein 0.0014 0.0037 0.0038
Brugia malayi hypothetical protein 0.0084 0.0276 0.0284
Brugia malayi nuclear receptor RXR 0.0084 0.0276 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0284
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Loa Loa (eye worm) RNA binding protein 0.0076 0.0251 0.0258
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0115 0.0816
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0017 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0159 0.0534 0.055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0009 0.0797
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0198 0.1403
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0037 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0251 0.1777
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0797
Schistosoma mansoni nuclear hormone receptor 0.0075 0.0245 0.1735
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0115 0.5816
Brugia malayi nuclear receptor NHR-67 0.0075 0.0245 0.0252
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0159 0.0534 0.3785
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.0245 0.1735
Loa Loa (eye worm) nuclear hormone receptor 0.0075 0.0245 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0159 0.0534 0.055
Schistosoma mansoni cpg binding protein 0.0029 0.0087 0.0613
Trichomonas vaginalis helicase, putative 0.0007 0.0009 0.0797
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0115 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0159 0.0534 0.3785
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0159 0.0534 0.3785
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0243 0.1722
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0159 0.0534 0.3785
Echinococcus multilocularis nuclear receptor nhr 48 0.0075 0.0245 0.1735
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0159 0.0534 0.055
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0159 0.0534 0.3785
Loa Loa (eye worm) steroid hormone receptor 0.0159 0.0534 0.055
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0159 0.0534 0.3785
Schistosoma mansoni RAR-like nuclear receptor 0.0159 0.0534 0.3785
Onchocerca volvulus 0.0075 0.0245 0.0245
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0198 1
Onchocerca volvulus 0.0075 0.0245 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0159 0.0534 0.055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0084 0.0276 0.1954
Brugia malayi ecdysone receptor 0.0075 0.0245 0.0252
Echinococcus multilocularis ecdysone induced protein 78C 0.0159 0.0534 0.3785
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0251 0.1777
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0159 0.0534 0.055
Echinococcus multilocularis tumor protein p63 0.0408 0.1395 0.9893
Schistosoma mansoni thyroid hormone receptor 0.0159 0.0534 0.3785
Brugia malayi Uncoordinated protein 44 0.0014 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.006 0.0193 0.0198
Brugia malayi conserved hypotetical protein 0.0075 0.0245 0.0252
Brugia malayi Nuclear hormone receptor E75 0.0075 0.0245 0.0252
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0176 0.889
Brugia malayi ecdysteroid receptor 0.0159 0.0534 0.055
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0075 0.0245 0.0245
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0115 0.5816
Onchocerca volvulus 0.006 0.0193 0.0193
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0174 0.0588 0.4168
Loa Loa (eye worm) inositol-1 0.0037 0.0115 0.0119
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0001 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0159 0.0534 0.055
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0124
Onchocerca volvulus Bile acid receptor homolog 0.0159 0.0534 0.0534
Brugia malayi RNA binding protein 0.0076 0.0251 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0198 1
Brugia malayi Death domain containing protein 0.0014 0.0037 0.0038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0011 0.0081
Echinococcus granulosus nuclear receptor nhr 48 0.0075 0.0245 0.1735
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.0276 0.0284
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0159 0.0534 0.3785
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0115 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0198 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0193 0.1366
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0159 0.0534 0.3785
Schistosoma mansoni nuclear hormone receptor 0.0159 0.0534 0.3785
Schistosoma mansoni hypothetical protein 0.0412 0.1411 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0011 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0251 0.1777
Brugia malayi Nuclear hormone receptor-like 1 0.0159 0.0534 0.055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0159 0.0534 0.3785
Schistosoma mansoni inositol monophosphatase 0.0037 0.0115 0.0816
Schistosoma mansoni inositol monophosphatase 0.0037 0.0115 0.0816
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0198 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0198 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0251 0.1777
Brugia malayi nuclear receptor NHR-88 0.0159 0.0534 0.055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0797
Brugia malayi nuclear hormone receptor 0.0159 0.0534 0.055
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0115 0.5816
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0004 0 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0075 0.0245 0.1735
Brugia malayi nuclear hormone receptor family member odr-7 0.0075 0.0245 0.0252
Brugia malayi Cytochrome P450 family protein 0.0023 0.0065 0.0067
Onchocerca volvulus 0.0029 0.0087 0.0087
Onchocerca volvulus Protein ultraspiracle homolog 0.0159 0.0534 0.0534
Schistosoma mansoni cpg binding protein 0.0031 0.0092 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0159 0.0534 0.055
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797
Brugia malayi Inositol-1 0.0037 0.0115 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0075 0.0245 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0159 0.0534 0.055
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0115 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0092 0.0654
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.0534 0.3785
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0159 0.0534 0.3785
Echinococcus granulosus thyroid hormone receptor alpha 0.0075 0.0245 0.1735
Brugia malayi orphan nuclear receptor NR2E1 0.0075 0.0245 0.0252
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0251 0.0258
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0159 0.0534 0.3785
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0084 0.0276 0.1954
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0037 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0159 0.0534 0.055
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0084 0.0276 0.1954
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Loa Loa (eye worm) DR-78 0.0075 0.0245 0.0252
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0084 0.0276 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0159 0.0534 0.055
Loa Loa (eye worm) hypothetical protein 0.0159 0.0534 0.055
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0102 0.5135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0159 0.0534 0.055
Brugia malayi steroid hormone receptor 0.0159 0.0534 0.055
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0199 0.1408
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0797
Loa Loa (eye worm) nuclear receptor nhr-7B 0.2816 0.9711 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0159 0.0534 0.3785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0159 0.0534 0.055
Brugia malayi nuclear receptor NHR-88 0.0075 0.0245 0.0252
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0037 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0159 0.0534 0.3785
Loa Loa (eye worm) nuclear receptor NHR-67 0.0075 0.0245 0.0252
Schistosoma mansoni nuclear receptor 0.0075 0.0245 0.1735
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Schistosoma mansoni zinc finger protein 0.0075 0.0245 0.1735
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0009 0.0797
Loa Loa (eye worm) hypothetical protein 0.0075 0.0245 0.0252
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0115 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0038
Giardia lamblia Hypothetical protein 0.0004 0 0.5
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0115 1
Schistosoma mansoni netrin receptor unc5 0.0014 0.0037 0.0259
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0017 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0284
Echinococcus granulosus FTZ F1 alpha 0.0159 0.0534 0.3785
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0115 0.0816
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0084 0.0276 0.1954
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0159 0.0534 0.055
Echinococcus granulosus tumor protein p63 0.0408 0.1395 0.9893
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0011 0.0081
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0037 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0797

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0089 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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