Detailed information for compound 1467407

Basic information

Technical information
  • TDR Targets ID: 1467407
  • Name: 5-[[4-(phenoxy)phenyl]methylidene]-2-sulfanyl idene-1,3-thiazolidin-4-one
  • MW: 313.394 | Formula: C16H11NO2S2
  • H donors: 1 H acceptors: 1 LogP: 4.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1S/C(=C\c2ccc(cc2)Oc2ccccc2)/C(=O)N1
  • InChi: 1S/C16H11NO2S2/c18-15-14(21-16(20)17-15)10-11-6-8-13(9-7-11)19-12-4-2-1-3-5-12/h1-10H,(H,17,18,20)/b14-10-
  • InChiKey: DNXCXYIPCYQEBG-UVTDQMKNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[[4-(phenoxy)phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • (5Z)-5-[[4-(phenoxy)phenyl]methylene]-2-thioxo-thiazolidin-4-one
  • 5-[[4-(phenoxy)phenyl]methylene]-2-thioxo-thiazolidin-4-one
  • (5Z)-5-[[4-(phenoxy)phenyl]methylene]-2-thioxo-4-thiazolidinone
  • 5-[[4-(phenoxy)phenyl]methylene]-2-thioxo-4-thiazolidinone
  • (5Z)-5-[4-(phenoxy)benzylidene]-2-thioxo-thiazolidin-4-one
  • 5-[4-(phenoxy)benzylidene]-2-thioxo-thiazolidin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 13 (collagenase 3) Starlite/ChEMBL No references
Bos taurus Aldose reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   315 aa 291 aa 21.3 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Onchocerca volvulus Aldose reductase   315 aa 316 aa 36.7 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   315 aa 314 aa 18.2 %
Leishmania mexicana aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   315 aa 349 aa 25.2 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 310 aa 20.0 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Onchocerca volvulus Aldose reductase   315 aa 324 aa 39.8 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 13 (collagenase 3) 471 aa 448 aa 34.1 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   315 aa 322 aa 24.8 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   315 aa 304 aa 29.3 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   315 aa 323 aa 25.4 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   315 aa 323 aa 40.2 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   315 aa 294 aa 24.8 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 326 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0237 0.0299 0.4861
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0038 0.0482
Loa Loa (eye worm) hypothetical protein 0.0081 0.0038 0.0621
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0081 0.0038 0.5
Entamoeba histolytica hypothetical protein 0.0237 0.0299 0.4601
Giardia lamblia GTOR 0.042 0.0606 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0038 0.0621
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0264 0.0344 0.5399
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0237 0.0299 0.0262
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0606 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0237 0.0299 0.077
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.042 0.0606 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.042 0.0606 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.042 0.0606 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.0164 0.2219
Plasmodium vivax hypothetical protein 0.0081 0.0038 0.5
Trypanosoma brucei target of rapamycin kinase 3, putative 0.042 0.0606 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0264 0.0344 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0299 0.4601
Schistosoma mansoni hypothetical protein 0.0183 0.0209 0.3017
Loa Loa (eye worm) matrixin family protein 0.0064 0.0009 0.0145
Leishmania major hypothetical protein, conserved 0.2189 0.3569 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0164 0.2702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0264 0.0344 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.042 0.0606 0.1673
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.042 0.0606 1
Entamoeba histolytica protein kinase rad3, putative 0.0237 0.0299 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0156 0.0164 0.0371
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0038 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0299 0.4601
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0038 0.5
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0237 0.0299 0.0262
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.042 0.0606 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.042 0.0606 1
Brugia malayi FAT domain containing protein 0.0183 0.0209 0.3353
Echinococcus multilocularis serine protein kinase ATM 0.0237 0.0299 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.0299 0.4936
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0081 0.0038 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0038 0.0482
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0038 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.0209 0.345
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.042 0.0606 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0299 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0237 0.0299 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0299 0.4601
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0081 0.0038 0.0621
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0081 0.0038 0.5
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.042 0.0606 0.1609
Loa Loa (eye worm) phosphatidylinositol kinase 0.0081 0.0038 0.0621
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0237 0.0299 0.4861
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Onchocerca volvulus 0.0081 0.0038 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0038 0.5
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0096 0.0062 0.0025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0038 0.0482
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.042 0.0606 0.1609
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0183 0.0209 0.0172
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.042 0.0606 0.1673
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0183 0.0209 0.0172
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0038 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0038 0.0482
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0081 0.0038 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0299 0.4601
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6029 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.042 0.0606 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.042 0.0606 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0038 0.0621
Loa Loa (eye worm) hypothetical protein 0.0081 0.0038 0.0621
Toxoplasma gondii FATC domain-containing protein 0.0237 0.0299 0.4601
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0237 0.0299 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis conserved hypothetical protein 0.0264 0.0344 0.5399
Schistosoma mansoni fkbp-rapamycin associated protein 0.0237 0.0299 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0038 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.0606 1
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0209 0.3017
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.042 0.0606 0.057
Loa Loa (eye worm) hypothetical protein 0.0264 0.0344 0.5684
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.0164 0.2219
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0038 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0299 0.4601
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.042 0.0606 0.1673
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0038 0.0621
Trypanosoma cruzi target of rapamycin kinase 3 0.042 0.0606 0.1673
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0038 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.042 0.0606 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0299 0.4601
Trypanosoma cruzi hypothetical protein, conserved 0.2109 0.3434 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.042 0.0606 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0081 0.0038 0.5
Onchocerca volvulus 0.0081 0.0038 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0299 0.4601
Echinococcus granulosus serine protein kinase ATM 0.0237 0.0299 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0081 0.0038 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.042 0.0606 0.1673
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0096 0.0062 0.0025
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0237 0.0299 0.077
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0606 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0237 0.0299 0.4601
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0038 0.0621
Leishmania major phosphatidylinositol 3-kinase, putative 0.042 0.0606 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0606 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.1 uM Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysis ChEMBL. 21129963
IC50 (binding) = 3.99 uM Inhibition of MMP13 (unknown origin) using Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 3 mins by fluorimetric assay ChEMBL. No reference
IC50 (binding) = 48.4 uM Inhibition of MMP3 (unknown origin) using Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 3 mins by fluorimetric assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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