Detailed information for compound 1469412

Basic information

Technical information
  • TDR Targets ID: 1469412
  • Name: 2-(1-cyclohexenyl)-N-(cyclopropylmethyl)ethan amine
  • MW: 179.302 | Formula: C12H21N
  • H donors: 1 H acceptors: 0 LogP: 2.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(=CC1)CCNCC1CC1
  • InChi: 1S/C12H21N/c1-2-4-11(5-3-1)8-9-13-10-12-6-7-12/h4,12-13H,1-3,5-10H2
  • InChiKey: DHRJFLBQNLJEIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1-cyclohexenyl)ethyl-(cyclopropylmethyl)amine
  • AN-329/15537674
  • STK120208

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lipoxygenase 0.012 0.234 0.2296
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0309 0.0285
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0314 1
Schistosoma mansoni hypothetical protein 0.002 0.0309 0.0253
Entamoeba histolytica fatty acid elongase, putative 0.0047 0.0863 1
Echinococcus granulosus RUN 0.002 0.0309 0.0285
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0531 0.2108
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0365 0.7308 1
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.8869 1
Brugia malayi MH2 domain containing protein 0.0129 0.2519 1
Entamoeba histolytica fatty acid elongase, putative 0.0047 0.0863 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0096 0.0382
Schistosoma mansoni cpg binding protein 0.0033 0.0567 0.0512
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0314 0.0006
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0309 0.0285
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0365 0.7308 1
Brugia malayi MH1 domain containing protein 0.0009 0.008 0.0316
Schistosoma mansoni smad 0.0009 0.008 0.0022
Brugia malayi CXXC zinc finger family protein 0.0031 0.0531 0.2108
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0314 0.1245
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0094 0.0372
Brugia malayi MH1 domain containing protein 0.0009 0.008 0.0316
Schistosoma mansoni rab6-interacting 0.002 0.0309 0.0253
Loa Loa (eye worm) doublecortin family protein 0.002 0.0309 0.1227
Echinococcus multilocularis smad 0.0009 0.008 0.0025
Schistosoma mansoni smad1 5 8 and 0.0009 0.008 0.0022
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0365 0.7308 1
Entamoeba histolytica fatty acid elongase, putative 0.0047 0.0863 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0314 0.5
Brugia malayi MH2 domain containing protein 0.0009 0.008 0.0316
Schistosoma mansoni ap endonuclease 0.002 0.0314 0.0257
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.008 0.0316
Echinococcus multilocularis cpg binding protein 0.0033 0.0567 0.0578
Echinococcus granulosus microsomal glutathione S transferase 3 0.0114 0.2216 0.2449
Echinococcus granulosus Smad4 0.0009 0.008 0.0025
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0365 0.7308 1
Echinococcus granulosus cpg binding protein 0.0033 0.0567 0.0578
Schistosoma mansoni polycystin 1-related 0.002 0.0309 0.0253
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.008 0.0022
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.008 0.0025
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0114 0.2216 0.2449
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.008 0.0316
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0314 0.1245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1094 0.4104
Schistosoma mansoni cpg binding protein 0.0033 0.0567 0.0512
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.008 0.0025
Schistosoma mansoni microsomal glutathione s-transferase 0.0114 0.2216 0.217
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0096 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0314 0.5
Brugia malayi MH2 domain containing protein 0.0009 0.008 0.0316
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0309 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0309 0.1227
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0365 0.7308 1
Brugia malayi hypothetical protein 0.002 0.0309 0.1227
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.234 0.2591
Schistosoma mansoni smad1 5 8 and 0.0009 0.008 0.0022
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0365 0.7308 0.5
Toxoplasma gondii MAPEG family protein 0.0114 0.2216 1
Entamoeba histolytica fatty acid elongase, putative 0.0047 0.0863 1
Echinococcus granulosus dnaJ subfamily B 0.0442 0.8869 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1237 0.1186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0314 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0314 0.029
Schistosoma mansoni smad1 5 8 and 0.0009 0.008 0.0022
Echinococcus multilocularis RUN 0.002 0.0309 0.0285
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0365 0.7308 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0309 0.1227
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.234 0.2591
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0309 0.0285
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0314 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0096 0.0044
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.2519 1
Entamoeba histolytica fatty acid elongase, putative 0.0047 0.0863 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0314 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0314 0.029
Schistosoma mansoni ap endonuclease 0.002 0.0314 0.0257
Loa Loa (eye worm) Smad1 0.0009 0.008 0.0316
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0314 0.0006
Onchocerca volvulus 0.0031 0.0531 1
Schistosoma mansoni cpg binding protein 0.0031 0.0531 0.0476
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0365 0.7308 1
Schistosoma mansoni rab6-interacting 0.002 0.0309 0.0253
Brugia malayi Doublecortin family protein 0.002 0.0309 0.1227
Schistosoma mansoni hypothetical protein 0.0442 0.8869 0.8862
Schistosoma mansoni lipoxygenase 0.0084 0.1607 0.1558
Echinococcus multilocularis Smad4 0.0009 0.008 0.0025
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.008 0.0025
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0309 0.0285
Schistosoma mansoni Smad4 0.0009 0.008 0.0022
Schistosoma mansoni loxhd1 0.002 0.0309 0.0253
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.2519 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0309 0.0285
Brugia malayi Smad1 0.0009 0.008 0.0316
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0314 1
Brugia malayi hypothetical protein 0.002 0.0309 0.1227
Echinococcus granulosus smad 0.0009 0.008 0.0025
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0314 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.008 0.0025

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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