Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0017 | 0.0201 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0017 | 0.0201 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0376 | 0.0193 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0464 | 0.927 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0017 | 0.0201 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0464 | 0.927 | 0.5 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0024 | 0.0343 | 0.0157 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0017 | 0.0201 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0464 | 0.927 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0017 | 0.0201 | 0.5 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0343 | 0.0157 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0376 | 0.0193 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0017 | 0.0201 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0166 | 0.3209 | 0.3446 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0464 | 0.927 | 0.927 |
Giardia lamblia | Kinase, PLK | 0.0464 | 0.927 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0464 | 0.927 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0024 | 0.0343 | 0.0343 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0464 | 0.927 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0464 | 0.927 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0027 | 0.0404 | 0.0224 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0017 | 0.0201 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0464 | 0.927 | 1 |
Schistosoma mansoni | nephrin | 0.0027 | 0.039 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0347 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0017 | 0.0201 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0166 | 0.3209 | 0.3317 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.0964 | 0.1018 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0464 | 0.927 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0017 | 0.0201 | 0.0193 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0376 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0451 | 0.0464 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0017 | 0.0201 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0347 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0017 | 0.0201 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0451 | 0.0464 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0017 | 0.0201 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0024 | 0.0343 | 0.0157 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0017 | 0.0201 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0464 | 0.927 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0347 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0017 | 0.0201 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0347 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0376 | 0.0383 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0017 | 0.0201 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0017 | 0.0201 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0464 | 0.927 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.0964 | 0.0841 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.022 | 0.4308 | 0.4529 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0347 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0464 | 0.927 | 1 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.022 | 0.4308 | 0.4529 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0017 | 0.0201 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0024 | 0.0343 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0404 | 0.0413 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.0376 | 0.0383 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.0376 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.014 | 0.27 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0343 | 0.0347 |
Schistosoma mansoni | cell adhesion molecule | 0.0027 | 0.0404 | 0.0404 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0017 | 0.0201 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0376 | 0.0193 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0201 | 0.0201 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0464 | 0.927 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0017 | 0.0201 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0464 | 0.927 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0024 | 0.0343 | 0.0343 |
Echinococcus multilocularis | Immunoglobulin | 0.0024 | 0.0343 | 0.0157 |
Echinococcus granulosus | twitchin | 0.0029 | 0.0427 | 0.025 |
Echinococcus granulosus | defective proboscis extension response | 0.0024 | 0.0343 | 0.0157 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0017 | 0.0201 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0376 | 0.0383 |
Echinococcus multilocularis | roundabout 2 | 0.003 | 0.0451 | 0.0276 |
Echinococcus granulosus | neuroglian | 0.0027 | 0.039 | 0.0209 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0017 | 0.0201 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0024 | 0.0343 | 0.0157 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0464 | 0.927 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0017 | 0.0201 | 0.0201 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0464 | 0.927 | 1 |
Echinococcus granulosus | roundabout 2 | 0.003 | 0.0451 | 0.0276 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0017 | 0.0201 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0464 | 0.927 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0464 | 0.927 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0024 | 0.0343 | 0.0157 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.0376 | 0.0193 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0376 | 0.0193 |
Echinococcus multilocularis | neuroglian | 0.0027 | 0.039 | 0.0209 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0024 | 0.0343 | 0.0343 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0017 | 0.0201 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0017 | 0.0201 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.