Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0119 | 0.0119 |
Echinococcus multilocularis | serotonin transporter | 0.009 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0539 | 0.0539 |
Leishmania major | silent information regulator 2, putative | 0.0161 | 0.3841 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0119 | 0.0119 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0161 | 0.3841 | 1 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0015 | 0.0119 | 0.0119 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0067 | 0.1441 | 0.1441 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0015 | 0.0119 | 0.0119 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0161 | 0.3841 | 0.3841 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0067 | 0.1441 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0161 | 0.3841 | 0.3841 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0015 | 0.0119 | 0.0119 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0015 | 0.0119 | 0.0119 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0748 | 0.0748 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.009 | 0.2022 | 0.2022 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.0662 | 0.0662 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0402 | 1 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 7 | 0.0067 | 0.1441 | 0.1441 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0067 | 0.1441 | 0.0894 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0161 | 0.3841 | 0.3447 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0161 | 0.3841 | 0.3841 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0161 | 0.3841 | 0.3841 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0161 | 0.3841 | 0.3841 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0402 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0015 | 0.0119 | 0.0119 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0662 | 0.0662 |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.0067 | 0.1441 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0015 | 0.0119 | 0.0119 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.009 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | transcriptional regulator | 0.0067 | 0.1441 | 0.1441 |
Giardia lamblia | Hypothetical protein | 0.0161 | 0.3841 | 0.2804 |
Loa Loa (eye worm) | transcriptional regulator | 0.0067 | 0.1441 | 0.1441 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0067 | 0.1441 | 0.0894 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.0662 | 0.0662 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0015 | 0.0119 | 0.0119 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0161 | 0.3841 | 0.3841 |
Echinococcus granulosus | serotonin transporter | 0.009 | 0.2022 | 0.2022 |
Onchocerca volvulus | 0.009 | 0.2022 | 1 | |
Loa Loa (eye worm) | serotonin transporter b | 0.009 | 0.2022 | 0.2022 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0067 | 0.1441 | 0.0894 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0015 | 0.0119 | 0.0119 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0067 | 0.1441 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0161 | 0.3841 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0015 | 0.0119 | 0.0119 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2022 | 0.2022 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0067 | 0.1441 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.1441 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0015 | 0.0119 | 0.0119 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0067 | 0.1441 | 1 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0119 | 0.0119 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0067 | 0.1441 | 0.1441 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0015 | 0.0119 | 0.0119 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0067 | 0.1441 | 0.1441 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0015 | 0.0119 | 0.0119 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0161 | 0.3841 | 0.3841 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0662 | 0.0662 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | sirtuin 4 | 0.0067 | 0.1441 | 0.1441 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0015 | 0.0119 | 0.0119 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 6 | 0.0067 | 0.1441 | 0.1441 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0067 | 0.1441 | 0.0894 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0067 | 0.1441 | 0.0894 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0161 | 0.3841 | 0.3841 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2022 | 0.2022 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0015 | 0.0119 | 0.0119 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0161 | 0.3841 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0748 | 0.0748 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.009 | 0.2022 | 0.2022 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0067 | 0.1441 | 0.1441 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.009 | 0.2022 | 0.2022 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0402 | 1 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0161 | 0.3841 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0402 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0161 | 0.3841 | 0.3447 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0015 | 0.0119 | 0.0119 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.009 | 0.2022 | 0.2022 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 6 | 0.0067 | 0.1441 | 0.1441 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0015 | 0.0119 | 0.0119 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0015 | 0.0119 | 0.0119 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0015 | 0.0119 | 0.5 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0119 | 0.0119 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | transcriptional regulator | 0.0161 | 0.3841 | 0.3841 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0402 | 1 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0015 | 0.0119 | 0.0119 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0067 | 0.1441 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 7 | 0.0067 | 0.1441 | 0.1441 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0119 | 0.0119 |
Toxoplasma gondii | histone deacetylase SIR2-like | 0.0067 | 0.1441 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0015 | 0.0119 | 0.0119 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0067 | 0.1441 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.009 | 0.2022 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0119 | 0.0119 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.8289 | 0.8289 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2022 | 0.2022 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0067 | 0.1441 | 0.1441 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0015 | 0.0119 | 0.0119 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0161 | 0.3841 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0015 | 0.0119 | 0.0119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.