Detailed information for compound 1472044

Basic information

Technical information
  • TDR Targets ID: 1472044
  • Name: (4aS,9bR)-5-(4-fluorophenyl)sulfonyl-2,8-dime thyl-3,4,4a,9b-tetrahydro-1H-pyrido[4,3-b]ind ole
  • MW: 360.446 | Formula: C19H21FN2O2S
  • H donors: 0 H acceptors: 2 LogP: 3.15 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CC[C@H]2[C@@H](C1)c1cc(C)ccc1N2S(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C19H21FN2O2S/c1-13-3-8-18-16(11-13)17-12-21(2)10-9-19(17)22(18)25(23,24)15-6-4-14(20)5-7-15/h3-8,11,17,19H,9-10,12H2,1-2H3/t17-,19-/m0/s1
  • InChiKey: OTLGTGQTFJKEOE-HKUYNNGSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STOCK2S-43794

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0417 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0125 0.0924 0.1332
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0125 0.0924 0.1332
Brugia malayi Nuclear hormone receptor-like 1 0.0125 0.0924 0.1332
Schistosoma mansoni hypothetical protein 0.0234 0.2152 0.2659
Schistosoma mansoni nuclear hormone receptor 0.0059 0.0185 0.0137
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Brugia malayi Uncoordinated protein 44 0.0049 0.0078 0.0113
Echinococcus granulosus lipoxygenase domain containing protein 0.0124 0.0921 0.117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0125 0.0924 0.1233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Onchocerca volvulus Chorion peroxidase homolog 0.0079 0.0417 0.202
Brugia malayi Steroid receptor seven-up type 2 0.0125 0.0924 0.1332
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.014 0.11 0.1489
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0125 0.0924 0.1233
Brugia malayi photoreceptor-specific nuclear receptor 0.0125 0.0924 0.1332
Schistosoma mansoni nuclear receptor 0.0059 0.0185 0.0137
Brugia malayi nuclear hormone receptor family member odr-7 0.0059 0.0185 0.0267
Loa Loa (eye worm) hypothetical protein 0.0125 0.0924 0.1233
Echinococcus multilocularis ecdysone induced protein 78C 0.0125 0.0924 0.1174
Onchocerca volvulus Netrin receptor homolog 0.0049 0.0078 0.038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0125 0.0924 0.1233
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0125 0.0924 0.1085
Echinococcus granulosus Nuclear hormone receptor HR96 0.0059 0.0185 0.0235
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0125 0.0924 0.1085
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0543 0.0678
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.3121 0.4436
Brugia malayi small heat shock protein 0.066 0.6937 1
Echinococcus granulosus RUN 0.0124 0.0921 0.117
Echinococcus granulosus Polycystic kidney disease protein 0.0124 0.0921 0.117
Schistosoma mansoni nuclear receptor nhr-48 0.0059 0.0185 0.0137
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0264 0.0381
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.015 0.0105
Schistosoma mansoni rab6-interacting 0.0124 0.0921 0.1081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0125 0.0924 0.1174
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0066 0.0264 0.0336
Loa Loa (eye worm) hypothetical protein 0.0066 0.0264 0.0271
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Echinococcus multilocularis peroxidasin 0.0079 0.0417 0.0529
Echinococcus granulosus Nuclear hormone receptor HR96 0.0059 0.0185 0.0235
Echinococcus multilocularis netrin receptor unc 5 0.0049 0.0078 0.01
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0059 0.0185 0.0235
Brugia malayi hypothetical protein 0.0066 0.0264 0.0381
Loa Loa (eye worm) tyrosinase 1 0.0091 0.0543 0.0678
Brugia malayi hypothetical protein 0.0059 0.0185 0.0267
Echinococcus granulosus lipoxygenase domain containing protein 0.0124 0.0921 0.117
Echinococcus multilocularis survival motor neuron protein 1 0.0278 0.2644 0.3357
Echinococcus granulosus death domain containing protein 0.0049 0.0078 0.01
Onchocerca volvulus 0.0124 0.0921 0.4465
Brugia malayi Cytochrome P450 family protein 0.0104 0.0692 0.0997
Brugia malayi Death domain containing protein 0.0049 0.0078 0.0113
Schistosoma mansoni nuclear hormone receptor 0.0059 0.0185 0.0137
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0049 0.0078 0.01
Schistosoma mansoni steroid hormone receptor ad4bp 0.0125 0.0924 0.1085
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0252 0.2359 0.2996
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0066 0.0264 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0125 0.0924 0.1332
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0367 1
Brugia malayi hypothetical protein 0.0278 0.2644 0.3811
Schistosoma mansoni rab6-interacting 0.0124 0.0921 0.1081
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0264 0.0381
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0128 0.0163
Loa Loa (eye worm) nuclear hormone receptor 0.0059 0.0185 0.0156
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0128 0.0073
Echinococcus multilocularis Ankyrin 0.005 0.0083 0.0106
Loa Loa (eye worm) hypothetical protein 0.0124 0.0921 0.1229
Brugia malayi nuclear receptor NHR-67 0.0059 0.0185 0.0267
Brugia malayi RNA recognition motif domain containing protein 0.014 0.11 0.1586
Loa Loa (eye worm) hypothetical protein 0.0125 0.0924 0.1233
Schistosoma mansoni loxhd1 0.0124 0.0921 0.1081
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0417 0.202
Schistosoma mansoni hypothetical protein 0.0199 0.1758 0.2154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0128 0.0064
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0059 0.0185 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0125 0.0924 0.1085
Loa Loa (eye worm) TAR-binding protein 0.014 0.11 0.1489
Loa Loa (eye worm) hypothetical protein 0.0125 0.0924 0.1233
Echinococcus multilocularis lipoxygenase domain containing protein 0.0124 0.0921 0.117
Loa Loa (eye worm) nuclear receptor NHR-67 0.0059 0.0185 0.0156
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Loa Loa (eye worm) hypothetical protein 0.0125 0.0924 0.1233
Schistosoma mansoni survival motor neuron protein 0.0057 0.0161 0.0106
Echinococcus granulosus Ankyrin 0.005 0.0083 0.0106
Echinococcus multilocularis Polycystic kidney disease protein 0.0124 0.0921 0.117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0125 0.0924 0.1174
Loa Loa (eye worm) hypothetical protein 0.0066 0.0264 0.0271
Schistosoma mansoni tar DNA-binding protein 0.014 0.11 0.131
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0125 0.0924 0.1332
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0125 0.0924 0.1174
Schistosoma mansoni zinc finger protein 0.0059 0.0185 0.0137
Brugia malayi Protein kinase domain containing protein 0.0049 0.0078 0.0113
Leishmania major cathepsin L-like protease 0.0075 0.0367 1
Schistosoma mansoni retinoic acid receptor RXR 0.024 0.2225 0.2752
Loa Loa (eye worm) hypothetical protein 0.008 0.0424 0.0503
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0195 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0125 0.0924 0.1332
Echinococcus multilocularis FTZ F1 alpha 0.0125 0.0924 0.1174
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0049 0.0078 0.01
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0125 0.0924 0.1332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Schistosoma mansoni single-minded 0.0057 0.0167 0.0113
Echinococcus multilocularis tar DNA binding protein 0.014 0.11 0.1396
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0059 0.0185 0.0235
Brugia malayi conserved hypotetical protein 0.0059 0.0185 0.0267
Loa Loa (eye worm) hypothetical protein 0.066 0.6937 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0288 0.2757 0.3501
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0128 0.0064
Loa Loa (eye worm) hypothetical protein 0.0066 0.0264 0.0271
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0059 0.0185 0.0235
Onchocerca volvulus 0.0124 0.0921 0.4465
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0059 0.0185 0.0267
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0125 0.0924 0.1174
Onchocerca volvulus 0.0226 0.2063 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0125 0.0924 0.1332
Schistosoma mansoni lipoxygenase 0.0743 0.7876 1
Brugia malayi bZIP transcription factor family protein 0.0288 0.2757 0.3974
Echinococcus granulosus FTZ F1 alpha 0.0125 0.0924 0.1174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0125 0.0924 0.1174
Schistosoma mansoni tar DNA-binding protein 0.014 0.11 0.131
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0294 0.5946
Leishmania major cathepsin L-like protease 0.0075 0.0367 1
Echinococcus granulosus peroxidasin 0.0079 0.0417 0.0529
Brugia malayi nuclear receptor RXR 0.0066 0.0264 0.0381
Brugia malayi hypothetical protein 0.0124 0.0921 0.1328
Loa Loa (eye worm) hypothetical protein 0.0066 0.0264 0.0271
Brugia malayi PAS domain containing protein 0.0057 0.0167 0.024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0125 0.0924 0.1085
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0195 0.0281
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Onchocerca volvulus Peroxidase homolog 0.0079 0.0417 0.202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0125 0.0924 0.1332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0125 0.0924 0.1233
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0417 0.0601
Onchocerca volvulus 0.0079 0.0417 0.202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0128 0.0163
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0743 0.7876 1
Echinococcus granulosus geminin 0.0199 0.1758 0.2232
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0125 0.0924 0.448
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0117 0.084 0.111
Brugia malayi Nuclear hormone receptor E75 0.0059 0.0185 0.0267
Loa Loa (eye worm) blistered cuticle protein 3 0.0079 0.0417 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0059 0.0185 0.0235
Schistosoma mansoni nuclear receptor 0.0059 0.0185 0.0137
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Onchocerca volvulus 0.0059 0.0185 0.0898
Loa Loa (eye worm) hypothetical protein 0.0117 0.084 0.111
Echinococcus multilocularis nuclear receptor nhr 48 0.0059 0.0185 0.0235
Loa Loa (eye worm) hypothetical protein 0.028 0.2669 0.3776
Loa Loa (eye worm) doublecortin family protein 0.0124 0.0921 0.1229
Onchocerca volvulus 0.0125 0.0924 0.448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0125 0.0924 0.1233
Loa Loa (eye worm) DR-78 0.0059 0.0185 0.0156
Schistosoma mansoni nuclear hormone receptor 0.0125 0.0924 0.1085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0125 0.0924 0.1174
Schistosoma mansoni peroxidasin 0.0079 0.0417 0.0434
Loa Loa (eye worm) hypothetical protein 0.0066 0.0264 0.0271
Brugia malayi Blistered cuticle protein 3 0.0079 0.0417 0.0601
Loa Loa (eye worm) hypothetical protein 0.0091 0.0543 0.0678
Brugia malayi MH2 domain containing protein 0.0124 0.092 0.1326
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.092 0.1227
Loa Loa (eye worm) cytochrome P450 family protein 0.0104 0.0692 0.0894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0367 1
Brugia malayi ecdysteroid receptor 0.0125 0.0924 0.1332
Echinococcus multilocularis thyroid hormone receptor alpha 0.0125 0.0924 0.1174
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0417 0.0493
Schistosoma mansoni jun-related protein 0.0234 0.2152 0.2659
Brugia malayi hypothetical protein 0.0192 0.1678 0.2418
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0417 0.0601
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0417 0.0493
Schistosoma mansoni hypothetical protein 0.032 0.3121 0.3902
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0128 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0125 0.0924 0.1332
Brugia malayi ecdysone receptor 0.0059 0.0185 0.0267
Schistosoma mansoni thyroid hormone receptor 0.0125 0.0924 0.1085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0125 0.0924 0.1233
Brugia malayi hypothetical protein 0.0079 0.0417 0.0601
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0543 0.0783
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0059 0.0185 0.0898
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0743 0.7876 1
Echinococcus granulosus survival motor neuron protein 1 0.0278 0.2644 0.3357
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Brugia malayi Peroxidasin 0.0079 0.0417 0.0601
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0288 0.2757 0.3501
Onchocerca volvulus 0.0091 0.0543 0.2634
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.0264 0.0238
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0125 0.0924 0.1332
Brugia malayi Common central domain of tyrosinase family protein 0.0091 0.0543 0.0783
Schistosoma mansoni tar DNA-binding protein 0.014 0.11 0.131
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Brugia malayi hypothetical protein 0.0059 0.0185 0.0267
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.092 0.1227
Brugia malayi tailless protein 0.0059 0.0185 0.0267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0117 0.084 0.121
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0543 0.0783
Echinococcus granulosus nuclear factor of activated T cells 5 0.0252 0.2359 0.2996
Echinococcus multilocularis snurportin 1 0.032 0.3121 0.3963
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0167 0.0113
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0125 0.0924 0.1085
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0417 0.0601
Leishmania major cathepsin L-like protease 0.0075 0.0367 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Brugia malayi nuclear receptor NHR-88 0.0059 0.0185 0.0267
Loa Loa (eye worm) hypothetical protein 0.0091 0.0543 0.0678
Schistosoma mansoni lipoxygenase 0.052 0.5363 0.6777
Brugia malayi steroid hormone receptor 0.0125 0.0924 0.1332
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0417 0.0601
Brugia malayi Calcitonin receptor-like protein seb-1 0.0117 0.084 0.121
Brugia malayi TAR-binding protein 0.014 0.11 0.1586
Onchocerca volvulus 0.0091 0.0543 0.2634
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0543 0.0678
Schistosoma mansoni coup transcription factor 0.0125 0.0924 0.1085
Plasmodium vivax multidomain scavenger receptor, putative 0.0124 0.0921 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0066 0.0264 0.0238
Brugia malayi orphan nuclear receptor NR2E1 0.0059 0.0185 0.0267
Schistosoma mansoni tyrosinase precursor 0.0091 0.0543 0.0596
Onchocerca volvulus 0.0091 0.0543 0.2634
Echinococcus multilocularis jun protein 0.0288 0.2757 0.3501
Schistosoma mansoni thyroid hormone receptor 0.0125 0.0924 0.1085
Onchocerca volvulus Bile acid receptor homolog 0.0125 0.0924 0.448
Loa Loa (eye worm) hypothetical protein 0.0125 0.0924 0.1233
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0125 0.0924 0.1174
Brugia malayi hypoxia-induced factor 1 0.0177 0.1511 0.2178
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0195 0.0248
Onchocerca volvulus 0.0079 0.0417 0.202
Schistosoma mansoni polycystin 1-related 0.0124 0.0921 0.1081
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Loa Loa (eye worm) RNA binding protein 0.014 0.11 0.1489
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0059 0.0185 0.0898
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0125 0.0924 0.1332
Loa Loa (eye worm) steroid hormone receptor 0.0125 0.0924 0.1233
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Onchocerca volvulus Dual oxidase homolog 0.0079 0.0417 0.202
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0066 0.0264 0.0336
Brugia malayi hypothetical protein 0.0226 0.2063 0.2974
Brugia malayi RNA, U transporter 1 0.0085 0.0483 0.0696
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.005 0.0083 0.0006
Schistosoma mansoni hypothetical protein 0.0124 0.0921 0.1081
Onchocerca volvulus Peroxidase homolog 0.0079 0.0417 0.202
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0059 0.0185 0.0156
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Echinococcus multilocularis geminin 0.0199 0.1758 0.2232
Loa Loa (eye worm) hypothetical protein 0.0192 0.1678 0.2332
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0125 0.0924 0.1174
Onchocerca volvulus 0.0091 0.0543 0.2634
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0174 0.1485 0.1886
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0543 0.0783
Schistosoma mansoni ankyrin 23/unc44 0.0049 0.0078 0.000000041142
Brugia malayi RNA binding protein 0.014 0.11 0.1586
Onchocerca volvulus 0.0079 0.0417 0.202
Schistosoma mansoni hypothetical protein 0.008 0.0424 0.0443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0128 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Echinococcus granulosus snurportin 1 0.032 0.3121 0.3963
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0417 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0195 0.015
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0464 0.4736 0.5973
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0417 0.202
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Mycobacterium ulcerans proteasome PrcA 0.0932 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0125 0.0924 0.1085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0125 0.0924 0.1332
Loa Loa (eye worm) hypothetical protein 0.0124 0.0921 0.1229
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0125 0.0924 0.1174
Brugia malayi hypothetical protein 0.0066 0.0264 0.0381
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Schistosoma mansoni tar DNA-binding protein 0.014 0.11 0.131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0125 0.0924 0.1233
Echinococcus granulosus retinoic acid receptor rxr beta a 0.024 0.2225 0.2824
Schistosoma mansoni hypothetical protein 0.0057 0.0161 0.0106
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0417 0.0601
Brugia malayi nuclear receptor RXR 0.0059 0.0185 0.0267
Onchocerca volvulus 0.0059 0.0185 0.0898
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0059 0.0185 0.0235
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Brugia malayi nuclear hormone receptor 0.0059 0.0185 0.0267
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Echinococcus granulosus nuclear receptor nhr 48 0.0059 0.0185 0.0235
Echinococcus granulosus ecdysone induced protein 78C 0.0125 0.0924 0.1174
Echinococcus granulosus thyroid hormone receptor alpha 0.0059 0.0185 0.0235
Schistosoma mansoni tyrosinase precursor 0.0091 0.0543 0.0596
Brugia malayi Nuclear hormone receptor E75 0.0059 0.0185 0.0267
Onchocerca volvulus 0.0057 0.0161 0.0782
Brugia malayi nuclear receptor NHR-88 0.0125 0.0924 0.1332
Echinococcus granulosus netrin receptor unc 5 0.0049 0.0078 0.01
Loa Loa (eye worm) hypothetical protein 0.0278 0.2644 0.374
Echinococcus multilocularis RUN 0.0124 0.0921 0.117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0128 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0059 0.0185 0.0235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0125 0.0924 0.1174
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0424 0.0611
Schistosoma mansoni tar DNA-binding protein 0.014 0.11 0.131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0049 0.0078 0.0113
Loa Loa (eye worm) hypothetical protein 0.0125 0.0924 0.1233
Brugia malayi nuclear hormone receptor family member nhr-6 0.0059 0.0185 0.0267
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0156
Schistosoma mansoni RAR-like nuclear receptor 0.0125 0.0924 0.1085
Loa Loa (eye worm) hypothetical protein 0.0079 0.0417 0.0493
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0195 0.0248
Schistosoma mansoni peroxidasin 0.0079 0.0417 0.0434
Onchocerca volvulus Protein ultraspiracle homolog 0.0125 0.0924 0.448
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0932 1 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0924 0.1233
Brugia malayi nuclear hormone receptor 0.0125 0.0924 0.1332
Plasmodium falciparum LCCL domain-containing protein 0.0124 0.0921 0.5
Brugia malayi hypothetical protein 0.0124 0.0921 0.1328
Echinococcus multilocularis lipoxygenase domain containing protein 0.0124 0.0921 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0125 0.0924 0.1332
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0091 0.0543 0.0783
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0367 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0924 0.1233
Brugia malayi Doublecortin family protein 0.0124 0.0921 0.1328
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0195 0.0195
Loa Loa (eye worm) hypoxia-induced factor 1 0.0177 0.1511 0.2088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0125 0.0924 0.1174
Echinococcus granulosus jun protein 0.0288 0.2757 0.3501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0367 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0367 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0125 0.0924 0.1174
Brugia malayi ShTK domain containing protein 0.0091 0.0543 0.0783
Echinococcus granulosus tar DNA binding protein 0.014 0.11 0.1396
Schistosoma mansoni hypothetical protein 0.0199 0.1758 0.2154
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0161 0.0232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0128 0.0185

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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