Detailed information for compound 1473085

Basic information

Technical information
  • TDR Targets ID: 1473085
  • Name: 2-(4-ethylpiperazin-1-yl)-N-(6-methoxy-1,3-be nzothiazol-2-yl)acetamide
  • MW: 334.436 | Formula: C16H22N4O2S
  • H donors: 1 H acceptors: 2 LogP: 2.11 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)CC(=O)Nc1nc2c(s1)cc(cc2)OC
  • InChi: 1S/C16H22N4O2S/c1-3-19-6-8-20(9-7-19)11-15(21)18-16-17-13-5-4-12(22-2)10-14(13)23-16/h4-5,10H,3,6-9,11H2,1-2H3,(H,17,18,21)
  • InChiKey: ZOZSICPMGAPOKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-ethyl-1-piperazinyl)-N-(6-methoxy-1,3-benzothiazol-2-yl)acetamide
  • 2-(4-ethylpiperazin-1-yl)-N-(6-methoxy-1,3-benzothiazol-2-yl)ethanamide
  • ASN 08240595

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica diacylglycerol kinase, putative 0.0041 0.0322 0.0107
Schistosoma mansoni hypothetical protein 0.0424 0.3945 0.3945
Echinococcus granulosus multidrug resistance associated protein 7 0.003 0.0218 0.0218
Schistosoma mansoni multidrug resistance protein 0.003 0.0218 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0552 0.0552
Leishmania major diacylglycerol kinase, putative 0.0041 0.0322 1
Brugia malayi hypothetical protein 0.0026 0.0174 0.2285
Trypanosoma brucei p-glycoprotein 0.003 0.0218 0.2984
Loa Loa (eye worm) hypothetical protein 0.0082 0.0706 0.069
Echinococcus granulosus cpg binding protein 0.0031 0.0228 0.0228
Trichomonas vaginalis bmru protein, putative 0.0041 0.0322 1
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0067
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0041 0.0322 0.0322
Echinococcus granulosus multidrug resistance associated protein 1 0.003 0.0218 0.0218
Schistosoma mansoni diacylglycerol kinase theta 0.0041 0.0322 0.0322
Mycobacterium tuberculosis Conserved protein 0.1063 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0283 0.0283
Brugia malayi Carboxylesterase family protein 0.0082 0.0706 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0061 0.0061
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0017
Echinococcus granulosus tar DNA binding protein 0.0066 0.0552 0.0552
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0041 0.0322 0.0306
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.003 0.0218 0.0201
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0061 0.0061
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0041 0.0322 0.0322
Entamoeba histolytica diacylglycerol kinase, putative 0.0041 0.0322 0.0107
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0283 0.0283
Echinococcus granulosus dnaJ subfamily B 0.0424 0.3945 0.3945
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.003 0.0218 0.2984
Loa Loa (eye worm) hypothetical protein 0.003 0.0218 0.0201
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0061 0.0061
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.003 0.0218 0.2984
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0229 0.6421
Echinococcus multilocularis Diacylglycerol kinase theta 0.0041 0.0322 0.0322
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0174 0.1318
Brugia malayi Ceramide kinase 0.0041 0.0322 0.4439
Echinococcus multilocularis multidrug resistance associated protein 4 0.0023 0.0151 0.0151
Brugia malayi Eye-specific diacylglycerol kinase 0.0041 0.0322 0.4439
Schistosoma mansoni multidrug resistance protein 0.003 0.0218 0.0218
Plasmodium falciparum diacylglycerol kinase, putative 0.0041 0.0322 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0044
Echinococcus multilocularis cpg binding protein 0.0031 0.0228 0.0228
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0039 0.0039
Trichomonas vaginalis sphingosine kinase, putative 0.0041 0.0322 1
Onchocerca volvulus 0.0041 0.0322 1
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0041 0.0322 1
Brugia malayi TAR-binding protein 0.0066 0.0552 0.777
Plasmodium vivax diacylglycerol kinase, putative 0.0041 0.0322 1
Leishmania major diacylglycerol kinase-like protein 0.0041 0.0322 1
Echinococcus granulosus carboxylesterase 5A 0.0082 0.0706 0.0706
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0067
Plasmodium vivax diacylglycerol kinase, putative 0.0041 0.0322 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0041 0.0322 0.0322
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0229 0.0229
Schistosoma mansoni diacylglycerol kinase theta 0.0041 0.0322 0.0322
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0041 0.0322 0.0322
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0041 0.0322 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.003 0.0218 0.3909
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0552 0.0536
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0157
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0041 0.0322 0.5113
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0041 0.0322 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0017
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0218 0.1526
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.003 0.0218 0.2984
Echinococcus multilocularis sphingosine kinase 1 0.1063 1 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.003 0.0218 0.0218
Echinococcus granulosus caspase 2 0.0032 0.0229 0.0229
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0044
Onchocerca volvulus 0.0032 0.0229 0.6421
Echinococcus multilocularis caspase 2 0.0032 0.0229 0.0229
Echinococcus multilocularis BC026374 protein (S09 family) 0.0014 0.0061 0.0061
Echinococcus granulosus acetylcholinesterase 0.0082 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0082 0.0706 0.069
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0041 0.0322 0.0322
Brugia malayi diacylglycerol kinase 0.0041 0.0322 0.4439
Echinococcus granulosus ceramide kinase 0.0041 0.0322 0.0322
Brugia malayi hypothetical protein 0.0037 0.0283 0.3873
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0044
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0067
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0014 0.0061 0.0061
Leishmania major pentamidine resistance protein 1 0.003 0.0218 0.2984
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0218 0.0201
Schistosoma mansoni cpg binding protein 0.0031 0.0228 0.0228
Toxoplasma gondii diacylglycerol kinase, putative 0.0041 0.0322 0.5113
Trichomonas vaginalis sphingosine kinase, putative 0.0041 0.0322 1
Loa Loa (eye worm) carboxylesterase 0.0082 0.0706 0.069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0229 0.0212
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0039 0.0039
Brugia malayi Carboxylesterase family protein 0.0014 0.0061 0.0652
Mycobacterium ulcerans diacylglycerol kinase 0.0041 0.0322 0.0263
Echinococcus multilocularis neuroligin 0.0014 0.0061 0.0061
Leishmania major hypothetical protein, conserved 0.0041 0.0322 1
Brugia malayi Carboxylesterase family protein 0.0014 0.0061 0.0652
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0552 0.0536
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0014 0.0061 0.0061
Brugia malayi hypothetical protein 0.0017 0.0087 0.1033
Trypanosoma brucei multidrug resistance protein E 0.003 0.0218 0.2984
Echinococcus granulosus Diacylglycerol kinase zeta 0.0041 0.0322 0.0322
Brugia malayi Carboxylesterase family protein 0.0014 0.0061 0.0652
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0044
Trypanosoma cruzi diacylglycerol kinase, putative 0.0041 0.0322 1
Brugia malayi Carboxylesterase family protein 0.0082 0.0706 1
Mycobacterium ulcerans hypothetical protein 0.1063 1 1
Schistosoma mansoni gliotactin 0.0014 0.0061 0.0061
Entamoeba histolytica hypothetical protein, conserved 0.1063 1 1
Loa Loa (eye worm) diacylglycerol kinase 2 0.0041 0.0322 0.0306
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0041 0.0322 0.0322
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0041 0.0322 1
Trichomonas vaginalis bmru protein, putative 0.0041 0.0322 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.003 0.0218 0.0218
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0229
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0528 0.0528
Brugia malayi diacylglycerol kinase 0.0041 0.0322 0.4439
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0044
Echinococcus multilocularis apoptotic protease activating factor 1 0.0032 0.0229 0.0229
Trypanosoma brucei Sphingosine kinase 0.0041 0.0322 1
Loa Loa (eye worm) carboxylesterase 0.0014 0.0061 0.0044
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0041 0.0322 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0552 0.0552
Giardia lamblia MRP-like ABC transporter 0.003 0.0218 1
Onchocerca volvulus 0.003 0.0212 0.5777
Loa Loa (eye worm) hypothetical protein 0.1063 1 1
Brugia malayi hypothetical protein 0.0014 0.0061 0.0652
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0041 0.0322 0.5113
Schistosoma mansoni hypothetical protein 0.0025 0.0166 0.0166
Echinococcus granulosus para nitrobenzyl esterase 0.0014 0.0061 0.0061
Entamoeba histolytica diacylglycerol kinase, putative 0.0041 0.0322 0.0107
Loa Loa (eye worm) hypothetical protein 0.0041 0.0322 0.0306
Schistosoma mansoni multidrug resistance protein 0.003 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0322 1
Echinococcus granulosus multidrug resistance associated protein 4 0.0023 0.0151 0.0151
Schistosoma mansoni multidrug resistance protein 0.003 0.0218 0.0218
Brugia malayi CXXC zinc finger family protein 0.003 0.0212 0.284
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0174 0.1318
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0552 0.0552
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0552 0.0552
Leishmania major ABC-thiol transporter 0.003 0.0218 0.2984
Schistosoma mansoni BC026374 protein (S09 family) 0.0014 0.0061 0.0061
Brugia malayi Cell death protein 3 precursor 0.0032 0.0229 0.3084
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0552 0.777
Trypanosoma brucei multidrug resistance-associated protein, putative 0.003 0.0218 0.2984
Entamoeba histolytica diacylglycerol kinase, putative 0.0041 0.0322 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0322 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0552 0.0536
Leishmania major hypothetical protein, conserved 0.0041 0.0322 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0044
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.0706 0.0706
Loa Loa (eye worm) multidrug resistance-associated protein 0.0024 0.0153 0.0136
Schistosoma mansoni hypothetical protein 0.0037 0.0283 0.0283
Brugia malayi hypothetical protein 0.0041 0.0322 0.4439
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.003 0.0218 0.2984
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0706 0.0706
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0212 0.0195
Trichomonas vaginalis diacylglycerol kinase, putative 0.0041 0.0322 1
Brugia malayi ABC transporter transmembrane region family protein 0.003 0.0218 0.2928
Leishmania major sphingosine kinase A, B, putative 0.0041 0.0322 1
Brugia malayi Diacylglycerol kinase protein 2 0.0041 0.0322 0.4439
Brugia malayi RNA binding protein 0.0066 0.0552 0.777
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0706 0.0706
Schistosoma mansoni sphingosine kinase A B 0.1063 1 1
Trypanosoma brucei diacylglycerol kinase, putative 0.0041 0.0322 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0216 0.0199
Loa Loa (eye worm) hypothetical protein 0.0041 0.0322 0.0306
Schistosoma mansoni neuroligin 3 (S09 family) 0.0014 0.0061 0.0061
Trypanosoma cruzi diacylglycerol kinase, putative 0.0041 0.0322 1
Loa Loa (eye worm) carboxylesterase 0.0014 0.0061 0.0044
Loa Loa (eye worm) ceramide kinase 0.0041 0.0322 0.0306
Trypanosoma brucei multidrug resistance-associated protein, putative 0.003 0.0218 0.2984
Trichomonas vaginalis diacylglycerol kinase, putative 0.0041 0.0322 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0464 1
Onchocerca volvulus Ceramide kinase 1 homolog 0.0041 0.0322 1
Brugia malayi Carboxylesterase family protein 0.0014 0.0061 0.0652
Schistosoma mansoni cpg binding protein 0.003 0.0212 0.0212
Schistosoma mansoni acetylcholinesterase 0.0014 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0012 0.0039 0.0039
Brugia malayi hypothetical protein 0.0032 0.0229 0.3084
Mycobacterium tuberculosis Diacylglycerol kinase 0.0041 0.0322 0.0263
Echinococcus granulosus apoptotic protease activating factor 1 0.0032 0.0229 0.0229
Echinococcus granulosus BC026374 protein S09 family 0.0014 0.0061 0.0061
Echinococcus multilocularis ceramide kinase 0.0041 0.0322 0.0322
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0041 0.0322 1
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.3945 0.3945
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0218 1
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0041 0.0322 0.0306
Loa Loa (eye worm) hypothetical protein 0.0032 0.0229 0.0212
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0041 0.0322 1
Plasmodium falciparum diacylglycerol kinase, putative 0.0041 0.0322 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0552 0.0552
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.003 0.0218 0.3909
Trypanosoma cruzi Sphingosine kinase 0.0041 0.0322 1
Leishmania major p-glycoprotein e 0.003 0.0218 0.2984
Echinococcus multilocularis para nitrobenzyl esterase 0.0014 0.0061 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0552 0.0552
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.0706 0.069
Echinococcus granulosus neuroligin 0.0014 0.0061 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0283 0.0283
Trypanosoma cruzi multidrug resistance protein E, putative 0.003 0.0218 0.3909
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0322 1
Trypanosoma cruzi Sphingosine kinase 0.0041 0.0322 1
Brugia malayi multidrug resistance related protein 1 0.003 0.0218 0.2928
Schistosoma mansoni hypothetical protein 0.0041 0.0322 0.0322
Giardia lamblia ABC transporter, putative 0.003 0.0218 1
Schistosoma mansoni cpg binding protein 0.0031 0.0228 0.0228
Echinococcus granulosus acetylcholinesterase 0.0082 0.0706 0.0706
Schistosoma mansoni sphingoid long chain base kinase 0.1063 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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