Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1897 | 0.1832 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0116 | 0.1533 | 0.1533 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0075 | 0.097 | 0.0924 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0075 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0142 | 0.1897 | 0.1834 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0142 | 0.1897 | 0.1856 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0067 | 0.0859 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.097 | 0.0897 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0116 | 0.1533 | 0.1466 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.041 | 0.041 |
Brugia malayi | ecdysteroid receptor | 0.0142 | 0.1897 | 0.1834 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0142 | 0.1897 | 0.1856 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1533 | 0.1466 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0142 | 0.1897 | 0.1832 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0116 | 0.1533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.097 | 0.0897 |
Brugia malayi | nuclear hormone receptor | 0.0142 | 0.1897 | 0.1834 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0142 | 0.1897 | 0.1832 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0142 | 0.1897 | 0.1897 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1897 | 0.1832 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0142 | 0.1897 | 0.1856 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0067 | 0.0859 | 0.0859 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0142 | 0.1897 | 0.1834 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0729 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0067 | 0.0859 | 0.0787 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0142 | 0.1897 | 0.1897 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0142 | 0.1897 | 0.1856 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.1897 | 0.1856 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0067 | 0.0859 | 0.0467 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0142 | 0.1897 | 0.1897 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0142 | 0.1897 | 0.1856 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0067 | 0.0859 | 0.0812 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0142 | 0.1897 | 0.1834 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0142 | 0.1897 | 0.155 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0142 | 0.1897 | 0.1834 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0142 | 0.1897 | 0.155 |
Brugia malayi | nuclear receptor RXR | 0.0075 | 0.097 | 0.0899 |
Brugia malayi | nuclear receptor NHR-88 | 0.0142 | 0.1897 | 0.1834 |
Brugia malayi | nuclear receptor RXR | 0.0067 | 0.0859 | 0.0787 |
Schistosoma mansoni | nuclear hormone receptor | 0.0067 | 0.0859 | 0.0859 |
Schistosoma mansoni | nuclear receptor | 0.0067 | 0.0859 | 0.0859 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.097 | 0.0899 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0067 | 0.0859 | 0.0812 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.6756 | 0.674 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0075 | 0.097 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.097 | 0.0897 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0116 | 0.1533 | 0.1533 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.041 | 0.0334 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0067 | 0.0859 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0142 | 0.1897 | 0.1856 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0438 | 0.0389 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0142 | 0.1897 | 0.1856 |
Schistosoma mansoni | nuclear hormone receptor | 0.0142 | 0.1897 | 0.1897 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0067 | 0.0859 | 0.0812 |
Brugia malayi | nuclear receptor NHR-67 | 0.0067 | 0.0859 | 0.0787 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0142 | 0.1897 | 0.1897 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0142 | 0.1897 | 0.1897 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0859 | 0.0787 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0142 | 0.1897 | 0.1856 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1897 | 0.1832 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0142 | 0.1897 | 0.1856 |
Brugia malayi | nuclear hormone receptor | 0.0067 | 0.0859 | 0.0787 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0116 | 0.1533 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0116 | 0.1533 | 0.1491 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0142 | 0.1897 | 0.1832 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0142 | 0.1897 | 0.1897 |
Loa Loa (eye worm) | hypothetical protein | 0.0729 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0142 | 0.1897 | 0.1856 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0142 | 0.1897 | 0.1834 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0859 | 0.0787 |
Brugia malayi | FXNA | 0.0116 | 0.1533 | 0.1467 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0142 | 0.1897 | 0.1832 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0067 | 0.0859 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0142 | 0.1897 | 0.1834 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0116 | 0.1533 | 0.1491 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0142 | 0.1897 | 0.1832 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0729 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0142 | 0.1897 | 0.1856 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1533 | 0.1466 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1897 | 0.1832 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.097 | 0.0897 |
Brugia malayi | tailless protein | 0.0067 | 0.0859 | 0.0787 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0142 | 0.1897 | 0.1834 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0116 | 0.1533 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.097 | 0.0897 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0067 | 0.0859 | 0.0812 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0729 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.6756 | 0.6756 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0729 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0067 | 0.0859 | 0.0812 |
Onchocerca volvulus | 0.0142 | 0.1897 | 0.155 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0142 | 0.1897 | 0.155 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.008 | 0.0029 |
Leishmania major | glutaminyl cyclase, putative | 0.0116 | 0.1533 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0067 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0142 | 0.1897 | 0.1832 |
Leishmania major | hypothetical protein, conserved | 0.0116 | 0.1533 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0116 | 0.1533 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0142 | 0.1897 | 0.1897 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1533 | 0.1466 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0142 | 0.1897 | 0.1897 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0116 | 0.1533 | 0.1533 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.097 | 0.0899 |
Onchocerca volvulus | 0.0116 | 0.1533 | 0.1171 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0142 | 0.1897 | 0.1856 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0067 | 0.0859 | 0.0787 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0067 | 0.0859 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0142 | 0.1897 | 0.1834 |
Brugia malayi | steroid hormone receptor | 0.0142 | 0.1897 | 0.1834 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0067 | 0.0859 | 0.0859 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0067 | 0.0859 | 0.0787 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0116 | 0.1533 | 0.1491 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0438 | 0.0438 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0116 | 0.1533 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0142 | 0.1897 | 0.1834 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0067 | 0.0859 | 0.0785 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.1897 | 0.1897 |
Onchocerca volvulus | 0.0067 | 0.0859 | 0.0467 | |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0142 | 0.1897 | 0.1856 |
Brugia malayi | ecdysone receptor | 0.0067 | 0.0859 | 0.0787 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0116 | 0.1533 | 0.5 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0067 | 0.0859 | 0.0787 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0142 | 0.1897 | 0.1832 |
Brugia malayi | hypothetical protein | 0.0075 | 0.097 | 0.0899 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0116 | 0.1533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1897 | 0.1832 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0948 | 0.0948 |
Brugia malayi | conserved hypotetical protein | 0.0067 | 0.0859 | 0.0787 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0075 | 0.097 | 0.0897 |
Schistosoma mansoni | nicalin (M28 family) | 0.0116 | 0.1533 | 0.1533 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.008 | 0.0029 |
Schistosoma mansoni | nuclear hormone receptor | 0.0067 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0142 | 0.1897 | 0.1856 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0116 | 0.1533 | 0.1171 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0438 | 0.0438 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0067 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1897 | 0.1832 |
Brugia malayi | hypothetical protein | 0.0075 | 0.097 | 0.0899 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0116 | 0.1533 | 0.1171 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1533 | 0.1466 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.005 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1897 | 0.1832 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0142 | 0.1897 | 0.1834 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0142 | 0.1897 | 0.1834 |
Mycobacterium tuberculosis | Conserved protein | 0.0116 | 0.1533 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0067 | 0.0859 | 0.0787 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0142 | 0.1897 | 0.1832 |
Brugia malayi | leucyl aminopeptidase | 0.0116 | 0.1533 | 0.1467 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0067 | 0.0859 | 0.0787 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0067 | 0.0859 | 0.0787 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0142 | 0.1897 | 0.1856 |
Schistosoma mansoni | nuclear receptor | 0.0067 | 0.0859 | 0.0859 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0116 | 0.1533 | 0.1491 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.1897 | 0.1897 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.6756 | 0.674 |
Mycobacterium ulcerans | hypothetical protein | 0.0116 | 0.1533 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0116 | 0.1533 | 0.1491 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0116 | 0.1533 | 0.5 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0067 | 0.0859 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0116 | 0.1533 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0067 | 0.0859 | 0.0812 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0438 | 0.0389 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0142 | 0.1897 | 0.1834 |
Schistosoma mansoni | coup transcription factor | 0.0142 | 0.1897 | 0.1897 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0067 | 0.0859 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Toxoplasma gondii | hypothetical protein | 0.0116 | 0.1533 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0142 | 0.1897 | 0.1834 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0142 | 0.1897 | 0.1834 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0075 | 0.097 | 0.0924 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0067 | 0.0859 | 0.0812 |
Loa Loa (eye worm) | DR-78 | 0.0067 | 0.0859 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1897 | 0.1832 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0116 | 0.1533 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0116 | 0.1533 | 0.1171 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.041 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0859 | 0.0785 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0142 | 0.1897 | 0.1856 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0067 | 0.0859 | 0.0812 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0142 | 0.1897 | 0.1897 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0142 | 0.1897 | 0.1834 |
Brugia malayi | nicalin | 0.0116 | 0.1533 | 0.1467 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0067 | 0.0859 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0142 | 0.1897 | 0.1834 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0142 | 0.1897 | 0.1856 |
Onchocerca volvulus | 0.0067 | 0.0859 | 0.0467 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.