Detailed information for compound 1482871

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 447.528 | Formula: C22H33N5O5
  • H donors: 3 H acceptors: 4 LogP: 2.57 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(c1c(=O)[nH]c(=O)n(c1N)CCCC)C(=O)c1[nH]c(c(c1C)C(=O)OCC)C
  • InChi: 1S/C22H33N5O5/c1-6-9-11-26(17-18(23)27(12-10-7-2)22(31)25-19(17)28)20(29)16-13(4)15(14(5)24-16)21(30)32-8-3/h24H,6-12,23H2,1-5H3,(H,25,28,31)
  • InChiKey: QXNDJDZTBNYZRA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0003 0.01 0.1503
Schistosoma mansoni hypothetical protein 0.0205 0.7932 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.3642 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0003 0.01 0.1503
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0003 0.01 0.01
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.001 0.036 0.1027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0003 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0003 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0009 0.0326 0.4003
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0003 0.01 0.0265
Echinococcus multilocularis liprin beta 1 0.0006 0.0189 0.0189
Echinococcus granulosus Ankyrin 0.0001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.1874 0.5142
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0189 0.284
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0009 0.0326 0.0407
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0664 0.1816
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0009 0.0326 0.0886
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0664 0.0664
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0003 0.01 0.1503
Echinococcus granulosus stromal interaction molecule 1 0.0006 0.0189 0.0189
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0664 0.0664
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0003 0.01 0.1503
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0009 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0205 0.7932 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0007 0.0225 0.0639
Brugia malayi WGR domain containing protein 0.0009 0.0326 0.0895
Brugia malayi FAT domain containing protein 0.0008 0.027 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0189 0.0509
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0003 0.01 0.01
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.036 0.0987
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0003 0.01 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.009 0.3475 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0326 0.0886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0003 0.01 0.1503
Loa Loa (eye worm) hypothetical protein 0.0094 0.3642 1
Giardia lamblia Hypothetical protein 0.0003 0.01 0.1462
Echinococcus granulosus poly ADP ribose polymerase 1 0.0009 0.0326 0.0326
Trichomonas vaginalis protein phosphatase 1 regulatory subunit 12C, putative 0.0001 0.0003 0.0048
Schistosoma mansoni hypothetical protein 0.0003 0.01 0.0122
Brugia malayi coiled-coil like protein 1 0.0006 0.0189 0.0518
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0003 0.01 0.0122
Entamoeba histolytica protein kinase rad3, putative 0.001 0.036 0.4601
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0003 0.01 0.01
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0009 0.0326 0.0929
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0006 0.0189 0.0234
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0003 0.01 0.1503
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.3642 1
Echinococcus multilocularis stromal interaction molecule 1 0.0006 0.0189 0.0189
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0006 0.0189 0.0509
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0664 0.1905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0003 0.01 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0003 0.01 0.1503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.001 0.036 0.539
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0003 0.01 0.0278
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0008 0.027 0.027
Schistosoma mansoni tankyrase 0.0065 0.2493 0.314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Brugia malayi WGR domain containing protein 0.0009 0.0326 0.0895
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.3642 1
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0009 0.0326 0.0929
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.1232 0.3196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0003 0.01 0.0265
Echinococcus multilocularis Zinc finger, PHD finger 0.0003 0.01 0.01
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0001 0.0003 0.0048
Schistosoma mansoni lip-related protein (liprin) alpha 0.0006 0.0189 0.0234
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0258 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0003 0.01 0.1503
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0003 0.0048
Toxoplasma gondii FATC domain-containing protein 0.001 0.036 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.3642 0.5
Leishmania major phosphatidylinositol 4-kinase, putative 0.0003 0.01 0.0268
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0003 0.01 0.0274
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0003 0.01 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.036 0.5412
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0003 0.01 0.0274
Echinococcus granulosus liprin alpha 2 0.0006 0.0189 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.036 0.5412
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0003 0.01 0.1462
Loa Loa (eye worm) hypothetical protein 0.0008 0.027 0.0733
Echinococcus multilocularis tankyrase 0.0065 0.2489 0.2489
Entamoeba histolytica hypothetical protein 0.0009 0.0326 0.4003
Entamoeba histolytica hypothetical protein 0.0009 0.0326 0.4003
Brugia malayi Neurabin protein 1 0.0006 0.0189 0.0518
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0003 0.0048
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.2375 1
Echinococcus multilocularis SAM domain containing protein 0.0006 0.0189 0.0189
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0003 0.01 0.1503
Schistosoma mansoni sarm1 0.0006 0.0189 0.0234
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.2375 0.2375
Loa Loa (eye worm) hypothetical protein 0.0003 0.01 0.0265
Onchocerca volvulus Tankyrase homolog 0.0058 0.2231 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0006 0.0189 0.0251
Loa Loa (eye worm) tnks protein 0.0059 0.2269 0.6227
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0664 0.1816
Plasmodium falciparum tyrosine kinase-like protein 0.0006 0.0189 0.0251
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.3642 0.5
Leishmania major phosphatidylinositol kinase related protein, putative 0.0003 0.01 0.0268
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0664 0.1834
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0189 0.284
Echinococcus granulosus serine protein kinase ATM 0.001 0.036 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0189 0.284
Echinococcus granulosus SAM domain containing protein 0.0006 0.0189 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trichomonas vaginalis ankyrin, putative 0.0001 0.0003 0.0048
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0003 0.01 0.01
Leishmania major hypothetical protein, unknown function 0.0003 0.01 0.0268
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0664 1
Echinococcus granulosus tankyrase 0.0065 0.2489 0.2489
Trichomonas vaginalis unc-44 ankyrins, putative 0.0001 0.0003 0.0048
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0006 0.0189 0.0251
Echinococcus granulosus liprin beta 1 0.0006 0.0189 0.0189
Plasmodium falciparum protein kinase, putative 0.0006 0.0189 0.0251
Trichomonas vaginalis ankyrin, putative 0.0001 0.0004 0.0053
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0664 0.1594
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0664 0.1905
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0001 0.002 0.0301
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0664 0.0834
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0009 0.0326 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.036 0.5412
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.2375 0.2375
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0664 0.1834
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.036 0.045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0003 0.01 0.0274
Echinococcus multilocularis serine protein kinase ATM 0.001 0.036 0.036
Loa Loa (eye worm) phosphatidylinositol 3 0.0003 0.01 0.0265
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0664 0.1905
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0004 0.0053
Leishmania major phosphatidylinositol 3-kinase, putative 0.0003 0.01 0.0268
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0003 0.01 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0225 0.3388
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0003 0.01 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0003 0.01 0.1503
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0003 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.027 0.4066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.036 0.0987
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0003 0.01 0.0268
Entamoeba histolytica hypothetical protein 0.0009 0.0326 0.4003
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.002 0.0306
Echinococcus multilocularis Ankyrin 0.0001 0.0004 0.0004
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0003 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.036 0.036
Loa Loa (eye worm) phosphatidylinositol kinase 0.0003 0.01 0.0265
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0001 0.0003 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0003 0.01 0.0278
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0664 0.1824
Entamoeba histolytica hypothetical protein 0.001 0.036 0.4601
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0003 0.01 0.1503
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0003 0.01 0.0278
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.1232 0.3196
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0003 0.0048
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0664 0.0834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.3642 1
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0009 0.0326 0.0407
Schistosoma mansoni hypothetical protein 0.0006 0.0189 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0405 0.609
Brugia malayi Tnks protein 0.0065 0.2478 0.6805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0001 0.0003 0.0048
Echinococcus multilocularis liprin alpha 2 0.0006 0.0189 0.0189
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.001 0.036 0.4601
Schistosoma mansoni hypothetical protein 0.0008 0.027 0.0337
Echinococcus multilocularis 0.0003 0.01 0.01
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0006 0.0189 0.0518
Entamoeba histolytica zinc finger protein, putative 0.0009 0.0326 0.4003
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.3642 0.5
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0664 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.3642 1
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0009 0.0326 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.036 0.5412
Trichomonas vaginalis ion channel nompc, putative 0.0001 0.0003 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0009 0.0326 0.4003
Toxoplasma gondii hypothetical protein 0.0033 0.1232 0.3196
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0664 0.1834
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0405 0.6071
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.036 0.5412
Leishmania major phosphatidylinositol kinase, putative 0.0003 0.01 0.0268
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0664 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0003 0.01 0.0265
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0006 0.0189 0.0189
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0003 0.01 0.01
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0664 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0009 0.0326 0.0638
Schistosoma mansoni hypothetical protein 0.0006 0.0189 0.0234
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.2375 1
Loa Loa (eye worm) hypothetical protein 0.0003 0.01 0.0265
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0003 0.0048
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.3642 0.3642
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.036 0.5412
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0003 0.01 0.1462
Schistosoma mansoni hypothetical protein 0.0006 0.0189 0.0234
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0003 0.01 0.1462
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.036 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.036 0.5412
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0003 0.01 0.0278
Loa Loa (eye worm) hypothetical protein 0.0006 0.0189 0.0509
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0003 0.0048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0664 0.1824
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0003 0.01 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0189 0.0509
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0664 0.1834
Echinococcus granulosus Sterile alpha motif SAM 0.0006 0.0189 0.0189
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0664 0.0664
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0003 0.01 0.1462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Echinococcus granulosus geminin 0.0205 0.7932 0.7932
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0003 0.01 0.0278
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0664 0.1905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0003 0.01 0.1462
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0003 0.01 0.1503
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.001 0.036 0.1027
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0003 0.01 0.0122
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0008 0.027 0.027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0003 0.01 0.0274
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0003 0.01 0.0278
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0003 0.01 0.1503
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.3642 0.4589
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0003 0.01 0.0274
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0003 0.01 0.0274
Loa Loa (eye worm) hypothetical protein 0.0006 0.0189 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0405 0.609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trypanosoma brucei poly(adp-ribose) polymerase 0.0009 0.0326 0.4879
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0664 0.1834
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.3642 1
Onchocerca volvulus 0.0006 0.0189 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0003 0.0048
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0001 0.0003 0.0003
Giardia lamblia GTOR 0.0018 0.0664 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.1232 0.3196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0225 0.3388
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0003 0.01 0.1462
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0003 0.01 0.1503
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0664 0.1905
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0006 0.0189 0.0189
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0003 0.01 0.0278
Leishmania major hypothetical protein, conserved 0.0094 0.361 1
Schistosoma mansoni hypothetical protein 0.0006 0.0189 0.0234
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.2375 0.6424
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0002 0.0024 0.036
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.3642 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.001 0.036 0.045
Loa Loa (eye worm) hypothetical protein 0.001 0.036 0.0979
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0006 0.0189 0.284
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0003 0.01 0.01
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0001 0.0003 0.0048
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0003 0.01 0.0122
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.3642 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0405 0.0861
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0003 0.01 0.0122
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0003 0.01 0.1462
Loa Loa (eye worm) hypothetical protein 0.0007 0.0225 0.0609
Brugia malayi Probable ClpP-like protease 0.0094 0.3642 1
Brugia malayi Liprin-alpha 2 0.0006 0.0189 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Brugia malayi hypothetical protein 0.0006 0.0189 0.0518
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0006 0.0189 0.0509
Brugia malayi Patatin-like phospholipase family protein 0.0001 0.0003 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0003 0.01 0.0122
Loa Loa (eye worm) phosphatidylinositol 3 0.0003 0.01 0.0265
Brugia malayi hypothetical protein 0.0006 0.0189 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0003 0.01 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.036 0.5412
Loa Loa (eye worm) phosphatidylinositol 3 0.0003 0.01 0.0265
Trichomonas vaginalis unc-44 ankyrins, putative 0.0001 0.0003 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0189 0.284
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0003 0.01 0.1462
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0001 0.0003 0.0048
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0001 0.0003 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0001 0.0003 0.0003
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0003 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.0011 0.0405 0.1102
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0003 0.01 0.1503
Echinococcus multilocularis geminin 0.0205 0.7932 0.7932
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0003 0.01 0.1503
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0326 0.4904
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0003 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Echinococcus granulosus poly adp ribose polymerase 2 0.0009 0.0326 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0664 1
Onchocerca volvulus 0.0006 0.0189 0.0417

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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